Receptor
PDB id Resolution Class Description Source Keywords
2B8W 2.22 Å EC: 3.-.-.- CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF H GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH GMP/ALF HOMO SAPIENS PROTEIN- GUANINE NUCLEOTIDE COMPLEX SIGNALING PROTEIN
Ref.: HOW GUANYLATE-BINDING PROTEINS ACHIEVE ASSEMBLY-STI PROCESSIVE CLEAVAGE OF GTP TO GMP. NATURE V. 440 101 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALF 5GP A:594;
B:594;
Valid;
Valid;
none;
none;
submit data
464.181 n/a P(=O)...
MG A:595;
B:595;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2B8W 2.22 Å EC: 3.-.-.- CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF H GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH GMP/ALF HOMO SAPIENS PROTEIN- GUANINE NUCLEOTIDE COMPLEX SIGNALING PROTEIN
Ref.: HOW GUANYLATE-BINDING PROTEINS ACHIEVE ASSEMBLY-STI PROCESSIVE CLEAVAGE OF GTP TO GMP. NATURE V. 440 101 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 2B8W - ALF 5GP n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2B8W - ALF 5GP n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1F5N - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 2B8W - ALF 5GP n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALF 5GP; Similar ligands found: 107
No: Ligand ECFP6 Tc MDL keys Tc
1 ALF 5GP 1 1
2 ALF GDP 0.857143 1
3 GDP ALF 0.857143 1
4 GDP AF3 0.772727 1
5 G 0.753086 0.9
6 5GP 0.753086 0.9
7 GDP 0.729412 0.888889
8 GP3 0.717647 0.86747
9 GP2 0.709302 0.857143
10 GNH 0.701149 0.878049
11 GCP 0.696629 0.86747
12 G2P 0.688889 0.857143
13 GTP 0.685393 0.888889
14 GMV 0.685393 0.890244
15 G G 0.680412 0.890244
16 G1R 0.677778 0.878049
17 GSP 0.67033 0.847059
18 GNP 0.67033 0.86747
19 9GM 0.67033 0.86747
20 GDP 7MG 0.666667 0.879518
21 GAV 0.655914 0.857143
22 GMP 0.6375 0.802469
23 G2R 0.635417 0.857143
24 GPG 0.628866 0.857143
25 YGP 0.61 0.827586
26 A G 0.609091 0.901235
27 6CK 0.607843 0.903614
28 G3A 0.607843 0.86747
29 Y9Z 0.60396 0.808989
30 GDC 0.60396 0.857143
31 GDD 0.60396 0.857143
32 GKE 0.60396 0.857143
33 U A G G 0.603604 0.901235
34 G5P 0.601942 0.86747
35 GFB 0.598039 0.857143
36 GTG 0.598039 0.858824
37 GDR 0.598039 0.857143
38 G A A A 0.594595 0.890244
39 GKD 0.580952 0.857143
40 JB2 0.580952 0.857143
41 GPD 0.575472 0.827586
42 GDX 0.575472 0.86747
43 GCP G 0.574257 0.8875
44 3GP 0.573034 0.864198
45 G3D 0.56701 0.876543
46 G4P 0.555556 0.876543
47 G1R G1R 0.554622 0.869048
48 PGD O 0.55 0.784946
49 JB3 0.54955 0.847059
50 NGD 0.544643 0.879518
51 FEG 0.544643 0.808989
52 U2G 0.544643 0.837209
53 ZGP 0.539823 0.8
54 G U 0.539823 0.869048
55 CG2 0.535088 0.837209
56 0O2 0.533981 0.876543
57 2MD 0.530435 0.8
58 G C 0.530435 0.869048
59 CAG 0.529915 0.811111
60 2GP 0.521739 0.853659
61 MGD 0.516949 0.8
62 FE9 0.516667 0.755102
63 MD1 0.512397 0.8
64 DBG 0.504065 0.847059
65 PGD 0.5 0.827586
66 TPG 0.491935 0.757895
67 G G G C 0.491803 0.858824
68 G G G RPC 0.491525 0.845238
69 GPX 0.490385 0.841463
70 A G C C 0.487805 0.879518
71 APC G U 0.487603 0.855422
72 DGI 0.484848 0.823529
73 DGP 0.484211 0.833333
74 DG 0.484211 0.833333
75 P2G 0.479167 0.807229
76 DG DG 0.476636 0.837209
77 ALF ADP 0.475248 0.9125
78 ADP ALF 0.475248 0.9125
79 G C C C 0.472441 0.869048
80 GH3 0.471154 0.865854
81 P1G 0.469388 0.797619
82 G4M 0.466165 0.791209
83 BGO 0.466102 0.825581
84 AKW 0.466102 0.818182
85 DGT 0.466019 0.823529
86 A G U 0.462687 0.858824
87 IMP 0.458333 0.875
88 IDP 0.45 0.864198
89 A G U U 0.446043 0.858824
90 GGM 0.442623 0.806818
91 5GP 5GP 0.441176 0.851852
92 G7M 0.438776 0.890244
93 G U34 0.438017 0.858824
94 SGP 0.434343 0.758621
95 GPC 0.432 0.872093
96 35G 0.431373 0.851852
97 PCG 0.431373 0.851852
98 C2E 0.431373 0.841463
99 G1G 0.425197 0.848837
100 R5I 0.419048 0.841463
101 R7I 0.419048 0.841463
102 DC DG 0.408 0.818182
103 ADP PO3 0.407767 0.8375
104 MGP 0.40566 0.879518
105 3PD UM3 0.403226 0.816092
106 6G0 0.401869 0.879518
107 GAP 0.4 0.819277
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2B8W; Ligand: ALF 5GP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2b8w.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2B8W; Ligand: ALF 5GP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2b8w.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
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