Receptor
PDB id Resolution Class Description Source Keywords
1zz2 2 Å EC: 2.7.11.24 TWO CLASSES OF P38ALPHA MAP KINASE INHIBITORS HAVING A COMMON DIPHENYLETHER CORE BUT EXHIBITING DIVERGENT BINDING M ODES HOMO SAPIENS PROTEIN-INHIBITOR COMPLEX TRANSFERASE
Ref.: TWO CLASSES OF P38ALPHA MAP KINASE INHIBITORS HAVING A COMMON DIPHENYLETHER CORE BUT EXHIBITING DIVERGENT BINDING MODES. BIOORG.MED.CHEM.LETT. V. 15 5274 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
B11 A:362;
Valid;
none;
ic50 = 6 uM
471.544 C24 H26 F N3 O4 S c1ccc...
BOG A:361;
Invalid;
none;
submit data
292.369 C14 H28 O6 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1OUK 2.5 Å EC: 2.7.11.24 THE STRUCTURE OF P38 ALPHA IN COMPLEX WITH A PYRIDINYLIMIDAZOLE INHIBITOR HOMO SAPIENS MAP KINASE HYDROPHOBIC POCKET KINASE DOMAIN ATP BINDING DOMAIN TRANSFERASE
Ref.: STRUCTURAL BASIS FOR P38ALPHA MAP KINASE QUINAZOLINONE AND PYRIDOL-PYRIMIDINE INHIBITOR SPECIFICITY NAT.STRUCT.BIOL. V. 10 764 2003
Members (137)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
4 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
5 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
6 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
7 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
8 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
9 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
10 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
11 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
12 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
13 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
14 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
15 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
16 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
17 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
18 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
19 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
20 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
21 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
22 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
23 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
24 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
25 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
26 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
27 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
28 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
29 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
30 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
31 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
32 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
33 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
34 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
35 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
36 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
37 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
38 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
39 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
40 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
41 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
42 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
43 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
44 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
45 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
46 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
47 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
48 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
49 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
50 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
51 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
52 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
53 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
54 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
55 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
56 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
57 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
58 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
59 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
60 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
61 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
62 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
63 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
64 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
65 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
66 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
67 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
68 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
69 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
70 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
71 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
72 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
73 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
74 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
75 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
76 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
77 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
78 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
79 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
80 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
81 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
82 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
83 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
84 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
85 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
86 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
87 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
88 3IPH Ki = 2.51e-05 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
89 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
90 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
91 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
92 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
93 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
94 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
95 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
96 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
97 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
98 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
99 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
100 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
101 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
102 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
103 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
104 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
105 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
106 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
107 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
108 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
109 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
110 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
111 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
112 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
113 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
114 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
115 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
116 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
117 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
118 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
119 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
120 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
121 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
122 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
123 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
124 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
125 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
126 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
127 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
128 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
129 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
130 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
131 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
132 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
133 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
134 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
135 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
136 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
137 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
70% Homology Family (142)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 3GCV Kd = 74 nM SS6 C29 H30 N8 O Cc1cccc(c1....
2 3L8S Kd = 99 nM BFF C20 H24 Br F2 N5 O3 S c1c(cc(c(c....
3 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
4 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
5 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
6 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
7 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
8 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
9 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
10 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
11 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
12 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
13 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
14 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
15 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
16 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
17 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
18 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
19 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
20 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
21 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
22 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
23 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
24 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
25 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
26 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
27 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
28 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
29 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
30 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
31 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
32 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
33 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
34 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
35 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
36 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
37 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
38 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
39 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
40 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
41 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
42 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
43 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
44 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
45 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
46 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
47 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
48 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
49 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
50 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
51 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
52 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
53 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
54 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
55 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
56 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
57 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
58 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
59 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
60 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
61 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
62 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
63 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
64 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
65 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
66 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
67 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
68 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
69 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
70 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
71 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
72 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
73 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
74 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
75 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
76 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
77 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
78 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
79 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
80 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
81 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
82 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
83 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
84 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
85 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
86 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
87 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
88 3IPH Ki = 2.51e-05 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
89 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
90 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
91 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
92 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
93 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
94 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
95 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
96 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
97 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
98 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
99 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
100 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
101 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
102 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
103 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
104 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
105 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
106 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
107 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
108 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
109 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
110 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
111 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
112 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
113 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
114 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
115 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
116 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
117 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
118 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
119 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
120 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
121 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
122 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
123 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
124 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
125 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
126 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
127 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
128 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
129 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
130 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
131 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
132 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
133 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
134 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
135 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
136 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
137 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
138 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
139 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
140 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
141 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
142 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
50% Homology Family (193)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2OJJ Ki = 0.002 uM 82A C22 H17 Cl2 F N4 O2 c1cc(cc(c1....
2 4O6E ic50 = 1 nM 2SH C21 H25 Cl F N5 O3 c1cc(c(cc1....
3 4QTA Kd = 0.013 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
4 2OJG Ki = 2.3 uM 19A C16 H16 N4 O CN(C)C(=O)....
5 4QYY Kd = 0.05 uM 3G7 C25 H29 Cl N4 O4 CC(=O)c1cc....
6 4I5H Ki < 2 nM G17 C26 H21 F3 N4 O Cc1ccc(cc1....
7 4QTE Kd = 0.084 uM 390 C24 H20 Cl2 F N5 O2 Cc1cnc(nc1....
8 3QYW - 6PB C11 H8 Br N5 c1cc(cc(c1....
9 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
10 2Z7L - S91 C20 H19 N5 O3 Cc1cccc(c1....
11 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
12 1WZY ic50 = 0.56 uM F29 C21 H17 N7 C=CCn1c2c(....
13 4N4S - 2H1 C25 H24 N6 O Cc1cc(cc2c....
14 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
15 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
16 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
17 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
18 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
19 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
20 3QYZ - Z8B C10 H11 Br N8 O3 c1nc(c2c(n....
21 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
22 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
23 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
24 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
25 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
26 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
27 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
28 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
29 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
30 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
31 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
32 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
33 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
34 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
35 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
36 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
37 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
38 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
39 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
40 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
41 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
42 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
43 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
44 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
45 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
46 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
47 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
48 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
49 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
50 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
51 3RIN ic50 = 1.3 nM I2O C23 H24 N2 O2 Cc1ccc(cc1....
52 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
53 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
54 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
55 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
56 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
57 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
58 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
59 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
60 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
61 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
62 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
63 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
64 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
65 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
66 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
67 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
68 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
69 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
70 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
71 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
72 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
73 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
74 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
75 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
76 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
77 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
78 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
79 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
80 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
81 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
82 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
83 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
84 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
85 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
86 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
87 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
88 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
89 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
90 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
91 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
92 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
93 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
94 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
95 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
96 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
97 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
98 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
99 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COC1=NC2=N....
100 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
101 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
102 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
103 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
104 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
105 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
106 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
107 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
108 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
109 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
110 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
111 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
112 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
113 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
114 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
115 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
116 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
117 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
118 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
119 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
120 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
121 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
122 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
123 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
124 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
125 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
126 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
127 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
128 3IPH Ki = 2.51e-05 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
129 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
130 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
131 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
132 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
133 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
134 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
135 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
136 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
137 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
138 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
139 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
140 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
141 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
142 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
143 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
144 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
145 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
146 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
147 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
148 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
149 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
150 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
151 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
152 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
153 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
154 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
155 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
156 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
157 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
158 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
159 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
160 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
161 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
162 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
163 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
164 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
165 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
166 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
167 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
168 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
169 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
170 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
171 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
172 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
173 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
174 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
175 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
176 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
177 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
178 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
179 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
180 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
181 4H3B Kd = 17.2 uM VAL VAL ARG PRO GLY SER LEU ASP LEU PRO n/a n/a
182 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
183 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
184 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
185 2F9G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
186 2B9F - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
187 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
188 4QTB Kd = 0.084 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
189 2ZOQ ic50 = 0.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
190 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
191 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
192 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
193 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: B11; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 B11 1 1
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 1OUK; Ligand: 084; Similar sites found: 453
This union binding pocket (no: 1) in the query (biounit: 1ouk.bio1) has 87 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 1OUK 084 3.925e-30 1
2 4MXO DB8 1.882e-09 0.43501
3 1PME SB2 8.734e-10 0.43248
4 4P5Z Q7M 8.005e-09 0.42265
5 3KF4 B90 6.175e-09 0.42088
6 3LQ8 88Z 1.489e-08 0.41924
7 3RWP ABQ 1.647e-07 0.41902
8 4F65 0S9 1.348e-08 0.40742
9 2BPM 529 1.354e-07 0.40654
10 3IOK 1P6 9.879e-08 0.39788
11 4NWM 2P5 6.991e-07 0.39415
12 3ZOS 0LI 2.627e-08 0.39158
13 4F4P 0SB 1.773e-07 0.39133
14 4NM5 ADP 1.137e-07 0.38684
15 4U0I 0LI 2.678e-06 0.38507
16 2GU8 796 1.725e-05 0.38151
17 2OFV 242 2.84e-07 0.37561
18 4WHZ 3NL 4.187e-05 0.37453
19 2XMY CDK 3.229e-05 0.37323
20 3BZ3 YAM 6.194e-06 0.36765
21 3E8N ATP 8.276e-06 0.36711
22 2JDR GLY 4.899e-05 0.3665
23 1XKK FMM 9.753e-08 0.36519
24 2WTV ZZL 7.342e-05 0.36497
25 2YAK OSV 2.789e-08 0.36305
26 4IWD 1JC 1.122e-06 0.36245
27 3E7O 35F 4.314e-08 0.36168
28 4AG8 AXI 1.346e-06 0.3615
29 2EVA ADN 1.91e-07 0.36014
30 4EQC XR1 3.138e-07 0.35877
31 2JLD AG1 7.377e-07 0.35868
32 4UXQ 0LI 1.801e-07 0.35826
33 3VHE 42Q 2.376e-07 0.35716
34 2XB7 GUI 4.883e-06 0.35504
35 3U6H 03X 7.049e-07 0.35444
36 3NW7 LGV 8.191e-06 0.35405
37 4QTB 38Z 2.619e-07 0.35257
38 2X4Z X4Z 5.756e-07 0.35199
39 3MVH GLY 0.0001316 0.34985
40 3SXF BK5 4.396e-06 0.3437
41 3V8T 477 3.594e-05 0.34273
42 4IZY 1J2 2.507e-08 0.34228
43 4CKR DI1 7.873e-08 0.34206
44 1RE8 BD2 0.0004492 0.3407
45 3AT4 CCK 2.232e-05 0.34022
46 2XVD AS6 2.856e-07 0.33997
47 3IGO ANP 1.218e-07 0.33729
48 3VBQ 0F5 0.0001505 0.33638
49 4E93 GUI 0.0001333 0.33571
50 4H1M 0YJ 5.546e-05 0.3347
51 2OO8 RAJ 4.372e-07 0.33447
52 1VJY 460 1.843e-06 0.33394
53 3RGF BAX 7.282e-08 0.33364
54 3THB 3TA 5.895e-05 0.33318
55 3BE2 RAJ 1.696e-07 0.33315
56 3VRY B43 1.895e-06 0.33249
57 4C2V YJA 3.922e-05 0.33246
58 4ASE AV9 9.548e-07 0.33227
59 3C1X CKK 1.101e-07 0.33216
60 3GC8 B45 5.09e-08 0.33008
61 2PVN P63 4.424e-05 0.32985
62 4NW6 2NS 3.596e-05 0.32876
63 4LOO SB4 4.543e-09 0.32862
64 4MQ1 2C3 5.853e-07 0.32785
65 2XNM WGZ 8.64e-06 0.32671
66 3TTI KBI 1.109e-07 0.32622
67 4BKY 82B 1.482e-06 0.32567
68 3BQC EMO 1.099e-06 0.3241
69 3EQR T74 5.132e-06 0.3229
70 3EFK MT4 2.92e-06 0.32108
71 2Y6O 1N1 5.971e-08 0.32103
72 2WU6 DKI 1.984e-06 0.32013
73 4BKJ STI 1.519e-06 0.31878
74 3LXK MI1 0.0001451 0.31772
75 1Y57 MPZ 8.819e-07 0.31767
76 4GJ3 0XP 0.0001266 0.31766
77 4EYM 0RX 2.196e-07 0.31764
78 2Z7R STU 4.594e-06 0.31673
79 4FL3 ANP 3.706e-06 0.31668
80 4M69 ANP 6.858e-06 0.31638
81 3PP0 03Q 1.547e-05 0.3163
82 3RI1 3RH 1.549e-05 0.31578
83 3SXS PP2 7.027e-07 0.31574
84 4H3Q ANP 3.35e-06 0.31561
85 1Q8Y ADP 5.362e-06 0.31531
86 3FHI ANP 6.568e-05 0.31513
87 3KRL KRL 5.396e-05 0.31425
88 4CQE CQE 1.223e-06 0.31394
89 2CSN CKI 0.008904 0.31337
90 4KS7 X4Z 2.726e-06 0.31314
91 3PVW QRX 0.0002828 0.31293
92 4QTC 38Z 5.35e-05 0.31281
93 2P2I 608 1.488e-05 0.31265
94 2B9F ADP 4.88e-06 0.31263
95 4JDI ARG 0.0007684 0.31259
96 3ORK AGS 9.135e-05 0.31259
97 1PHK ATP 6.53e-06 0.31184
98 1Q8Y ADE 3.017e-08 0.31176
99 2B9I ADP 3.999e-06 0.31131
100 2QU6 857 2.473e-05 0.31115
101 3TKI S25 5.309e-05 0.31101
102 3PLS ANP 4.358e-07 0.31065
103 2X2M X2M 1.353e-05 0.31023
104 4DCE 0JF 1.978e-05 0.30976
105 3BI6 396 9.215e-06 0.3097
106 3A7H ATP 5.183e-07 0.30844
107 2B9H ADP 4.344e-06 0.30674
108 2B9J ADP 4.181e-06 0.30653
109 3F7Z 34O 4.326e-06 0.30625
110 4F99 ADP 1.235e-06 0.30568
111 1OPK P16 4.691e-06 0.30519
112 2PVF ACP 1.029e-05 0.30497
113 3SG8 TOY 0.001829 0.3049
114 3FI3 JK2 0.0001532 0.30477
115 3EKK GS2 2.481e-05 0.30425
116 2QCS ANP 0.0001487 0.30418
117 4BTK DTQ 2.382e-05 0.30407
118 4O1P ANP 5.788e-06 0.30285
119 4OAC ADP 1.312e-05 0.30248
120 2J90 IZA 3.211e-05 0.30233
121 3ZRM ZRM 4.874e-07 0.30201
122 4L3L 5FI 8.547e-05 0.30158
123 3E5A VX6 0.0007079 0.30131
124 4PMP 31W 1.623e-06 0.30131
125 4PMM 31V 8.896e-06 0.30083
126 1V0O INR 7.861e-05 0.30044
127 2HK5 1BM 1.584e-06 0.30039
128 3IDB ANP 0.0004994 0.29985
129 4OTH DRN 7.114e-05 0.2994
130 4H3P ANP 4.974e-07 0.29928
131 4I5C C5I 2.389e-05 0.29927
132 4BHN BH9 0.0003115 0.29926
133 3LKM AMP 0.0001552 0.2992
134 4E6Q 0NV 4.082e-05 0.299
135 3ALN ANP 3.744e-06 0.29898
136 3A8W ATP 1.641e-05 0.29891
137 4F9A ADP 3.112e-06 0.29876
138 3SLS ANP 5.209e-05 0.29851
139 4FG8 ATP 8.189e-05 0.2985
140 4KNB 1RU 3.01e-06 0.29836
141 1XJD STU 6.16e-05 0.29818
142 3GNI ATP 2.622e-05 0.29798
143 4E4N 0NL 5.057e-05 0.29797
144 4NST ADP 1.012e-05 0.29781
145 3LXN MI1 4.748e-05 0.29774
146 4E6D 0NU 2.345e-05 0.2973
147 2VAG V25 1.898e-05 0.29729
148 1TQP ATP 0.0001783 0.29724
149 3HMO STU 9.118e-06 0.29714
150 4ANW O92 0.004833 0.29659
151 4EUU BX7 0.0004489 0.29652
152 4FOB 0US 1.402e-05 0.29638
153 4CFU 2WC 3.338e-06 0.29614
154 3TZM 085 2.387e-05 0.29597
155 4MKC 4MK 4.1e-05 0.29595
156 2J7T 274 0.04021 0.29587
157 4LFI GNP 0.0001326 0.29587
158 3UYT 0CK 6.881e-07 0.29568
159 2NRY STU 4.636e-05 0.29565
160 1U5R ATP 9.649e-06 0.29559
161 1UNH IXM 3.241e-05 0.2954
162 4CD0 AWJ 6.334e-05 0.29483
163 4OAV ACP 5.831e-05 0.29479
164 4IJP 1EH 9.997e-05 0.29471
165 4AOI 4K0 4.208e-05 0.29424
166 4IVD 15T 0.0001991 0.29362
167 4C4F 7CE 0.0001182 0.29307
168 4CMT GWH 3.38e-05 0.29281
169 4OCJ NDG 0.009474 0.29278
170 2YAB AMP 0.0002118 0.29235
171 1CM8 ANP 2.397e-05 0.2923
172 4OH4 ANP 0.0002031 0.29217
173 2RFN AM7 3.87e-05 0.29203
174 1PK8 ATP 0.0007865 0.292
175 2H8H H8H 3.125e-05 0.29192
176 4MK0 29X 0.0009854 0.29192
177 3C0I 3AM 5.906e-05 0.2917
178 3QUP LUN 1.732e-05 0.29153
179 1IA9 ANP 0.0003896 0.29141
180 4IX4 ADP 0.0002239 0.2911
181 4KBA 1QM 3.316e-06 0.291
182 3BRB ADP 5.333e-06 0.29092
183 4CTB KVC 2.384e-05 0.29026
184 4LRJ ANP 2.997e-05 0.29014
185 4X2J 3WN 5.069e-06 0.28992
186 4X2K 3WO 5.069e-06 0.28992
187 2RIO ADP 0.0002847 0.28975
188 3EYG MI1 8.775e-05 0.2897
189 4BFM ANP 6.912e-05 0.2893
190 4QPM ADP 0.0005919 0.28915
191 3GQI ACP 7.333e-05 0.28899
192 4OTI MI1 0.0001568 0.28873
193 4E1Z 0MX 0.0001363 0.28851
194 3M2W L8I 4.637e-05 0.28807
195 3DAK ANP 2.652e-06 0.28792
196 4OA2 ADP 4.585e-05 0.28791
197 3UZP 0CK 2.415e-06 0.28791
198 3SRV S19 7.726e-05 0.28763
199 4CCU AWF 9.913e-06 0.28734
200 3FHR P4O 0.0002671 0.28718
201 3O0G 3O0 6.831e-05 0.28686
202 4BCM T7Z 1.975e-05 0.28656
203 2OIC STU 6.593e-05 0.2862
204 1BYG STU 5.988e-05 0.28594
205 4JR7 GNP 0.0002717 0.28593
206 3KMW ATP 3.244e-05 0.28553
207 3TDV GDP 0.0001861 0.28543
208 4BBF O19 0.0001256 0.2852
209 2WEI VGG 5.015e-06 0.28507
210 2R5T ANP 9.472e-05 0.2849
211 2P2H 994 7.681e-05 0.28475
212 3W0O ADP 0.01204 0.28471
213 4FHD EEM 0.02048 0.28465
214 4MWH ATP 0.0003408 0.2844
215 4ORK GDP 0.0001354 0.28423
216 3PE2 E1B 0.0001052 0.2842
217 2PUL ACP 0.0002423 0.28401
218 3VPB ADP 0.007028 0.28395
219 2WXG ZZN 0.007219 0.28387
220 4CLJ 5P8 1.99e-05 0.28384
221 2V7O DRN 1.196e-05 0.28361
222 3UIM ANP 0.0001064 0.28353
223 2A19 ANP 1.722e-06 0.28348
224 4CCB OFG 7.223e-06 0.2833
225 4PMT 31Y 6.202e-05 0.28318
226 1IOW ADP 0.01359 0.28317
227 2OID ANP 0.0002175 0.28298
228 1MQB ANP 5.417e-07 0.28289
229 3PDT ADP 0.0009634 0.28269
230 4F9C 0SX 2.235e-05 0.28263
231 3R0T FU9 6.735e-05 0.2825
232 3TM0 ANP 0.03454 0.28249
233 3V8S 0HD 4.455e-05 0.28241
234 4OCV ANP 0.00308 0.2824
235 4U44 3D9 0.0003542 0.28223
236 3DLS ADP 0.0006758 0.28219
237 3HAV ATP 0.002326 0.28202
238 4BCN T9N 6.667e-05 0.28201
239 4I6H 1C8 0.0001218 0.2819
240 2WQN ADP 4.577e-06 0.28173
241 4CTC J99 4.343e-05 0.28137
242 2VPQ ANP 0.00322 0.28111
243 4CLI 5P8 4.798e-05 0.28099
244 1ZP9 ATP 0.0002754 0.28078
245 4OUC 5ID 6.248e-05 0.28046
246 4NFN 2KC 1.397e-05 0.28045
247 4TW9 386 0.0001149 0.2803
248 3ZBF VGH 0.0001388 0.28024
249 4F0F ACP 8.235e-05 0.28024
250 4IVB 1J5 0.0005381 0.28021
251 4FVQ ATP 0.0007509 0.28004
252 3EYH IZA 0.0006022 0.28002
253 4N70 2HX 0.0008129 0.27951
254 3RE4 TO1 0.0001773 0.27948
255 4TWC 37J 9.163e-05 0.27928
256 4K1B 1OC 0.0004281 0.27889
257 4ITH RCM 0.000271 0.27888
258 1Z2P ACP 0.04731 0.27872
259 1U59 STU 0.0002029 0.27861
260 4CMO YPW 2.321e-05 0.2786
261 1K3A ACP 4.935e-06 0.27849
262 4IVC 1J6 0.001182 0.27774
263 2VQD AP2 0.006334 0.27764
264 4IDT T28 0.00101 0.27737
265 4FK6 0UJ 0.0003497 0.277
266 4EJN 0R4 0.0008988 0.27694
267 2X6T NAP 0.03968 0.27691
268 4F1M ACP 1.152e-05 0.27671
269 1ZTH ADP 0.0001475 0.27647
270 3BU5 ATP 1.599e-05 0.27632
271 3PE1 3NG 0.0002577 0.27631
272 4G16 0VM 0.0001824 0.27618
273 3WOL VAL 0.03605 0.27618
274 3GGF GVD 0.0002373 0.27551
275 2ZV2 609 8.725e-05 0.27551
276 4C2W ANP 6.695e-05 0.27549
277 4JQE ANP 0.001057 0.27545
278 4CMU IV7 1.258e-05 0.27537
279 3Q60 ATP 0.0007054 0.27525
280 4DEH 0JK 5.519e-05 0.27482
281 2VN9 GVD 4.119e-06 0.27473
282 3CXW 7CP 0.0002086 0.27467
283 4E5W 0NT 0.001537 0.27458
284 1WBP ADP 1.906e-05 0.27457
285 4I94 ANP 0.0009212 0.2744
286 3E2M E2M 0.0279 0.27435
287 4G17 0VN 0.0003306 0.27412
288 1XR1 ANP 0.0004728 0.27407
289 4CYI ATP 0.001398 0.27405
290 4F9B 0SY 5.42e-05 0.27396
291 3KN5 ANP 8.795e-05 0.27389
292 4KBC 1QJ 3.821e-07 0.27385
293 3UDZ ADP 0.003965 0.27373
294 4PU5 ANP 0.0122 0.27344
295 4GW8 3RA 0.0004057 0.2734
296 3VPC ADP 0.003903 0.2733
297 3GC0 AMP 4.707e-05 0.27323
298 3CY2 MB9 3.313e-05 0.27323
299 1I7L ATP 0.002784 0.27321
300 4Q5H ANP 0.001833 0.2728
301 3I0O ADP 0.0004823 0.27268
302 2BE2 R22 0.006355 0.27257
303 4HNF 16W 3.041e-06 0.27249
304 4FOC 0UU 0.0002493 0.27236
305 2NRU T12 0.0004851 0.27234
306 1VL0 NAI 0.0226 0.27205
307 3TXO 07U 9.232e-05 0.27194
308 2YW2 ATP 0.01003 0.27186
309 3PTG 932 4.203e-05 0.27127
310 4N6Z 2HW 0.002266 0.27117
311 4EWH T77 0.002452 0.27079
312 4K77 1Q4 0.0005117 0.27074
313 3ETH ATP 0.03501 0.27073
314 3VOT ADP 0.0007965 0.27064
315 4JX7 1N6 0.003425 0.26917
316 4AZW ATP 0.009329 0.26859
317 1ZY5 ANP 0.0007113 0.26857
318 1GQG DCD 0.01101 0.2683
319 3H9R TAK 0.0001984 0.26802
320 3DNT ATP 0.02211 0.26786
321 4BBE 3O4 0.0001391 0.26777
322 4GYI ADP 0.001901 0.26738
323 4EHZ JAK 0.001078 0.26727
324 2BKK ADP 0.005275 0.26727
325 2WEL K88 4.174e-07 0.26703
326 2PYW ADP 0.002547 0.26675
327 4E4L 0NH 0.003879 0.26667
328 1KRH FAD 0.03807 0.26658
329 4EI4 0Q2 0.00117 0.2665
330 2O2U 738 5.851e-06 0.26648
331 4LWA Q13 0.0489 0.2663
332 4IPH 1FJ 0.02342 0.26627
333 2VZ6 FEF 0.0006959 0.26585
334 1EHI ADP 0.01811 0.26565
335 2PZI AXX 0.0001499 0.26514
336 4BCQ TJF 0.0001657 0.26495
337 2AQX ATP 0.03623 0.26494
338 4GRB 0XG 0.0005221 0.26444
339 3FW4 CAQ 0.04106 0.26417
340 3AKK ADP 0.02391 0.26413
341 4CNH 3U9 1.546e-05 0.26382
342 2PR5 FMN 0.005976 0.26372
343 2V0U FMN 0.009734 0.2634
344 4KWP EXX 0.000354 0.26335
345 2Z6D FMN 0.008307 0.26313
346 3ORQ ADP 0.02069 0.2631
347 4AU8 Z3R 0.001025 0.26291
348 3TPV ADE 0.02458 0.26281
349 4EES FMN 0.01629 0.26248
350 2ZM3 575 0.001816 0.26247
351 1NCQ W11 0.01245 0.26221
352 2C43 COA 0.03987 0.26211
353 1GT4 UNA 0.007635 0.26195
354 3QXV MTX 0.03372 0.2618
355 3C0G 3AM 5.206e-05 0.26167
356 2GC0 PAN 0.01448 0.26122
357 3EUF BAU 0.01031 0.26113
358 4F1O ACP 0.0002992 0.26071
359 1TLL FAD 0.03642 0.25918
360 4BG4 ADP 0.006942 0.25911
361 4JZU GCP 0.04262 0.25872
362 3KYF 5GP 0.03714 0.25855
363 3OWL 19E 0.0007895 0.2581
364 1QY1 PRZ 0.01495 0.2581
365 3P2H NOO 0.006405 0.25809
366 1Q6O LG6 0.04431 0.25699
367 3THR C2F 0.03893 0.25696
368 3WVR AMP 0.03645 0.25574
369 4X0M 3WA 8.031e-05 0.25564
370 2GQS C2R 0.04044 0.25546
371 3C0H AMP 0.0001319 0.25508
372 4MBI 26K 0.008434 0.25494
373 1DZK PRZ 0.02762 0.25472
374 3JPV 1DR 0.001113 0.25447
375 4DC2 ADE 0.0003215 0.25374
376 2GQR ADP 0.04848 0.25368
377 2RDE C2E 0.03958 0.25323
378 3OFM 4B0 0.001077 0.2532
379 3UBQ SIA 0.04714 0.25252
380 2VAT COA 0.01163 0.2525
381 2FP2 TSA 0.04969 0.2521
382 4F1T H52 0.003524 0.25199
383 3GD9 GLC 0.01321 0.25196
384 4CU1 71S 0.0225 0.25169
385 3OWK 18E 0.002269 0.25143
386 1WS1 BB2 0.01899 0.2514
387 3HZT J60 0.0237 0.25132
388 3TII ANP 0.03557 0.25075
389 4UWH JXM 0.03951 0.25026
390 4JE7 BB2 0.02679 0.25001
391 1CKM GTP 0.04682 0.24985
392 3MB6 01I 0.00011 0.24947
393 2ORO 228 0.0485 0.24899
394 4AUA 4AU 0.0006133 0.24892
395 3G5K BB2 0.01872 0.24886
396 4KU7 PCG 0.02033 0.24833
397 2OXY K17 0.001551 0.24749
398 2HAL ACE 0.03494 0.24711
399 3TL1 JRO 0.02253 0.24711
400 2QLU ADE 0.0005729 0.24697
401 4DSU BZI 0.001331 0.24654
402 3SE5 ANP 0.03144 0.24652
403 2HJ4 PNZ 0.0397 0.24645
404 3AQV TAK 0.01765 0.24641
405 3SAO DBH 0.01768 0.24635
406 2QK4 ATP 0.01462 0.2459
407 1N7F ALA 0.02909 0.24569
408 1W9O ASN 0.02874 0.24482
409 1XN0 ROL 0.02428 0.24434
410 4G31 0WH 0.002738 0.24417
411 2XCU C5P 0.03293 0.24414
412 4FF8 14S 0.01184 0.24401
413 3ZHF ASN 0.04783 0.24345
414 3PHZ NAG 0.04034 0.24344
415 3WAR NIO 0.001012 0.24283
416 1T73 DHT 0.04748 0.24186
417 1JPA ANP 1.789e-05 0.24117
418 4RLL E91 0.01032 0.24093
419 1VRP ADP 0.01741 0.24074
420 4IKN ASP 0.006405 0.24067
421 2QHV OC9 0.01929 0.24036
422 3CBC DBS 0.001623 0.23982
423 4AZT LY2 0.03848 0.23966
424 3JU6 ANP 0.01485 0.23938
425 1NQ7 HIS 0.006601 0.23931
426 4K55 H6P 0.0001531 0.239
427 1ZNY GDP 0.04302 0.23876
428 2VJ0 PHE 0.0131 0.23727
429 3M3E GAL 0.02222 0.23714
430 2XG5 EC5 0.02054 0.237
431 1LOP SIN 0.03644 0.23664
432 2YKL NLD 0.005382 0.23653
433 2WZ5 MET 0.0005637 0.23651
434 2G30 ALA 4.979e-05 0.23644
435 1FWV SGA 0.00902 0.23619
436 4WLB SER 0.02761 0.23581
437 3ZJX BOG 0.01351 0.23467
438 2ZL7 FUC 0.0199 0.23365
439 3SQP 3J8 0.04901 0.23334
440 4NY3 PRO 0.02561 0.23294
441 1GPM AMP 0.02226 0.23256
442 1MJT ITU 0.02957 0.23133
443 1KQR MNA 0.02792 0.22999
444 3ETG GWD 0.008863 0.22788
445 3R6U CHT 0.03109 0.22769
446 3B9Q MLI 0.01461 0.22687
447 1TV5 N8E 0.02825 0.22644
448 2OG2 MLI 0.01969 0.22644
449 4WH9 3M8 0.01168 0.2256
450 4G9Z C 0.04811 0.2238
451 3SXU ASP 0.005302 0.22217
452 4NST AF3 5.589e-05 0.22158
453 3O01 DXC 0.02979 0.22136
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