Receptor
PDB id Resolution Class Description Source Keywords
1z5m 2.17 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF N1-[3-[[5-BROMO-2-[[3-[(1-PYRROLIDINYLC AMINO]PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PROPYL]-2,2- D IMETHYLPROPANEDIAMIDE COMPLEXED WITH HUMAN PDK1 HOMO SAPIENS PROTEIN INHIBITOR COMPLEX SERINE KINASE TRANSFERASE
Ref.: NOVEL SMALL MOLECULE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT KINASE-1. J.BIOL.CHEM. V. 280 19867 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:698;
Invalid;
none;
submit data
35.453 Cl [Cl-]
GOL A:602;
A:606;
A:607;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
LI8 A:501;
Valid;
none;
ic50 = 30 nM
547.448 C23 H31 Br N8 O3 CC(C)...
SO4 A:600;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3RWP 1.92 Å EC: 2.7.11.1 DISCOVERY OF A NOVEL, POTENT AND SELECTIVE INHIBITOR OF 3- PHOSPHOINOSITIDE DEPENDENT KINASE (PDK1) HOMO SAPIENS KINASE DOMAIN TRANSFERASE PHOSPHOSERINE: SEP TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF NOVEL, POTENT, AND SELECTIVE INHIBITOR 3-PHOSPHOINOSITIDE-DEPENDENT KINASE (PDK1). J.MED.CHEM. V. 54 8490 2011
Members (37)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 129 families.
1 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 CC1CCC(CN1....
2 2BIY - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
3 1UU9 ic50 = 3.8 uM BI3 C23 H20 N4 O2 c1ccc2c(c1....
4 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 CC12C(C(CC....
5 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
6 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
7 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
8 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
9 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
10 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
11 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
12 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 CC1CC(CN(C....
13 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
14 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
15 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
16 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
17 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O CC1CCC(CN1....
18 3ORZ - BI4 C27 H26 N4 O2 CN1CCCC1CC....
19 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
20 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
21 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
22 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
23 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 CN1CCCC1CC....
24 3OTU - BI4 C27 H26 N4 O2 CN1CCCC1CC....
25 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
26 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
27 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O CC1COCCN1c....
28 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)CC1CC....
29 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
30 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
31 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
32 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
33 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
34 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
35 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
36 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
37 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1C....
70% Homology Family (37)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 94 families.
1 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 CC1CCC(CN1....
2 2BIY - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
3 1UU9 ic50 = 3.8 uM BI3 C23 H20 N4 O2 c1ccc2c(c1....
4 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 CC12C(C(CC....
5 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
6 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
7 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
8 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
9 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
10 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
11 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
12 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 CC1CC(CN(C....
13 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
14 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
15 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
16 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
17 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O CC1CCC(CN1....
18 3ORZ - BI4 C27 H26 N4 O2 CN1CCCC1CC....
19 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
20 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
21 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
22 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
23 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 CN1CCCC1CC....
24 3OTU - BI4 C27 H26 N4 O2 CN1CCCC1CC....
25 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
26 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
27 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O CC1COCCN1c....
28 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)CC1CC....
29 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
30 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
31 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
32 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
33 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
34 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
35 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
36 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
37 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1C....
50% Homology Family (385)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 68 families.
1 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
2 4UZH ic50 = 9800 nM JVE C15 H13 F N4 O c1ccc(c(c1....
3 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
4 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
5 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
6 2C6E - HPM C28 H31 N7 O4 COc1cc2c(c....
7 3H0Y ic50 = 0.006 uM 48B C23 H17 Cl F N5 O2 c1ccc(c(c1....
8 4B0G ic50 = 0.015 uM VEK C19 H21 Br N8 O Cc1cc(no1)....
9 4JBP ic50 = 41 nM YPH C34 H36 N6 O4 c1ccc(cc1)....
10 3H10 - 97B C30 H25 Cl F2 N6 O CN1CCN(CC1....
11 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
12 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
13 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
14 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
15 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
16 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
17 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
18 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
19 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
20 4UYN ic50 = 2 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
21 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
22 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
23 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
24 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
25 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
26 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
27 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
28 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
29 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
30 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
31 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
32 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
33 1JSV - U55 C10 H11 N5 O2 S c1cc(ccc1N....
34 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
35 1OIQ ic50 = 2.9 uM HDU C14 H13 N5 O Cc1c(n2ccc....
36 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
37 2W17 ic50 = 0.002 uM I19 C24 H30 F N7 O Cc1ncc(n1C....
38 2VTP ic50 = 0.003 uM LZ9 C17 H11 F3 N4 O2 c1cc(c(c(c....
39 1JVP ic50 = 1.6 uM LIG C15 H11 N3 c1ccc-2c(c....
40 1FVT - 106 C14 H9 Br N4 O3 S c1cc(ccc1N....
41 4KD1 - 1QK C21 H29 N6 O2 CCc1cnn2c1....
42 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
43 3LE6 ic50 = 0.035 uM 2BZ C17 H10 Cl N5 O2 Cc1c-2nc(c....
44 2VTI ic50 = 0.66 uM LZ3 C14 H12 N4 O3 S c1ccc2c(c1....
45 3LFS Ki = 2.5 uM A07 C17 H16 Cl N3 O CCCC(=O)Nc....
46 1PXI - CK1 C8 H5 Cl2 N3 S c1cnc(nc1c....
47 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
48 4LYN - 1YG C20 H23 N3 O2 S2 CC(c1ccccc....
49 1YKR ic50 = 0.56 uM 628 C20 H14 Cl2 N4 O3 S c1cc(c(c(c....
50 1PXN Ki ~ 0.32 uM CK6 C15 H15 N5 O S Cc1c(sc(n1....
51 1CKP - PVB C20 H25 Cl N6 O3 CC(C)C(CO)....
52 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
53 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
54 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
55 2R3J ic50 = 10 nM SCJ C18 H14 Br N5 c1ccc(cc1)....
56 3IG7 ic50 = 9 nM EFP C18 H22 N4 O3 CC(=O)NC1C....
57 2VTS ic50 = 0.03 uM LZC C16 H23 N7 CC(C)Nc1cc....
58 1P2A ic50 = 12 nM 5BN C17 H15 F N4 O c1cc([nH]c....
59 2BHE ic50 = 1 uM BRY C16 H9 Br N2 O2 c1ccc2c(c1....
60 3UNK ic50 = 15 uM 0BY C17 H13 Cl N4 O2 c1ccc(c(c1....
61 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
62 2VTQ ic50 = 0.14 uM LZA C16 H17 F2 N5 O2 c1cc(c(c(c....
63 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
64 2C68 ic50 = 1.8 uM CT6 C18 H15 Br N5 c1cc(cc(c1....
65 3TIZ - 3TI C17 H13 N O2 c1ccc2c(c1....
66 3PXY ic50 = 5.9 uM JWS C10 H11 N5 O2 COc1ccc(c(....
67 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)CC(CO....
68 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
69 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S CC(CO)Nc1c....
70 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
71 2R3M ic50 = 10 nM SCX C19 H17 F2 N7 CCc1cnn2c1....
72 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
73 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
74 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
75 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)CC(CO....
76 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
77 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
78 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
79 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
80 4EZ7 - STU C28 H26 N4 O3 CC12C(C(CC....
81 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
82 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
83 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
84 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
85 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
86 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
87 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
88 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
89 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
90 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
91 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
92 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
93 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
94 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
95 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
96 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
97 2A0C - CK9 C19 H26 N6 O2 CCC(CO)Nc1....
98 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
99 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
100 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
101 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
102 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
103 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
104 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
105 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
106 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
107 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
108 1AQ1 - STU C28 H26 N4 O3 CC12C(C(CC....
109 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]N=C1NC(....
110 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
111 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
112 3PJ8 - 404 C19 H26 N6 O CCC(CO)Nc1....
113 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
114 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
115 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
116 1H08 - BYP BWP n/a n/a
117 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
118 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
119 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
120 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
121 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
122 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
123 3LFN Ki = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
124 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
125 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
126 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
127 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 CC(C(C(C#C....
128 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
129 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
130 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
131 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
132 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CCC(CO)Nc1....
133 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
134 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
135 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
136 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
137 1PYE ic50 = 0.32 uM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
138 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
139 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
140 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1N....
141 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
142 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
143 2DS1 ic50 = 6.4 nM 1CD C22 H21 N5 O3 CC1CC2CN1C....
144 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
145 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
146 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
147 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
148 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
149 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
150 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
151 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
152 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
153 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
154 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)CC(CO....
155 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
156 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
157 2V0D - C53 C9 H7 N3 O S [H]N=C1NC(....
158 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
159 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
160 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
161 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
162 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
163 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
164 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
165 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
166 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
167 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
168 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
169 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
170 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
171 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
172 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
173 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
174 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
175 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
176 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
177 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
178 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
179 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
180 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
181 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
182 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
183 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
184 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 CC12C(C(CC....
185 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
186 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
187 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
188 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
189 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
190 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
191 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
192 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
193 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
194 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
195 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
196 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
197 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
198 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
199 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
200 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
201 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
202 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 CC12C(C(CC....
203 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
204 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
205 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
206 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
207 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
208 1JKL - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
209 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
210 3F5G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
211 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
212 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
213 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCNC(....
214 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
215 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
216 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
217 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
218 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
219 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
220 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
221 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 c1nc(c2c(n....
222 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 c1nc(c2c(n....
223 3AGL Ki = 16 nM A03 C37 H63 N17 O9 CC(C(=O)NC....
224 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
225 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
226 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
227 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 CC12C(C(CC....
228 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 CC1CC(CN(C....
229 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
230 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
231 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
232 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
233 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O CC1CCC(CN1....
234 3ORZ - BI4 C27 H26 N4 O2 CN1CCCC1CC....
235 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
236 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
237 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
238 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
239 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 CN1CCCC1CC....
240 3OTU - BI4 C27 H26 N4 O2 CN1CCCC1CC....
241 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
242 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
243 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O CC1COCCN1c....
244 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)CC1CC....
245 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
246 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
247 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
248 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
249 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
250 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
251 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
252 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
253 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1C....
254 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
255 4KS8 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
256 4DGO ic50 = 0.57 uM 0JW C10 H10 N2 O3 c1cc(c(cc1....
257 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
258 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
259 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
260 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
261 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
262 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 CN1CCn2c1n....
263 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
264 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
265 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
266 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1C....
267 3SLS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
268 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
269 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
270 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
271 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
272 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1C2CCC1C....
273 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
274 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
275 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
276 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
277 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
278 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
279 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
280 2XNN - 430 C21 H16 F3 N3 O2 S CC(c1ccccc....
281 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CCC1CN(CCC....
282 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
283 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
284 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
285 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
286 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
287 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
288 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
289 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
290 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
291 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
292 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
293 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
294 4OBO ic50 = 0.077 uM 2QV C14 H10 Cl N3 c1cc(cc(c1....
295 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
296 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
297 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
298 4EL9 - AFE C21 H20 O10 CC1C(C(C(C....
299 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
300 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
301 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
302 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCCC(=NNC(....
303 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]N=C(N)N....
304 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 CC(=NNC(=N....
305 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
306 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 CC(=NNC(=N....
307 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O CC(=NNC(=N....
308 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 CC(=NNC(=N....
309 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
310 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 c1cc2cc([n....
311 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)(C1CN....
312 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
313 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
314 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O CC(=NNC1=N....
315 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O CC(=NNC(=N....
316 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
317 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
318 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
319 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
320 4JDI - ARG ARG ARG ARG SER TRP TYR n/a n/a
321 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
322 3A7J - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
323 3A7I - ADE C5 H5 N5 c1[nH]c2c(....
324 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
325 3EQC - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
326 3EQH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
327 3EQI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
328 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
329 2UV2 - GVD C22 H19 N7 c1ccc2c(c1....
330 2JFL - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
331 4FG9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
332 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
333 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
334 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
335 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
336 2F57 - 23D C19 H24 Cl N7 CCn1cnc2c1....
337 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 CC12C(C(CC....
338 3A62 - STU C28 H26 N4 O3 CC12C(C(CC....
339 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S CC1CCc2c(c....
340 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
341 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
342 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
343 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
344 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
345 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
346 4OTI ic50 = 43 nM MI1 C16 H20 N6 O CC1CCN(CC1....
347 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
348 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
349 2V7O - DRN C25 H23 N5 O2 S [H]N=C(N)S....
350 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
351 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
352 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
353 3QKL - SMR C29 H40 N4 O5 S CCOCCN(CC(....
354 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1C....
355 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(CC(....
356 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
357 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
358 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
359 4O0R Ki = 0.036 uM X4Z C25 H28 N8 O S Cc1nc2ccsc....
360 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
361 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
362 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
363 3Q4Z - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
364 3GC0 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
365 3MFU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
366 3C0I - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
367 3MFS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
368 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
369 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
370 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]N=C(N)S....
371 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
372 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
373 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)C(CO)....
374 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
375 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
376 4APP Ki = 0.064 uM N53 C33 H36 N6 O3 CC1(c2c(c(....
377 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
378 2X4Z Ki = 18.7 nM X4Z C25 H28 N8 O S Cc1nc2ccsc....
379 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
380 2CDZ - 23D C19 H24 Cl N7 CCn1cnc2c1....
381 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
382 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
383 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
384 2YAB - AMP C10 H14 N5 O7 P c1nc(c2c(n....
385 2YAA - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LI8; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 LI8 1 1
2 BX7 0.539823 0.805195
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3RWP; Ligand: ABQ; Similar sites found: 466
This union binding pocket(no: 1) in the query (biounit: 3rwp.bio2) has 77 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 2X2M X2M 0.0000000002571 0.80749
2 1U59 STU 0.000000001107 0.80491
3 4CFU 2WC 0.000000008747 0.78887
4 4BCN T9N 0.000000006943 0.78366
5 4CFU 2WC 0.000000007219 0.78275
6 3F7Z 34O 0.00000001343 0.77872
7 3F7Z 34O 0.00000001008 0.76508
8 2PVF ACP 0.0000000107 0.76373
9 1XJD STU 0.000000007314 0.76282
10 2F2U M77 0.00000004795 0.75895
11 2F2U M77 0.00000004807 0.75889
12 4DCE 0JF 0.000000002927 0.75611
13 2ZV2 609 0.00000006127 0.75303
14 3PVW QRX 0.0000000008931 0.74847
15 4BCN T9N 0.00000005335 0.74609
16 3IDB ANP 0.000000003206 0.74597
17 4DCE 0JF 0.00000000722 0.74533
18 4MQ1 2C3 0.000000009052 0.74047
19 3RI1 3RH 0.000000001345 0.74037
20 4MQ1 2C3 0.000000009618 0.73917
21 2CSN CKI 0.000000001787 0.73476
22 3LXN MI1 0.00000001216 0.73413
23 2VAG V25 0.00000002666 0.73398
24 4IVD 15T 0.00000001528 0.72922
25 4MQ1 2C3 0.00000002358 0.72811
26 1U5R ATP 0.00000003532 0.72771
27 2JLD AG1 0.0000000008729 0.72741
28 3EYG MI1 0.00000002478 0.72702
29 3GQI ACP 0.00000003675 0.72682
30 4OAV ACP 0.00000005456 0.72671
31 2P2H 994 0.00000008138 0.7266
32 3HMO STU 0.00000005519 0.72644
33 4E6D 0NU 0.0000000255 0.72639
34 3EYH IZA 0.00000003809 0.72602
35 4IVD 15T 0.00000001839 0.72524
36 4QTB 38Z 0.000000001491 0.72406
37 4MQ1 2C3 0.00000001498 0.72162
38 3THB 3TA 0.0000000002052 0.7214
39 3THB 3TA 0.0000000002052 0.7214
40 2B9I ADP 0.00000005181 0.71917
41 4E1Z 0MX 0.00000001226 0.71812
42 2F57 23D 0.0000001229 0.71704
43 1U5R ATP 0.00000008612 0.71633
44 1U5R ATP 0.00000008612 0.71633
45 2JLD AG1 0.000000000793 0.71599
46 2Y6O 1N1 0.00000001983 0.71571
47 4FG8 ATP 0.00000002871 0.71566
48 4K77 1Q4 0.0000002921 0.71528
49 4C4F 7CE 0.00000003167 0.71356
50 4E4N 0NL 0.00000007067 0.71225
51 4QTB 38Z 0.000000002763 0.71224
52 4E6Q 0NV 0.000000035 0.71141
53 2A19 ANP 0.0000003497 0.71093
54 4E4N 0NL 0.00000005324 0.71028
55 4X0M 3WA 0.000001152 0.70602
56 4K77 1Q4 0.0000006451 0.70573
57 2WU6 DKI 0.00000002306 0.70499
58 4IVB 1J5 0.0000002091 0.70473
59 4IVC 1J6 0.00000006902 0.7046
60 3EKK GS2 0.00000002378 0.70435
61 4IVB 1J5 0.0000001508 0.7036
62 4AT3 LTI 0.0000001529 0.70329
63 2B9J ADP 0.0000001534 0.70322
64 4E6Q 0NV 0.00000007677 0.70227
65 2JLD AG1 0.000000001228 0.70177
66 3IGO ANP 0.00000003909 0.70137
67 4IVC 1J6 0.00000008065 0.70119
68 4X2K 3WO 0.0000002478 0.70079
69 4X2J 3WN 0.0000002478 0.70079
70 4K33 ACP 0.00000008343 0.70045
71 3KRL KRL 0.00000004085 0.70044
72 4BCQ TJF 0.0000005415 0.70036
73 3RI1 3RH 0.0000000118 0.69742
74 1V0O INR 0.0000001458 0.6961
75 4FL3 ANP 0.0000000514 0.69559
76 4PNI KQQ 0.000000008103 0.69161
77 2EVA ADN 0.000000006082 0.69074
78 4IWD 1JC 0.000000001771 0.68923
79 4H3Q ANP 0.000000051 0.68851
80 1V0O INR 0.0000001465 0.68813
81 2B9F ADP 0.0000002115 0.6878
82 3SXS PP2 0.0000001052 0.68776
83 3VHE 42Q 0.000000008246 0.68499
84 4AG8 AXI 0.000000004696 0.68336
85 4IDT T28 0.0000003799 0.6826
86 4E4L 0NH 0.0000005802 0.68107
87 4HNF 16W 0.000001255 0.68005
88 4E4L 0NH 0.000000632 0.67909
89 2QLU ADE 0.000002997 0.67823
90 4E4L 0NH 0.0000004703 0.67775
91 4BCQ TJF 0.000002016 0.67757
92 4EHZ JAK 0.000001034 0.67595
93 3GNI ATP 0.0000001835 0.67579
94 2O2U 738 0.0000007407 0.67541
95 4CD0 AWJ 0.0000001388 0.6746
96 4CLJ 5P8 0.0000005438 0.67446
97 4CCU AWF 0.00000055 0.6742
98 1Y57 MPZ 0.0000001026 0.67399
99 3A7H ATP 0.0000005582 0.67386
100 3A7H ATP 0.0000005582 0.67386
101 2VZ6 FEF 0.000001654 0.67338
102 4HNF 16W 0.0000005805 0.67297
103 3H9R TAK 0.000002502 0.67224
104 3UIM ANP 0.0000004366 0.67165
105 4CNH 3U9 0.000000448 0.67107
106 4CNH 3U9 0.000001834 0.67087
107 3BRB ADP 0.000002699 0.67036
108 4AU8 Z3R 0.000001899 0.67003
109 4AU8 Z3R 0.000001899 0.67003
110 4MKC 4MK 0.0000002414 0.66989
111 4FG8 ATP 0.0000001803 0.66908
112 2VZ6 FEF 0.000001549 0.66638
113 4AOI 4K0 0.000001284 0.66266
114 3ZRM ZRM 0.0000006777 0.66184
115 4EHZ JAK 0.000002025 0.66004
116 4EHZ JAK 0.000002115 0.65902
117 3LXK MI1 0.00000006046 0.65899
118 1CM8 ANP 0.000001081 0.65883
119 1CM8 ANP 0.00000109 0.65864
120 4FOC 0UU 0.000001095 0.65855
121 3HZT J60 0.000003079 0.65836
122 3TTI KBI 0.0000005919 0.65757
123 4AU8 Z3R 0.000003184 0.65754
124 4AUA 4AU 0.000006944 0.65589
125 3A7H ATP 0.000008025 0.65586
126 3C1X CKK 0.0000003427 0.65552
127 3QUP LUN 0.000001256 0.65543
128 3GC8 B45 0.0000003608 0.65443
129 4EHZ JAK 0.000002605 0.65409
130 2QU6 857 0.0000001527 0.65287
131 4P5Z Q7M 0.000000007678 0.65243
132 3FI3 JK2 0.0000007701 0.65181
133 4FOB 0US 0.0000003001 0.65171
134 3SLS ANP 0.000000438 0.65033
135 1VJY 460 0.0000001312 0.6498
136 3GC8 B45 0.0000003379 0.64925
137 4IZY 1J2 0.0000006636 0.64816
138 2GU8 796 0.00000000008687 0.648
139 1O9U ADZ 0.00001073 0.64719
140 3TDC 0EU 0.00003617 0.64584
141 3ALN ANP 0.000002092 0.64384
142 3PP0 03Q 0.0000004619 0.64276
143 3ZBF VGH 0.000003212 0.64141
144 3SLS ANP 0.0000006708 0.64133
145 4E93 GUI 0.00000005216 0.63918
146 2QU6 857 0.0000005588 0.63881
147 3BRB ADP 0.00001133 0.6349
148 3ALN ANP 0.000001365 0.63265
149 1OPK P16 0.000001019 0.63249
150 4PMM 31V 0.000001195 0.62914
151 1ZTH ADP 0.00001057 0.62854
152 4TWC 37J 0.00000416 0.62821
153 1ZTH ADP 0.00001074 0.62816
154 1ZY5 ANP 0.00000441 0.62689
155 1ZP9 ATP 0.000006342 0.62563
156 4TW9 386 0.000004975 0.62415
157 3ALN ANP 0.0000137 0.62228
158 3RGF BAX 0.0000009541 0.62176
159 1ZTH ADP 0.00001023 0.62172
160 1ZTH ADP 0.00001403 0.6217
161 3U6H 03X 0.00000004528 0.62163
162 4TWC 37J 0.000003228 0.62044
163 1ZP9 ATP 0.000008257 0.61952
164 1XKK FMM 0.00000004241 0.61806
165 2BPM 529 0.000000001658 0.61774
166 1ZP9 ATP 0.000006691 0.61741
167 1ZP9 ATP 0.000007297 0.61544
168 1PME SB2 0.00000000254 0.61144
169 3VRY B43 0.000001258 0.6105
170 2BPM 529 0.000000002824 0.6021
171 4LOO SB4 0.00001016 0.60148
172 3PP0 03Q 0.000001541 0.60108
173 4AT5 MUJ 0.000004565 0.60083
174 4Q5H ANP 0.00001075 0.60023
175 3TDV GDP 0.00001079 0.60013
176 4DEH 0JK 0.00002619 0.59948
177 4I6H 1C8 0.00001149 0.59873
178 3VRY B43 0.000001445 0.59719
179 3TDV GDP 0.00001272 0.59647
180 2P2I 608 0.00000349 0.59528
181 3SXF BK5 0.0000003651 0.59418
182 2PUL ACP 0.00001993 0.5926
183 2PUL ACP 0.00001993 0.5926
184 2P2I 608 0.000004869 0.58848
185 3BZ3 YAM 0.000000006037 0.58748
186 4PMT 31Y 0.00001773 0.58316
187 4AT4 T6E 0.00001548 0.58046
188 4KBA 1QM 0.00002801 0.57887
189 3LKM AMP 0.00002466 0.57595
190 1TQP ATP 0.00001008 0.57361
191 4KBA 1QM 0.00008167 0.57257
192 3WG3 A2G GAL NAG FUC 0.0002098 0.57215
193 3E8N ATP 0.000000182 0.56917
194 3E8N VRA 0.000000182 0.56917
195 3E8N ATP 0.000000182 0.56917
196 3E8N VRA 0.000000182 0.56917
197 2PYW ADP 0.00003312 0.56411
198 3PDT ADP 0.00009672 0.56247
199 1TV5 N8E 0.0003872 0.56216
200 4KBA 1QM 0.00006046 0.56171
201 4KBA 1QM 0.00006046 0.56171
202 1IA9 ANP 0.00006293 0.55544
203 4KBA 1QM 0.0001097 0.55384
204 4GYI ADP 0.0002172 0.54943
205 2IF8 ADP 0.000477 0.54891
206 4CKR DI1 0.0000222 0.54834
207 4WHZ 3NL 0.000001681 0.54763
208 3B6C SDN 0.0005859 0.54371
209 3KMW ATP 0.0001725 0.54356
210 1SN0 T44 0.0003431 0.5386
211 3WG3 A2G GAL NAG FUC 0.0005962 0.53697
212 3I0O ADP 0.0005166 0.53454
213 3I0O ADP 0.0005166 0.53454
214 1OBD ATP 0.0004182 0.53392
215 3SLS 77D 0.0002893 0.5268
216 3SG8 TOY 0.00004552 0.52223
217 3SG8 TOY 0.00004552 0.52223
218 4OCV ANP 0.0003528 0.51771
219 3ZJX BOG 0.002088 0.51674
220 1W2D ADP 0.001207 0.51402
221 4IAW LIZ 0.001242 0.51332
222 3SLS 77D 0.0008437 0.51226
223 4BKJ STI 0.0002149 0.51114
224 4BKJ STI 0.0003283 0.51052
225 1W2D ADP 0.001674 0.5061
226 2ZL7 FUC GAL NGA 0.002764 0.5048
227 4AZT LY2 0.001776 0.50467
228 1RE8 BD2 0.00000000001691 0.49941
229 3ZJX BOG 0.003896 0.49888
230 3ZJX BOG 0.003901 0.49885
231 3ZJX BOG 0.003974 0.49835
232 3SG8 TOY 0.0001623 0.49822
233 4F4P 0SB 0.00000000001832 0.49604
234 1TV5 N8E 0.003878 0.49587
235 3W0O ADP 0.0002304 0.49496
236 1NF8 BOG 0.004976 0.49389
237 1YP6 PRZ 0.001513 0.4899
238 1AUX AGS 0.001642 0.48808
239 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 0.007168 0.48737
240 3W0O HY0 0.0002888 0.48733
241 4IAW LIZ 0.004002 0.48501
242 2XG5 EC5 0.005012 0.48284
243 2XG5 EC2 0.005012 0.48284
244 1DZK PRZ 0.003135 0.4818
245 1DZK PRZ 0.002645 0.48149
246 2XMY CDK 0.000000002848 0.48068
247 2HHP FLC 0.004729 0.47845
248 4P25 FUC GAL NAG FUC 0.007967 0.47761
249 1QY1 PRZ 0.001937 0.47663
250 1QY1 PRZ 0.001937 0.47663
251 4FE2 ADP 0.004882 0.47573
252 4LO2 GAL BGC 0.009057 0.47569
253 4FE2 AIR 0.007028 0.47136
254 1QKQ MAN 0.002415 0.47036
255 4DFU QUE 0.009226 0.46917
256 4AXD ANP 0.0002547 0.46904
257 3B9Z CO2 0.01102 0.46807
258 1I7L ATP 0.001844 0.46723
259 1I7L ATP 0.001844 0.46723
260 1OFL NGK GCD 0.008748 0.46715
261 2VQD AP2 0.003145 0.4662
262 3WXL ADP 0.01665 0.46547
263 3A16 PXO 0.004898 0.46439
264 2R5V HHH 0.007958 0.46413
265 3LQ8 88Z 0.000000004351 0.46273
266 4UWH JXM 0.0072 0.46248
267 3VPB ADP 0.002016 0.46222
268 2V1O COA 0.001826 0.46112
269 3RGA LSB 0.006542 0.46086
270 3T4V MD3 0.004945 0.45988
271 2CFM AMP 0.0124 0.45758
272 2AQX ATP 0.004088 0.45721
273 4NWM 2P5 0.000000006578 0.45693
274 4IEN COA 0.004378 0.45576
275 1XPJ TLA 0.0287 0.45544
276 1UBY DMA 0.00739 0.45448
277 1UBY DMA 0.00739 0.45448
278 4H2W AMP 0.008784 0.45414
279 4DFU QUE 0.02054 0.4535
280 4W9F 3JU 0.02066 0.45335
281 4F65 0S9 0.00000000102 0.45162
282 2WH8 II2 0.01599 0.45139
283 3VPC ADP 0.005575 0.45064
284 3KF4 B90 0.00000000417 0.45052
285 3I6B KDO 0.02337 0.45019
286 3I6B KDO 0.02337 0.45019
287 1D2S DHT 0.01051 0.45004
288 2IO8 ADP 0.004346 0.44969
289 3ACL 3F1 0.0108 0.44941
290 2ALG DAO 0.024 0.44921
291 2ALG DAO 0.024 0.44921
292 1PK8 ATP 0.003872 0.44909
293 4OCJ NDG 0.0008239 0.44893
294 4MXO DB8 0.0000001287 0.44854
295 4IEN GDP 0.01132 0.44835
296 2PXJ OGA 0.02889 0.44753
297 4FMS BDP 0.03056 0.44715
298 3TM0 ANP 0.001854 0.44691
299 1KDK DHT 0.005901 0.44637
300 2XB7 GUI 0.000000003068 0.44629
301 2PNC CLU 0.02766 0.44601
302 3UUA 0CZ 0.01483 0.44564
303 3UUA 0CZ 0.01483 0.44564
304 1PK8 ATP 0.004682 0.44526
305 3KO0 TFP 0.03302 0.4451
306 3PUR 2HG 0.0306 0.44491
307 4ANW O92 0.002157 0.44413
308 2R5V HHH 0.01852 0.44402
309 3W54 RNB 0.01609 0.44373
310 1W2D 4IP 0.004594 0.44284
311 1OUK 084 0.000000415 0.44253
312 1XVB 3BR 0.02354 0.44195
313 3KYF 5GP 5GP 0.02362 0.44186
314 1N5S ADL 0.01511 0.44175
315 4MPO AMP 0.02523 0.44145
316 3PNA CMP 0.02811 0.4414
317 3PNA CMP 0.02811 0.4414
318 4IEN COA 0.009987 0.44129
319 4F4S EFO 0.03312 0.44125
320 3SP6 IL2 0.0116 0.44113
321 2GC0 PAN 0.01342 0.44112
322 3DOO SKM 0.03631 0.4411
323 1O6U PLM 0.01563 0.44096
324 3FAL REA 0.02457 0.44089
325 3TM0 B31 0.002256 0.44084
326 4FFG 0U8 0.03382 0.44071
327 3PUR 2HG 0.03668 0.44015
328 1EPB REA 0.01623 0.44011
329 4PU5 ANP 0.008413 0.43898
330 4OCT AKG 0.0267 0.43886
331 4F4S EFO 0.0364 0.43882
332 2WPU KYT 0.01001 0.43824
333 2YG2 S1P 0.00893 0.43774
334 3PNA CMP 0.03283 0.4375
335 3DFR MTX 0.02445 0.43737
336 3QBC B55 0.03671 0.43724
337 4CS9 AMP 0.02093 0.43684
338 1SBR VIB 0.03952 0.4367
339 1J78 OLA 0.03768 0.43602
340 1LNM DTX 0.01289 0.43578
341 2EB5 OXL 0.04095 0.43576
342 4OCT AKG 0.03083 0.43534
343 3W54 RNB 0.02449 0.43391
344 3F8C HT1 0.04789 0.43383
345 4I67 G G G RPC 0.0329 0.43374
346 3K5I ADP 0.01418 0.43371
347 3FAL REA 0.02491 0.4335
348 3FAL REA 0.02491 0.4335
349 4NB5 2JT 0.01662 0.43321
350 1UMZ BGC BGC XYS BGC XYS GAL 0.04626 0.43262
351 1UNB AKG 0.00602 0.43235
352 4NJH SAM 0.004141 0.43215
353 4NJH 2K8 0.004141 0.43215
354 3D72 FAD 0.004728 0.43206
355 1EHI ADP 0.01798 0.43148
356 4RC7 PL3 0.02374 0.43137
357 4MXO DB8 0.0000002436 0.43132
358 2XZ9 PYR 0.04851 0.43101
359 4IEU 2CO 0.04955 0.43064
360 2CM4 RCL 0.01442 0.43048
361 1OMO NAD 0.009833 0.4303
362 3IHG VAK 0.02524 0.42996
363 4HT2 V50 0.02271 0.42928
364 4LNP VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.04552 0.42927
365 4ELG 52J 0.01348 0.42914
366 3IX9 MTX 0.02618 0.42912
367 1I7M CG 0.04586 0.42908
368 4LWU 20U 0.03094 0.42841
369 4MPN PV0 0.01083 0.42836
370 4O9S 2RY 0.009554 0.42832
371 4O9S 2RY 0.009554 0.42832
372 4IEN GDP 0.02381 0.42821
373 1WAP TRP 0.0273 0.42815
374 3VSV XYP 0.04843 0.4277
375 1YYE 196 0.03223 0.42745
376 2Q7D ANP 0.01287 0.42744
377 1W2D 4IP 0.007863 0.42721
378 4O2B ACP 0.02181 0.42721
379 3SE5 ANP 0.02871 0.42699
380 1H8S AIC 0.04998 0.4269
381 3UDG TMP 0.04961 0.42618
382 4GJ3 0XP 0.0000000006241 0.42616
383 2WA4 069 0.04146 0.42467
384 3V8T 477 0.0000001232 0.42421
385 3V8T 477 0.0000001232 0.42421
386 3OJI PYV 0.02208 0.42411
387 3IX9 MTX 0.04264 0.424
388 3ORQ ADP 0.02272 0.42349
389 4OAS 2SW 0.03816 0.42346
390 1SU2 ATP 0.02997 0.42301
391 4JPS 1LT 0.03437 0.42284
392 2YW2 ATP 0.02346 0.42278
393 3LQV ADE 0.04493 0.42259
394 2GJ5 VD3 0.01322 0.42186
395 3T4L ZEA 0.03212 0.42144
396 2BYC FMN 0.04164 0.42139
397 4LA7 A1O 0.01609 0.42034
398 4BG4 ADP 0.03395 0.42018
399 1E4I NFG 0.01747 0.42011
400 2XGT NSS 0.01284 0.42005
401 3IX9 MTX 0.03473 0.41967
402 1ODM ASV 0.01668 0.41961
403 4OHT NAP 0.04536 0.41937
404 3GWN FAD 0.02881 0.41831
405 3W54 RNB 0.03707 0.41819
406 4ELG 52J 0.01817 0.41788
407 4ELG 52J 0.01832 0.41772
408 2W90 6PG 0.01858 0.41743
409 2P8B NSK 0.02387 0.41716
410 1UNB PN1 0.01087 0.4165
411 2C5U APC 0.03567 0.41629
412 3P7N FMN 0.03573 0.41625
413 3RY9 1CA 0.0414 0.41567
414 1T7R DHT 0.04693 0.41561
415 1OPB RET 0.03686 0.41556
416 1OPB RET 0.04182 0.41545
417 186L N4B 0.02337 0.41514
418 1TMX HGX 0.02969 0.41506
419 1T5Z DHT 0.04805 0.41506
420 4F7E 0SH 0.004859 0.41462
421 2YW2 ATP 0.03417 0.41458
422 3FEI CTM 0.03043 0.41453
423 4HWS 1B3 0.01921 0.41441
424 3V4S ATP 0.03063 0.41439
425 4EIL FOL 0.04404 0.41427
426 3L9R L9Q 0.00913 0.41345
427 4ELG 52J 0.02038 0.41322
428 1IHU AF3 0.03252 0.41311
429 2GMH UQ5 0.03316 0.41268
430 4ELG 52J 0.02375 0.41244
431 2PX8 SAH 0.04288 0.41218
432 2C9E DGD 0.04954 0.41158
433 2UXI G50 0.04448 0.41136
434 1VCE SAH 0.04467 0.41126
435 4M8E 29V 0.03981 0.41124
436 2B96 ANN 0.03551 0.41122
437 4R38 RBF 0.04562 0.41079
438 1E4E ADP 0.04611 0.41055
439 2Q7D ANP 0.02351 0.41037
440 2Q7D ANP 0.02351 0.41037
441 2C5U APC 0.04156 0.4103
442 4OAS 2SW 0.0483 0.40951
443 4BVN P32 0.03188 0.40871
444 2OFV 242 0.00000007841 0.40818
445 4ELG 52J 0.0332 0.40787
446 3PG7 PTY 0.01799 0.40706
447 1ZB6 GST 0.02006 0.40704
448 2RC5 FAD 0.04835 0.40697
449 4CG8 G8V 0.008738 0.40658
450 4CG8 G8S 0.008738 0.40658
451 3P7N FMN 0.0494 0.40649
452 4ELG 52J 0.02614 0.40608
453 3E7O 35F 0.00000002183 0.40589
454 3A16 PXO 0.01535 0.40587
455 1HG4 LPP 0.02647 0.40583
456 1IHU ADP 0.04189 0.4053
457 4WLB 3QQ 0.02464 0.40515
458 1DRV A3D 0.04492 0.40381
459 2E56 MYR 0.02145 0.40375
460 3KF4 B90 0.0000002047 0.40331
461 1I7M PUT 0.04484 0.40213
462 4O9S 2RY 0.04481 0.40162
463 3E2M E2M 0.03288 0.40155
464 4ELG 52J 0.04289 0.40037
465 4ELG 52I 0.04289 0.40037
466 3NW7 LGV 0.00000168 0.40028
Pocket No.: 2; Query (leader) PDB : 3RWP; Ligand: ABQ; Similar sites found: 466
This union binding pocket(no: 2) in the query (biounit: 3rwp.bio1) has 77 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 2X2M X2M 0.0000000002571 0.80749
2 1U59 STU 0.000000001107 0.80491
3 4CFU 2WC 0.000000008747 0.78887
4 4BCN T9N 0.000000006943 0.78366
5 4CFU 2WC 0.000000007219 0.78275
6 3F7Z 34O 0.00000001343 0.77872
7 3F7Z 34O 0.00000001008 0.76508
8 2PVF ACP 0.0000000107 0.76373
9 1XJD STU 0.000000007314 0.76282
10 2F2U M77 0.00000004795 0.75895
11 2F2U M77 0.00000004807 0.75889
12 4DCE 0JF 0.000000002927 0.75611
13 2ZV2 609 0.00000006127 0.75303
14 3PVW QRX 0.0000000008931 0.74847
15 4BCN T9N 0.00000005335 0.74609
16 3IDB ANP 0.000000003206 0.74597
17 4DCE 0JF 0.00000000722 0.74533
18 4MQ1 2C3 0.000000009052 0.74047
19 3RI1 3RH 0.000000001345 0.74037
20 4MQ1 2C3 0.000000009618 0.73917
21 2CSN CKI 0.000000001787 0.73476
22 3LXN MI1 0.00000001216 0.73413
23 2VAG V25 0.00000002666 0.73398
24 4IVD 15T 0.00000001528 0.72922
25 4MQ1 2C3 0.00000002358 0.72811
26 1U5R ATP 0.00000003532 0.72771
27 2JLD AG1 0.0000000008729 0.72741
28 3EYG MI1 0.00000002478 0.72702
29 3GQI ACP 0.00000003675 0.72682
30 4OAV ACP 0.00000005456 0.72671
31 2P2H 994 0.00000008138 0.7266
32 3HMO STU 0.00000005519 0.72644
33 4E6D 0NU 0.0000000255 0.72639
34 3EYH IZA 0.00000003809 0.72602
35 4IVD 15T 0.00000001839 0.72524
36 4QTB 38Z 0.000000001491 0.72406
37 4MQ1 2C3 0.00000001498 0.72162
38 3THB 3TA 0.0000000002052 0.7214
39 3THB 3TA 0.0000000002052 0.7214
40 2B9I ADP 0.00000005181 0.71917
41 4E1Z 0MX 0.00000001226 0.71812
42 2F57 23D 0.0000001229 0.71704
43 1U5R ATP 0.00000008612 0.71633
44 1U5R ATP 0.00000008612 0.71633
45 2JLD AG1 0.000000000793 0.71599
46 2Y6O 1N1 0.00000001983 0.71571
47 4FG8 ATP 0.00000002871 0.71566
48 4K77 1Q4 0.0000002921 0.71528
49 4C4F 7CE 0.00000003167 0.71356
50 4E4N 0NL 0.00000007067 0.71225
51 4QTB 38Z 0.000000002763 0.71224
52 4E6Q 0NV 0.000000035 0.71141
53 2A19 ANP 0.0000003497 0.71093
54 4E4N 0NL 0.00000005324 0.71028
55 4X0M 3WA 0.000001152 0.70602
56 4K77 1Q4 0.0000006451 0.70573
57 2WU6 DKI 0.00000002306 0.70499
58 4IVB 1J5 0.0000002091 0.70473
59 4IVC 1J6 0.00000006902 0.7046
60 3EKK GS2 0.00000002378 0.70435
61 4IVB 1J5 0.0000001508 0.7036
62 4AT3 LTI 0.0000001529 0.70329
63 2B9J ADP 0.0000001534 0.70322
64 4E6Q 0NV 0.00000007677 0.70227
65 2JLD AG1 0.000000001228 0.70177
66 3IGO ANP 0.00000003909 0.70137
67 4IVC 1J6 0.00000008065 0.70119
68 4X2J 3WN 0.0000002478 0.70079
69 4X2K 3WO 0.0000002478 0.70079
70 4K33 ACP 0.00000008343 0.70045
71 3KRL KRL 0.00000004085 0.70044
72 4BCQ TJF 0.0000005415 0.70036
73 3RI1 3RH 0.0000000118 0.69742
74 1V0O INR 0.0000001458 0.6961
75 4FL3 ANP 0.0000000514 0.69559
76 4PNI KQQ 0.000000008103 0.69161
77 2EVA ADN 0.000000006082 0.69074
78 4IWD 1JC 0.000000001771 0.68923
79 4H3Q ANP 0.000000051 0.68851
80 1V0O INR 0.0000001465 0.68813
81 2B9F ADP 0.0000002115 0.6878
82 3SXS PP2 0.0000001052 0.68776
83 3VHE 42Q 0.000000008246 0.68499
84 4AG8 AXI 0.000000004696 0.68336
85 4IDT T28 0.0000003799 0.6826
86 4E4L 0NH 0.0000005802 0.68107
87 4HNF 16W 0.000001255 0.68005
88 4E4L 0NH 0.000000632 0.67909
89 2QLU ADE 0.000002997 0.67823
90 4E4L 0NH 0.0000004703 0.67775
91 4BCQ TJF 0.000002016 0.67757
92 4EHZ JAK 0.000001034 0.67595
93 3GNI ATP 0.0000001835 0.67579
94 2O2U 738 0.0000007407 0.67541
95 4CD0 AWJ 0.0000001388 0.6746
96 4CLJ 5P8 0.0000005438 0.67446
97 4CCU AWF 0.00000055 0.6742
98 1Y57 MPZ 0.0000001026 0.67399
99 3A7H ATP 0.0000005582 0.67386
100 3A7H ATP 0.0000005582 0.67386
101 2VZ6 FEF 0.000001654 0.67338
102 4HNF 16W 0.0000005805 0.67297
103 3H9R TAK 0.000002502 0.67224
104 3UIM ANP 0.0000004366 0.67165
105 4CNH 3U9 0.000000448 0.67107
106 4CNH 3U9 0.000001834 0.67087
107 3BRB ADP 0.000002699 0.67036
108 4AU8 Z3R 0.000001899 0.67003
109 4AU8 Z3R 0.000001899 0.67003
110 4MKC 4MK 0.0000002414 0.66989
111 4FG8 ATP 0.0000001803 0.66908
112 2VZ6 FEF 0.000001549 0.66638
113 4AOI 4K0 0.000001284 0.66266
114 3ZRM ZRM 0.0000006777 0.66184
115 4EHZ JAK 0.000002025 0.66004
116 4EHZ JAK 0.000002115 0.65902
117 3LXK MI1 0.00000006046 0.65899
118 1CM8 ANP 0.000001081 0.65883
119 1CM8 ANP 0.00000109 0.65864
120 4FOC 0UU 0.000001095 0.65855
121 3HZT J60 0.000003079 0.65836
122 3TTI KBI 0.0000005919 0.65757
123 4AU8 Z3R 0.000003184 0.65754
124 4AUA 4AU 0.000006944 0.65589
125 3A7H ATP 0.000008025 0.65586
126 3C1X CKK 0.0000003427 0.65552
127 3QUP LUN 0.000001256 0.65543
128 3GC8 B45 0.0000003608 0.65443
129 4EHZ JAK 0.000002605 0.65409
130 2QU6 857 0.0000001527 0.65287
131