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Receptor
PDB id Resolution Class Description Source Keywords
2C5L 1.9 Å EC: 3.6.5.2 STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS HOMO SAPIENS SIGNALING PROTEIN-COMPLEX RAS UBIQUITIN SUPERFOLD ONCOGENBINDING NUCLEOTIDE- BINDING SIGNALING PROTEIN DISEASE MULIPOPROTEIN PALMITATE PRENYLATION PROTO-ONCOGENE
Ref.: STRUCTURAL AND MECHANISTIC INSIGHTS INTO RAS ASSOCI DOMAINS OF PHOSPHOLIPASE C EPSILON MOL.CELL V. 21 495 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1169;
A:1170;
B:1169;
C:3240;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
GTP A:1167;
B:1167;
Valid;
Valid;
none;
none;
submit data
523.18 C10 H16 N5 O14 P3 c1nc2...
MG A:1168;
B:1168;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2C5L 1.9 Å EC: 3.6.5.2 STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS HOMO SAPIENS SIGNALING PROTEIN-COMPLEX RAS UBIQUITIN SUPERFOLD ONCOGENBINDING NUCLEOTIDE- BINDING SIGNALING PROTEIN DISEASE MULIPOPROTEIN PALMITATE PRENYLATION PROTO-ONCOGENE
Ref.: STRUCTURAL AND MECHANISTIC INSIGHTS INTO RAS ASSOCI DOMAINS OF PHOSPHOLIPASE C EPSILON MOL.CELL V. 21 495 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
70% Homology Family (34)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 250 families.
1 5WFO - 5UU C19 H16 Cl F N2 c1cc(ccc1N....
2 6FA3 Kd = 0.038 uM D1Z C30 H36 N4 O5 CN(C)Cc1cc....
3 5WFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
4 5O2T Kd = 3.9 nM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
5 5WPM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
6 5WFR - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 5UFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 6AMB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 6FA1 - D2Z C20 H25 N2 O4 C[NH+](C)C....
10 5UFE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
11 5WFP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 5WHB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
13 5WPL - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
14 5XCO - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
15 1NVU - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
16 5WHE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
17 3KUC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
18 1C1Y - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
19 5TAR - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
20 4DXA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
21 4HDO - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
22 5E95 Kd = 15.7 nM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
23 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
24 6FA4 Kd = 0.051 uM D1W C23 H25 N3 O3 CN(C)Cc1cc....
25 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
26 4K81 - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
27 1LFD - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
28 4KVG - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
29 1WQ1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
30 3DDC - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
31 3KUD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
32 4URZ Kd = 3 mM VJP C11 H14 N2 O3 S c1cc(ccc1N....
33 4URX Kd = 1.3 mM HXY C11 H14 Br N c1cc(ccc1C....
34 4URY Kd = 6 mM RV1 C10 H12 N2 O3 S c1cc(ccc1N....
50% Homology Family (47)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 204 families.
1 3QBT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 5WFO - 5UU C19 H16 Cl F N2 c1cc(ccc1N....
3 6FA3 Kd = 0.038 uM D1Z C30 H36 N4 O5 CN(C)Cc1cc....
4 5WFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
5 5O2T Kd = 3.9 nM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
6 5WPM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 5WFR - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 5UFQ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 6AMB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 6FA1 - D2Z C20 H25 N2 O4 C[NH+](C)C....
11 5UFE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 5WFP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
13 5WHB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
14 5WPL - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
15 5XCO - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
16 1NVU - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
17 5WHE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
18 3KUC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
19 1C1Y - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
20 5TAR - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
21 4DXA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
22 4HDO - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
23 3MJH - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
24 5E95 Kd = 15.7 nM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
25 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
26 2CJW Kd = 2.5 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
27 6FA4 Kd = 0.051 uM D1W C23 H25 N3 O3 CN(C)Cc1cc....
28 2C5L - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
29 4K81 - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
30 1LFD - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
31 4KVG - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
32 3TNF - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
33 1ZC4 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
34 1ZC3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
35 2A9K - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
36 2A78 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
37 1WQ1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
38 3TKL - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
39 3DDC - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
40 3KUD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
41 1TU3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
42 1UAD Ka = 7260000 M^-1 GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
43 5O74 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
44 3SFV - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
45 4URZ Kd = 3 mM VJP C11 H14 N2 O3 S c1cc(ccc1N....
46 4URX Kd = 1.3 mM HXY C11 H14 Br N c1cc(ccc1C....
47 4URY Kd = 6 mM RV1 C10 H12 N2 O3 S c1cc(ccc1N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GTP; Similar ligands found: 156
No: Ligand ECFP6 Tc MDL keys Tc
1 GTP 1 1
2 GP3 0.921053 0.973684
3 GDP 0.909091 1
4 GSP 0.853659 0.948718
5 GNH 0.82716 0.986667
6 G1R 0.819277 0.986667
7 GAV 0.811765 0.961039
8 9GM 0.809524 0.973684
9 GNP 0.809524 0.973684
10 GCP 0.797619 0.973684
11 5GP 0.797468 0.986486
12 G 0.797468 0.986486
13 GMV 0.764706 0.973684
14 G2R 0.764045 0.961039
15 G5P 0.755319 0.973684
16 GTG 0.752688 0.936709
17 G2P 0.747126 0.961039
18 G3A 0.744681 0.973684
19 GDD 0.741935 0.961039
20 GDC 0.741935 0.961039
21 GKE 0.741935 0.961039
22 0O2 0.736264 0.986486
23 GP2 0.729412 0.961039
24 6CK 0.726316 0.936709
25 Y9Z 0.723404 0.902439
26 GPG 0.717391 0.961039
27 GFB 0.715789 0.961039
28 GDR 0.715789 0.961039
29 GPD 0.704082 0.925
30 GKD 0.693878 0.961039
31 JB2 0.693878 0.961039
32 GDX 0.686869 0.973684
33 ALF 5GP 0.685393 0.888889
34 GH3 0.681319 0.973333
35 YGP 0.677083 0.901235
36 G3D 0.67033 0.986486
37 GDP AF3 0.659574 0.888889
38 ALF GDP 0.659574 0.888889
39 GDP ALF 0.659574 0.888889
40 DGT 0.659341 0.923077
41 GMP 0.658228 0.88
42 G4P 0.655914 0.986486
43 JB3 0.653846 0.948718
44 NGD 0.647619 0.961039
45 CAG 0.642202 0.880952
46 2MD 0.62963 0.891566
47 MGP 0.619565 0.961039
48 U2G 0.616822 0.936709
49 6G0 0.612903 0.961039
50 MGD 0.612613 0.891566
51 TPG 0.608696 0.840909
52 CG2 0.605505 0.936709
53 GDP 7MG 0.601942 0.911392
54 FEG 0.601852 0.879518
55 G G 0.598039 0.948052
56 ZGP 0.59633 0.869048
57 PGD 0.591304 0.925
58 MD1 0.591304 0.891566
59 3GP 0.590909 0.946667
60 GPX 0.581633 0.946667
61 DGI 0.580645 0.923077
62 IDP 0.576087 0.972973
63 DBG 0.567797 0.948718
64 2GP 0.555556 0.96
65 FE9 0.555556 0.776596
66 G4M 0.547619 0.880952
67 BGO 0.544643 0.924051
68 GCP G 0.543689 0.921053
69 ATP 0.537634 0.92
70 HEJ 0.537634 0.92
71 G1G 0.533898 0.925
72 AQP 0.531915 0.92
73 5FA 0.531915 0.92
74 A G 0.525862 0.935065
75 G A A A 0.525862 0.923077
76 U A G G 0.521368 0.935065
77 HFD 0.520833 0.873418
78 R5I 0.520408 0.946667
79 R7I 0.520408 0.946667
80 01G 0.518868 0.902439
81 P2G 0.510638 0.883117
82 ITT 0.510638 0.868421
83 AKW 0.504348 0.890244
84 GGM 0.504274 0.901235
85 G1R G1R 0.504065 0.924051
86 DGP 0.5 0.910256
87 PGD O 0.5 0.850575
88 MGO 0.5 0.864198
89 DG 0.5 0.910256
90 P1G 0.5 0.871795
91 GTA 0.495495 0.936709
92 PRT 0.490741 0.959459
93 B4P 0.489362 0.894737
94 AP5 0.489362 0.894737
95 IMP 0.489362 0.959459
96 G U 0.487179 0.9
97 7DT 0.484536 0.906667
98 GPC 0.479339 0.879518
99 G C 0.478992 0.9
100 BA3 0.478723 0.894737
101 ADP 0.473684 0.92
102 G2Q 0.471698 0.961039
103 6YZ 0.470588 0.896104
104 G7M 0.46875 0.948052
105 C1Z 0.462963 0.986486
106 25L 0.458716 0.907895
107 A2D 0.457447 0.894737
108 RGT 0.45045 0.909091
109 AGS 0.45 0.873418
110 SAP 0.45 0.873418
111 SGP 0.44898 0.82716
112 A4P 0.445378 0.869048
113 G G G RPC 0.442623 0.875
114 ANP 0.441176 0.896104
115 ACQ 0.441176 0.896104
116 8GT 0.441176 0.875
117 APC G U 0.44 0.886076
118 AT4 0.438776 0.884615
119 G U34 0.438017 0.888889
120 6AD 0.436893 0.841463
121 G G G C 0.433071 0.9125
122 UP5 0.432203 0.873418
123 PCG 0.431373 0.933333
124 C2E 0.431373 0.921053
125 35G 0.431373 0.933333
126 A G C C 0.429688 0.911392
127 T99 0.427184 0.884615
128 5GP 5GP 0.427184 0.883117
129 TAT 0.427184 0.884615
130 AR6 0.425743 0.894737
131 APR 0.425743 0.894737
132 7DD 0.424242 0.906667
133 AN2 0.424242 0.907895
134 DG DG 0.423423 0.865854
135 AD9 0.421569 0.896104
136 M33 0.42 0.883117
137 7D4 0.42 0.835443
138 UCG 0.419847 0.911392
139 HDV 0.419048 0.825
140 H6Y 0.419048 0.946667
141 G C C C 0.416667 0.924051
142 ACP 0.415842 0.896104
143 T5A 0.414634 0.802326
144 A1R 0.412844 0.839506
145 ADQ 0.412844 0.871795
146 MGQ 0.412844 0.935897
147 A3R 0.412844 0.839506
148 MGT 0.411215 0.823529
149 A G U 0.410072 0.888889
150 93A 0.41 0.833333
151 A22 0.407407 0.907895
152 CA0 0.405941 0.896104
153 ATF 0.40566 0.884615
154 AGO 0.404762 0.888889
155 MGV 0.401786 0.890244
156 CGP 0.4 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2C5L; Ligand: GTP; Similar sites found with APoc: 598
This union binding pocket(no: 1) in the query (biounit: 2c5l.bio2) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 1GXU 2HP None
2 2YY8 MTA None
3 1SQL GUN None
4 2JDU MFU None
5 1PTR PRB None
6 2VOH CIT 1.91083
7 5EXT ADP 2.31214
8 4PYA 2X3 2.48447
9 4KAX GTP 2.5641
10 3N5C GDP 2.5641
11 3IIJ ADP 2.5641
12 4KJU 1RH 2.5641
13 2WCU FUC 2.68456
14 1T3D CYS 2.89017
15 1R18 SAH 2.89017
16 1A78 TDG 3.4188
17 1P72 ADP 3.4188
18 1TE2 PGA 3.4188
19 1TQ4 GDP 3.46821
20 3EZ2 ADP 3.46821
21 2ZTS ADP 3.46821
22 4MZQ 1VU 3.47222
23 5L3W GDP 4.04624
24 5UIV ADP 4.04624
25 3BER AMP 4.04624
26 4E3Q PMP 4.04624
27 1BO4 COA 4.16667
28 2X77 GDP 4.2735
29 5GVR LMR 4.2735
30 1NJF ADP 4.2735
31 1NJF AGS 4.2735
32 2Q37 3AL 4.2735
33 1ZVX FIN 4.29448
34 2GNK ATP 4.46429
35 1UPT GTP 4.62428
36 3DC4 ADP 4.62428
37 1G6O ADP 4.62428
38 3BOS CDP 4.62428
39 3B7G ANP 4.62428
40 1L2T ATP 4.62428
41 1IWE IMP 4.62428
42 5FTB ANP 5.12821
43 2J5V PCA 5.12821
44 1KO8 6PG 5.12821
45 3ITJ CIT 5.12821
46 3H86 AP5 5.12821
47 5FHD ADP ALF 5.12821
48 5VHC BEF ADP 5.12821
49 1V0O INR 5.12821
50 5CZY SAM 5.12821
51 1G6H ADP 5.20231
52 5K5Z ANP 5.20231
53 1K4M CIT 5.20231
54 4U60 SIA GAL NGA 5.20231
55 3QXC ATP 5.20231
56 4GBM A3P 5.26316
57 2B8W ALF 5GP 5.78035
58 2OBM ADP 5.78035
59 3ZS9 ADP ALF 5.78035
60 5MZN ADP 5.78035
61 2WOJ ADP ALF 5.78035
62 4YJ1 ADP 5.78035
63 4QRH 0O2 5.78035
64 2Z5F A3P 5.78035
65 5VYQ FON 5.78035
66 3ENV ABF 5.78035
67 1W7J ADP BEF 5.96026
68 2A5F GTP 5.98291
69 1VHT BA3 5.98291
70 1YTM ATP 5.98291
71 2BEK ATP 5.98291
72 5Z69 AGS 5.98291
73 4Q1A 2XZ 5.98291
74 4Q1A UDP 5.98291
75 1GVF PGH 5.98291
76 5H68 AGS 5.98291
77 5I34 GDP 5.98291
78 1T8U UAP SGN IDS SGN 5.98291
79 3FSY SCA 5.98291
80 4U36 TNR 5.98291
81 4GOX A3P 5.98291
82 1T8U A3P 5.98291
83 1APZ ASP 6.17284
84 1HTW ADP 6.32911
85 5KUT GDP 6.34921
86 2PZE ATP 6.35838
87 4WZ6 ATP 6.35838
88 2DPY ADP 6.35838
89 4R43 GDP 6.35838
90 2ZPA ADP 6.35838
91 4QOS ADP 6.35838
92 2NZ5 226 6.35838
93 1EXF GLY 6.35838
94 3RC3 ANP 6.35838
95 1E2K TMC 6.35838
96 5NM7 GLY 6.35838
97 1QF9 ALF 6.35838
98 1QF9 ADP 6.35838
99 1QF9 C5P 6.35838
100 3WYA GDP 6.45161
101 1G8S MET 6.52174
102 4WOP CTP 6.66667
103 2HCJ GDP 6.83761
104 3U6B GDP 6.83761
105 2BVN GNP 6.83761
106 1D8T GDP 6.83761
107 5JBQ GDP 6.83761
108 4G5G GDP 6.83761
109 3U6K GDP 6.83761
110 3H4S ADP 6.83761
111 4FRZ ADP 6.83761
112 3NHB ADP 6.83761
113 1B0U ATP 6.83761
114 5TSH ADP 6.83761
115 5TSH ANP 6.83761
116 5BQ5 ADP BEF 6.83761
117 4ZNL BEF ADP 6.83761
118 4FCW ADP 6.83761
119 3IO3 ADP 6.83761
120 3ZQ6 ADP ALF 6.83761
121 4LJ9 ACP 6.83761
122 2O66 FLC 6.83761
123 2OZE AGS 6.83761
124 4HE2 AMP 6.83761
125 5W7Q GDP 6.93642
126 3CNL GNP 6.93642
127 5W75 GDP 6.93642
128 1GOJ ADP 6.93642
129 3ZFD ANP 6.93642
130 1M7G AV2 6.93642
131 2X7I CIT 6.93642
132 3BFX A3P 6.93642
133 6B8B ADP 6.93642
134 1M7G ADP 6.93642
135 1Z83 AP5 6.93642
136 1U2Z SAH 6.93642
137 1M7G ADX 6.93642
138 2WPB ZZI 6.93642
139 1DAK ADP 7.14286
140 1DAK DPU 7.14286
141 1TAD GDP 7.51445
142 1TAD ALF 7.51445
143 1LVG ADP 7.51445
144 2Y65 ADP 7.51445
145 4H1V GNP 7.51445
146 1IN4 ADP 7.51445
147 4X8O AP5 7.51445
148 5H4S RAM 7.51445
149 5MEX PAP 7.51445
150 5I0H ADP BEF 7.69231
151 2ZFI ADP 7.69231
152 5LB3 ADP 7.69231
153 3T34 GDP 7.69231
154 4PX9 ADP 7.69231
155 2C9O ADP 7.69231
156 4YS0 ADP 7.69231
157 1S3G AP5 7.69231
158 2Z48 NGA 7.69231
159 1O8B ABF 7.69231
160 3EF0 ALF 7.69231
161 3QDK QDK 7.69231
162 2Z49 AMG 7.69231
163 5G09 6DF 7.69231
164 2RCN GDP 8.09249
165 4P3Y GDP 8.09249
166 1CS4 GSP 8.09249
167 3LRE ADP 8.09249
168 5IRR GSP 8.09249
169 1G7C 5GP 8.09249
170 6AU6 GDP 8.09249
171 5U32 GDP 8.09249
172 4CVN ADP 8.09249
173 4IDN GNP 8.09249
174 2BIF SIN 8.09249
175 2BIF ANP 8.09249
176 1K6M AGS 8.09249
177 5E5U MLI 8.09249
178 3KIH GDL 8.24742
179 6CS8 F9Y 8.25082
180 4PU6 ASP 8.39695
181 5EE5 GTP 8.54701
182 5M04 GDP 8.54701
183 3PCR GTP 8.54701
184 2XT3 ADP 8.54701
185 1OXV ANP 8.54701
186 1ION ADP 8.54701
187 2GK6 ADP 8.54701
188 5AK0 8V1 8.54701
189 4ZDJ UTP 8.54701
190 5XQL C2E 8.54701
191 4LZB URA 8.54701
192 5XLS URA 8.54701
193 5ZB0 ADP 8.54701
194 5ZB0 TYD 8.54701
195 3WXM GTP 8.67052
196 3VMF GTP 8.67052
197 3COB ADP 8.67052
198 1D2E GDP 8.67052
199 1XKV ATP 8.67052
200 4IOK XPO 8.67052
201 4IOK ADP 8.67052
202 2R4V GSH 8.67052
203 2IL4 COA 8.73786
204 4LC1 GDP 9.24856
205 4PC3 GDP 9.24856
206 2HF9 GSP 9.24856
207 6DEF GCP 9.24856
208 1W5T ANP 9.24856
209 1W5T ADP 9.24856
210 4NU0 AP5 9.24856
211 3R7F CP 9.24856
212 4WEI GLC GAL 9.24856
213 1AKY AP5 9.24856
214 2GWH A3P 9.24856
215 2HXW FLC 9.24856
216 2NCD ADP 9.24856
217 2OAT PFM 9.24856
218 5TQZ GLC 9.33333
219 2C78 GNP 9.40171
220 2C77 GNP 9.40171
221 1V8K ANP 9.40171
222 2KIN ADP 9.40171
223 1JI0 ATP 9.40171
224 4V03 ADP 9.40171
225 3FWY ADP 9.40171
226 3Q9L ATP 9.40171
227 1G3Q ADP 9.40171
228 1FP6 ADP 9.40171
229 2VB6 ADP BEF 9.40171
230 3TBK ANP 9.40171
231 4D81 ADP 9.40171
232 2FAH GDP 9.40171
233 4PFO ADP 9.40171
234 5M7P ADP 9.40171
235 2FSH ANP 9.40171
236 6FAA ADP 9.40171
237 2OFW ADX 9.40171
238 2PEZ DAT 9.40171
239 2PEZ GGZ 9.40171
240 1X6V ADP 9.40171
241 3FB4 AP5 9.40171
242 4Z7X 3CX 9.40171
243 1KJ8 GAR 9.40171
244 3DOE GTP 9.69697
245 1WDT GTP 9.82659
246 2CBZ ATP 9.82659
247 1BG2 ADP 9.82659
248 1F9V ADP 9.82659
249 2D2F ADP 9.82659
250 5IFS ADP 9.82659
251 1MLY ACZ PLP 9.82659
252 1D2N ANP 9.82659
253 3HU3 AGS 9.82659
254 4NZ6 DGL 9.82659
255 5XKT GNP 10
256 5ZXD ATP 10.2564
257 1R0X ATP 10.2564
258 1F5N GNP 10.2564
259 3KTA AP5 10.2564
260 1U0J ADP 10.2564
261 4A4Z ANP 10.2564
262 4OI4 ATP 10.2564
263 4MKG AP5 10.2564
264 4MKF AP5 10.2564
265 3IUY AMP 10.2564
266 2BO4 FLC 10.2564
267 1SKQ GDP 10.4046
268 3TK1 GDP 10.4046
269 5VGR GDP 10.4046
270 1OYY AGS 10.4046
271 1P4V GLY 10.4046
272 4GNI ATP 10.4046
273 1OSS BEN 10.4046
274 2WIC GNP 10.9827
275 4R98 GNH 10.9827
276 5ZBR ANP 10.9827
277 1NY5 ADP 10.9827
278 4TL6 ANP 10.9827
279 4PVR ASP 10.9827
280 1SVM ATP 10.9827
281 3MD0 GDP 11.1111
282 5W76 GDP 11.1111
283 2IYL GDP 11.1111
284 3UIE ANP 11.1111
285 2OG2 MLI 11.1111
286 5MVR ADP 11.1111
287 1KK8 BEF ADP 11.1111
288 3B9Q MLI 11.1111
289 1B7T ADP 11.1111
290 1XP8 AGS 11.1111
291 6B4K ANP 11.1111
292 1QAN SAH 11.1111
293 3VM7 GLC 11.1111
294 2RGX AP5 11.1111
295 3KC1 2T6 11.1111
296 3AB4 THR 11.1111
297 2QZ4 ADP 11.1111
298 1OS1 PYR 11.1111
299 1OS1 ATP 11.1111
300 5HR5 ADP 11.1111
301 5CIC 51R 11.1111
302 4O48 ASP 11.1111
303 5H67 ATP 11.25
304 1ZUI SKM 11.3095
305 2WJG GDP 11.5607
306 1JJV ATP 11.5607
307 5N69 ADP 11.5607
308 1XEX ATP 11.5607
309 1WY7 SAH 11.5607
310 1KSH GDP 11.9658
311 5HCN GCP 11.9658
312 2W58 ADP 11.9658
313 2VVG ADP 11.9658
314 1T5C ADP 11.9658
315 3A4M ADP 11.9658
316 4JLV ADP 11.9658
317 1G41 ADP 11.9658
318 2CE7 ADP 11.9658
319 4PJ3 ANP 11.9658
320 2O0J ADP 11.9658
321 3QOX SAH 11.9658
322 1NST A3P 11.9658
323 4CTA ATP 11.9658
324 6FMC DUE 12.0253
325 2WJH GDP 12.0482
326 2WJH FLC 12.0482
327 4NON GDP 12.1387
328 3P4X ADP 12.1387
329 3FKQ ATP 12.1387
330 1LVK MNT BEF 12.1387
331 3VPD CIT 12.1387
332 2XTZ GSP 12.7168
333 4ZKD GDP 12.7168
334 1JJ7 ADP 12.7168
335 4YDS ATP 12.7168
336 5KGS 6SR 12.7168
337 3EC1 GDP 12.8205
338 1SVK ALF GDP 12.8205
339 1Y3A GDP 12.8205
340 2OM2 GDP 12.8205
341 2CDN ADP 12.8205
342 5Y6N ADP 12.8205
343 4XGU ADP 12.8205
344 5J1J ANP 12.8205
345 5G3Y ADP 12.8205
346 3QKT ANP 12.8205
347 2UVO NDG 12.8205
348 1F2U ATP 12.8205
349 4NE2 SH2 12.8205
350 4NE2 ADP 12.8205
351 4P83 U5P 12.8205
352 5O96 SAM 12.8205
353 1BH2 GSP 13.0159
354 1FQK ALF 13.2308
355 1FQJ ALF 13.2308
356 1FQJ GDP 13.2308
357 1FQK GDP 13.2308
358 4YMU ATP 13.2948
359 1Y63 ADP 13.2948
360 2QEN ADP 13.2948
361 2IXE ATP 13.2948
362 4MDB RLT 13.2948
363 3K5I AIR 13.2948
364 2ODE ALF GDP 13.6752
365 1R6B ADP 13.6752
366 1SQ5 ADP 13.6752
367 3FVQ ATP 13.6752
368 6C90 ADP 13.6752
369 1OFH ADP 13.6752
370 1R4A GNP 13.7255
371 3PQC GDP 13.8728
372 4LYA ATP 13.8728
373 5L3R GCP 13.8728
374 2PL3 ADP 13.8728
375 5J1S ATP 13.8728
376 4KFU ACP 14.4509
377 2GKS ADP 14.4509
378 2IS6 ADP 14.4509
379 2GDJ ANP 14.4509
380 1IHU AF3 14.4509
381 1IHU ADP 14.4509
382 4R2I ANP 14.4509
383 1AQU A3P 14.4509
384 3FYH ADP 14.4509
385 3UG4 AHR 14.4509
386 5YV5 ADP 14.5299
387 1YQT ADP 14.5299
388 3E70 GDP 14.5299
389 5C2N NAG 14.5833
390 1MKY GDP 15.0289
391 4NCN GTP 15.0289
392 4TMZ GSP 15.0289
393 3AB3 GDP 15.0289
394 3CX8 GSP 15.0289
395 1ZCB GDP 15.0289
396 3ZIA ADP 15.0289
397 3ZIA ATP 15.0289
398 4UOX PLP 15.0289
399 4UOX PUT 15.0289
400 4U00 ADP 15.3846
401 1RRC ADP 15.3846
402 3BFV ADP 15.3846
403 3EWA ANP 15.3846
404 5G41 AP5 15.3846
405 1UTJ ABN 15.3846
406 2AWN ADP 15.6069
407 4QM7 GTP 15.6069
408 2CHG ANP 15.6069
409 3RLF ANP 15.6069
410 6AR9 3L4 16.185
411 6G14 G4P 16.2393
412 2WHX ADP 16.2393
413 4IEE AGS 16.2393
414 2JLR ANP 16.2393
415 5XDR ADP 16.2393
416 2FNA ADP 16.2393
417 2Q8M AMP 16.2393
418 4RLQ 3SK 16.2393
419 2FJK 13P 16.2393
420 1PUJ GNP 16.763
421 5X40 ACP 16.763
422 5T96 79J 16.763
423 5GOE GDP 17.094
424 4AG5 ADP 17.094
425 3B5J 12D 17.094
426 1QF5 GDP 17.094
427 1QF5 RPL 17.094
428 4JLS 3ZE 17.1053
429 3QF7 ANP 17.341
430 1GOT GDP 17.8082
431 5CK5 GDP 17.9191
432 4ZG4 VO4 ADP 17.9487
433 4XTR ADP 17.9487
434 4XTR ATP 17.9487
435 4XVU ATP 17.9487
436 2XAU ADP 17.9487
437 1QHH ATP 17.9487
438 1GP2 GDP 18.3099
439 6CRK GDP 18.3099
440 4P4T GDP 18.4971
441 1TL2 NDG 18.4971
442 2ATJ BHO 18.4971
443 4BQS ADP 18.4971
444 4BQS K2Q 18.4971
445 4RD0 GDP 18.8034
446 4WZA ACP 18.8034
447 4WZA ADP 18.8034
448 1FNN ADP 18.8034
449 1Z6T ADP 18.8034
450 6GSG RCO 18.8034
451 1P9B GDP 18.8034
452 4Y4V DAL 18.8034
453 1P9B HDA 18.8034
454 2FPU HSO 18.8034
455 1LOB MMA 18.8034
456 4PPF FLC 19.0751
457 5L3V GDP 19.0751
458 5L3S GNP 19.0751
459 2ZR9 DTP 19.0751
460 1UJ2 C5P 19.0751
461 1UJ2 ADP 19.0751
462 5L3S G 19.0751
463 2W83 GTP 19.4805
464 4HI0 GDP 19.6532
465 2D7D ADP 19.6532
466 6AIC AMP 19.6532
467 5ODQ 9SB 19.6532
468 1KK1 GNP 19.6581
469 5IRN ADP 19.6581
470 1VKJ A3P 19.6581
471 4LPS GDP 20.2312
472 4J0Q GDP 20.5128
473 2XTN GTP 20.5128
474 4TTQ ATP 20.5128
475 3DKP ADP 20.5128
476 1ZIN AP5 20.5128
477 1H65 GDP 20.8092
478 5LTJ ADP 20.8092
479 4E03 ADP 21.3675
480 1RJ9 GCP 21.3873
481 3WY9 GDP 21.875
482 5BN3 ADP 21.9653
483 1CR1 TTP 21.9653
484 4IHQ ADP 22.2222
485 4OHY ANP 22.2222
486 2Q2Y ADP 22.2222
487 2Q2Y MKR 22.2222
488 1XMV ADP 22.5434
489 4RZ3 ADP 23.0769
490 1QHG ATP 23.0769
491 5WRI A3P 23.6994
492 5WRJ A3P 23.6994
493 3W5J GDP 24.2775
494 1W0J ADP 24.2775
495 2CK3 ANP 24.2775
496 1W0J ADP BEF 24.2775
497 2CK3 ADP 24.2775
498 2V7Q ADP 24.2775
499 2V7Q ATP 24.2775
500 2FH5 GTP 24.8555
501 3DZD ADP 24.8555
502 3VX3 ADP 24.8555
503 5H7K GDP 25.4335
504 5H7J GCP 25.4335
505 4KVA GTP 26.0116
506 1XX6 ADP 26.0116
507 6A20 ADP 26.5896
508 3KJI ADP 26.5896
509 4B47 GDP 27.1676
510 5WC2 ADP 27.3504
511 4KBF AMP 27.3504
512 4HSE ADP 28.2051
513 1YRB GDP 28.3237
514 1G7S GDP 28.9017
515 1RE0 GDP 31.2139
516 1S9D GDP 31.2139
517 4DCT GDP 31.7919
518 3AQ4 GDP 31.7919
519 1WF3 GNP 31.7919
520 1NRJ GTP 32.2785
521 1ZD9 GDP 32.3699
522 1YZG GDP 32.3699
523 4YLG GDP 32.3699
524 1ZJ6 G3D 32.948
525 2QN6 GDP 33.3333
526 1J2J GTP 33.7349
527 2J59 GTP 33.7349
528 1O3Y GTP 33.7349
529 1SVI GDP 35.2601
530 5KSP GDP 36.4162
531 5KSZ GCP 36.4162
532 1DAR GDP 36.4162
533 2QTV GNP 38.1503
534 2ZEJ GDP 38.1503
535 4GOJ GNP 38.7283
536 4ZI2 GNP 38.7283
537 1FZQ GDP 38.7283
538 5KDO GDP 39.1892
539 1M2O GNP 39.3064
540 1F6B GDP 39.8844
541 5DI3 GNP 40.4624
542 2GJ8 ALF GDP 40.4624
543 4V0K GDP 40.8284
544 5YT0 GDP 42.1965
545 5FG3 GDP 42.1965
546 1MR3 G3D 42.1965
547 3A1S GDP 43.3526
548 1M7B GTP 43.9306
549 1GWN GTP 43.9306
550 3REF GDP 46.2428
551 3RAB GNP 46.8208
552 3GJX GTP 46.8208
553 3GJ4 GDP 46.8208
554 3GJ7 GDP 46.8208
555 3GJ8 GDP 46.8208
556 3GJ5 GDP 46.8208
557 5UWQ GNP 47.3988
558 5UWI GNP 47.3988
559 5UWJ GNP 47.3988
560 4HAT GNP 47.3988
561 5UWR GNP 47.3988
562 5DHF GNP 47.3988
563 6CIT GNP 47.3988
564 5UWO GNP 47.3988
565 5UWW GNP 47.3988
566 5UWT GNP 47.3988
567 5UWU GNP 47.3988
568 5UWH GNP 47.3988
569 1IBR GNP 47.3988
570 5UWP GNP 47.3988
571 5DI9 GNP 47.3988
572 5UWS GNP 47.3988
573 1NF3 GNP 47.3988
574 3GJ0 GDP 47.3988
575 5BXQ GDP 47.3988
576 3GJ3 GDP 47.3988
577 3CH5 GDP 47.3988
578 1WA5 GTP 47.3988
579 3M1I GTP 47.9769
580 3WYF GTP 47.9769
581 3WYG GTP 47.9769
582 5UPK GNP 47.9769
583 5OEC GDP 47.9769
584 2WMO GTP 48.5549
585 1GRN GDP 48.5549
586 5XC5 GTP 48.5549
587 4DID GDP 48.5549
588 1GRN AF3 48.5549
589 4ITR GDP 48.5549
590 2NGR GDP 48.5549
591 2NGR AF3 48.5549
592 1D5C GDP 48.7654
593 1A4R GNH 49.1329
594 1A4R GDP 49.1329
595 1Z0J GTP 49.4118
596 5LEF GTP 49.711
597 3E5H GNP 49.711
598 4YC7 GNP 49.711
Pocket No.: 2; Query (leader) PDB : 2C5L; Ligand: GTP; Similar sites found with APoc: 27
This union binding pocket(no: 2) in the query (biounit: 2c5l.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 1DCP HBI 2.88462
2 5URY PAM 4.10959
3 4BFW ZVW 4.62428
4 5OCM 9RH 4.811
5 1YXM ADE 5.12821
6 1V6A TRE 5.12821
7 6CBO DOW 5.12821
8 1NU4 MLA 5.15464
9 4U60 SIA 5.20231
10 4U60 SIA GAL BGC NGA GAL 5.20231
11 6EKZ SNP 6.83761
12 3MBI HSX 6.83761
13 4ZU4 4TG 7.69231
14 3BP1 GUN 8.09249
15 3KAL HGS 8.54701
16 1ZQ9 SAM 8.54701
17 1UYY BGC BGC 9.24856
18 2JC9 ADN 9.40171
19 2G36 TRP 9.82659
20 1D8C SOR 11.9658
21 2B99 RDL 11.9658
22 4B9E FAH 11.9658
23 6AYU F6P 12.8205
24 3CM2 X23 13.8462
25 5YLF BGC 17.341
26 1LES GLC FRU 19.6581
27 5LTJ BEF 20.8092
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