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Receptor
PDB id Resolution Class Description Source Keywords
2CJW 2.1 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THE SMALL GTPASE GEM (GEMDNDCAM) IN COMPLEX TO MG.GDP HOMO SAPIENS G-PROTEIN NUCLEOTIDE-BINDING GTP-BINDING SMALL GTPASE CONFORMATIONAL CHANGE CYSTEINE-MODIFIED G-PROTEIN HYDROLASE
Ref.: BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE GEM GTPASE. J.BIOL.CHEM. V. 282 1905 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP A:999;
B:999;
Valid;
Valid;
none;
none;
Kd = 2.5 uM
443.201 C10 H15 N5 O11 P2 c1nc2...
MG A:1000;
B:1000;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2CJW 2.1 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THE SMALL GTPASE GEM (GEMDNDCAM) IN COMPLEX TO MG.GDP HOMO SAPIENS G-PROTEIN NUCLEOTIDE-BINDING GTP-BINDING SMALL GTPASE CONFORMATIONAL CHANGE CYSTEINE-MODIFIED G-PROTEIN HYDROLASE
Ref.: BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE GEM GTPASE. J.BIOL.CHEM. V. 282 1905 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2CJW Kd = 2.5 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 2CJW Kd = 2.5 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (47)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 204 families.
1 3QBT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 5WFO - 5UU C19 H16 Cl F N2 c1cc(ccc1N....
3 6FA3 Kd = 0.038 uM D1Z C30 H36 N4 O5 CN(C)Cc1cc....
4 5WFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
5 5O2T Kd = 3.9 nM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
6 5WPM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 5WFR - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 5UFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 6AMB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 6FA1 - D2Z C20 H25 N2 O4 C[NH+](C)C....
11 5UFE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 5WFP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
13 5WHB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
14 5WPL - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
15 5XCO - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
16 1NVU - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
17 5WHE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
18 3KUC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
19 1C1Y - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
20 5TAR - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
21 4DXA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
22 4HDO - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
23 3MJH - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
24 5E95 Kd = 15.7 nM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
25 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
26 2CJW Kd = 2.5 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
27 6FA4 Kd = 0.051 uM D1W C23 H25 N3 O3 CN(C)Cc1cc....
28 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
29 4K81 - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
30 1LFD - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
31 4KVG - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
32 3TNF - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
33 1ZC4 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
34 1ZC3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
35 2A9K - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
36 2A78 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
37 1WQ1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
38 3TKL - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
39 3DDC - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
40 3KUD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
41 1TU3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
42 1UAD Ka = 7260000 M^-1 GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
43 5O74 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
44 3SFV - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
45 4URZ Kd = 3 mM VJP C11 H14 N2 O3 S c1cc(ccc1N....
46 4URX Kd = 1.3 mM HXY C11 H14 Br N c1cc(ccc1C....
47 4URY Kd = 6 mM RV1 C10 H12 N2 O3 S c1cc(ccc1N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP; Similar ligands found: 161
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 9GM 0.839506 0.973684
6 GNP 0.839506 0.973684
7 G 0.828947 0.986486
8 5GP 0.828947 0.986486
9 G1R 0.82716 0.986667
10 GCP 0.82716 0.973684
11 GSP 0.817073 0.948718
12 GAV 0.797619 0.961039
13 GMV 0.792683 0.973684
14 G2P 0.77381 0.961039
15 G2R 0.770115 0.961039
16 GP2 0.756098 0.961039
17 GDC 0.747253 0.961039
18 GKE 0.747253 0.961039
19 GDD 0.747253 0.961039
20 GPG 0.741573 0.961039
21 G3D 0.732558 0.986486
22 ALF 5GP 0.729412 0.888889
23 Y9Z 0.728261 0.902439
24 G5P 0.723404 0.973684
25 GFB 0.72043 0.961039
26 GTG 0.72043 0.936709
27 GDR 0.72043 0.961039
28 G4P 0.715909 0.986486
29 G3A 0.712766 0.973684
30 6CK 0.712766 0.936709
31 GDP AF3 0.7 0.888889
32 ALF GDP 0.7 0.888889
33 GDP ALF 0.7 0.888889
34 YGP 0.698925 0.901235
35 GKD 0.697917 0.961039
36 JB2 0.697917 0.961039
37 GDX 0.690722 0.973684
38 GPD 0.690722 0.925
39 GMP 0.684211 0.88
40 0O2 0.666667 0.986486
41 JB3 0.656863 0.948718
42 NGD 0.650485 0.961039
43 DGI 0.636364 0.923077
44 GDP 7MG 0.636364 0.911392
45 U2G 0.634615 0.936709
46 GPX 0.634409 0.946667
47 G G 0.632653 0.948052
48 IDP 0.632184 0.972973
49 2MD 0.632075 0.891566
50 CAG 0.62963 0.880952
51 CG2 0.622642 0.936709
52 FEG 0.619048 0.879518
53 MGD 0.614679 0.891566
54 ZGP 0.613208 0.869048
55 GH3 0.612903 0.973333
56 3GP 0.611765 0.946667
57 MD1 0.607143 0.891566
58 PGD 0.59292 0.925
59 DGT 0.591398 0.923077
60 BGO 0.588785 0.924051
61 TPG 0.582609 0.840909
62 DBG 0.582609 0.948718
63 2GP 0.574713 0.96
64 FE9 0.570175 0.776596
65 GCP G 0.56 0.921053
66 A G 0.553571 0.935065
67 G A A A 0.553571 0.923077
68 MGP 0.553191 0.961039
69 U A G G 0.548673 0.935065
70 G4M 0.548387 0.880952
71 6G0 0.547368 0.961039
72 G1R G1R 0.542373 0.924051
73 P2G 0.527473 0.883117
74 PGD O 0.525 0.850575
75 ADP 0.522222 0.92
76 R5I 0.520833 0.946667
77 R7I 0.520833 0.946667
78 GGM 0.517544 0.901235
79 DGP 0.516484 0.910256
80 DG 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G U 0.513274 0.9
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 AKW 0.504425 0.890244
86 G C 0.504348 0.9
87 GPC 0.491525 0.879518
88 G7M 0.483871 0.948052
89 6AD 0.479592 0.841463
90 ATP 0.473684 0.92
91 HEJ 0.473684 0.92
92 G2Q 0.471154 0.961039
93 5FA 0.46875 0.92
94 AQP 0.46875 0.92
95 GTA 0.468468 0.936709
96 7DD 0.468085 0.906667
97 G G G RPC 0.466102 0.875
98 SGP 0.463158 0.82716
99 01G 0.462963 0.902439
100 HFD 0.459184 0.873418
101 B4P 0.457447 0.894737
102 AP5 0.457447 0.894737
103 A2D 0.456522 0.894737
104 6YZ 0.455446 0.896104
105 G G G C 0.455285 0.9125
106 5GP 5GP 0.454545 0.883117
107 ANP 0.454545 0.896104
108 ACQ 0.454545 0.896104
109 AT4 0.452632 0.884615
110 A G C C 0.451613 0.911392
111 APC G U 0.45082 0.886076
112 PRT 0.449541 0.959459
113 G U34 0.449153 0.888889
114 DG DG 0.448598 0.865854
115 ITT 0.447917 0.868421
116 BA3 0.446809 0.894737
117 C2E 0.444444 0.921053
118 PCG 0.444444 0.933333
119 35G 0.444444 0.933333
120 MGO 0.441176 0.864198
121 AN2 0.4375 0.907895
122 G C C C 0.4375 0.924051
123 M33 0.43299 0.883117
124 UCG 0.429688 0.911392
125 A G U 0.42963 0.888889
126 ACP 0.428571 0.896104
127 MGQ 0.424528 0.935897
128 AR6 0.424242 0.894737
129 7DT 0.424242 0.906667
130 APR 0.424242 0.894737
131 93A 0.42268 0.833333
132 A4P 0.420168 0.869048
133 G8D 0.42 0.875
134 AD9 0.42 0.896104
135 SAP 0.42 0.873418
136 AGS 0.42 0.873418
137 CA0 0.418367 0.896104
138 ATF 0.417476 0.884615
139 AGO 0.414634 0.888889
140 A G U U 0.414286 0.888889
141 NIA 0.413043 0.82716
142 MGV 0.412844 0.890244
143 TAT 0.411765 0.884615
144 T99 0.411765 0.884615
145 ADQ 0.411215 0.871795
146 A1R 0.411215 0.839506
147 RGT 0.410714 0.909091
148 CGP 0.409836 0.86747
149 C1Z 0.409091 0.986486
150 A 0.408602 0.893333
151 AMP 0.408602 0.893333
152 UP5 0.40678 0.873418
153 AMZ 0.406593 0.918919
154 C2R 0.406593 0.906667
155 JBT 0.405882 0.778947
156 A22 0.40566 0.907895
157 25L 0.405405 0.907895
158 ADX 0.40404 0.809524
159 8OD 0.401961 0.946667
160 50T 0.4 0.883117
161 4TC 0.4 0.851852
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2CJW; Ligand: GDP; Similar sites found with APoc: 658
This union binding pocket(no: 1) in the query (biounit: 2cjw.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 3H86 AP5 None
2 2QQ0 ANP None
3 2QQ0 THM None
4 2QQ0 TMP None
5 2QQ0 ADP None
6 3QXC ATP None
7 3DKP ADP None
8 3B7G ANP None
9 2B8T THM None
10 1DCP HBI None
11 1X8J A3P None
12 2JEV NHQ None
13 2ZFZ ARG None
14 2B4D COA None
15 4UTG ANP None
16 1GHE ACO None
17 4KVX ACO None
18 2B4B COA None
19 5O3Q CMP None
20 3WR7 COA None
21 1U0J ADP 1.04167
22 1OE0 TTP 1.04167
23 2I4I AMP 1.04167
24 4Z7X 3CX 1.04167
25 4PPF FLC 1.5625
26 2Q2Y MKR 1.5625
27 2Q2Y ADP 1.5625
28 2ORV 4TA 1.5625
29 4KBF AMP 1.5625
30 5ZB0 TYD 1.5625
31 5ZB0 ADP 1.5625
32 1Q20 A3P 1.5625
33 1Q20 PLO 1.5625
34 1H74 ADP 1.5625
35 4Q9N 0WE 1.5625
36 1S7N COA 1.64835
37 2VBQ BSJ 1.81818
38 3DEF GDP 2.08333
39 4NCN GTP 2.08333
40 4TMZ GSP 2.08333
41 5BYK OAQ 2.08333
42 5BYK A3P 2.08333
43 1Y63 ADP 2.17391
44 2RCN GDP 2.60417
45 4NU0 AP5 2.60417
46 5H68 AGS 2.60417
47 1D2N ANP 2.60417
48 5MEX SZZ 2.60417
49 1KNR FAD 2.60417
50 5MEX PAP 2.60417
51 4Z0G 5GP 2.60417
52 4Z87 5GP 2.60417
53 3L9W GSH 2.60417
54 3SXN COA 2.60417
55 1BG2 ADP 3.125
56 5FHD ADP ALF 3.125
57 1UJ2 ADP 3.125
58 1UJ2 C5P 3.125
59 2PL3 ADP 3.125
60 2GDJ ANP 3.125
61 5FTB ANP 3.125
62 3BFX A3P 3.125
63 3FYH ADP 3.125
64 4M0R 644 3.125
65 4AVB ACO 3.125
66 1Q0S SAH 3.125
67 3IQE F42 3.125
68 6AIC AMP 3.27103
69 3BOS CDP 3.30579
70 1B0U ATP 3.43511
71 5XKT GNP 3.64583
72 1F9V ADP 3.64583
73 2WHX ADP 3.64583
74 4PX9 ADP 3.64583
75 3TMK T5A 3.64583
76 4NE2 SH2 3.64583
77 4NE2 ADP 3.64583
78 4IHQ ADP 3.64583
79 5GVR LMR 3.64583
80 1SQ5 ADP 3.64583
81 1DAK ADP 3.64583
82 1DAK DPU 3.64583
83 1Z83 AP5 3.64583
84 1SVM ATP 3.64583
85 4FCW ADP 3.64583
86 3T34 GDP 3.64583
87 4ZNL BEF ADP 3.64583
88 3TBK ANP 3.64583
89 2FNA ADP 3.64583
90 2GK6 ADP 3.64583
91 5LLB 6YZ 3.64583
92 4A4Z ANP 3.64583
93 4ZDJ UTP 3.64583
94 2QZS 250 3.64583
95 2QZS GLC 3.64583
96 2QZS ADP 3.64583
97 1PVN MZP 3.64583
98 2GWH A3P 3.64583
99 4DDY DN6 3.64583
100 3VM7 GLC 3.64583
101 1NST A3P 3.64583
102 1XX6 ADP 3.66492
103 4HUT ATP 3.66492
104 2O66 FLC 3.7037
105 3R96 ACO 3.7234
106 3R96 AMP 3.7234
107 1QF9 C5P 4.12371
108 1QF9 ADP 4.12371
109 1QF9 ALF 4.12371
110 1RRC ADP 4.16667
111 2PZE ATP 4.16667
112 2NCD ADP 4.16667
113 4WZ6 ATP 4.16667
114 4BFW ZVW 4.16667
115 4XGU ADP 4.16667
116 5J1J ANP 4.16667
117 2FAH GDP 4.16667
118 4IOK ADP 4.16667
119 4IEE AGS 4.16667
120 4IOK XPO 4.16667
121 2ZPA ADP 4.16667
122 5TIV A3P 4.16667
123 5K5Z ANP 4.16667
124 2JJK R15 4.16667
125 5EP2 AZU 4.16667
126 4ITM ATP 4.16667
127 2QXL ATP 4.16667
128 2ZE3 AKG 4.16667
129 1VJ7 GPX 4.16667
130 4UXH T5A 4.34783
131 2ZTS ADP 4.38247
132 3TK1 GDP 4.6875
133 2W58 ADP 4.6875
134 1T5C ADP 4.6875
135 4H1V GNP 4.6875
136 5TSH ADP 4.6875
137 3UIE ANP 4.6875
138 5TSH ANP 4.6875
139 1LVK MNT BEF 4.6875
140 1CR1 TTP 4.6875
141 4PFO ADP 4.6875
142 4ZKD GDP 4.6875
143 5I34 GDP 4.6875
144 1YTM ATP 4.6875
145 2HF9 GSP 4.6875
146 2ZR9 DTP 4.6875
147 4R43 GDP 4.6875
148 5Z69 AGS 4.6875
149 2GMV UN8 4.6875
150 1NHX PEP 4.6875
151 2GMV PEP 4.6875
152 1NHX FTB 4.6875
153 5WRJ A3P 4.6875
154 5WRI A3P 4.6875
155 2C9O ADP 4.6875
156 5I0H ADP BEF 4.6875
157 5VGR GDP 4.6875
158 2J5V PCA 4.6875
159 2ZW5 COA 4.6875
160 2VZZ SCA 4.6875
161 5J1S ATP 4.87805
162 1XEX ATP 4.94506
163 1NRJ GTP 5.06329
164 5YT0 GDP 5.20833
165 5FG3 GDP 5.20833
166 1KK1 GNP 5.20833
167 1GOJ ADP 5.20833
168 2OG2 MLI 5.20833
169 4AG5 ADP 5.20833
170 4KFU ACP 5.20833
171 3B9Q MLI 5.20833
172 4JLV ADP 5.20833
173 1ZIN AP5 5.20833
174 5G3Y ADP 5.20833
175 3FWY ADP 5.20833
176 3FB4 AP5 5.20833
177 3HU3 AGS 5.20833
178 4ZG4 VO4 ADP 5.20833
179 1W7J ADP BEF 5.20833
180 4MKG AP5 5.20833
181 5AK0 8V1 5.20833
182 2RGX AP5 5.20833
183 5G41 AP5 5.20833
184 3EZ2 ADP 5.20833
185 5VHC BEF ADP 5.20833
186 2BIF ANP 5.20833
187 2BIF SIN 5.20833
188 5LTJ ADP 5.20833
189 5HR5 ADP 5.20833
190 4D81 ADP 5.20833
191 2JLR ANP 5.20833
192 4LJ9 ACP 5.20833
193 5XDR ADP 5.20833
194 2XAU ADP 5.20833
195 1W4R TTP 5.20833
196 6B4K ANP 5.20833
197 1FNN ADP 5.20833
198 4QRH 0O2 5.20833
199 1W5T ADP 5.20833
200 4R2I ANP 5.20833
201 1W5T ANP 5.20833
202 1OYY AGS 5.20833
203 3ZS9 ADP ALF 5.20833
204 2WOJ ADP ALF 5.20833
205 5X40 ACP 5.20833
206 2Z5F A3P 5.20833
207 1G3M PCQ 5.20833
208 1G3M A3P 5.20833
209 3EVF GTA 5.20833
210 1Q19 SSC 5.20833
211 3IUY AMP 5.20833
212 1J99 AND 5.20833
213 3ITJ CIT 5.20833
214 1Q19 APC 5.20833
215 5XFV FMN 5.20833
216 2HJ3 FAD 5.6
217 3MD0 GDP 5.72917
218 1SKQ GDP 5.72917
219 1G7C 5GP 5.72917
220 5L3W GDP 5.72917
221 3DC4 ADP 5.72917
222 2QZ4 ADP 5.72917
223 1S3G AP5 5.72917
224 1AKY AP5 5.72917
225 4X8O AP5 5.72917
226 5EXT ADP 5.72917
227 1F5N GNP 5.72917
228 2IS6 ADP 5.72917
229 1G6O ADP 5.72917
230 2B8W ALF 5GP 5.72917
231 3DZD ADP 5.72917
232 3Q9L ATP 5.72917
233 2JAQ DCP 5.72917
234 5MZN ADP 5.72917
235 1T8U A3P 5.72917
236 1T8U UAP SGN IDS SGN 5.72917
237 2RDT 2RD 5.72917
238 2RDT FMN 5.72917
239 2XWL CTP 5.72917
240 3AB4 THR 6.17978
241 5HCN GCP 6.25
242 6AU6 GDP 6.25
243 3COB ADP 6.25
244 4U00 ADP 6.25
245 5U32 GDP 6.25
246 1M7G AV2 6.25
247 5IRN ADP 6.25
248 4NON GDP 6.25
249 1WDT GTP 6.25
250 6B8B ADP 6.25
251 4LYA ATP 6.25
252 2GKS ADP 6.25
253 2XTN GTP 6.25
254 2BEK ATP 6.25
255 4OI4 ATP 6.25
256 2QG6 NMN 6.25
257 2CHG ANP 6.25
258 6C90 ADP 6.25
259 6FAA ADP 6.25
260 4TMK T5A 6.25
261 1D6Z HY1 6.25
262 1AQU A3P 6.25
263 5K04 COA 6.25
264 3WQT ANP 6.25
265 1M7G ADP 6.25
266 4JZ8 CIT 6.25
267 1M7G ADX 6.25
268 1HTW ADP 6.32911
269 3KTA AP5 6.35838
270 4QM7 GTP 6.43275
271 5W76 GDP 6.49351
272 5NUL FMN 6.52174
273 1YZG GDP 6.70391
274 3WYA GDP 6.77083
275 3WY9 GDP 6.77083
276 4B47 GDP 6.77083
277 5CK5 GDP 6.77083
278 1PUJ GNP 6.77083
279 2C78 GNP 6.77083
280 1G7S GDP 6.77083
281 6G14 G4P 6.77083
282 5W75 GDP 6.77083
283 1DAR GDP 6.77083
284 5GOE GDP 6.77083
285 2VVG ADP 6.77083
286 6A20 ADP 6.77083
287 1LVG ADP 6.77083
288 2C77 GNP 6.77083
289 6CS8 F9Y 6.77083
290 1JI0 ATP 6.77083
291 2QEN ADP 6.77083
292 2CDN ADP 6.77083
293 4HSE ADP 6.77083
294 1OXV ANP 6.77083
295 2XTZ GSP 6.77083
296 4MKF AP5 6.77083
297 1G6H ADP 6.77083
298 1R6B ADP 6.77083
299 5UIV ADP 6.77083
300 4TL6 ANP 6.77083
301 2YOH WMJ 6.77083
302 4QOS ADP 6.77083
303 2CE7 ADP 6.77083
304 5L3R GCP 6.77083
305 1W0J ADP 6.77083
306 4GBM A3P 6.77083
307 1W0J ADP BEF 6.77083
308 1VKJ A3P 6.77083
309 2O0J ADP 6.77083
310 1GPJ CIT 6.77083
311 5GLN XYS 6.77083
312 5TVJ COA 6.77083
313 5WQP NCA 6.77083
314 1TB3 FMN 6.77083
315 5MVR ADP 6.79012
316 4CVN ADP 6.80628
317 4BQS K2Q 6.81818
318 4BQS ADP 6.81818
319 3IO3 ADP 6.89655
320 5EE5 GTP 7.01754
321 1ZUI SKM 7.14286
322 3IIJ ADP 7.22222
323 3CNL GNP 7.29167
324 2OFW ADX 7.29167
325 1UKZ ADP 7.29167
326 4YMU ATP 7.29167
327 1NY5 ADP 7.29167
328 4OHY ANP 7.29167
329 3VX3 ADP 7.29167
330 6DEF GCP 7.29167
331 2F3R G5P 7.29167
332 3V2U ATP 7.29167
333 3QVV A3P 7.29167
334 3QVV 3QV 7.29167
335 5LU5 M7P 7.29167
336 2VB6 ADP BEF 7.38255
337 1KO8 6PG 7.42857
338 5H67 ATP 7.44681
339 1GXU 2HP 7.69231
340 1MR3 G3D 7.73481
341 2IL4 COA 7.76699
342 5W7Q GDP 7.7748
343 2FH5 GTP 7.8125
344 4WZA ACP 7.8125
345 4WZA ADP 7.8125
346 1YQT ADP 7.8125
347 1FQJ GDP 7.8125
348 1FQK GDP 7.8125
349 4V03 ADP 7.8125
350 1ZCB GDP 7.8125
351 1FP6 ADP 7.8125
352 5IRR GSP 7.8125
353 1V8K ANP 7.8125
354 1OS1 PYR 7.8125
355 1OS1 ATP 7.8125
356 5M7P ADP 7.8125
357 4IDN GNP 7.8125
358 5IFS ADP 7.8125
359 1IHU AF3 7.8125
360 1IHU ADP 7.8125
361 1IN4 ADP 7.8125
362 2FSH ANP 7.8125
363 1I0B PEL 7.8125
364 2PEZ GGZ 7.82123
365 2PEZ DAT 7.82123
366 1ZJ6 G3D 8.02139
367 1TAD GDP 8.33333
368 1TAD ALF 8.33333
369 4LC1 GDP 8.33333
370 3E70 GDP 8.33333
371 4RZ3 ADP 8.33333
372 5YV5 ADP 8.33333
373 5BN3 ADP 8.33333
374 3FKQ ATP 8.33333
375 1XKV ATP 8.33333
376 1NJF ADP 8.33333
377 1NJF AGS 8.33333
378 2ZPT A3P 8.33333
379 3RC3 ANP 8.33333
380 2X7I CIT 8.33333
381 5E5U MLI 8.33333
382 3QDK QDK 8.33333
383 3O9L LPN 8.43373
384 1F6B GDP 8.85417
385 1IWE IMP 8.85417
386 2ZFI ADP 8.85417
387 5N69 ADP 8.85417
388 4GOX A3P 8.85417
389 4WOP CTP 8.85417
390 1Z6T ADP 8.85417
391 1L2T ATP 8.85417
392 2A2C ADP 8.85417
393 2A2C NG1 8.85417
394 1BO4 COA 8.92857
395 4M7V RAR 9.14286
396 4M7V NAP 9.14286
397 1BH2 GSP 9.375
398 1Y3A GDP 9.375
399 1RJ9 GCP 9.375
400 2IYL GDP 9.375
401 2OM2 GDP 9.375
402 1G41 ADP 9.375
403 1OFH ADP 9.375
404 2CBZ ATP 9.375
405 2OZE AGS 9.375
406 3FVQ ATP 9.375
407 1SVK ALF GDP 9.375
408 5ZBR ANP 9.375
409 5Y6N ADP 9.375
410 3MGB PAP 9.375
411 3BER AMP 9.375
412 1EP2 ORO 9.375
413 1P72 ADP 9.375
414 1QHH ATP 9.58084
415 3LRE ADP 9.89583
416 2Y65 ADP 9.89583
417 3ZQ6 ADP ALF 9.89583
418 5L3V GDP 9.89583
419 1X6V ADP 9.89583
420 5L3S GNP 9.89583
421 3U6B GDP 10.4167
422 4P3Y GDP 10.4167
423 1D8T GDP 10.4167
424 5JBQ GDP 10.4167
425 4G5G GDP 10.4167
426 3U6K GDP 10.4167
427 2BVN GNP 10.4167
428 4PC3 GDP 10.4167
429 2XT3 ADP 10.4167
430 4KVA GTP 10.4167
431 4HI0 GDP 10.4167
432 5LB3 ADP 10.4167
433 1R0X ATP 10.4167
434 2ZE7 AMP 10.4167
435 2ZE7 DST 10.4167
436 2D2F ADP 10.4167
437 5ULP KB1 10.4167
438 1WWZ ACO 10.6918
439 4J0Q GDP 10.9375
440 1TQ4 GDP 10.9375
441 1D2E GDP 10.9375
442 2AWN ADP 10.9375
443 1GP2 GDP 10.9375
444 1GOT GDP 10.9375
445 1CS4 GSP 10.9375
446 4LPS GDP 10.9375
447 3A4M ADP 10.9375
448 4E03 ADP 10.9375
449 4YJ1 ADP 10.9375
450 1QHG ATP 10.9375
451 3RLF ANP 10.9375
452 3VMF GTP 11.4583
453 1SVI GDP 11.4583
454 2KIN ADP 11.4583
455 4YDS ATP 11.4583
456 3WXM GTP 11.4583
457 2DPY ADP 11.4583
458 2WOX NDP 11.4583
459 2HCJ GDP 11.6418
460 4KAX GTP 11.8343
461 3BFV ADP 11.9792
462 3QKT ANP 11.9792
463 2YCH ATP 11.9792
464 2W83 GTP 12.1212
465 1E2K TMC 12.5
466 1P9B GDP 12.5
467 1T3D CYS 12.5
468 3ZIA ADP 12.6984
469 3ZIA ATP 12.6984
470 1B7T ADP 12.8205
471 2V7Q ATP 13.0137
472 2V7Q ADP 13.0137
473 2CK3 ANP 13.0137
474 2CK3 ADP 13.0137
475 5M04 GDP 13.0208
476 1M2O GNP 13.1579
477 1J2J GTP 13.253
478 1O3Y GTP 13.253
479 2J59 GTP 13.253
480 1QF5 RPL 13.5417
481 1QF5 GDP 13.5417
482 3P4X ADP 14.0436
483 3EC1 GDP 14.0625
484 1H65 GDP 14.0625
485 2GJ8 ALF GDP 14.5349
486 3B5J 12D 14.5833
487 3KJI ADP 14.5833
488 4ZY1 4U5 14.5833
489 2QTV GNP 14.9701
490 1UPT GTP 15
491 1KK8 BEF ADP 15.1079
492 4V0K GDP 15.3846
493 1F2U ATP 15.4362
494 1NN5 ANP 15.625
495 1NN5 2DT 15.625
496 3ZFD ANP 15.625
497 1ION ADP 16.1458
498 4YS0 ADP 16.6667
499 3AQ4 GDP 16.8478
500 4XTR ATP 17.1875
501 4XTR ADP 17.1875
502 4XVU ATP 17.1875
503 1JJV ATP 17.7083
504 5J6H NCA 18
505 1S9D GDP 18.2927
506 1RE0 GDP 18.2927
507 2QN6 GDP 18.75
508 4RD0 GDP 18.75
509 3EWA ANP 18.75
510 4Q1A 2XZ 19.2708
511 4Q1A UDP 19.2708
512 2D7D ADP 20
513 2X77 GDP 20.1058
514 2OBM ADP 20.3125
515 1JJ7 ADP 20.8333
516 3PCR GTP 20.9877
517 2IXE ATP 21.875
518 5WC2 ADP 22.3958
519 4TTQ ATP 22.3958
520 1K6M AGS 23.4375
521 1R4A GNP 23.5294
522 4YLG GDP 24.8555
523 5DI3 GNP 25.5208
524 4M9Q GNP 25.5208
525 4BAS GNP 26.0417
526 3A1S GDP 27.5194
527 3DOE GTP 27.6042
528 1ZD9 GDP 27.6596
529 5KUT GDP 28.0423
530 1WF3 GNP 28.125
531 1KSH GDP 28.4946
532 5H7J GCP 28.6458
533 5H7K GDP 28.6458
534 2ZEJ GDP 29.3478
535 3T12 GDP ALF 30.2083
536 3T1O GDP 30.2083
537 1FZQ GDP 30.9392
538 2WIC GNP 31.25
539 5KSZ GCP 31.25
540 5KSP GDP 31.5789
541 1VHT BA3 31.7708
542 4R98 GNH 32.8125
543 2A5F GTP 33.1429
544 1G3Q ADP 33.3333
545 4ZI2 GNP 33.6842
546 4GOJ GNP 33.8624
547 3N5C GDP 34.5679
548 2G77 GDP 35.4167
549 1Z06 GNP 35.9788
550 3E5H GNP 37.0787
551 1GWN GTP 38.0208
552 3REF GDP 38.5417
553 4DID GDP 39.0625
554 2WMO GTP 39.4737
555 1NF3 GNP 39.5833
556 1M7B GTP 39.6739
557 2NGR GDP 39.7906
558 1A4R GNH 39.7906
559 1GRN GDP 39.7906
560 1A4R GDP 39.7906
561 4ITR GDP 39.7906
562 2EW1 GNP 40.1042
563 5JCP GDP ALF 40.1042
564 5UPK GNP 40.5405
565 2W2X GSP 41.0811
566 3W5J GDP 41.1458
567 1KMQ GNP 41.3043
568 1Z0F GDP 41.3408
569 5IRC GDP 41.3979
570 4D0N GDP 41.6216
571 6BC0 GSP 41.6216
572 3LXR GDP 41.6216
573 5HPY GDP 41.6216
574 6BCB GSP 41.6216
575 6BCA GSP 41.6216
576 2WKQ GTP 41.6667
577 4YC7 GNP 41.9889
578 2WJG GDP 42.0213
579 4XOI GTP 42.2222
580 1CXZ GSP 42.3077
581 1OW3 GDP 42.7083
582 2WJH GDP 42.7711
583 2WJH FLC 42.7711
584 4XSH GSP 43.0168
585 3BC1 GNP 43.2292
586 1VG0 GDP 43.2292
587 1VG8 GNP 43.2292
588 3GJX GTP 43.2292
589 4D0G GTP 43.4286
590 1TX4 ALF GDP 43.5028
591 5UWQ GNP 43.75
592 5UWP GNP 43.75
593 5UWO GNP 43.75
594 6CIT GNP 43.75
595 5UWU GNP 43.75
596 5UWS GNP 43.75
597 4HAT GNP 43.75
598 5UWH GNP 43.75
599 5DHF GNP 43.75
600 3WYF GTP 43.75
601 5UWT GNP 43.75
602 3M1I GTP 43.75
603 3GJ0 GDP 43.75
604 3GJ3 GDP 43.75
605 5BXQ GDP 43.75
606 3CH5 GDP 43.75
607 1DS6 GDP 43.75
608 5UWJ GNP 43.75
609 5UWW GNP 43.75
610 5DIF GNP 43.75
611 5UWI GNP 43.75
612 5UWR GNP 43.75
613 1IBR GNP 43.75
614 5DI9 GNP 43.75
615 3SBD GNP 43.8503
616 3GJ8 GDP 44.2708
617 3GJ7 GDP 44.2708
618 3GJ4 GDP 44.2708
619 3GJ5 GDP 44.2708
620 1RYH GNP 44.2708
621 1OIX GDP 44.5026
622 1MH1 GNP 44.6237
623 1E96 GTP 44.7917
624 1VG1 GDP 44.8649
625 1VG9 GDP 44.8649
626 2A5J GDP 45.0262
627 1OIV GDP 45.0262
628 1Z2A GDP 45.2381
629 2BCG GDP 45.3125
630 5SZH GNP 45.3125
631 1Z0K GTP 45.3488
632 1YZN GNP 45.4054
633 5XC5 GTP 45.4545
634 1G4U GDP 45.6522
635 3CPJ GDP 45.8333
636 1I4D GDP 45.8333
637 1Z0J GTP 45.8824
638 5OEC GDP 45.9016
639 3WYG GTP 46.1538
640 3RAB GNP 46.1538
641 2BME GNP 46.2366
642 2F9L GDP 46.3542
643 1HE1 GDP 46.5909
644 2FJU GSP 46.6292
645 6BSX GDP 47.191
646 6BSX E7S 47.191
647 1YVD GNP 47.3373
648 5JCZ GDP 47.486
649 1Z08 GNP 47.6471
650 1WA5 GTP 47.7273
651 1S8F GDP 48.0226
652 5LEF GTP 48.1675
653 1Z0A GDP 48.2759
654 4DKX GDP 48.4375
655 4LX0 BEF GDP 48.5876
656 2HV8 GTP 49.4186
657 4C4P GNP 49.711
658 3NKV GNP 49.7143
659 1G16 GDP 50
Pocket No.: 2; Query (leader) PDB : 2CJW; Ligand: GDP; Similar sites found with APoc: 45
This union binding pocket(no: 2) in the query (biounit: 2cjw.bio1) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 6EDV COA None
2 5HGZ ACO None
3 3SVL FMN None
4 1GAD NAD 1.04167
5 1I1D 16G 1.86335
6 1I1D COA 1.86335
7 1WMA NDP 2.08333
8 1WMA AB3 2.08333
9 3F8K COA 2.5
10 3L9W AMP 2.60417
11 4R57 ACO 2.84091
12 4AUT FAD 3.125
13 3BD9 A3P 3.125
14 1YBU APC 3.26087
15 5AZC PGT 3.64583
16 5EOB 5QQ 3.64583
17 1P31 EPU 3.64583
18 3KC1 2T6 4.16667
19 2VOH CIT 4.4586
20 3ELW GP3 4.6875
21 3ELW SAM 4.6875
22 3ZJ0 ACO 4.6875
23 1V0C ACO 4.6875
24 1V0C KNC 4.6875
25 4H6U ACO 4.6875
26 4KOT CE3 4.93827
27 5LTJ BEF 5.20833
28 3EVF SAH 5.20833
29 2QA1 FAD 5.72917
30 5ZBC FAD 5.72917
31 4R3L COA 6.25
32 4NSQ COA 6.31579
33 5YGE GLU 6.32184
34 5YGE ACO 6.32184
35 1CM0 COA 7.14286
36 5FVJ ACO 7.83133
37 6G96 ACO 7.95455
38 6H5E ANP 8.33333
39 2OHH FMN 8.85417
40 5KF9 ACO 8.85417
41 2FXV 5GP 9.375
42 1U1I NAD 9.89583
43 4EHU ANP 9.89583
44 4B9Q ATP 13.0208
45 2ZJ5 ADP 26.0417
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