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Receptor
PDB id Resolution Class Description Source Keywords
2G77 2.26 Å EC: 3.-.-.- CRYSTAL STRUCTURE OF GYP1 TBC DOMAIN IN COMPLEX WITH RAB33 GTPASE BOUND TO GDP AND ALF3 SACCHAROMYCES CEREVISIAE PROTEIN TRANSPORT GYP1 TBC DOMAIN RAB33 VESICULAR TRAFFICKING HYDROLASE ACTIVATOR/PROTEIN TRANSPORT COMPLEX
Ref.: TBC-DOMAIN GAPS FOR RAB GTPASES ACCELERATE GTP HYDROLYSIS BY A DUAL-FINGER MECHANISM. NATURE V. 442 303 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AF3 B:502;
Valid;
none;
submit data
83.977 Al F3 F[Al]...
GDP B:501;
Valid;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
MG B:503;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2G77 2.26 Å EC: 3.-.-.- CRYSTAL STRUCTURE OF GYP1 TBC DOMAIN IN COMPLEX WITH RAB33 GTPASE BOUND TO GDP AND ALF3 SACCHAROMYCES CEREVISIAE PROTEIN TRANSPORT GYP1 TBC DOMAIN RAB33 VESICULAR TRAFFICKING HYDROLASE ACTIVATOR/PROTEIN TRANSPORT COMPLEX
Ref.: TBC-DOMAIN GAPS FOR RAB GTPASES ACCELERATE GTP HYDROLYSIS BY A DUAL-FINGER MECHANISM. NATURE V. 442 303 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 2G77 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2G77 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 2G77 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AF3; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 AF3 1 1
Ligand no: 2; Ligand: GDP; Similar ligands found: 161
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 9GM 0.839506 0.973684
6 GNP 0.839506 0.973684
7 G 0.828947 0.986486
8 5GP 0.828947 0.986486
9 G1R 0.82716 0.986667
10 GCP 0.82716 0.973684
11 GSP 0.817073 0.948718
12 GAV 0.797619 0.961039
13 GMV 0.792683 0.973684
14 G2P 0.77381 0.961039
15 G2R 0.770115 0.961039
16 GP2 0.756098 0.961039
17 GDC 0.747253 0.961039
18 GKE 0.747253 0.961039
19 GDD 0.747253 0.961039
20 GPG 0.741573 0.961039
21 G3D 0.732558 0.986486
22 ALF 5GP 0.729412 0.888889
23 Y9Z 0.728261 0.902439
24 G5P 0.723404 0.973684
25 GFB 0.72043 0.961039
26 GTG 0.72043 0.936709
27 GDR 0.72043 0.961039
28 G4P 0.715909 0.986486
29 G3A 0.712766 0.973684
30 6CK 0.712766 0.936709
31 GDP AF3 0.7 0.888889
32 ALF GDP 0.7 0.888889
33 GDP ALF 0.7 0.888889
34 YGP 0.698925 0.901235
35 GKD 0.697917 0.961039
36 JB2 0.697917 0.961039
37 GDX 0.690722 0.973684
38 GPD 0.690722 0.925
39 GMP 0.684211 0.88
40 0O2 0.666667 0.986486
41 JB3 0.656863 0.948718
42 NGD 0.650485 0.961039
43 DGI 0.636364 0.923077
44 GDP 7MG 0.636364 0.911392
45 U2G 0.634615 0.936709
46 GPX 0.634409 0.946667
47 G G 0.632653 0.948052
48 IDP 0.632184 0.972973
49 2MD 0.632075 0.891566
50 CAG 0.62963 0.880952
51 CG2 0.622642 0.936709
52 FEG 0.619048 0.879518
53 MGD 0.614679 0.891566
54 ZGP 0.613208 0.869048
55 GH3 0.612903 0.973333
56 3GP 0.611765 0.946667
57 MD1 0.607143 0.891566
58 PGD 0.59292 0.925
59 DGT 0.591398 0.923077
60 BGO 0.588785 0.924051
61 TPG 0.582609 0.840909
62 DBG 0.582609 0.948718
63 2GP 0.574713 0.96
64 FE9 0.570175 0.776596
65 GCP G 0.56 0.921053
66 A G 0.553571 0.935065
67 G A A A 0.553571 0.923077
68 MGP 0.553191 0.961039
69 U A G G 0.548673 0.935065
70 G4M 0.548387 0.880952
71 6G0 0.547368 0.961039
72 G1R G1R 0.542373 0.924051
73 P2G 0.527473 0.883117
74 PGD O 0.525 0.850575
75 ADP 0.522222 0.92
76 R5I 0.520833 0.946667
77 R7I 0.520833 0.946667
78 GGM 0.517544 0.901235
79 DGP 0.516484 0.910256
80 DG 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G U 0.513274 0.9
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 AKW 0.504425 0.890244
86 G C 0.504348 0.9
87 GPC 0.491525 0.879518
88 G7M 0.483871 0.948052
89 6AD 0.479592 0.841463
90 ATP 0.473684 0.92
91 HEJ 0.473684 0.92
92 G2Q 0.471154 0.961039
93 5FA 0.46875 0.92
94 AQP 0.46875 0.92
95 GTA 0.468468 0.936709
96 7DD 0.468085 0.906667
97 G G G RPC 0.466102 0.875
98 SGP 0.463158 0.82716
99 01G 0.462963 0.902439
100 HFD 0.459184 0.873418
101 B4P 0.457447 0.894737
102 AP5 0.457447 0.894737
103 A2D 0.456522 0.894737
104 6YZ 0.455446 0.896104
105 G G G C 0.455285 0.9125
106 5GP 5GP 0.454545 0.883117
107 ANP 0.454545 0.896104
108 ACQ 0.454545 0.896104
109 AT4 0.452632 0.884615
110 A G C C 0.451613 0.911392
111 APC G U 0.45082 0.886076
112 PRT 0.449541 0.959459
113 G U34 0.449153 0.888889
114 DG DG 0.448598 0.865854
115 ITT 0.447917 0.868421
116 BA3 0.446809 0.894737
117 C2E 0.444444 0.921053
118 PCG 0.444444 0.933333
119 35G 0.444444 0.933333
120 MGO 0.441176 0.864198
121 AN2 0.4375 0.907895
122 G C C C 0.4375 0.924051
123 M33 0.43299 0.883117
124 UCG 0.429688 0.911392
125 A G U 0.42963 0.888889
126 ACP 0.428571 0.896104
127 MGQ 0.424528 0.935897
128 AR6 0.424242 0.894737
129 7DT 0.424242 0.906667
130 APR 0.424242 0.894737
131 93A 0.42268 0.833333
132 A4P 0.420168 0.869048
133 G8D 0.42 0.875
134 AD9 0.42 0.896104
135 SAP 0.42 0.873418
136 AGS 0.42 0.873418
137 CA0 0.418367 0.896104
138 ATF 0.417476 0.884615
139 AGO 0.414634 0.888889
140 A G U U 0.414286 0.888889
141 NIA 0.413043 0.82716
142 MGV 0.412844 0.890244
143 TAT 0.411765 0.884615
144 T99 0.411765 0.884615
145 ADQ 0.411215 0.871795
146 A1R 0.411215 0.839506
147 RGT 0.410714 0.909091
148 CGP 0.409836 0.86747
149 C1Z 0.409091 0.986486
150 A 0.408602 0.893333
151 AMP 0.408602 0.893333
152 UP5 0.40678 0.873418
153 AMZ 0.406593 0.918919
154 C2R 0.406593 0.906667
155 JBT 0.405882 0.778947
156 A22 0.40566 0.907895
157 25L 0.405405 0.907895
158 ADX 0.40404 0.809524
159 8OD 0.401961 0.946667
160 50T 0.4 0.883117
161 4TC 0.4 0.851852
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2G77; Ligand: GDP; Similar sites found with APoc: 561
This union binding pocket(no: 1) in the query (biounit: 2g77.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 5X40 ACP 1.51515
2 3U6B GDP 1.77665
3 3U6K GDP 1.77665
4 5JBQ GDP 1.77665
5 4G5G GDP 1.77665
6 2BVN GNP 1.78117
7 1D8T GDP 1.78117
8 4ZNL BEF ADP 1.82482
9 1XP8 AGS 1.91257
10 1LVG ADP 2.0202
11 5W75 GDP 2.04082
12 2HCJ GDP 2.08955
13 3FKQ ATP 2.41287
14 4PC3 GDP 2.48227
15 5W76 GDP 2.52525
16 5W7Q GDP 2.52525
17 5M04 GDP 2.52525
18 2RGX AP5 2.52525
19 4P3Y GDP 2.74725
20 4TTQ ATP 2.7907
21 1ION ADP 2.88066
22 1JJV ATP 2.91262
23 3BFV ADP 2.95203
24 3E70 GDP 3.0303
25 1JI0 ATP 3.0303
26 6B4K ANP 3.0303
27 6AIC AMP 3.0303
28 2QZ4 ADP 3.05344
29 2C78 GNP 3.20988
30 5FTB ANP 3.23326
31 5FHD ADP ALF 3.23326
32 2R4V GSH 3.23887
33 1KK1 GNP 3.53535
34 4RD0 GDP 3.53535
35 1QF5 GDP 3.53535
36 1QF5 RPL 3.53535
37 2OG2 MLI 3.53535
38 1P9B GDP 3.53535
39 1YTM ATP 3.53535
40 4IEE AGS 3.53535
41 2O0J ADP 3.53535
42 3BFX A3P 3.53535
43 2ZPT A3P 3.53535
44 1P9B HDA 3.53535
45 1Q19 SSC 3.53535
46 3K5I AIR 3.53535
47 3ITJ CIT 3.5503
48 1W4R TTP 3.58974
49 2DPY ADP 3.65854
50 1XX6 ADP 3.66492
51 2GJ5 VD3 3.7037
52 4PPF FLC 3.71429
53 2ZR9 DTP 3.72493
54 1Y63 ADP 3.80435
55 2WHX ADP 3.90244
56 4R43 GDP 3.90244
57 3LRE ADP 3.94366
58 3B9Q MLI 3.97351
59 1D2E GDP 4.03023
60 1GOJ ADP 4.0404
61 6AU6 GDP 4.0404
62 5TSH ADP 4.0404
63 5TSH ANP 4.0404
64 1XMV ADP 4.0404
65 5WC2 ADP 4.0404
66 2C9O ADP 4.0404
67 5J1J ANP 4.0404
68 5Y6N ADP 4.0404
69 1ZIN AP5 4.0404
70 4NU0 AP5 4.0404
71 3RC3 ANP 4.0404
72 1X8J A3P 4.0404
73 1U0J ADP 4.0404
74 4ZJS 4P0 4.0404
75 5MZN ADP 4.0404
76 1D2N ANP 4.04412
77 4JLV ADP 4.08922
78 1FNN ADP 4.11311
79 5K5Z ANP 4.14013
80 4MKG AP5 4.14747
81 2RCN GDP 4.18994
82 1IN4 ADP 4.19162
83 2FNA ADP 4.20168
84 1TQ4 GDP 4.39024
85 1WDT GTP 4.39024
86 2OZE AGS 4.39024
87 5UIV ADP 4.40529
88 6B8B ADP 4.41767
89 1HTW ADP 4.43038
90 3WY9 GDP 4.54545
91 3WYA GDP 4.54545
92 2W58 ADP 4.54545
93 3DEF GDP 4.54545
94 4PFO ADP 4.54545
95 1LVK MNT BEF 4.54545
96 2CE7 ADP 4.54545
97 3IO3 ADP 4.54545
98 4XGU ADP 4.54545
99 5M7P ADP 4.54545
100 5H68 AGS 4.54545
101 4AUT FAD 4.54545
102 4R2I ANP 4.54545
103 3H86 AP5 4.6875
104 2C77 GNP 4.69136
105 1BO4 COA 4.7619
106 5Z69 AGS 4.83871
107 1T5C ADP 4.87106
108 4DDY DN6 4.94297
109 4KVL PLM 4.99195
110 3BD9 A3P 5
111 3W5J GDP 5.05051
112 5GOE GDP 5.05051
113 5ZXD ATP 5.05051
114 1E2K TMC 5.05051
115 5EXT ADP 5.05051
116 5AK0 8V1 5.05051
117 1NY5 ADP 5.05051
118 1NHX FTB 5.05051
119 1NHX PEP 5.05051
120 2GMV UN8 5.05051
121 2GMV PEP 5.05051
122 1F5N GNP 5.05051
123 1K6M AGS 5.05051
124 6FAA ADP 5.05051
125 4A4Z ANP 5.05051
126 2Z5F A3P 5.05051
127 1G6H ADP 5.05837
128 4MKF AP5 5.06912
129 1OXV ANP 5.09915
130 4IHQ ADP 5.12195
131 4LYA ATP 5.12195
132 2FAH GDP 5.12195
133 3B7G ANP 5.21739
134 2OFW ADX 5.28846
135 1Z6T ADP 5.36585
136 4PJ3 ANP 5.36585
137 3BOS CDP 5.3719
138 3WXM GTP 5.55556
139 4NON GDP 5.55556
140 4TMZ GSP 5.55556
141 4NCN GTP 5.55556
142 3COB ADP 5.55556
143 4P4T GDP 5.55556
144 5L3V GDP 5.55556
145 4FRZ ADP 5.55556
146 5HR5 ADP 5.55556
147 1UJ2 ADP 5.55556
148 1UJ2 C5P 5.55556
149 3P4X ADP 5.55556
150 5ZB0 TYD 5.55556
151 5ZB0 ADP 5.55556
152 3IUY AMP 5.55556
153 1W5T ADP 5.55556
154 1W5T ANP 5.55556
155 1XPJ TLA 5.55556
156 2IYL GDP 5.6338
157 2YOH WMJ 5.71429
158 3QXC ATP 5.78512
159 5BYK A3P 5.79151
160 5BYK OAQ 5.79151
161 1U1I NAD 5.86735
162 2CBZ ATP 5.90717
163 4UXH T5A 5.97826
164 2ORV 4TA 5.98291
165 1S3G AP5 5.99078
166 1SKQ GDP 6.06061
167 5H7J GCP 6.06061
168 1BH2 GSP 6.06061
169 6CRK GDP 6.06061
170 2ODE ALF GDP 6.06061
171 1SVK ALF GDP 6.06061
172 1V8K ANP 6.06061
173 1FP6 ADP 6.06061
174 2OBM ADP 6.06061
175 1OFH ADP 6.06061
176 1G41 ADP 6.06061
177 4YJ1 ADP 6.06061
178 2QG6 NMN 6.06061
179 3DC4 ADP 6.06061
180 3IIJ ADP 6.11111
181 2PEZ DAT 6.14525
182 2PEZ GGZ 6.14525
183 3NHB ADP 6.20915
184 3FYH ADP 6.21118
185 2B8T THM 6.27803
186 2CHT TSA 6.29921
187 4E03 ADP 6.31068
188 5IRN ADP 6.34146
189 3BER AMP 6.34146
190 2WIC GNP 6.36704
191 2QN6 GDP 6.45161
192 3ZQ6 ADP ALF 6.48148
193 3UIE ANP 6.5
194 1NN5 2DT 6.51163
195 1NN5 ANP 6.51163
196 3DKP ADP 6.53061
197 3EZ2 ADP 6.53266
198 1CS4 GSP 6.56566
199 3B5J 12D 6.56566
200 1AKY AP5 6.56566
201 1XKV ATP 6.56566
202 5MVR ADP 6.56566
203 5VGR GDP 6.56566
204 1OS1 ATP 6.56566
205 1OS1 PYR 6.56566
206 3TMK T5A 6.56566
207 3EWA ANP 6.56566
208 3TBK ANP 6.56566
209 1RRC ADP 6.56566
210 5DT6 GLU 6.56566
211 5FG3 GDP 6.58106
212 6A20 ADP 6.58537
213 1GXU 2HP 6.59341
214 4WOP CTP 6.66667
215 5BQ5 ADP BEF 6.87831
216 4J0Q GDP 7.07071
217 1W0J ADP 7.07071
218 3KJI ADP 7.07071
219 1P72 ADP 7.07071
220 4HSE ADP 7.07071
221 2ZPA ADP 7.07071
222 1W0J ADP BEF 7.07071
223 3FVQ ATP 7.07071
224 3QVV A3P 7.07071
225 3QVV 3QV 7.07071
226 2VWT PYR 7.07071
227 5TIV A3P 7.11462
228 5YT0 GDP 7.14286
229 3PQC GDP 7.17949
230 5HCN GCP 7.27969
231 2BIF SIN 7.31707
232 2BIF ANP 7.31707
233 1UKZ ADP 7.38916
234 1KO8 6PG 7.42857
235 1WRA PC 7.46753
236 3MGB PAP 7.52351
237 4PX9 ADP 7.53425
238 3CNL GNP 7.57576
239 1M7G AV2 7.57576
240 4KVA GTP 7.57576
241 1M7G ADX 7.57576
242 1F9V ADP 7.57576
243 1M7G ADP 7.57576
244 5U32 GDP 7.62712
245 1B7T ADP 7.69231
246 1XEX ATP 7.69231
247 1QF9 C5P 7.73196
248 1QF9 ADP 7.73196
249 1QF9 ALF 7.73196
250 2BEK ATP 7.7821
251 4LPS GDP 7.85124
252 2ZE7 DST 7.90514
253 2ZE7 AMP 7.90514
254 2XTZ GSP 8.08081
255 4ZG4 VO4 ADP 8.08081
256 1NJF ADP 8.08081
257 1VKJ A3P 8.08081
258 1NJF AGS 8.08081
259 1L2T ATP 8.08081
260 5WRI A3P 8.08081
261 1Q20 PLO 8.08081
262 1Q20 A3P 8.08081
263 2FSH ANP 8.08081
264 4TMK T5A 8.08081
265 2QQ0 ADP 8.15217
266 2QQ0 TMP 8.15217
267 2QQ0 THM 8.15217
268 2QQ0 ANP 8.15217
269 2J5V PCA 8.17439
270 2GKS ADP 8.29268
271 4CVN ADP 8.37696
272 5GVR LMR 8.54701
273 1RJ9 GCP 8.55263
274 1YRB GDP 8.58586
275 1G7C 5GP 8.58586
276 1G7S GDP 8.58586
277 5L3W GDP 8.58586
278 5L3S GNP 8.58586
279 5G3Y ADP 8.58586
280 2X7I CIT 8.58586
281 1W7J ADP BEF 8.60927
282 1KK8 BEF ADP 8.63309
283 4QM7 GTP 8.77193
284 4ZKD GDP 8.78049
285 5IFS ADP 8.78049
286 2GK6 ADP 8.78049
287 5ZBR ANP 8.8
288 2HF9 GSP 8.84956
289 5MEX SZZ 9.00621
290 5MEX PAP 9.00621
291 4WZA ADP 9.02439
292 4WZA ACP 9.02439
293 4IDN GNP 9.02439
294 3VMF GTP 9.09091
295 2WOJ ADP ALF 9.09091
296 4XVU ATP 9.09091
297 4NE2 SH2 9.09091
298 4NE2 ADP 9.09091
299 2GWH A3P 9.09091
300 4RZ3 ADP 9.15254
301 1SQ5 ADP 9.41558
302 2ZTS ADP 9.56175
303 5BN3 ADP 9.59596
304 4GOX A3P 9.59596
305 4D81 ADP 9.59596
306 3FB4 AP5 9.59596
307 4GBM A3P 9.59596
308 5G41 AP5 9.59596
309 3Q9L ATP 9.59596
310 2AWN ADP 9.59596
311 2ZJ5 ADP 9.59596
312 1NST A3P 9.59596
313 1IXE CIT 9.59596
314 1OE0 TTP 9.59596
315 6H5E ANP 9.59596
316 5K2M ADP 9.59596
317 3W6G FLC 9.59596
318 1H65 GDP 9.62963
319 4Q1A 2XZ 9.64286
320 4Q1A UDP 9.64286
321 5J1S ATP 9.7561
322 4X8O AP5 9.81308
323 4ZDJ UTP 10
324 4BFW ZVW 10.0629
325 4DCT GDP 10.101
326 1X6V ADP 10.101
327 2NCD ADP 10.101
328 4IOK XPO 10.101
329 4IOK ADP 10.101
330 1OYY AGS 10.101
331 1ZUI SKM 10.119
332 3AB3 GDP 10.4972
333 1ZCB GDP 10.4972
334 1J99 AND 10.5802
335 1IWE IMP 10.6061
336 2Q2Y ADP 10.6061
337 2Q2Y MKR 10.6061
338 3A4M ADP 10.6061
339 2IS6 ADP 10.6061
340 2JLR ANP 10.6061
341 2XAU ADP 10.6061
342 3RLF ANP 10.6061
343 5E5U MLI 10.6061
344 1AQU A3P 10.6061
345 1G3M A3P 10.6061
346 1G3M PCQ 10.6061
347 2VB6 ADP BEF 10.7383
348 5HWK BEZ 10.8333
349 5XKT GNP 11
350 1BG2 ADP 11.1111
351 4FCW ADP 11.1111
352 2CHG ANP 11.1111
353 4WEI GLC GAL 11.1111
354 4LJ9 ACP 11.1111
355 3QKT ANP 11.2094
356 3FWY ADP 11.6162
357 4YS0 ADP 11.6162
358 4TL6 ANP 11.6162
359 5ZHO A2G GLA FUC 11.7284
360 2KIN ADP 12
361 2VVG ADP 12.1212
362 4YDS ATP 12.1212
363 5I34 GDP 12.1212
364 4YMU ATP 12.1212
365 4QRH 0O2 12.1212
366 4OI4 ATP 12.1739
367 1Z0N BCD 12.5
368 3H4S ADP 12.5926
369 5H7K GDP 12.6263
370 4U00 ADP 12.6263
371 4H1V GNP 12.6263
372 2ZFI ADP 12.6263
373 2D7D ADP 12.6263
374 4B47 GDP 12.6722
375 5N69 ADP 13.0653
376 4QOS ADP 13.2075
377 6FMC DUE 13.2911
378 5IRR GSP 13.3117
379 2CDN ADP 13.4328
380 4XTR ATP 13.5135
381 4XTR ADP 13.5135
382 4HI0 GDP 13.5678
383 3DZD ADP 13.587
384 4BQS ADP 13.6364
385 4BQS K2Q 13.6364
386 1B0U ATP 13.7405
387 3CX8 GSP 13.7931
388 1JJ7 ADP 13.8462
389 3KTA AP5 13.8728
390 2O66 FLC 14.0741
391 3TK1 GDP 14.1414
392 1DAK DPU 14.2857
393 1DAK ADP 14.2857
394 3A1S GDP 14.3411
395 5KDO GDP 14.8649
396 3T34 GDP 15.1515
397 1IHU AF3 15.1515
398 1IHU ADP 15.1515
399 1SVM ATP 15.1515
400 5VHC BEF ADP 15.1515
401 5XDR ADP 15.1515
402 1PUJ GNP 15.6566
403 2XT3 ADP 15.6566
404 5LB3 ADP 15.6566
405 1G3Q ADP 16.0338
406 2PL3 ADP 16.5254
407 5L3R GCP 16.6113
408 1NRJ GTP 16.6667
409 2PZE ATP 16.6667
410 5LTJ ADP 16.6667
411 4WZ6 ATP 16.6667
412 5H67 ATP 17.5
413 5CK5 GDP 17.6768
414 2CK3 ANP 18
415 2CK3 ADP 18
416 5I0H ADP BEF 18.6869
417 1VHT BA3 18.8073
418 1R0X ATP 19.697
419 4R98 GNH 20.6642
420 1MKY GDP 20.7071
421 2Y65 ADP 20.7071
422 3ZIA ATP 21.0145
423 3ZIA ADP 21.0145
424 6C90 ADP 21.1538
425 3ZFD ANP 21.2121
426 1F2U ATP 21.4765
427 1FQJ GDP 21.7687
428 1FQJ ALF 21.7687
429 1UPT GTP 23.3918
430 1Z83 AP5 23.4694
431 3ZS9 ADP ALF 23.6842
432 5KUT GDP 23.8095
433 1CR1 TTP 24.7475
434 1F6B GDP 25.2525
435 3AQ4 GDP 25.5435
436 1DAR GDP 25.7576
437 4M9Q GNP 27.2727
438 2FH5 GTP 27.7778
439 6CS8 F9Y 28.2828
440 5DI3 GNP 28.6486
441 4V03 ADP 28.7879
442 1M2O GNP 28.9474
443 5KSZ GCP 29.798
444 3QF7 ANP 30
445 1YZG GDP 30.1676
446 4BAS GNP 30.303
447 4ZI2 GNP 30.5263
448 4GOJ GNP 30.6878
449 1DS6 GDP 30.7292
450 1E96 GTP 30.7292
451 2WKQ GTP 30.8081
452 5KSP GDP 31.0526
453 1I4D GDP 31.25
454 2WJG GDP 31.383
455 1FZQ GDP 32.0442
456 1MR3 G3D 32.0442
457 2ZEJ GDP 32.0652
458 1MH1 GNP 32.2581
459 3DOE GTP 32.2917
460 1RYH GNP 32.3232
461 1G4U GDP 32.6087
462 3SBD GNP 32.6203
463 2QTV GNP 32.9341
464 2W2X GSP 32.973
465 1ZJ6 G3D 33.1551
466 1KSH GDP 33.3333
467 5WRJ A3P 33.3333
468 1ZD9 GDP 33.5106
469 2FJU GSP 33.7079
470 2J0V GDP 33.8384
471 3T12 GDP ALF 33.8384
472 3T1O GDP 33.8384
473 4OHY ANP 33.8384
474 2X77 GDP 33.8624
475 1HE1 GDP 34.0909
476 4DID GDP 34.8485
477 4YC7 GNP 34.8485
478 2WMO GTP 34.8485
479 1J2J GTP 34.9398
480 1O3Y GTP 34.9398
481 2J59 GTP 34.9398
482 3E5H GNP 35.3933
483 2CJW GDP 35.4167
484 2WJH GDP 35.5422
485 2WJH FLC 35.5422
486 4U5X GNP 35.9551
487 1RE0 GDP 35.9756
488 1S9D GDP 35.9756
489 4V0K GDP 36.0947
490 4ITR GDP 36.1257
491 2GCO GNP 36.3636
492 5JCP GDP ALF 36.3636
493 2GCN GDP 36.3636
494 5UPK GNP 36.8687
495 1M7B GTP 36.9565
496 1GWN GTP 37.0732
497 1Y3A GDP 37.5
498 4YLG GDP 38.7283
499 2OM2 GDP 38.8889
500 5HPY GDP 38.9189
501 2W83 GTP 39.3939
502 4XOI GTP 39.4444
503 4D0N GDP 39.4595
504 3LXR GDP 39.4595
505 6BC0 GSP 39.4595
506 6BCB GSP 39.4595
507 6BCA GSP 39.4595
508 3PCR GTP 39.5062
509 4KAX GTP 39.645
510 2HT6 GDP 39.6552
511 3GJ4 GDP 39.899
512 3GJ7 GDP 39.899
513 3GJ5 GDP 39.899
514 3GJ8 GDP 39.899
515 3GJX GTP 39.899
516 2A5F GTP 40
517 4XSH GSP 40.2235
518 3CH5 GDP 40.404
519 5UWQ GNP 40.404
520 5UWP GNP 40.404
521 5UWO GNP 40.404
522 5UWU GNP 40.404
523 5DIF GNP 40.404
524 4HAT GNP 40.404
525 5UWH GNP 40.404
526 5UWW GNP 40.404
527 6CIT GNP 40.404
528 5UWI GNP 40.404
529 5UWT GNP 40.404
530 5UWR GNP 40.404
531 5DHF GNP 40.404
532 5UWS GNP 40.404
533 3GJ3 GDP 40.404
534 5UWJ GNP 40.404
535 5DI9 GNP 40.404
536 3N5C GDP 40.7407
537 3Q85 GNP 41.4201
538 3M1I GTP 42.4242
539 3WYF GTP 42.4242
540 4DKX GDP 43.9394
541 2V7Q ATP 43.9394
542 2V7Q ADP 43.9394
543 3T5G GDP 44.7514
544 5LEF GTP 45.0262
545 5EE5 GTP 45.0292
546 1WA5 GTP 45.4545
547 6BSX GDP 45.5056
548 6BSX E7S 45.5056
549 3WYG GTP 46.1538
550 5OCG GNP 47.0899
551 3Q72 GNP 47.5904
552 1R4A GNP 47.8788
553 5TB5 GDP 48.1081
554 5TAR GDP 48.1081
555 3BC1 GNP 48.7179
556 1X1R GDP 48.8764
557 1VG0 GDP 48.9899
558 1VG8 GNP 48.9899
559 2Y8E GNP 49.7207
560 2EFE GNH 49.7238
561 5UQW GDP 49.7355
Pocket No.: 2; Query (leader) PDB : 2G77; Ligand: AF3; Similar sites found with APoc: 298
This union binding pocket(no: 2) in the query (biounit: 2g77.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 3C56 PH4 1.62866
2 3U6B GDP 1.77665
3 3U6K GDP 1.77665
4 2BVN GNP 1.78117
5 3IID APR 1.89573
6 1LVG ADP 2.0202
7 5W75 GDP 2.04082
8 4PC3 GDP 2.48227
9 5M04 GDP 2.52525
10 5W76 GDP 2.52525
11 5W7Q GDP 2.52525
12 4P3Y GDP 2.74725
13 6B4K ANP 3.0303
14 6AIC AMP 3.0303
15 2C78 GNP 3.20988
16 5FHD ADP ALF 3.23326
17 3QFU ADP 3.29949
18 5OBU ANP 3.41463
19 4RD0 GDP 3.53535
20 2V7Y ADP 3.53535
21 1YTM ATP 3.53535
22 1H2B NAJ 3.53535
23 1W4R TTP 3.58974
24 4PPF FLC 3.71429
25 2ZR9 DTP 3.72493
26 2WHX ADP 3.90244
27 3LRE ADP 3.94366
28 1D2E GDP 4.03023
29 6AU6 GDP 4.0404
30 1GOJ ADP 4.0404
31 5Y6N ADP 4.0404
32 2ZRU FMN 4.0404
33 3OTI C0T 4.0404
34 5TSH ANP 4.0404
35 5K5Z ANP 4.14013
36 1WDT GTP 4.39024
37 1LVK MNT BEF 4.54545
38 3WY9 GDP 4.54545
39 5LLB 6YZ 4.54545
40 2BLE 5GP 4.63215
41 2C77 GNP 4.69136
42 1T5C ADP 4.87106
43 1F5N GNP 5.05051
44 5AK0 8V1 5.05051
45 1K6M AGS 5.05051
46 1GAR U89 5.05051
47 1OXV ANP 5.09915
48 2FAH GDP 5.12195
49 2OFW ADX 5.28846
50 3WXM GTP 5.55556
51 4NON GDP 5.55556
52 4NCN GTP 5.55556
53 4TMZ GSP 5.55556
54 3COB ADP 5.55556
55 4FRZ ADP 5.55556
56 1UJ2 ADP 5.55556
57 4P4T GDP 5.55556
58 1UJ2 C5P 5.55556
59 3GBR PRP 5.55556
60 5HR5 ADP 5.55556
61 2YOH WMJ 5.71429
62 3QXC ATP 5.78512
63 4UXH T5A 5.97826
64 2ORV 4TA 5.98291
65 1BH2 GSP 6.06061
66 3DC4 ADP 6.06061
67 1V8K ANP 6.06061
68 2QG6 NMN 6.06061
69 2ODE ALF GDP 6.06061
70 1SVK ALF GDP 6.06061
71 6CRK GDP 6.06061
72 2PEZ DAT 6.14525
73 2PEZ GGZ 6.14525
74 2B8T THM 6.27803
75 3BER AMP 6.34146
76 2WIC GNP 6.36704
77 3ZQ6 ADP ALF 6.48148
78 1NN5 2DT 6.51163
79 1NN5 ANP 6.51163
80 1CS4 GSP 6.56566
81 3TMK T5A 6.56566
82 5VGR GDP 6.56566
83 4LWA Q13 6.56566
84 1OS1 ATP 6.56566
85 1OS1 PYR 6.56566
86 3EWA ANP 6.56566
87 4WOP CTP 6.66667
88 3FVQ ATP 7.07071
89 1W0J ADP 7.07071
90 4J0Q GDP 7.07071
91 1A5Z NAD 7.07071
92 5YT0 GDP 7.14286
93 3PQC GDP 7.17949
94 5HCN GCP 7.27969
95 2BIF SIN 7.31707
96 2BIF ANP 7.31707
97 3NRZ FAD 7.56098
98 1M7G ADP 7.57576
99 1M7G ADX 7.57576
100 1M7G AV2 7.57576
101 4KVA GTP 7.57576
102 3CNL GNP 7.57576
103 1B7T ADP 7.69231
104 5WS9 AMP 7.80488
105 2ZE7 DST 7.90514
106 2ZE7 AMP 7.90514
107 2A8X FAD 8.04878
108 2XTZ GSP 8.08081
109 4ZG4 VO4 ADP 8.08081
110 1L2T ATP 8.08081
111 2QQ0 ANP 8.15217
112 2QQ0 THM 8.15217
113 2GKS ADP 8.29268
114 1RJ9 GCP 8.55263
115 1G7S GDP 8.58586
116 1YRB GDP 8.58586
117 5L3S GNP 8.58586
118 1W7J ADP BEF 8.60927
119 1KK8 BEF ADP 8.63309
120 4QM7 GTP 8.77193
121 4ZKD GDP 8.78049
122 5ZBR ANP 8.8
123 2HF9 GSP 8.84956
124 4IDN GNP 9.02439
125 4WZA ACP 9.02439
126 4WZA ADP 9.02439
127 3VMF GTP 9.09091
128 2WOJ ADP ALF 9.09091
129 3WG6 NDP 9.09091
130 4XVU ATP 9.09091
131 1R18 SAH 9.09091
132 1SQ5 ADP 9.41558
133 2ZTS ADP 9.56175
134 2AWN ADP 9.59596
135 1OE0 TTP 9.59596
136 2JAQ DCP 9.7561
137 4X8O AP5 9.81308
138 4BFW ZVW 10.0629
139 1X6V ADP 10.101
140 1JXZ BCA 10.101
141 1NZY BCA 10.101
142 1ZUI SKM 10.119
143 1ZCB GDP 10.4972
144 3AB3 GDP 10.4972
145 2Q2Y MKR 10.6061
146 2Q2Y ADP 10.6061
147 3RLF ANP 10.6061
148 2JLR ANP 10.6061
149 1IWE IMP 10.6061
150 3A4M ADP 10.6061
151 2VB6 ADP BEF 10.7383
152 5APG EEM 10.8108
153 5XKT GNP 11
154 4DHY GLC 11.1111
155 3QKT ANP 11.2094
156 4QRH 0O2 12.1212
157 4YDS ATP 12.1212
158 4OI4 ATP 12.1739
159 1W85 TDP 12.2449
160 3H4S ADP 12.5926
161 5IRR GSP 13.3117
162 4HI0 GDP 13.5678
163 5AR0 GB8 13.6364
164 4BQS K2Q 13.6364
165 4BQS ADP 13.6364
166 6G3R ADP 13.6364
167 3CX8 GSP 13.7931
168 3KTA AP5 13.8728
169 1DAK ADP 14.2857
170 1DAK DPU 14.2857
171 3A1S GDP 14.3411
172 2Q1W NAD 14.6465
173 5KDO GDP 14.8649
174 5VHC BEF ADP 15.1515
175 1SVM ATP 15.1515
176 1PUJ GNP 15.6566
177 5L3R GCP 16.6113
178 1NRJ GTP 16.6667
179 5LTJ BEF 16.6667
180 2PZE ATP 16.6667
181 4WZ6 ATP 16.6667
182 5CK5 GDP 17.6768
183 5I0H ADP BEF 18.6869
184 2QWO ADP 20.6522
185 4R98 GNH 20.6642
186 2Y65 ADP 20.7071
187 3ZIA ADP 21.0145
188 3ZFD ANP 21.2121
189 1F2U ATP 21.4765
190 1FQJ ALF 21.7687
191 1FQJ GDP 21.7687
192 1UPT GTP 23.3918
193 3ZS9 ADP ALF 23.6842
194 5KUT GDP 23.8095
195 1F6B GDP 25.2525
196 3AQ4 GDP 25.5435
197 4M9Q GNP 27.2727
198 2FH5 GTP 27.7778
199 5DI3 GNP 28.6486
200 1M2O GNP 28.9474
201 5KSZ GCP 29.798
202 3QF7 ANP 30
203 1YZG GDP 30.1676
204 4BAS GNP 30.303
205 4ZI2 GNP 30.5263
206 4GOJ GNP 30.6878
207 1E96 GTP 30.7292
208 1DS6 GDP 30.7292
209 2WKQ GTP 30.8081
210 1FZQ GDP 32.0442
211 1MH1 GNP 32.2581
212 3DOE GTP 32.2917
213 1RYH GNP 32.3232
214 1G4U AF3 32.6087
215 3SBD GNP 32.6203
216 2QTV GNP 32.9341
217 2W2X GSP 32.973
218 1ZJ6 G3D 33.1551
219 1KSH GDP 33.3333
220 1ZD9 GDP 33.5106
221 2FJU GSP 33.7079
222 3T12 GDP ALF 33.8384
223 4OHY ANP 33.8384
224 2J0V GDP 33.8384
225 2X77 GDP 33.8624
226 1HE1 AF3 34.0909
227 4YC7 GNP 34.8485
228 2WMO GTP 34.8485
229 4DID GDP 34.8485
230 1J2J GTP 34.9398
231 1O3Y GTP 34.9398
232 2J59 GTP 34.9398
233 3E5H GNP 35.3933
234 2WJH FLC 35.5422
235 4U5X GNP 35.9551
236 1RE0 GDP 35.9756
237 4V0K GDP 36.0947
238 2GCO GNP 36.3636
239 5JCP GDP ALF 36.3636
240 2GCN GDP 36.3636
241 5UPK GNP 36.8687
242 1M7B GTP 36.9565
243 1GWN GTP 37.0732
244 1Y3A GDP 37.5
245 2OM2 GDP 38.8889
246 5HPY GDP 38.9189
247 2W83 GTP 39.3939
248 4XOI GTP 39.4444
249 6BC0 GSP 39.4595
250 6BCB GSP 39.4595
251 6BCA GSP 39.4595
252 4D0N GDP 39.4595
253 3LXR GDP 39.4595
254 3PCR GTP 39.5062
255 4KAX GTP 39.645
256 2HT6 GDP 39.6552
257 3GJX GTP 39.899
258 3GJ7 GDP 39.899
259 3GJ5 GDP 39.899
260 3GJ8 GDP 39.899
261 3GJ4 GDP 39.899
262 2A5F GTP 40
263 4XSH GSP 40.2235
264 5UWQ GNP 40.404
265 5UWP GNP 40.404
266 5UWU GNP 40.404
267 5UWT GNP 40.404
268 5UWI GNP 40.404
269 4HAT GNP 40.404
270 5UWO GNP 40.404
271 5UWR GNP 40.404
272 5UWS GNP 40.404
273 5UWH GNP 40.404
274 5DIF GNP 40.404
275 6CIT GNP 40.404
276 5UWW GNP 40.404
277 5DHF GNP 40.404
278 5UWJ GNP 40.404
279 5DI9 GNP 40.404
280 3GJ3 GDP 40.404
281 3Q85 GNP 41.4201
282 3M1I GTP 42.4242
283 3WYF GTP 42.4242
284 4DKX GDP 43.9394
285 5LEF GTP 45.0262
286 5EE5 GTP 45.0292
287 1WA5 GTP 45.4545
288 6BSX E7S 45.5056
289 6BSX GDP 45.5056
290 3WYG GTP 46.1538
291 5OCG GNP 47.0899
292 1R4A GNP 47.8788
293 3BC1 GNP 48.7179
294 1X1R GDP 48.8764
295 1VG8 GNP 48.9899
296 1VG0 GDP 48.9899
297 2Y8E GNP 49.7207
298 5UQW GDP 49.7355
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