Receptor
PDB id Resolution Class Description Source Keywords
2FPZ 2 Å EC: 3.4.21.59 HUMAN TRYPTASE WITH 2-AMINO BENZIMIDAZOLE HOMO SAPIENS SERINE PROTEASE DRUG DESIGN HYDROLASE
Ref.: STRUCTURE-GUIDED DESIGN OF PEPTIDE-BASED TRYPTASE INHIBITORS. BIOCHEMISTRY V. 45 5964 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
270 A:1000;
B:1001;
C:1002;
D:1003;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
Ki = 110 uM
133.151 C7 H7 N3 C1=CC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZA5 2.3 Å EC: 3.4.21.59 CRYSTAL STRUCTURE OF HUMAN TRYPTASE WITH POTENT NON-PEPTIDE HOMO SAPIENS TRYPTASE SERINE PROTEASE TETRAMER HYDROLASE
Ref.: POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TR SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SPIROC PIPERIDINE AMIDE DERIVATIVES BIOORG.MED.CHEM.LETT. V. 18 2114 2008
Members (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5F03 - 5TA C24 H20 Cl N3 O3 c1cc(cc(c1....
2 2ZA5 Ki = 3.7 nM 2FF C26 H24 N2 O3 c1ccc(cc1)....
3 2FPZ Ki = 110 uM 270 C7 H7 N3 C1=CC2=NC(....
4 2BM2 Ki = 15 nM PM2 C26 H29 N3 O c1ccc(cc1)....
5 3V7T Ki = 62 nM 0GX C23 H28 Br F N2 O2 S CCCOc1c(c(....
6 2ZEB - 11M C23 H24 N2 O2 S2 CSc1c2cccc....
7 4A6L Ki = 10 nM P43 C25 H23 F N2 O2 c1ccc(c(c1....
8 2ZEC - 11N C22 H24 N2 O2 c1ccc(cc1)....
70% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5F03 - 5TA C24 H20 Cl N3 O3 c1cc(cc(c1....
2 2ZA5 Ki = 3.7 nM 2FF C26 H24 N2 O3 c1ccc(cc1)....
3 2FPZ Ki = 110 uM 270 C7 H7 N3 C1=CC2=NC(....
4 2BM2 Ki = 15 nM PM2 C26 H29 N3 O c1ccc(cc1)....
5 3V7T Ki = 62 nM 0GX C23 H28 Br F N2 O2 S CCCOc1c(c(....
6 2ZEB - 11M C23 H24 N2 O2 S2 CSc1c2cccc....
7 4A6L Ki = 10 nM P43 C25 H23 F N2 O2 c1ccc(c(c1....
8 2ZEC - 11N C22 H24 N2 O2 c1ccc(cc1)....
50% Homology Family (468)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1V2V Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
2 2ZDN - 49U C21 H30 N4 O2 [H]/N=C(c1....
3 2ZQ1 - 11U C21 H31 N5 O2 [H]/N=C(/c....
4 1TNH Ki = 0.43 mM FBA C7 H9 F N c1cc(ccc1C....
5 2BYA - BAM C7 H9 N2 c1ccc(cc1)....
6 6SV0 - BEN C7 H8 N2 [H]/N=C(c1....
7 1Y5A Ki = 1.33 uM TL2 C20 H22 N4 O4 [H]/N=C(c1....
8 5MNG - BAM C7 H9 N2 c1ccc(cc1)....
9 6SW0 - BEN C7 H8 N2 [H]/N=C(c1....
10 2AYW - ONO C28 H31 N5 O6 CC(C)(C)[C....
11 6SV9 - BEN C7 H8 N2 [H]/N=C(c1....
12 6SVR - BEN C7 H8 N2 [H]/N=C(c1....
13 1Y3Y Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
14 3PTB - BEN C7 H8 N2 [H]/N=C(c1....
15 5FXL - BEN C7 H8 N2 [H]/N=C(c1....
16 1O2I Ki = 0.052 uM 655 C19 H20 N4 O2 c1cc(c(c(c....
17 1GI6 Ki = 1.7 uM 124 C15 H14 N3 O c1ccc(c(c1....
18 5MON Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
19 1O3D Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
20 5F6M - BEN C7 H8 N2 [H]/N=C(c1....
21 1Y59 Ki = 1.19 uM TL1 C20 H22 N4 O4 c1cc(cc(c1....
22 1O39 Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
23 1QL7 Kd = 15 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
24 2ZDM - 46U C21 H30 N4 O3 [H]/N=C(/c....
25 3NK8 - JKZ C9 H8 F3 N O C1CC2=C(C1....
26 1C2I - BAK C17 H16 N8 O c1cc2c(cc1....
27 1C2E - BAK C17 H16 N8 O c1cc2c(cc1....
28 1G3C Ki = 1.6 uM 109 FE 109 n/a n/a
29 1YP9 Ki = 7700 nM UIZ C31 H32 N4 O3 [H]/N=C(/c....
30 6B6T - BEN C7 H8 N2 [H]/N=C(c1....
31 1V2L Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
32 1Y3X Ki = 7315 nM UIB C26 H32 N4 O3 CC[C@@H]1[....
33 1OYQ Ki = 110 nM T87 C29 H31 N7 O3 [H]/N=C(/c....
34 6SY3 Ki = 497 uM LXW C26 H28 N4 O2 c1ccc(cc1)....
35 1XUG Ki = 0.09 uM BAB C17 H19 N8 c1cc2c(cc1....
36 3AAU Ki = 9 uM GZC CU n/a n/a
37 1C5S Ki = 1 uM ESX C9 H9 N2 S c1ccc2c(c1....
38 1V2N Ki = 1.25 uM BBA C23 H28 N4 O c1cc(ccc1C....
39 1XUH - BAO C17 H14 N8 O c1cc2c(cc1....
40 2G8T - MI2 C16 H15 N3 [H]/N=C(c1....
41 2BY8 - BAM C7 H9 N2 c1ccc(cc1)....
42 5MN1 Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
43 1XUK Ki = 19 uM BAB C17 H19 N8 c1cc2c(cc1....
44 1V2J Ki = 566 uM BEN C7 H8 N2 [H]/N=C(c1....
45 5EG4 Ki = 21 nM 5N7 C42 H56 N10 O6 S [H]/N=C(c1....
46 6SVJ - BEN C7 H8 N2 [H]/N=C(c1....
47 1K1N Kd = 153 nM CCR C29 H39 N5 O7 S Cc1cc(c(c(....
48 1V2M Ki = 51 uM BEN C7 H8 N2 [H]/N=C(c1....
49 1C1T - BAB C17 H19 N8 c1cc2c(cc1....
50 1G3E Ki = 4.2 uM 109 C11 H15 N3 O3 C[C@@H](C(....
51 2FX6 Ki = 200 uM 270 C7 H7 N3 C1=CC2=NC(....
52 2ZQ2 Kd = 276 nM 13U C23 H35 N5 O2 [H]/N=C(/c....
53 1MTW - DX9 C26 H28 N4 O3 [H]/N=C(C)....
54 1QA0 - 270 C7 H7 N3 C1=CC2=NC(....
55 1F0T Ki = 1000 nM PR1 C19 H19 N5 O4 S2 c1cc2c(cc(....
56 1O3E Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
57 1AZ8 - IN4 C20 H24 N4 O2 [H]/N=C(c1....
58 1Y3W Ki = 1680 nM UIP C26 H30 N4 O3 CC[C@@H]1[....
59 2BY9 - BAM C7 H9 N2 c1ccc(cc1)....
60 1QB6 Ki = 870 nM 623 C20 H18 F2 N5 O2 [H]/N=C(/c....
61 1O3N - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
62 3GY3 Kd = 2.36 uM PNT C19 H24 N4 O2 c1cc(ccc1C....
63 3NKK Kd = 20 uM JLZ C8 H9 F N2 [H]/N=C(/c....
64 3GY4 Kd = 8 uM PBZ C7 H10 N3 c1cc(ccc1C....
65 1TNL Ki = 13.3 mM TPA C9 H12 N c1ccc(cc1)....
66 1C2K - ABI C8 H9 N4 c1cc2c(cc1....
67 1V2K Ki = 0.65 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
68 1O3J Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
69 2BZA Ki = 1.58 mM ABN C7 H9 N c1ccc(cc1)....
70 2ZDK - 50U C22 H32 N4 O2 [H]/N=C(/c....
71 5MNQ Kd = 3.6 uM J3I C21 H32 N6 O2 [H]/N=C(N)....
72 1C5P Ki = 21 uM BAM C7 H9 N2 c1ccc(cc1)....
73 1K1M Kd = 40 nM FD4 C26 H29 N5 O4 S CC(=O)N1CC....
74 6B6R - BEN C7 H8 N2 [H]/N=C(c1....
75 1MTS - BX3 C27 H30 N4 O3 CC(=N)N1CC....
76 1UTO Kd = 5.32 mM PEA C8 H12 N c1ccc(cc1)....
77 3AAS Ki = 31 uM GUS C11 H14 N4 O3 [H]/N=C(N)....
78 1TNK Ki = 32.5 mM PRA C9 H13 N c1ccc(cc1)....
79 3GY7 Kd = 30 uM BEN C7 H8 N2 [H]/N=C(c1....
80 1O30 Ki = 0.17 uM 693 C24 H17 F N4 O5 c1ccc(c(c1....
81 2BY6 - BAM C7 H9 N2 c1ccc(cc1)....
82 2AGG - SIN ALA ALA PRO LYS n/a n/a
83 6T5W Ki = 47 uM J5K C20 H25 N5 O2 c1ccc(cc1)....
84 3GY5 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
85 1S0R - BEN C7 H8 N2 [H]/N=C(c1....
86 6B6N - BEN C7 H8 N2 [H]/N=C(c1....
87 1C5Q Ki = 0.44 uM ESI C9 H8 I N2 S c1cc2c(cc(....
88 3T25 - BEN C7 H8 N2 [H]/N=C(c1....
89 1GHZ Ki = 16 uM 120 C13 H12 N5 O c1cc2c(cc1....
90 1C5U - ESP C8 H8 N3 S c1cc2cc(sc....
91 1N6X - ABN C7 H9 N c1ccc(cc1)....
92 1O2V Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
93 1V2Q Ki = 73.62 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
94 6SV8 - BEN C7 H8 N2 [H]/N=C(c1....
95 1TNG Ki = 1.17 mM AMC C7 H16 N C1CCC(CC1)....
96 3T26 - BEN C7 H8 N2 [H]/N=C(c1....
97 6FID - BEN C7 H8 N2 [H]/N=C(c1....
98 5MNO Kd = 143 uM MRZ C6 H13 N3 [H]/N=C(N)....
99 4YTA - BEN C7 H8 N2 [H]/N=C(c1....
100 1GI4 Ki = 0.065 uM 122 C14 H13 N4 O c1ccc(c(c1....
101 1BTY - BEN C7 H8 N2 [H]/N=C(c1....
102 1K1P - MEL C22 H31 N5 O4 c1cc(ccc1C....
103 1V2T Ki = 19.56 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
104 1O3G Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
105 2TIO - BEN C7 H8 N2 [H]/N=C(c1....
106 1C2D Ki = 0.0052 uM BAK C17 H16 N8 O c1cc2c(cc1....
107 1C1R Ki = 0.0235 uM BAI C16 H14 N6 c1ccc2c(c1....
108 1C2H - BAK C17 H16 N8 O c1cc2c(cc1....
109 1O36 Ki = 1.1 uM 607 C24 H19 N5 O5 c1ccc(c(c1....
110 2BY7 - BAM C7 H9 N2 c1ccc(cc1)....
111 3GY8 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
112 5T3H - BEN C7 H8 N2 [H]/N=C(c1....
113 3ITI ic50 = 0.27 uM BRV C8 H4 Br3 N O4 c1(c(c(c(c....
114 2ZFS - 12U C22 H33 N5 O2 [H]/N=C(/c....
115 3GY6 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
116 1O3L - 678 C17 H13 Br N3 O3 c1cc2c(cc1....
117 1BJU Ki = 6.2 uM GP6 C14 H13 Cl N4 O [H]/N=C(c1....
118 1XUJ Ki < 1 nM BOZ C17 H18 N8 O Zn c1cc2c(cc1....
119 1TX7 Ki = 25 uM 4CM C8 H11 N2 O2 P C[P@](=O)(....
120 6B6O - BEN C7 H8 N2 [H]/N=C(c1....
121 3M35 - M35 C25 H20 F4 N4 O3 S CS(=O)(=O)....
122 1MTU - BX3 C27 H30 N4 O3 CC(=N)N1CC....
123 1O32 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
124 3T27 - BEN C7 H8 N2 [H]/N=C(c1....
125 5LH4 - 6W4 C32 H34 N6 O2 c1ccc(cc1)....
126 1O2Q Ki = 0.021 uM 991 C20 H20 Cl N3 O2 c1cc(c(c(c....
127 1K1J Kd = 28 nM FD2 C27 H30 N4 O5 S [H]/N=C(/c....
128 5MNN - MRZ C6 H13 N3 [H]/N=C(N)....
129 1C1S - BAB C17 H19 N8 c1cc2c(cc1....
130 1QBO Ki = 18 nM 711 C27 H31 N6 O Cc1[nH]c2c....
131 1V2R Ki = 278.96 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
132 1C5R - ESI C9 H8 I N2 S c1cc2c(cc(....
133 6SVV - BEN C7 H8 N2 [H]/N=C(c1....
134 1K1O - IGN C21 H38 N6 O4 C1CCC(CC1)....
135 2ZFT - 10U C20 H29 N5 O2 c1cc(ccc1C....
136 1TIO - BAM C7 H9 N2 c1ccc(cc1)....
137 1V2U Ki = 427 uM BEN C7 H8 N2 [H]/N=C(c1....
138 1MTV - BX3 C27 H30 N4 O3 CC(=N)N1CC....
139 1Y5B Kd = 1.26 uM TL3 C20 H22 N4 O4 c1cc(ccc1C....
140 1G36 Ki = 67 nM R11 C25 H25 N7 [H]/N=C(/c....
141 6SVZ - BEN C7 H8 N2 [H]/N=C(c1....
142 1O2L - 762 C20 H15 Cl N4 O c1ccc(cc1)....
143 1TX8 Ki = 1800 uM AM4 C8 H10 N2 O2 S CS(=O)(=O)....
144 1GI1 Ki = 3.6 uM BMZ C14 H13 N4 O c1ccc(c(c1....
145 1V2W Ki = 97.79 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
146 6SV6 - BEN C7 H8 N2 [H]/N=C(c1....
147 1O3H Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
148 4NCY - BEN C7 H8 N2 [H]/N=C(c1....
149 1O35 - 802 C14 H11 F N4 O c1cc2c(cc1....
150 1PPC Ki = 0.69 uM MID C27 H31 N5 O4 S [H]/N=C(/c....
151 1TNI Ki = 0.1 mM PBN C10 H15 N c1ccc(cc1)....
152 6SVU - BEN C7 H8 N2 [H]/N=C(c1....
153 1V2S Ki = 68 uM BEN C7 H8 N2 [H]/N=C(c1....
154 1LQE Ki = 1507 nM IMA C34 H36 N5 O2 C[N+](C)(C....
155 1O2S Ki = 3.4 uM CR4 C14 H12 N4 O c1ccc(c(c1....
156 1O3M - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
157 6E5M - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
158 1O2X Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
159 1O38 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
160 1G3B Ki = 1.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
161 1BJV Ki = 13 uM GP8 C20 H18 N4 O2 c1ccc(cc1)....
162 1C1P - BAI C16 H14 N6 c1ccc2c(c1....
163 1C2J - BAK C17 H16 N8 O c1cc2c(cc1....
164 1C2F - BAH C17 H18 N8 O2 c1cc2c(cc1....
165 3LJJ Kd = 300 nM 10U C20 H29 N5 O2 c1cc(ccc1C....
166 1O3I Ki = 0.05 uM 907 C16 H14 Br N3 O Cc1cc(c(c(....
167 1Y3V Ki = 2300 nM UIR C27 H30 N4 O3 c1cc(ccc1[....
168 1UTP Kd = 36 mM PBN C10 H15 N c1ccc(cc1)....
169 2BLV - BEN C7 H8 N2 [H]/N=C(c1....
170 6SVG - BEN C7 H8 N2 [H]/N=C(c1....
171 1TNJ Ki = 11 mM PEA C8 H12 N c1ccc(cc1)....
172 3GY2 Kd = 1.8 uM BRN C14 H15 N7 c1cc(ccc1C....
173 6T0M Ki = 39 uM GOZ C20 H26 N6 O2 c1ccc(cc1)....
174 6B6S - BEN C7 H8 N2 [H]/N=C(c1....
175 1O2P - 972 C18 H19 Cl N4 O2 CC(C)COc1c....
176 1K1I Kd = 264 nM FD1 C26 H28 N4 O5 S [H]/N=C(c1....
177 1GJ6 Ki = 0.23 uM 132 C21 H17 Cl N3 O c1ccc(cc1)....
178 3LJO Kd = 239 nM 11U C21 H31 N5 O2 [H]/N=C(/c....
179 1O2Y Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
180 6SVN - BEN C7 H8 N2 [H]/N=C(c1....
181 1O31 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
182 2BY5 - BAM C7 H9 N2 c1ccc(cc1)....
183 1XUI - BAO C17 H14 N8 O c1cc2c(cc1....
184 1C5T Ki = 80 uM ESP C8 H8 N3 S c1cc2cc(sc....
185 1EB2 Ki = 16 nM BPO C28 H28 N4 O3 [H]/N=C(c1....
186 6SVB - BEN C7 H8 N2 [H]/N=C(c1....
187 1O2K Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
188 5LGO - 6VZ C27 H36 N6 O4 CNC(=O)[C@....
189 1GI0 - BMZ C14 H13 N4 O c1ccc(c(c1....
190 1V2P Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
191 1TPS ic50 = 10 nM OSL DLE THR ARG GLU LEU YNM VAL n/a n/a
192 1N6Y - ABN C7 H9 N c1ccc(cc1)....
193 1O34 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
194 6SUX - BEN C7 H8 N2 [H]/N=C(c1....
195 2ZDL - 45U C20 H28 N4 O3 [H]/N=C(/c....
196 1PPH Ki = 1.2 uM 0ZG C22 H28 N4 O3 S [H]/N=C(/c....
197 2G5N - 23M C16 H15 N3 [H]/N=C(c1....
198 1G3D Ki = 2.8 uM 108 C11 H15 N3 O3 C[C@@H](C(....
199 5MOO Kd = 48.5 mM WOT C6 H8 N c1ccc(cc1)....
200 1O2U Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
201 1O2R - CR9 C21 H23 F N4 O2 C[C@H]1CCC....
202 3QK1 - BEN C7 H8 N2 [H]/N=C(c1....
203 6SVX - BEN C7 H8 N2 [H]/N=C(c1....
204 5MNH Kd = 20.7 uM BAM C7 H9 N2 c1ccc(cc1)....
205 6B6P - BEN C7 H8 N2 [H]/N=C(c1....
206 3T29 - BEN C7 H8 N2 [H]/N=C(c1....
207 6EAT - CYS THR LYS SER ILE PRO PRO GLN CYS n/a n/a
208 1O2H Ki = 0.068 uM CR3 C20 H21 N3 O2 c1cc(c(c(c....
209 1QB9 Ki = 36 nM 806 C31 H31 N5 O [H]/N=C(/C....
210 2BLW - BEN C7 H8 N2 [H]/N=C(c1....
211 1O3B Ki = 0.074 uM 780 C20 H16 N4 O c1ccc(cc1)....
212 1O2Z Ki = 0.78 uM 312 C25 H20 N4 O6 COc1ccccc1....
213 1K1L Kd = 125 nM FD3 C24 H27 N5 O3 S [H]/N=C(/c....
214 1O2O Ki = 0.44 uM 950 C18 H19 F N4 O2 CC(C)COc1c....
215 1C1Q - BAI C16 H14 N6 c1ccc2c(c1....
216 1F0U Ki = 69 nM RPR C27 H30 N4 O3 C[C@H]([C@....
217 1C2G - BAH C17 H18 N8 O2 c1cc2c(cc1....
218 1O37 Ki = 0.15 uM 653 C22 H22 N5 O c1ccc(cc1)....
219 1O3F Ki = 0.011 uM 696 C21 H17 N3 O c1ccc(cc1)....
220 1JIR - AML C5 H13 N CCCCCN
221 1O2N Ki = 0.81 uM 762 C20 H15 Cl N4 O c1ccc(cc1)....
222 1O3O - 785 C15 H11 F3 N4 O2 c1cc2c(cc1....
223 1CE5 Ki = 18.4 uM BEN C7 H8 N2 [H]/N=C(c1....
224 5MNB Kd = 3.3 mM 2AP C5 H7 N2 c1cc[nH+]c....
225 6DZF - BEN C7 H8 N2 [H]/N=C(c1....
226 5LH8 - 6WH C31 H38 N6 O3 COc1cc(ccc....
227 2ZHD - 12U C22 H33 N5 O2 [H]/N=C(/c....
228 1O2J Ki = 0.12 uM 656 C18 H20 N4 O2 CC(C)COc1c....
229 1AQ7 ic50 = 0.9 uM 34H DIL XPR AG2 n/a n/a
230 1O3K Ki = 0.17 uM 334 C15 H13 Br N4 O Cc1cc(c(c(....
231 2G5V - 22M C16 H15 N3 [H]/N=C(c1....
232 1Y5U Kd = 0.22 uM TL4 C20 H22 N4 O4 c1cc(cc(c1....
233 6SVI - BEN C7 H8 N2 [H]/N=C(c1....
234 1J8A - BEN C7 H8 N2 [H]/N=C(c1....
235 6B6Q - BEN C7 H8 N2 [H]/N=C(c1....
236 1QB1 Ki = 170 nM 974 C28 H27 F2 N6 O5 Cn1ccnc1c2....
237 1O2W Ki = 1.4 uM 847 C18 H13 Br N4 O5 c1cc2c(cc1....
238 1XUF Ki = 0.09 uM BAZ C17 H16 N8 Zn [H]/N=C(c1....
239 1QBN Ki = 1400 nM 688 C22 H17 N5 O5 c1cc(cc(c1....
240 1O33 Ki = 1.8 uM 801 C13 H11 N5 O c1cc(c(nc1....
241 1V2O Ki = 18.45 uM ANH C20 H24 N4 O5 S Cc1ccc(cc1....
242 1C1N - BAM C7 H9 N2 c1ccc(cc1)....
243 1UTN Kd = 0.321 mM ABN C7 H9 N c1ccc(cc1)....
244 6SVD - BEN C7 H8 N2 [H]/N=C(c1....
245 6T0P Ki = 62 uM M6Q C20 H25 N5 O2 c1ccc(cc1)....
246 6SVW - BEN C7 H8 N2 [H]/N=C(c1....
247 4NA8 Ki = 1.5 nM 1T6 C31 H28 N4 O3 [H]/N=C(/c....
248 5WB6 Ki = 0.02 nM 9ZM C31 H26 Cl F N10 O4 COC(=O)Nc1....
249 5Q0H Ki = 12 nM 9F1 C27 H26 Cl F2 N5 O4 Cc1cc(c(c(....
250 5TKT Ki = 3.2 nM 7DS C28 H26 Cl N9 O4 COC(=O)Nc1....
251 4CRG - J4X C22 H18 N6 O [H]/N=C(c1....
252 5EXL Ki = 3.7 nM 5SS C28 H31 N5 O2 c1ccc(cc1)....
253 6TS5 ic50 = 0.003 uM NW2 C27 H29 N O5 CC(C)c1cc(....
254 6VLU Ki = 149.1 nM R2Y C27 H37 F2 N5 O2 CC(C)C[C@H....
255 5E2O Ki = 2 nM 5JM C26 H21 Cl N6 O4 c1ccc(cc1)....
256 4CRB Ki = 0.027 uM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
257 6TS6 ic50 = 0.004 uM NW5 C27 H26 N2 O4 CC(C)(C#N)....
258 5TKS Ki = 68 nM 7DL C29 H30 Cl2 N8 O3 COC(=O)Nc1....
259 5QTY Ki = 2.5 nM QLJ C32 H33 Cl N8 O5 CCOC(=O)[C....
260 5Q0E Ki = 0.69 nM 9FD C29 H30 Cl N9 O4 C[C@H]1CCC....
261 4CRE - MVN C10 H8 Cl N O CC1=CC(=O)....
262 4CRA Ki = 0.06 uM XJ8 C29 H25 N5 O4 c1ccc(cc1)....
263 1ZHR - BEN C7 H8 N2 [H]/N=C(c1....
264 5E2P Ki = 1.6 nM 7P0 C28 H24 Cl N7 O4 c1ccc(cc1)....
265 3BG8 - BEN C7 H8 N2 [H]/N=C(c1....
266 4X6P Ki = 5 nM 3YU C28 H23 Cl N10 O c1ccc(cc1)....
267 5Q0D Ki = 1 nM 9EY C27 H26 Cl N9 O4 COC(=O)Nc1....
268 4X6O Ki = 1.9 nM 3Y4 C29 H26 Cl2 N8 O3 COC(=O)Nc1....
269 5EXN Ki = 23 nM 5SU C31 H26 Cl N7 O3 COC(=O)Nc1....
270 4CR9 Ki = 80 uM OTW C10 H11 N3 Cc1cc(nc2c....
271 6TS4 ic50 = 2.8 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
272 6USY Ki = 0.0004 uM QGS C28 H28 N2 O4 CC(C)c1cc(....
273 4CRC Ki = 0.0019 uM OTM C26 H21 Cl N10 O2 c1ccc(cc1)....
274 5QCL Ki = 11 nM BUY C27 H21 Cl N6 O4 c1ccc2c(c1....
275 1ZHM - BEN C7 H8 N2 [H]/N=C(c1....
276 5EXM Ki = 6.3 nM 5ST C29 H34 N4 O3 COC(=O)Nc1....
277 4TY7 Ki = 0.3 nM 39F C26 H30 Cl N7 O c1ccc(cc1)....
278 5QTT Ki = 3.4 nM QEY C30 H29 Cl F N7 O4 C[C@@H]1CC....
279 6W50 Ki = 0.3 nM SWP C31 H29 Cl F2 N4 O4 C[C@@H]1CC....
280 5QQP Ki = 5.3 nM NR7 C29 H30 Cl N5 O4 COC(=O)Nc1....
281 6C0S Ki = 89 nM EEJ C31 H31 Cl2 N9 O4 CC(=O)N1CC....
282 4CRF Ki = 0.0005 uM R9B C29 H23 Cl N4 O5 c1ccc(cc1)....
283 5QCN Ki = 6 nM BVM C36 H34 Cl N7 O7 CCOC(=O)[C....
284 6VLV Ki = 5.33 nM R3A C19 H25 Cl N6 O4 S [H]/N=C(/N....
285 5QTV Ki = 1.1 nM QLS C28 H27 Cl F3 N9 O3 COC(=O)Nc1....
286 4X6M Ki = 5.8 nM 3Y3 C27 H26 Cl2 N8 O c1ccc(cc1)....
287 5QTW Ki = 0.46 nM QLM C29 H30 Cl N9 O5 COC(=O)[C@....
288 4CR5 Ki = 70 uM 0TU C9 H6 Cl N O c1cc2c(cc1....
289 4CRD Ki = 0.08 uM OTJ C22 H22 Cl2 N8 O3 COC(=O)Nc1....
290 5QCM Ki = 110 nM BVJ C28 H23 Cl F N7 O4 COC(=O)Nc1....
291 5NB6 ic50 = 0.5 uM 8S2 C22 H21 F3 N6 O4 c1ccc2c(c1....
292 6FTY - E7H C20 H24 N4 O2 c1cc2c(cc(....
293 6QMR ic50 = 0.012 uM J6T C23 H23 N O4 c1ccc(c(c1....
294 5NAW ic50 = 0.05 uM 8RZ C23 H20 F3 N5 O4 c1ccc2c(c1....
295 5MT0 Kd ~ 500 uM QJS C19 H15 F N2 O3 c1ccc(cc1)....
296 6FUG Kd = 50 uM E85 C18 H17 N7 O c1cc(cc(c1....
297 5NAR ic50 = 0.5 uM 8RW C22 H20 F3 N5 O4 c1ccc2c(c1....
298 5FBE ic50 = 14 uM 5W5 C22 H22 F3 N3 O5 COC(=O)c1c....
299 6FUH Kd = 170 uM E88 C20 H23 N5 O2 CC(C)[C@@H....
300 5FBI Kd = 1600 uM 5WD C17 H14 N2 O4 c1cc(cc(c1....
301 6QMT ic50 = 0.12 uM J7B C22 H20 N2 O3 c1ccc(c(c1....
302 6FUT Kd = 20 uM E82 C24 H24 N2 O c1ccc2c(c1....
303 6FUJ ic50 = 120 uM E8B C18 H22 N2 O CC(C)CC(=O....
304 5FCK Kd = 0.006 uM 5WC C23 H22 Cl F N6 O3 C[C@H](c1c....
305 5NB7 ic50 = 0.006 uM 8NQ C21 H19 Br N6 O3 c1ccc2c(c1....
306 5MT4 Kd ~ 500 uM M7O C15 H14 N2 O3 c1ccc(cc1)....
307 5NBA ic50 = 0.05 uM 8S5 C22 H19 F4 N5 O4 c1ccc2c(c1....
308 6FUI Kd = 35 uM E7W C22 H25 N5 O2 c1ccc2c(c1....
309 6FTZ Kd = 1000 uM E7E C17 H16 N4 O2 c1cc(cc(c1....
310 6A8N Ki = 6.8 nM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
311 1ELC - 0Z3 C26 H34 F3 N4 O3 CC(C)c1ccc....
312 1ELD Ki = 0.2 uM 0Z0 C21 H19 F6 N3 O3 NULL
313 7EST - 0Z2 C18 H21 F6 N3 O3 CC(C)C[C@@....
314 2BD4 - LYS TYR PRO PHE VAL GLU PRO ILE n/a n/a
315 1ELB Ki = 70 nM 0Z4 C23 H36 F3 N4 O3 CC(C)C[C@@....
316 6TH7 ic50 = 1.18 nM O4Q 5XU ABA ILE ABA VAL N9K PHA AA4 n/a n/a
317 1ELE Ki = 0.14 uM 0QN C17 H19 F6 N3 O3 NULL
318 4GVU ic50 = 30 nM 6NA GLN THR DBU GLJ PHE YNM VAL n/a n/a
319 1NES - ACE ALA PRO ALA n/a n/a
320 2BDB - ALA ALA n/a n/a
321 1BMA Ki = 26 uM 0QH C27 H36 F3 N4 O3 NULL
322 2EST - 2Z5 C18 H23 F6 N4 O3 NULL
323 1ELA Ki = 0.44 uM 0Z1 C22 H32 F3 N4 O3 CC(C)c1ccc....
324 1QR3 ic50 = 0.26 uM ALQ CIR THR DBU GLJ PHE TYJ VAL n/a n/a
325 1BIT - BEN C7 H8 N2 [H]/N=C(c1....
326 1HJ8 - BAM C7 H9 N2 c1ccc(cc1)....
327 1UTL Ka = 293 M^-1 PRA C9 H13 N c1ccc(cc1)....
328 2TBS - BEN C7 H8 N2 [H]/N=C(c1....
329 2ZPQ - BEN C7 H8 N2 [H]/N=C(c1....
330 1UTJ Kd = 0.144 mM ABN C7 H9 N c1ccc(cc1)....
331 1UTM Ka = 243 M^-1 PEA C8 H12 N c1ccc(cc1)....
332 1MBQ - BEN C7 H8 N2 [H]/N=C(c1....
333 2ZPS - BEN C7 H8 N2 [H]/N=C(c1....
334 2ZPR - BEN C7 H8 N2 [H]/N=C(c1....
335 1L2E - BEN C7 H8 N2 [H]/N=C(c1....
336 3VFE - 0HL C26 H26 N4 O4 S3 [H]/N=C(c1....
337 6QH9 - J3B C13 H16 N4 O2 [H]/N=C(/c....
338 6QFH ic50 = 1.38 uM J08 C23 H22 N6 O [H]/N=C(/c....
339 6QHB - J2W C15 H15 N3 O3 [H]/N=C(/c....
340 6SKC - BEN C7 H8 N2 [H]/N=C(c1....
341 1LO6 - BEN C7 H8 N2 [H]/N=C(c1....
342 6QFF ic50 = 2.04 uM J08 C23 H22 N6 O [H]/N=C(/c....
343 6QHC - 135 C14 H13 N3 O2 [H]/N=C(c1....
344 4D8N ic50 = 1.8 uM 0HM C24 H24 N5 O2 c1ccc(cc1)....
345 6QFG ic50 = 3.01 uM J08 C23 H22 N6 O [H]/N=C(/c....
346 6QHA - J2Q C16 H17 N3 O3 [H]/N=C(/c....
347 3P8G - BEN C7 H8 N2 [H]/N=C(c1....
348 1EAX - BEN C7 H8 N2 [H]/N=C(c1....
349 2GV6 Ki = 0.046 uM 730 C28 H35 N7 O3 S [H]/N=C(c1....
350 4R0I Ki = 0.3 uM 3KM C27 H33 N5 O4 S [H]/N=C(c1....
351 4O97 Ki = 3 nM NTX C29 H34 N6 O3 [H]/N=C(N)....
352 2GV7 Ki = 0.014 uM 672 C36 H54 N8 O4 S [H]/N=C(c1....
353 4O9V Ki = 10 nM NT4 C27 H30 N6 O3 [H]/N=C(N)....
354 1IAU Ki = 80 nM ACE ILE GLU PRO ASJ n/a n/a
355 1ANE - BEN C7 H8 N2 [H]/N=C(c1....
356 1J16 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
357 1J14 Ki = 32.2 uM BEN C7 H8 N2 [H]/N=C(c1....
358 1BRA Ki = 15000 uM BEN C7 H8 N2 [H]/N=C(c1....
359 1J15 Ki = 143 uM BEN C7 H8 N2 [H]/N=C(c1....
360 1TRM - BEN C7 H8 N2 [H]/N=C(c1....
361 1J17 Ki = 6.05 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
362 1ANC - BEN C7 H8 N2 [H]/N=C(c1....
363 1QL9 Ki = 4.45 uM ZEN C25 H27 Cl N4 O3 S c1cc(cc2c1....
364 1DPO - BEN C7 H8 N2 [H]/N=C(c1....
365 1AND - BEN C7 H8 N2 [H]/N=C(c1....
366 1W0Z Ki = 21 nM SI1 C18 H29 N5 O5 S [H]/N=C(c1....
367 4ZHL Kd = 0.0147 uM CYS PRO ALA TYR SER ARG TYR ILE GLY CYS n/a n/a
368 2VIV ic50 = 520 nM VG2 C22 H28 Cl N3 O2 Cc1cc(cc(c....
369 1SC8 Ki = 0.036 uM 2IN C20 H25 N5 O5 S c1ccc(cc1)....
370 1OWE Ki = 0.631 uM 675 C18 H15 N3 O [H]/N=C(/c....
371 4X1Q - CYS PRO ALA TYR SER ARG TYR LEU ASP CYS n/a n/a
372 2VIP ic50 = 5.2 uM L1R C18 H20 Cl2 N2 O3 CC(C)Oc1cc....
373 5ZAF Ki = 166 nM 28I C16 H21 N7 O2 [H]/N=C(N)....
374 1SQT Ki = 0.63 uM UI3 C16 H16 N4 O3 S [H]/N=C(/c....
375 1W13 Ki = 2 nM SM1 C21 H28 N6 O5 S [H]/N=C(/N....
376 1OWH Ki = 40 nM 239 C19 H18 N4 O [H]/N=C(/c....
377 1EJN Ki = 2.4 uM AGB C19 H27 N5 O [H]/N=C(/N....
378 4ZHM Kd = 0.00081 uM MRZ CYS PRO ALA TYR SER ALA TYR ILE GLY CYS n/a n/a
379 2VIN ic50 > 1 mM 505 C11 H17 N O Cc1cccc(c1....
380 5ZA8 Ki = 508 nM 27I C16 H23 N9 O [H]/N=C(/N....
381 5ZA7 Ki = 1356 nM HMX C12 H18 Cl N7 O C1CCCN(CC1....
382 4X0W - MRZ CYS PRO ALA TYR SER DAL TYR LEU ASP CYS n/a n/a
383 1U6Q - 745 C20 H18 N2 [H]/N=C(/c....
384 5ZA9 Ki = 183 nM 50I C20 H23 N7 O2 [H]/N=C(/N....
385 2VIQ ic50 = 1.3 uM D55 C21 H28 N2 O4 CCOc1ccc(c....
386 4X1P - CYS PRO ALA TYR SER DAL TYR LEU ASP CYS MRZ n/a n/a
387 6NMB Ki = 2.01 mM AMH C8 H15 N O2 C1CC(CCC1C....
388 5ZAG Ki = 108 nM 94I C16 H21 N9 O [H]/N=C(N)....
389 5ZC5 Ki = 88 nM 09I C20 H22 F N7 O2 [H]/N=C(/N....
390 1VJ9 Ki = 0.028 uM 5IN C28 H33 N5 O6 S c1ccc(cc1)....
391 1F5K Ki = 180 uM BAM C7 H9 N2 c1ccc(cc1)....
392 5ZAE Ki = 156 nM EAU C16 H21 N7 O2 [H]/N=C(/N....
393 1OWD Ki = 6.3 nM 497 C23 H24 N4 O CC[C@H]1CN....
394 2VNT Ki = 9.9 nM QGG C15 H16 Cl N5 O4 S c1cc2c(cc1....
395 2VIO ic50 = 40 uM L1O C9 H9 Cl2 N O3 c1c(cc(c(c....
396 1F5L Ki = 5.3 uM AMR C6 H8 Cl N7 O c1(c(nc(c(....
397 5ZAJ Ki = 42 nM 32I C18 H25 N9 O3 [H]/N=C(/N....
398 2R2W Ki = 34 uM 4PG C15 H15 N3 O [H]/N=C(/N....
399 2VIW ic50 = 72 nM D56 C24 H32 Cl N3 O3 CCOc1c(cc(....
400 1W11 Ki = 6 nM SK1 C21 H27 N5 O5 S [H]/N=C(c1....
401 1SQA Ki = 0.00062 uM UI1 C23 H21 N7 O c1cnc(nc1)....
402 1VJA Ki = 0.02 uM 7IN C21 H27 N5 O6 S c1ccc(cc1)....
403 1SQO Ki = 0.035 uM UI2 C15 H13 N5 c1cc2ccc(c....
404 1GDN - GLY ALA LYS n/a n/a
405 1FY5 - GLY ALA LYS n/a n/a
406 1FY4 - GLY ALA ARG n/a n/a
407 1PQ8 - GLY GLY ARG n/a n/a
408 1FN8 - GLY ALA ARG n/a n/a
409 1PQ7 - ARG C6 H15 N4 O2 C(C[C@@H](....
410 1PQ5 - ARG C6 H15 N4 O2 C(C[C@@H](....
411 1H4W Ki = 22 uM BEN C7 H8 N2 [H]/N=C(c1....
412 5TP0 Ki = 3.66 uM BRN C14 H15 N7 c1cc(ccc1C....
413 1T32 Ki = 38 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
414 4K60 ic50 = 570 uM 1P8 C8 H6 Br N O c1cc2c(cc1....
415 1T31 Ki = 2.3 nM OHH C40 H35 N2 O6 P CN(C1CCN(C....
416 4K5Z - 1P7 C8 H6 Cl N O c1cc2c(cc1....
417 3N7O Ki = 72 nM N7O C19 H15 Cl F2 N O3 P S C[P@@](=O)....
418 3S0N ic50 = 180 nM 0BB C21 H20 N2 O3 S Cc1cccc2c1....
419 5YJM Kd = 0.000000064 M 8W3 C30 H32 Cl N5 O6 CC[C@H](c1....
420 4K2Y ic50 = 470 uM ES2 C8 H6 Cl N O c1cc2c(cc1....
421 5YJP ic50 = 0.24 uM 8W6 C26 H31 Cl N4 O6 CC[C@H](c1....
422 4K69 ic50 = 0.04 uM 1P9 C22 H22 Br N3 O4 CCC[C@@H](....
423 1OSS Ki = 16.4 uM BEN C7 H8 N2 [H]/N=C(c1....
424 3BEU - BEN C7 H8 N2 [H]/N=C(c1....
425 5XWL - ACE THR ARG GLU n/a n/a
426 5XWJ - ACE THR ARG GLU n/a n/a
427 1V6D - PRO ASP AIB LEU AIB LEU ALA TBF NME n/a n/a
428 1YF4 Ki = 5 nM CYS TYR PHE GLN ASN CYS PRO ARG GLY NH2 n/a n/a
429 1S6H - 4BZ C8 H10 N2 O [H]/N=C(c1....
430 1S83 - 4HA C4 H12 N O C(CCO)C[NH....
431 1S5S - PG3 C4 H12 N3 O C(CNC(=[NH....
432 5A09 ic50 = 3.5 nM JJD C23 H18 F3 N3 O4 CC1=C([C@H....
433 5A8X ic50 = 6.5 nM IUY C24 H20 F3 N4 O2 CCOC(=O)C1....
434 5ABW ic50 = 17 nM WQQ C26 H24 Cl N3 O5 S Cc1c(c(on1....
435 5A8Y ic50 = 0.17 nM VBM C23 H16 F3 N7 O2 CC1=C([C@H....
436 5A0B ic50 = 5 nM JJX C29 H29 F3 N6 O2 CC1=C([C@H....
437 5A8Z ic50 = 28 nM IUL C21 H16 F3 N5 O2 CN1CC2=C([....
438 3Q77 ic50 = 6 nM 2HY C22 H18 F3 N3 O4 CC1=C([C@H....
439 5A0C ic50 = 0.54 nM JJV C21 H15 F3 N4 O3 S CC1=C([C@H....
440 5A0A Ki = 15 nM JJS C20 H15 F3 N4 O2 CC1=C([C@H....
441 2AIQ - BEN C7 H8 N2 [H]/N=C(c1....
442 2OQ5 - BEN C7 H8 N2 [H]/N=C(c1....
443 5F03 - 5TA C24 H20 Cl N3 O3 c1cc(cc(c1....
444 2ZA5 Ki = 3.7 nM 2FF C26 H24 N2 O3 c1ccc(cc1)....
445 2FPZ Ki = 110 uM 270 C7 H7 N3 C1=CC2=NC(....
446 2BM2 Ki = 15 nM PM2 C26 H29 N3 O c1ccc(cc1)....
447 3V7T Ki = 62 nM 0GX C23 H28 Br F N2 O2 S CCCOc1c(c(....
448 2ZEB - 11M C23 H24 N2 O2 S2 CSc1c2cccc....
449 4A6L Ki = 10 nM P43 C25 H23 F N2 O2 c1ccc(c(c1....
450 2ZEC - 11N C22 H24 N2 O2 c1ccc(cc1)....
451 4NFE - BEN C7 H8 N2 [H]/N=C(c1....
452 2ANW - BAM C7 H9 N2 c1ccc(cc1)....
453 2ANY - BAM C7 H9 N2 c1ccc(cc1)....
454 5TJX - GBT C29 H33 N7 O3 Cc1c2c(cc(....
455 6O1S - 7SD C23 H25 N7 O Cc1cc(nc(c....
456 6T7P Ki = 0.97 uM MU8 C26 H24 Cl N3 O3 c1ccc(cc1)....
457 6QFE ic50 = 0.08 uM J08 C23 H22 N6 O [H]/N=C(/c....
458 6B74 - BEN C7 H8 N2 [H]/N=C(c1....
459 1A0J - BEN C7 H8 N2 [H]/N=C(c1....
460 2ZGJ - SER SER GLY LYS VAL PRO LEU SER n/a n/a
461 2ZGH - SER SER GLY LYS VAL PRO LEU n/a n/a
462 2BDG - PBZ C7 H10 N3 c1cc(ccc1C....
463 5Y9L ic50 = 1.9 uM 8R3 C24 H28 Cl N5 O5 CN(C)/N=C1....
464 5YJK ic50 = 0.82 uM 8VX C24 H30 Cl N5 O5 S CN(C)/N=C1....
465 5FAH ic50 = 0.7 uM 5VT C26 H29 N3 O3 COc1ccc(cc....
466 3TJV - PRO THR SER TYR ALA GLY ASP ASP SER GLY n/a n/a
467 6AHS ic50 = 1.5 uM 9YO C19 H18 Cl N3 O2 S Cc1ccc2c(c....
468 5ZFI ic50 = 1.2 uM 9C9 C26 H29 Cl2 N7 O2 Cn1cc(cn1)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 270; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 270 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 270; Similar ligands found: 1257
No: Ligand Similarity coefficient
1 AX7 1.0000
2 2MI 1.0000
3 P92 0.9986
4 ABV 0.9941
5 XM0 0.9913
6 1PT 0.9863
7 LZ1 0.9798
8 5WV 0.9797
9 0R1 0.9789
10 BZI 0.9781
11 BZF 0.9781
12 MPI 0.9779
13 DEN 0.9776
14 NPO 0.9773
15 ET2 0.9770
16 IND 0.9764
17 Q88 0.9756
18 03V 0.9752
19 ES0 0.9746
20 0CT 0.9745
21 NPY 0.9744
22 QUZ 0.9743
23 BZX 0.9742
24 GVH 0.9740
25 4JP 0.9735
26 PHB 0.9731
27 COU 0.9730
28 4FS 0.9724
29 CWM 0.9721
30 BEZ 0.9719
31 JAE 0.9712
32 ISN 0.9712
33 NCA 0.9711
34 BEN 0.9709
35 BAM 0.9709
36 H42 0.9687
37 5H1 0.9682
38 2AQ 0.9682
39 VGD 0.9681
40 JB5 0.9681
41 14O 0.9679
42 F60 0.9676
43 ES7 0.9674
44 CLW 0.9674
45 36R 0.9669
46 6PC 0.9668
47 HBD 0.9664
48 6AI 0.9663
49 5MI 0.9662
50 KKN 0.9661
51 717 0.9661
52 5VM 0.9658
53 7W4 0.9658
54 1M2 0.9654
55 11S 0.9652
56 1P8 0.9651
57 IDM 0.9651
58 XIY 0.9646
59 2K4 0.9645
60 ES5 0.9643
61 PAB 0.9642
62 4XR 0.9639
63 1Y6 0.9638
64 5MB 0.9636
65 XQ0 0.9636
66 NTN 0.9635
67 YCP 0.9634
68 ES2 0.9631
69 NIO 0.9630
70 3ID 0.9621
71 AHR 0.9612
72 2CK 0.9610
73 KOJ 0.9608
74 K2T 0.9602
75 FBB 0.9601
76 ES9 0.9596
77 RSO 0.9594
78 HBA 0.9593
79 JZ9 0.9590
80 NBZ 0.9588
81 ISZ 0.9588
82 NIZ 0.9584
83 FK1 0.9583
84 OCH 0.9582
85 VGL 0.9575
86 GLC 0.9574
87 TH7 0.9569
88 DMD 0.9568
89 2D0 0.9567
90 H4N 0.9565
91 HMH 0.9564
92 FPI 0.9564
93 FYU 0.9558
94 AMC 0.9554
95 HPA 0.9552
96 Z82 0.9551
97 ADE 0.9548
98 UNU 0.9542
99 10L 0.9539
100 5XC 0.9537
101 XYP 0.9536
102 A7W 0.9530
103 DOB 0.9529
104 826 0.9528
105 AC0 0.9528
106 3PF 0.9527
107 BHA 0.9526
108 FA0 0.9526
109 P72 0.9526
110 4MA 0.9525
111 PBZ 0.9525
112 67N 0.9523
113 5NU 0.9522
114 9EW 0.9521
115 DHB 0.9520
116 URF 0.9518
117 PEA 0.9515
118 4M0 0.9514
119 1MC 0.9514
120 H8N 0.9513
121 1SQ 0.9513
122 MCT 0.9509
123 CFI 0.9509
124 NK 0.9508
125 5CU 0.9508
126 5OB 0.9508
127 M1A 0.9507
128 SAL 0.9506
129 PZA 0.9503
130 BE7 0.9500
131 BZ3 0.9498
132 5SG 0.9497
133 282 0.9497
134 F05 0.9496
135 JA8 0.9494
136 5Q0 0.9493
137 BGC 0.9493
138 6RQ 0.9492
139 1LQ 0.9492
140 5IQ 0.9491
141 LXC 0.9491
142 4P5 0.9490
143 173 0.9487
144 0RW 0.9485
145 TH0 0.9485
146 N5J 0.9483
147 6M9 0.9483
148 174 0.9482
149 WBU 0.9479
150 BHO 0.9479
151 HLR 0.9478
152 HQY 0.9477
153 OAA 0.9477
154 7HP 0.9475
155 SVN 0.9475
156 TDR 0.9473
157 9DA 0.9472
158 24W 0.9471
159 4HO 0.9469
160 1NP 0.9467
161 ES1 0.9466
162 SS1 0.9466
163 PBC 0.9465
164 TPA 0.9464
165 7WA 0.9462
166 1DW 0.9462
167 BE2 0.9462
168 6M4 0.9461
169 4VP 0.9461
170 BP1 0.9456
171 4YS 0.9455
172 2BG 0.9455
173 PYD 0.9454
174 ICP 0.9454
175 8GC 0.9453
176 9HX 0.9452
177 4JU 0.9452
178 6MP 0.9451
179 275 0.9451
180 URC 0.9451
181 MWM 0.9451
182 8NY 0.9450
183 5QY 0.9450
184 JPZ 0.9448
185 DIN 0.9445
186 PXL 0.9444
187 PZI 0.9443
188 FAN 0.9438
189 JLZ 0.9437
190 QWN 0.9436
191 4NC 0.9435
192 4CS 0.9432
193 NOJ 0.9432
194 XBZ 0.9430
195 HBX 0.9429
196 2AC 0.9428
197 I3A 0.9425
198 INO 0.9425
199 2MH 0.9420
200 4ZE 0.9419
201 4SV 0.9417
202 MZG 0.9417
203 MRW 0.9414
204 XYD 0.9413
205 12Q 0.9413
206 86J 0.9413
207 PRO 0.9413
208 4FA 0.9413
209 KJH 0.9411
210 JBE 0.9411
211 3AB 0.9411
212 G3E 0.9411
213 SYN 0.9410
214 R8V 0.9409
215 34A 0.9407
216 BTY 0.9407
217 2MP 0.9406
218 MR1 0.9405
219 8ZE 0.9405
220 F9P 0.9404
221 A1U 0.9403
222 P9P 0.9402
223 4CL 0.9401
224 5UC 0.9401
225 FBM 0.9400
226 5JQ 0.9397
227 1P7 0.9397
228 SYV 0.9396
229 ABN 0.9396
230 3HB 0.9396
231 7W1 0.9395
232 J1Z 0.9394
233 PLQ 0.9391
234 OK7 0.9391
235 PHU 0.9390
236 GAB 0.9390
237 CTL 0.9390
238 F9Y 0.9388
239 3NT 0.9388
240 PYF 0.9387
241 XX2 0.9386
242 2HQ 0.9385
243 4JJ 0.9384
244 8H8 0.9384
245 5JC 0.9384
246 FOA 0.9383
247 5HN 0.9381
248 5MH 0.9381
249 75K 0.9379
250 NBE 0.9378
251 23A 0.9378
252 3U4 0.9377
253 TTL 0.9377
254 RSF 0.9377
255 D48 0.9376
256 HQE 0.9375
257 7HQ 0.9375
258 NNO 0.9375
259 FPN 0.9371
260 JZ2 0.9371
261 LG4 0.9371
262 PM6 0.9370
263 ES4 0.9367
264 3HA 0.9367
265 3F0 0.9365
266 DA1 0.9362
267 4JT 0.9361
268 PY7 0.9361
269 5QX 0.9360
270 BR9 0.9359
271 FPY 0.9359
272 3OC 0.9359
273 K34 0.9358
274 27Y 0.9358
275 2YU 0.9357
276 4XH 0.9356
277 KUF 0.9354
278 PCR 0.9352
279 FHB 0.9351
280 B55 0.9350
281 HH8 0.9350
282 JZ3 0.9350
283 NMJ 0.9350
284 MYJ 0.9349
285 2HO 0.9348
286 SW7 0.9348
287 QXW 0.9348
288 CWS 0.9348
289 8TX 0.9347
290 54D 0.9347
291 I1E 0.9347
292 4A3 0.9347
293 PXY 0.9344
294 ADZ 0.9344
295 XAZ 0.9344
296 0P6 0.9342
297 HQT 0.9342
298 MWJ 0.9342
299 ES6 0.9340
300 J9Q 0.9340
301 O72 0.9339
302 BML 0.9339
303 B57 0.9338
304 HIS 0.9336
305 3HM 0.9335
306 TM7 0.9332
307 BTE 0.9331
308 8WT 0.9331
309 OXQ 0.9330
310 5JL 0.9329
311 G3F 0.9329
312 FP1 0.9327
313 0R0 0.9326
314 IV2 0.9326
315 261 0.9325
316 53C 0.9325
317 43M 0.9324
318 CXF 0.9324
319 HH5 0.9323
320 MLT 0.9323
321 25R 0.9322
322 DBH 0.9322
323 JBK 0.9319
324 3M0 0.9318
325 HT4 0.9316
326 93K 0.9315
327 M4T 0.9315
328 FBA 0.9315
329 SOE 0.9314
330 RM1 0.9312
331 EA1 0.9311
332 QSC 0.9311
333 4JQ 0.9310
334 4ZA 0.9309
335 SE2 0.9307
336 E5X 0.9307
337 J5I 0.9306
338 PYC 0.9306
339 BSX 0.9304
340 JKE 0.9304
341 MQN 0.9303
342 AZA 0.9301
343 XAN 0.9301
344 BZ2 0.9300
345 GUN 0.9300
346 JBH 0.9299
347 FE DB1 0.9298
348 AC6 0.9298
349 4HS 0.9293
350 3XX 0.9293
351 5B1 0.9292
352 SKA 0.9292
353 4CH 0.9291
354 TP5 0.9289
355 SWA 0.9289
356 WCE 0.9286
357 P3K 0.9285
358 0TU 0.9285
359 FUL 0.9285
360 1LM 0.9284
361 GCS 0.9284
362 4BZ 0.9283
363 1WD 0.9282
364 WOT 0.9280
365 1MR 0.9280
366 4WL 0.9280
367 9DG 0.9278
368 8CM 0.9275
369 XYS 0.9274
370 82I 0.9272
371 A2F 0.9271
372 5RG 0.9268
373 KJU 0.9268
374 OVV 0.9267
375 7WV 0.9265
376 6GU 0.9264
377 4JL 0.9264
378 HX3 0.9261
379 8IG 0.9260
380 CFP 0.9260
381 GBD 0.9259
382 9TW 0.9258
383 CHB 0.9258
384 4YO 0.9254
385 92K 0.9253
386 ICB 0.9253
387 0TR 0.9251
388 5RN 0.9251
389 C2B 0.9250
390 RIP 0.9248
391 4JO 0.9247
392 NSP 0.9247
393 6F0 0.9247
394 TZC 0.9246
395 4JN 0.9245
396 G2F 0.9245
397 DFB 0.9244
398 GAL 0.9241
399 PCA 0.9241
400 6AP 0.9240
401 4HM 0.9240
402 14J 0.9238
403 JIF 0.9237
404 0HN 0.9234
405 AZG 0.9233
406 BRT 0.9233
407 7MU 0.9233
408 97T 0.9233
409 0JD 0.9232
410 C21 0.9228
411 PAC 0.9228
412 IGA 0.9226
413 BPN 0.9226
414 8S0 0.9226
415 YRL 0.9225
416 2ZV 0.9224
417 PNZ 0.9224
418 0MK 0.9223
419 5NI 0.9223
420 6NT 0.9222
421 M58 0.9218
422 PIM 0.9218
423 IUR 0.9217
424 DX4 0.9217
425 2PC 0.9216
426 AZ8 0.9215
427 MAE 0.9215
428 KT7 0.9214
429 SHA 0.9214
430 DGJ 0.9213
431 141 0.9212
432 0HO 0.9212
433 4JM 0.9211
434 3SK 0.9210
435 FDB 0.9208
436 5AC 0.9205
437 265 0.9204
438 FUC 0.9204
439 JZ5 0.9204
440 GDE 0.9203
441 B53 0.9202
442 IFL 0.9201
443 IPB 0.9200
444 VNJ 0.9200
445 2EC 0.9200
446 TIU 0.9200
447 3BZ 0.9197
448 0CU 0.9197
449 DHK 0.9197
450 6FZ 0.9197
451 HY3 0.9196
452 E7S 0.9196
453 ZZT 0.9195
454 ANN 0.9195
455 DYA 0.9194
456 EQT 0.9193
457 IT2 0.9193
458 7B4 0.9192
459 IDH 0.9192
460 LDU 0.9192
461 HMU 0.9191
462 5GU 0.9191
463 ASO 0.9190
464 N2I 0.9189
465 ESP 0.9188
466 XBT 0.9187
467 KDV 0.9186
468 UGC 0.9185
469 GRE 0.9184
470 BEA 0.9184
471 IOL 0.9183
472 LT2 0.9183
473 YH7 0.9182
474 3NY 0.9182
475 MS9 0.9181
476 290 0.9180
477 R8S 0.9180
478 GAG 0.9180
479 RCO 0.9180
480 ZBT 0.9179
481 HSM 0.9177
482 IF7 0.9176
483 FCR 0.9175
484 273 0.9175
485 BOA 0.9174
486 2ZM 0.9174
487 1DU 0.9174
488 M1Q 0.9174
489 24B 0.9173
490 1XM 0.9170
491 6M1 0.9170
492 SWD 0.9169
493 IHB 0.9169
494 AZ9 0.9169
495 F81 0.9167
496 TLA 0.9166
497 ADK 0.9165
498 XRG 0.9165
499 ARB 0.9165
500 Q24 0.9163
501 GTQ 0.9163
502 DHR 0.9161
503 FQI 0.9161
504 5M0 0.9161
505 1XN 0.9161
506 L3Q 0.9160
507 3Z8 0.9160
508 R8A 0.9159
509 PKU 0.9158
510 6CS 0.9157
511 AEF 0.9156
512 ECE 0.9156
513 Y8I 0.9155
514 DE5 0.9155
515 EUG 0.9153
516 9FL 0.9153
517 SAN 0.9153
518 4AA 0.9152
519 HHA 0.9150
520 M2K 0.9150
521 PZM 0.9149
522 TSU 0.9148
523 TLD 0.9147
524 2HU 0.9145
525 MUA 0.9144
526 R9Y 0.9143
527 3DM 0.9141
528 MEW 0.9141
529 150 0.9140
530 JAB 0.9137
531 54G 0.9137
532 BCP 0.9136
533 3WA 0.9136
534 1WG 0.9135
535 RIB 0.9135
536 ABI 0.9132
537 GIO 0.9132
538 RMN 0.9132
539 JZ7 0.9131
540 1F1 0.9131
541 J6W 0.9131
542 8OZ 0.9131
543 HIO 0.9130
544 GYE 0.9130
545 UY7 0.9129
546 JBN 0.9128
547 7WG 0.9128
548 HDH 0.9127
549 2AL 0.9126
550 LZM 0.9122
551 8WO 0.9121
552 LMR 0.9120
553 4HC 0.9120
554 QSB 0.9120
555 7MH 0.9119
556 2FG 0.9119
557 069 0.9118
558 7N0 0.9118
559 PEL 0.9117
560 M6W 0.9117
561 PIY 0.9117
562 PE0 0.9116
563 AJ2 0.9116
564 E7Z 0.9114
565 APY 0.9114
566 CWJ 0.9113
567 CRS 0.9113
568 SKM 0.9113
569 M5K 0.9112
570 2H5 0.9111
571 M6N 0.9110
572 EKZ 0.9110
573 42A 0.9109
574 F0J 0.9108
575 2CQ 0.9106
576 64K 0.9106
577 OHG 0.9103
578 AKG 0.9103
579 DFU 0.9102
580 60P 0.9100
581 9TZ 0.9100
582 285 0.9100
583 AQO 0.9099
584 OTR 0.9099
585 SRT 0.9098
586 6NI 0.9097
587 23W 0.9096
588 AGK 0.9095
589 9R5 0.9094
590 IFM 0.9092
591 BDP 0.9091
592 JBQ 0.9090
593 NOY 0.9090
594 ICO 0.9089
595 GLL 0.9089
596 1DV 0.9088
597 9CL 0.9086
598 15E 0.9084
599 V55 0.9083
600 3A9 0.9083
601 0W8 0.9083
602 J9W 0.9083
603 PYJ 0.9083
604 HY1 0.9081
605 GIF 0.9081
606 FB2 0.9081
607 GLA 0.9081
608 2A9 0.9080
609 NDH 0.9080
610 2FY 0.9080
611 TGX 0.9080
612 H3M 0.9080
613 PYG 0.9080
614 51R 0.9079
615 R9S 0.9079
616 ORO 0.9078
617 MAK 0.9077
618 LDP 0.9077
619 AAS 0.9077
620 4ZC 0.9075
621 4NM 0.9075
622 7CZ 0.9075
623 T6C 0.9075
624 149 0.9074
625 G4D 0.9073
626 AZF 0.9073
627 QOS 0.9071
628 B24 0.9070
629 3ZQ 0.9069
630 N8Y 0.9068
631 GJZ 0.9068
632 DOR 0.9068
633 HQJ 0.9066
634 VNL 0.9066
635 52C 0.9066
636 JAW 0.9065
637 FA1 0.9065
638 BCU 0.9064
639 5RO 0.9064
640 GAF 0.9064
641 S76 0.9064
642 LG3 0.9063
643 GZL 0.9063
644 URA 0.9062
645 DHQ 0.9061
646 94W 0.9059
647 APZ 0.9058
648 4J8 0.9057
649 TFB 0.9057
650 HQD 0.9055
651 3CH 0.9055
652 MT0 0.9054
653 TYL 0.9054
654 ASP 0.9052
655 IFP 0.9051
656 PBA 0.9051
657 AFR 0.9049
658 BNS 0.9049
659 RHU 0.9048
660 B62 0.9046
661 GCU 0.9045
662 SS2 0.9044
663 286 0.9044
664 2A7 0.9042
665 G6D 0.9042
666 KPL 0.9041
667 5MK 0.9040
668 FCA 0.9040
669 FBS 0.9040
670 TEP 0.9039
671 25W 0.9039
672 2LP 0.9038
673 CYT 0.9037
674 JFD 0.9035
675 259 0.9034
676 FGZ 0.9033
677 GIV 0.9033
678 UNC 0.9031
679 HZQ 0.9030
680 284 0.9029
681 42C 0.9027
682 32X 0.9026
683 C2A 0.9026
684 M1E 0.9025
685 QY9 0.9025
686 OXC 0.9023
687 3MC 0.9022
688 SN4 0.9022
689 FEH 0.9021
690 4ME 0.9021
691 3FH 0.9020
692 MSR 0.9020
693 R2B 0.9019
694 KIV 0.9019
695 ESX 0.9018
696 0N7 0.9017
697 SMV 0.9017
698 7NI 0.9016
699 1P3 0.9015
700 LCN 0.9014
701 9CA 0.9014
702 0FO 0.9014
703 F31 0.9014
704 495 0.9013
705 A29 0.9013
706 OXE 0.9013
707 D1X 0.9012
708 QX2 0.9010
709 XHP 0.9010
710 KJY 0.9010
711 X6X 0.9008
712 Q6T 0.9003
713 CAQ 0.9003
714 MWP 0.9003
715 SJ5 0.9003
716 PMB 0.9002
717 QWW 0.8999
718 BNF 0.8998
719 G5V 0.8997
720 HPY 0.8997
721 DHS 0.8996
722 RB5 0.8996
723 FBW 0.8996
724 DUC 0.8995
725 0FN 0.8993
726 BVF 0.8992
727 BP9 0.8991
728 X0V 0.8991
729 ODO 0.8991
730 XQG 0.8990
731 9MG 0.8989
732 YHO 0.8989
733 URP 0.8987
734 MNM 0.8987
735 3FA 0.8986
736 SX1 0.8985
737 45L 0.8984
738 L99 0.8984
739 JFJ 0.8983
740 15N 0.8983
741 4Z4 0.8982
742 OXZ 0.8980
743 DTL 0.8980
744 TZF 0.8979
745 GVG 0.8978
746 34D 0.8977
747 ABE 0.8976
748 LG5 0.8976
749 26D 0.8975
750 MAN 0.8974
751 9X7 0.8974
752 GXL 0.8974
753 HGQ 0.8973
754 4XX 0.8973
755 4XV 0.8972
756 OTW 0.8971
757 1DQ 0.8970
758 4FH 0.8969
759 ZXD 0.8969
760 RM4 0.8969
761 TAR 0.8968
762 PRS 0.8967
763 PYQ 0.8966
764 GTR 0.8966
765 TTY 0.8965
766 V1L 0.8964
767 3IT 0.8962
768 IP0 0.8962
769 HYP 0.8961
770 CXL 0.8961
771 1IT 0.8960
772 L5V 0.8960
773 JZ1 0.8959
774 4M4 0.8958
775 RNS 0.8958
776 PAF 0.8957
777 AW5 0.8957
778 45C 0.8956
779 FLM 0.8956
780 FFP 0.8956
781 DQU 0.8956
782 MBD 0.8956
783 AJV 0.8953
784 44W 0.8952
785 47J 0.8951
786 URQ 0.8951
787 258 0.8950
788 FOT 0.8949
789 3Z7 0.8949
790 MBG 0.8949
791 MZW 0.8945
792 Z6J 0.8941
793 1AB 0.8940
794 2AK 0.8940
795 3MA 0.8940
796 KYD 0.8940
797 36E 0.8940
798 FBV 0.8939
799 F4Z 0.8939
800 4MU 0.8938
801 FB1 0.8938
802 JDN 0.8935
803 TBP 0.8935
804 J9N 0.8934
805 GUA 0.8934
806 F5B 0.8933
807 CTS 0.8932
808 3SL 0.8932
809 M3H 0.8932
810 EDG 0.8931
811 CEE 0.8930
812 280 0.8930
813 NCT 0.8930
814 HAI 0.8929
815 AKH 0.8927
816 QMP 0.8926
817 1GN 0.8923
818 8GF 0.8922
819 FUF 0.8922
820 2XX 0.8921
821 SNU 0.8921
822 XXR 0.8921
823 GMN 0.8920
824 MO8 0.8920
825 268 0.8920
826 428 0.8919
827 BDF 0.8918
828 ASN 0.8917
829 2C9 0.8916
830 6MH 0.8916
831 PFB 0.8916
832 6TZ 0.8916
833 EVA 0.8916
834 CYH 0.8916
835 AMS 0.8912
836 L89 0.8912
837 RUU 0.8912
838 92Z 0.8911
839 ICC 0.8911
840 AMH 0.8911
841 4XS 0.8910
842 42J 0.8909
843 HJP 0.8909
844 DBX 0.8909
845 UNJ 0.8909
846 9YL 0.8908
847 NQ 0.8907
848 LGC 0.8907
849 HSO 0.8906
850 39A 0.8905
851 5LA 0.8904
852 M0Q 0.8904
853 MLA 0.8902
854 ARA 0.8901
855 HSE 0.8901
856 3DO 0.8900
857 8LG 0.8900
858 BEW 0.8899
859 TC7 0.8898
860 3RK 0.8898
861 TEO 0.8897
862 DMG 0.8896
863 69O 0.8895
864 PA1 0.8894
865 3CE 0.8892
866 40O 0.8892
867 TM4 0.8890
868 AX3 0.8890
869 6LW 0.8889
870 HEW 0.8889
871 FBJ 0.8889
872 IPH 0.8889
873 CPZ 0.8889
874 MRZ 0.8888
875 93Q 0.8888
876 DMJ 0.8886
877 GOO 0.8886
878 HLZ 0.8885
879 TMZ 0.8885
880 TSS 0.8885
881 37T 0.8884
882 E1T 0.8884
883 2MY 0.8883
884 4SX 0.8883
885 MVN 0.8882
886 SHG 0.8882
887 DRL 0.8880
888 1AN 0.8879
889 ESI 0.8877
890 ADA 0.8877
891 3MB 0.8875
892 K5W 0.8874
893 2CM 0.8874
894 YIO 0.8874
895 2AF 0.8873
896 FP2 0.8873
897 OVM 0.8873
898 B3R 0.8873
899 SIN 0.8872
900 QBK 0.8872
901 YTB 0.8872
902 LKA 0.8871
903 XCZ 0.8870
904 LYL 0.8870
905 XUL 0.8870
906 NK2 0.8870
907 EV0 0.8868
908 A13 0.8867
909 6ME 0.8867
910 APG 0.8867
911 4AP 0.8866
912 MBN 0.8865
913