Receptor
PDB id Resolution Class Description Source Keywords
1yvm 1.6 Å EC: 3.4.11.18 E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH THIABENDAZOLE ESCHERICHIA COLI HYDROLASE(ALPHA-AMINOACYLPEPTIDE) METAL COMPLEX THIABENDAZOLE METHIONINE AMINOPEPTIDASE INHIBITOR
Ref.: METAL IONS AS COFACTORS FOR THE BINDING OF INHIBITORS TO METHIONINE AMINOPEPTIDASE: A CRITICAL VIEW OF THE RELEVANCE OF IN VITRO METALLOENZYME ASSAYS. ANGEW.CHEM.INT.ED.ENGL. V. 44 3620 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CO A:401;
A:402;
A:403;
A:404;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
 submit data
58.933 Co [Co+2...
NA A:2001;
 Part of Protein;
 none;
 submit data
22.99 Na [Na+]
TMG A:501;
 Valid;
 none;
 Ki = 0.4 uM
201.248 C10 H7 N3 S c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YVM 1.6 Å EC: 3.4.11.18 E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH THIABENDAZOLE ESCHERICHIA COLI HYDROLASE(ALPHA-AMINOACYLPEPTIDE) METAL COMPLEX THIABENDAZOLE METHIONINE AMINOPEPTIDASE INHIBITOR
Ref.: METAL IONS AS COFACTORS FOR THE BINDING OF INHIBITORS TO METHIONINE AMINOPEPTIDASE: A CRITICAL VIEW OF THE RELEVANCE OF IN VITRO METALLOENZYME ASSAYS. ANGEW.CHEM.INT.ED.ENGL. V. 44 3620 2005
Members (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
70% Homology Family (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
50% Homology Family (69)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
21 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
22 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
23 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
24 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
25 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
26 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
27 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
28 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
29 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
30 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
31 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
32 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
33 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
34 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
35 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
36 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
37 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
38 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
39 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
40 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
41 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
42 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
43 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
44 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
45 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
46 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
47 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
48 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
49 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
50 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
51 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
52 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
53 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
54 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
55 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
56 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
57 4IU6 - FZ1 C24 H23 N5 O COc1ccc(cc....
58 1QXZ ic50 = 19 uM M3C C8 H14 N2 O2 S2 CSCC[C@@H]....
59 1QXY ic50 = 16 uM M2C C10 H16 N2 O2 S CSCC[C@@H]....
60 1QXW ic50 = 7 uM M1C C10 H22 N2 O2 CCCC[C@@H]....
61 3IU9 ic50 = 0.24 uM T07 C9 H8 Cl2 N4 S c1cc(c(cc1....
62 3IU7 ic50 = 16 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
63 3PKE - Y10 C21 H31 N O5 CC(C)(C)/C....
64 3PKB ic50 = 0.62 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
65 3PKA ic50 = 0.54 uM Y02 C23 H37 N O6 Cc1cc(c(c(....
66 3PKC ic50 = 0.96 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
67 3IU8 ic50 = 0.58 uM T03 C9 H8 F N3 S c1cc(ccc1C....
68 3PKD ic50 = 0.76 uM Y10 C21 H31 N O5 CC(C)(C)/C....
69 1YJ3 - MET C5 H11 N O2 S CSCC[C@@H]....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: TMG; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 TMG 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: TMG; Similar ligands found: 991
No: Ligand Similarity coefficient
1 XCG 0.9959
2 S0D 0.9808
3 FZM 0.9799
4 363 0.9772
5 0SY 0.9720
6 GO2 0.9711
7 ZRK 0.9682
8 2FX 0.9674
9 X48 0.9664
10 QIV 0.9635
11 N1E 0.9629
12 JCZ 0.9623
13 3VS 0.9589
14 VC3 0.9579
15 BP7 0.9572
16 Y3L 0.9572
17 QME 0.9570
18 X0U 0.9565
19 3VX 0.9559
20 6FB 0.9541
21 GZ2 0.9533
22 E3X 0.9530
23 BQ2 0.9530
24 JAH 0.9521
25 ALE 0.9517
26 N91 0.9514
27 ENO 0.9508
28 3VQ 0.9506
29 4I8 0.9505
30 LR8 0.9504
31 7O4 0.9496
32 5E5 0.9492
33 2P3 0.9492
34 S7G 0.9491
35 FF2 0.9484
36 4XF 0.9478
37 RKV 0.9477
38 G14 0.9476
39 EQA 0.9473
40 AN3 0.9470
41 4BL 0.9469
42 GVY 0.9468
43 4BX 0.9467
44 795 0.9466
45 2JX 0.9466
46 LVD 0.9466
47 LZ5 0.9464
48 TYR 0.9463
49 C82 0.9450
50 4BY 0.9446
51 HC4 0.9441
52 ESX 0.9440
53 ODK 0.9435
54 6P3 0.9433
55 F4E 0.9432
56 2QC 0.9430
57 3IL 0.9430
58 DHC 0.9429
59 4HB 0.9426
60 DAH 0.9426
61 PPY 0.9425
62 2D2 0.9425
63 EYV 0.9420
64 BZ2 0.9419
65 MSR 0.9419
66 HPP 0.9416
67 A5E 0.9415
68 4FF 0.9414
69 0FR 0.9412
70 92G 0.9412
71 0UL 0.9411
72 ZZA 0.9410
73 ICB 0.9408
74 ESP 0.9405
75 6SD 0.9403
76 78Y 0.9398
77 833 0.9397
78 PQS 0.9393
79 ZHA 0.9392
80 PQM 0.9392
81 N9J 0.9390
82 1A5 0.9389
83 C4E 0.9387
84 AHC 0.9384
85 PRL 0.9383
86 3ZB 0.9376
87 P81 0.9375
88 KMY 0.9373
89 P80 0.9370
90 FYR 0.9370
91 6N4 0.9364
92 FQX 0.9362
93 TYE 0.9361
94 I2E 0.9356
95 ANC 0.9353
96 PPT 0.9351
97 5H6 0.9351
98 CPZ 0.9348
99 AOT 0.9347
100 E1T 0.9347
101 PUE 0.9345
102 YIP 0.9343
103 EYJ 0.9342
104 HXY 0.9342
105 RSV 0.9341
106 MD6 0.9341
107 4LW 0.9340
108 F4K 0.9340
109 TOH 0.9340
110 HRM 0.9340
111 KLS 0.9337
112 SWX 0.9335
113 6QF 0.9333
114 MPV 0.9333
115 5TY 0.9331
116 FHV 0.9330
117 PO6 0.9328
118 H75 0.9328
119 TCA 0.9328
120 SLS 0.9326
121 LR2 0.9322
122 0JD 0.9321
123 2HC 0.9317
124 SNU 0.9314
125 KLE 0.9313
126 OLU 0.9312
127 QBP 0.9310
128 5VU 0.9308
129 ITE 0.9304
130 JMG 0.9304
131 6KT 0.9304
132 EN1 0.9304
133 0ON 0.9303
134 6J5 0.9303
135 68B 0.9303
136 9ZE 0.9301
137 428 0.9300
138 PFF 0.9298
139 MMS 0.9297
140 LL1 0.9297
141 HCI 0.9295
142 A51 0.9295
143 TID 0.9295
144 11X 0.9295
145 UNJ 0.9289
146 1F1 0.9281
147 L22 0.9280
148 8D6 0.9280
149 XI7 0.9280
150 S0W 0.9278
151 ZYQ 0.9278
152 1FE 0.9278
153 GNW 0.9274
154 5B2 0.9273
155 MXD 0.9272
156 MJW 0.9272
157 7MW 0.9271
158 4NP 0.9271
159 ERZ 0.9271
160 0NX 0.9270
161 RLG 0.9270
162 848 0.9269
163 2PK 0.9269
164 SYE 0.9268
165 KTW 0.9268
166 DTR 0.9267
167 AAN 0.9267
168 K97 0.9265
169 9NB 0.9265
170 SOJ 0.9265
171 YZM 0.9264
172 LTN 0.9262
173 S7D 0.9262
174 HX4 0.9260
175 1PS 0.9259
176 M6H 0.9258
177 KF5 0.9258
178 ZRL 0.9256
179 5LA 0.9254
180 7EH 0.9253
181 MR6 0.9253
182 AOY 0.9252
183 BNL 0.9251
184 0OK 0.9250
185 IOP 0.9248
186 PIQ 0.9247
187 TB8 0.9247
188 2GQ 0.9246
189 SKF 0.9245
190 CXH 0.9244
191 15N 0.9243
192 XIZ 0.9242
193 4WL 0.9241
194 4AU 0.9239
195 B41 0.9239
196 M78 0.9238
197 80G 0.9237
198 JBZ 0.9237
199 PHE 0.9237
200 EAT 0.9232
201 2PV 0.9231
202 36Y 0.9230
203 TZF 0.9230
204 XDK 0.9230
205 EVF 0.9228
206 BGU 0.9227
207 4V2 0.9226
208 FCD 0.9226
209 3IP 0.9226
210 CH9 0.9224
211 BPY 0.9224
212 9BF 0.9220
213 4NB 0.9217
214 9JT 0.9217
215 36E 0.9215
216 ESI 0.9213
217 657 0.9211
218 LQ2 0.9211
219 8XL 0.9210
220 4MB 0.9210
221 TRP 0.9207
222 RA7 0.9206
223 6MW 0.9205
224 K4V 0.9205
225 3R4 0.9204
226 6H2 0.9203
227 61M 0.9196
228 C1M 0.9196
229 B1J 0.9195
230 4FP 0.9195
231 V1T 0.9192
232 EYY 0.9191
233 M4N 0.9191
234 7VP 0.9189
235 F40 0.9188
236 GB5 0.9187
237 F90 0.9185
238 IAC 0.9185
239 8NB 0.9185
240 ZEC 0.9185
241 2J1 0.9184
242 1A7 0.9184
243 0K7 0.9183
244 C53 0.9183
245 0HN 0.9181
246 AVX 0.9180
247 4CN 0.9180
248 A7H 0.9178
249 K3D 0.9177
250 ZSP 0.9177
251 EQW 0.9177
252 12T 0.9176
253 M5H 0.9176
254 JDN 0.9175
255 6FZ 0.9175
256 492 0.9174
257 H4B 0.9174
258 FWD 0.9173
259 9CA 0.9170
260 ANF 0.9170
261 XYP XIF 0.9169
262 XIF XYP 0.9169
263 FER 0.9167
264 LGT 0.9167
265 S60 0.9165
266 THA 0.9165
267 47V 0.9165
268 7L4 0.9164
269 N4E 0.9163
270 9UL 0.9160
271 BZJ 0.9159
272 LSQ 0.9159
273 LJ3 0.9159
274 GO8 0.9159
275 4NS 0.9158
276 GJK 0.9157
277 1IT 0.9155
278 4BF 0.9154
279 APS 0.9152
280 PJW 0.9152
281 JB8 0.9151
282 3D3 0.9150
283 NFA 0.9149
284 397 0.9148
285 4RU 0.9148
286 DTY 0.9148
287 IOS 0.9145
288 M5E 0.9145
289 TCR 0.9144
290 JA5 0.9143
291 OQC 0.9143
292 PNP 0.9141
293 PPN 0.9140
294 TSR 0.9139
295 AA 0.9139
296 NK5 0.9139
297 AJG 0.9137
298 GJP 0.9136
299 4G2 0.9136
300 A6W 0.9136
301 NAL 0.9134
302 0BP 0.9134
303 2LT 0.9133
304 JAW 0.9133
305 LO1 0.9132
306 BIK 0.9131
307 YOF 0.9131
308 A5H 0.9130
309 4FE 0.9130
310 5GV 0.9130
311 8CC 0.9130
312 DXK 0.9130
313 L14 0.9129
314 TYC 0.9127
315 S0E 0.9126
316 A5Q 0.9126
317 PLP 0.9125
318 PBA 0.9124
319 P7Y 0.9124
320 CX6 0.9122
321 D2G 0.9121
322 N2M 0.9121
323 I3E 0.9118
324 JP2 0.9117
325 BVS 0.9117
326 2J5 0.9117
327 4ZA 0.9116
328 F18 0.9116
329 1EB 0.9114
330 MES 0.9114
331 6TZ 0.9114
332 56D 0.9113
333 EXD 0.9113
334 0HO 0.9112
335 J6W 0.9110
336 EUH 0.9110
337 U13 0.9109
338 2QU 0.9108
339 KWB 0.9105
340 9FL 0.9104
341 F06 0.9104
342 R20 0.9101
343 2O8 0.9101
344 27B 0.9100
345 KYN 0.9096
346 F02 0.9095
347 1VK 0.9095
348 K7H 0.9095
349 68A 0.9094
350 HNT 0.9093
351 V2Z 0.9091
352 4Z1 0.9088
353 1HN 0.9087
354 YE6 0.9087
355 MP5 0.9086
356 AMR 0.9086
357 6ZX 0.9086
358 2ZM 0.9085
359 2WU 0.9082
360 0DF 0.9081
361 6NT 0.9081
362 6FG 0.9081
363 GB4 0.9080
364 4AF 0.9080
365 1Z6 0.9079
366 BL0 0.9079
367 DHY 0.9078
368 ATX 0.9077
369 3A9 0.9077
370 S0A 0.9077
371 6NI 0.9074
372 D3G 0.9073
373 B5A 0.9073
374 CC5 0.9072
375 ST3 0.9072
376 K80 0.9072
377 IWT 0.9072
378 4AB 0.9072
379 TYL 0.9071
380 VM1 0.9071
381 1L5 0.9071
382 M3E 0.9070
383 PHI 0.9068
384 6C5 0.9067
385 5GT 0.9065
386 28A 0.9064
387 88L 0.9063
388 ARP 0.9063
389 RNO 0.9062
390 8ZE 0.9062
391 GF4 0.9061
392 7AP 0.9061
393 DRG 0.9061
394 4NZ 0.9061
395 SNO 0.9060
396 9R5 0.9060
397 HIC 0.9059
398 L2K 0.9055
399 FCW 0.9055
400 P4L 0.9054
401 S98 0.9054
402 HBO 0.9052
403 CFA 0.9051
404 EUE 0.9048
405 EES 0.9048
406 MAJ 0.9048
407 5SJ 0.9048
408 JG8 0.9046
409 4LV 0.9046
410 WA1 0.9046
411 CWD 0.9046
412 BIO 0.9045
413 3AE 0.9044
414 LUM 0.9044
415 II4 0.9044
416 YF3 0.9044
417 5F5 0.9043
418 5DS 0.9043
419 H35 0.9042
420 4Z9 0.9042
421 CIY 0.9041
422 344 0.9040
423 3D8 0.9040
424 HA5 0.9039
425 R9J 0.9038
426 YE7 0.9038
427 MR4 0.9038
428 4GU 0.9037
429 G6P 0.9035
430 BG6 0.9034
431 PLR 0.9034
432 AEG 0.9034
433 1M2 0.9033
434 6C8 0.9032
435 2HU 0.9032
436 A5P 0.9032
437 MR5 0.9030
438 LNR 0.9030
439 JGB 0.9030
440 8HC 0.9029
441 BHS 0.9028
442 4R1 0.9028
443 3NY 0.9028
444 14N 0.9027
445 0FK 0.9027
446 94W 0.9025
447 GCO 0.9024
448 7FU 0.9024
449 5NI 0.9023
450 4P5 0.9021
451 HWD 0.9020
452 NAG 0.9020
453 HHS 0.9020
454 Z70 0.9017
455 HBI 0.9017
456 H2B 0.9017
457 A9B 0.9017
458 LR5 0.9016
459 5F8 0.9014
460 LEL 0.9014
461 2K8 0.9013
462 XIY 0.9012
463 72D 0.9011
464 BWD 0.9011
465 ABI 0.9010
466 B21 0.9010
467 BDI 0.9010
468 FK8 0.9008
469 CK2 0.9005
470 L03 0.9005
471 1ZC 0.9005
472 S7J 0.9003
473 P9E 0.9003
474 8NX 0.9001
475 6C4 0.9001
476 DEW 0.9000
477 0XR 0.9000
478 SQV 0.8999
479 E7S 0.8997
480 4TB 0.8997
481 BZQ 0.8997
482 1XS 0.8994
483 9FH 0.8993
484 5OR 0.8993
485 KDV 0.8992
486 0OY 0.8992
487 5O6 0.8991
488 36M 0.8991
489 N2I 0.8991
490 FBF 0.8990
491 OJD 0.8990
492 A7N 0.8989
493 URO 0.8988
494 RCV 0.8988
495 8U3 0.8988
496 PBN 0.8988
497 HFA 0.8986
498 KTJ 0.8986
499 IWD 0.8986
500 XDL XYP 0.8985
501 WV7 0.8985
502 AVA 0.8983
503 XDN XYP 0.8982
504 XYP XDN 0.8982
505 S7A 0.8982
506 4FC 0.8981
507 GAE 0.8981
508 EWG 0.8981
509 6HP 0.8981
510 BVA 0.8980
511 5OO 0.8980
512 N7I 0.8979
513 BBY 0.8978
514 PIY 0.8978
515 VUP 0.8977
516 D9Z 0.8977
517 PIM 0.8976
518 TJM 0.8976
519 3J8 0.8976
520 3VW 0.8975
521 5TT 0.8973
522 CWJ 0.8973
523 HL4 0.8972
524 5AD 0.8970
525 AJ1 0.8970
526 6C9 0.8969
527 HJH 0.8968
528 BRH 0.8968
529 J38 0.8967
530 CHQ 0.8967
531 FHC 0.8965
532 BZE 0.8964
533 CNI 0.8963
534 27K 0.8962
535 9CE 0.8962
536 UA5 0.8961
537 AM4 0.8960
538 F5C 0.8959
539 YIE 0.8958
540 0OP 0.8957
541 JF8 0.8957
542 SZ7 0.8957
543 IYR 0.8957
544 X6W 0.8955
545 OOG 0.8954
546 1KN 0.8954
547 8V8 0.8954
548 GNM 0.8954
549 6HO 0.8953
550 DEZ 0.8953
551 NE2 0.8952
552 AJY 0.8952
553 K7M 0.8952
554 CTE 0.8951
555 R2P 0.8951
556 NY4 0.8950
557 DDU 0.8949
558 PH3 0.8947
559 M3H 0.8947
560 AZM 0.8946
561 HSX 0.8946
562 3LJ 0.8944
563 ZTW 0.8944
564 1DR 0.8944
565 KYA 0.8940
566 NKI 0.8939
567 ZEA 0.8938
568 EE8 0.8938
569 N0Z 0.8937
570 H4E 0.8937
571 2UD 0.8937
572 PMP 0.8936
573 M1Z 0.8936
574 M4E 0.8936
575 DPN 0.8935
576 15E 0.8933
577 92P 0.8930
578 RP3 0.8930
579 NFM 0.8929
580 3H2 0.8928
581 Q06 0.8927
582 1YO 0.8927
583 4CM 0.8926
584 SJK 0.8926
585 5TO 0.8924
586 9FE 0.8924
587 2QV 0.8924
588 J0Z 0.8924
589 HNL 0.8923
590 HNK 0.8923
591 14W 0.8923
592 5LD 0.8920
593 GWM 0.8920
594 DUR 0.8919
595 AHN 0.8919
596 54X 0.8918
597 0W1 0.8917
598 2BG 0.8917
599 NDD 0.8917
600 92O 0.8916
601 3Y7 0.8916
602 WLH 0.8915
603 NIY 0.8914
604 1OS 0.8914
605 Z21 0.8914
606 HQJ 0.8913
607 NFZ 0.8912
608 9F8 0.8911
609 5WN 0.8910
610 78U 0.8910
611 LDP 0.8910
612 3QV 0.8910
613 NEO 0.8909
614 30G 0.8908
615 3SU 0.8908
616 SB7 0.8908
617 2O6 0.8907
618 RGK 0.8905
619 5FL 0.8904
620 A6P 0.8903
621 D8Q 0.8902
622 P4T 0.8900
623 GLP 0.8899
624 ZME 0.8899
625 ABF 0.8899
626 ARG 0.8899
627 CS2 0.8898
628 OA1 0.8895
629 6DQ 0.8894
630 6Q3 0.8894
631 YZ9 0.8893
632 BGP 0.8892
633 SZ5 0.8892
634 ANN 0.8891
635 TIA 0.8890
636 5NN 0.8890
637 96Z 0.8890
638 6L6 0.8889
639 1V1 0.8888
640 3D1 0.8888
641 3F4 0.8886
642 HH6 0.8884
643 HNH 0.8882
644 HDH 0.8882
645 UAY 0.8880
646 SSC 0.8880
647 DNQ 0.8879
648 22F 0.8879
649 M45 0.8877
650 5ER 0.8874
651 50C 0.8872
652 A73 0.8871
653 MPP 0.8871
654 EXR 0.8870
655 JF1 0.8869
656 AP6 0.8869
657 KW8 0.8868
658 XQI 0.8867
659 Q0K 0.8865
660 EV2 0.8865
661 3YP 0.8864
662 IIH 0.8864
663 PNZ 0.8864
664 6ZW 0.8863
665 SX2 0.8863
666 VFG 0.8860
667 L5V 0.8860
668 49P 0.8859
669 MUK 0.8857
670 FY8 0.8856
671 ZEZ 0.8854
672 A7Q 0.8854
673 NOK 0.8854
674 TSS 0.8854
675 KP2 0.8853
676 20D 0.8852
677 4NM 0.8850
678 DFL 0.8850
679 FMQ 0.8850
680 RYV 0.8849
681 FDR 0.8849
682 0LO 0.8848
683 NDG 0.8848
684 PEY 0.8847
685 HJ7 0.8847
686 TIH 0.8847
687 D1G 0.8846
688 1BW 0.8846
689 QMR 0.8845
690 HIS 0.8845
691 PRO GLY 0.8845
692 ZIQ 0.8845
693 4BZ 0.8844
694 XYS XYP 0.8843
695 ZYR 0.8843
696 P93 0.8842
697 YTX 0.8842
698 0F3 0.8841
699 X11 0.8841
700 OHJ 0.8841
701 1X4 0.8840
702 245 0.8839
703 PYU 0.8839
704 TT4 0.8838
705 TZP 0.8838
706 BNF 0.8837
707 97T 0.8837
708 API 0.8836
709 CBE 0.8836
710 AES 0.8836
711 RE4 0.8836
712 L1T 0.8835
713 BSA 0.8834
714 DBS 0.8834
715 AEH 0.8832
716 QUS 0.8831
717 22L 0.8831
718 J9Q 0.8830
719 E1K 0.8829
720 GGB 0.8829
721 5TZ 0.8828
722 5RP 0.8828
723 A29 0.8827
724 3EB 0.8827
725 25F 0.8826
726 4JE 0.8825
727 1FD 0.8825
728 TU0 0.8824
729 X2M 0.8823
730 N3W 0.8823
731 SG2 0.8821
732 PLP PMP 0.8818
733 1V3 0.8818
734 549 0.8816
735 3GX 0.8816
736 VXX 0.8815
737 5WT 0.8814
738 TXW 0.8814
739 PH2 0.8810
740 E9S 0.8809
741 6RQ 0.8809
742 0NJ 0.8808
743 E5X 0.8807
744 GLO 0.8806
745 MUX 0.8806
746 5VL 0.8805
747 NRA 0.8805
748 IS2 0.8805
749 3XH 0.8803
750 NPA 0.8801
751 3W8 0.8801
752 IDZ 0.8800
753 1HP 0.8799
754 YPN 0.8799
755 S8G 0.8797
756 ZIP 0.8796
757 ONR 0.8795
758 HHI 0.8792
759 E4P 0.8792
760 54E 0.8791
761 W29 0.8790
762 1AJ 0.8790
763 JF2 0.8789
764 PZP 0.8789
765 ALX 0.8786
766 BY5 0.8786
767 DPT 0.8784
768 0F9 0.8784
769 RES 0.8784
770 K82 0.8783
771 613 0.8783
772 KLV 0.8781
773 H5B 0.8781
774 NPX 0.8780
775 EGV 0.8779
776 3L1 0.8778
777 LFN 0.8777
778 MQN 0.8777
779 XYP XYP 0.8775
780 CKA 0.8775
781 8WT 0.8775
782 268 0.8771
783 RD4 0.8769
784 MKN 0.8768
785 J9N 0.8768
786 CSN 0.8768
787 GZV 0.8767
788 WS7 0.8767
789 R9Y 0.8766
790 B40 0.8765
791 DJN 0.8764
792 1V4 0.8764
793 AKG 0.8764
794 AH9 0.8763
795 DHI 0.8762
796 JOV 0.8762
797 B4O 0.8759
798 RP5 0.8757
799 M02 0.8754
800 1QV 0.8754
801 DZA 0.8754
802 X04 0.8754
803 4F8 0.8753
804 EXG 0.8752
805 AUV 0.8752
806 7G0 0.8752
807 K25 0.8752
808 2LW 0.8751
809 SN4 0.8750
810 RVE 0.8750
811 PRA 0.8749
812 N8Y 0.8748
813 D25 0.8748
814 9B3 0.8747
815 JRB 0.8746
816 11C 0.8743
817 L15 0.8743
818 M6Z 0.8742
819 DX7 0.8740
820 NYL 0.8740
821 THM 0.8738
822 9KZ 0.8738
823 MTL 0.8735
824 AC2 0.8735
825 52F 0.8735
826 U7E 0.8735
827 DNA 0.8735
828 5WZ 0.8735
829 S2G 0.8734
830 AMH 0.8734
831 RK4 0.8733
832 2FQ 0.8732
833 B56 0.8732
834 F9Y 0.8731
835 42J 0.8730
836 PXP 0.8730
837 5XC 0.8729
838 8WO 0.8727
839 J1K 0.8726
840 3XR 0.8725
841 KPV 0.8725
842 5F1 0.8725
843 AY4 0.8723
844 NCT 0.8723
845 DCZ 0.8721
846 5V7 0.8720
847 BX4 0.8719
848 M83 0.8716
849 D1Y 0.8715
850 4CF 0.8714
851 259 0.8714
852 BPN 0.8714
853 7G2 0.8713
854 LIG 0.8710
855 8YH 0.8709
856 0TU 0.8709
857 2JK 0.8709
858 8W9 0.8708
859 SOR 0.8706
860 MW5 0.8704
861 PQT 0.8704
862 A2G 0.8703
863 OTR 0.8703
864 OCZ 0.8702
865 5JT 0.8701
866 QUB 0.8700
867 26C 0.8700
868 NGA 0.8699
869 TZM 0.8697
870 OGA 0.8697
871 ZZU 0.8696
872 1FL 0.8695
873 54Z 0.8695
874 HRD 0.8693
875 1OT 0.8693
876 TR4 0.8692
877 52C 0.8692
878 5RO 0.8691
879 4FA 0.8691
880 38E 0.8690
881 4ZF 0.8689
882 JND 0.8686
883 2HG 0.8686
884 IPO 0.8686
885 ODO 0.8685
886 801 0.8684
887 4JQ 0.8682
888 DE5 0.8682
889 39Z 0.8680
890 IQ5 0.8680
891 BPW 0.8679
892 BA5 0.8679
893 TAG 0.8674
894 SV4 0.8672
895 INO 0.8671
896 4YO 0.8668
897 SRO 0.8664
898 JZA 0.8663
899 STT 0.8663
900 TGX 0.8662
901 S1D 0.8660
902 VBC 0.8660
903 EQU 0.8660
904 K44 0.8658
905 Q9T 0.8657
906 M4S 0.8655
907 YRL 0.8654
908 FUD 0.8651
909 4TU 0.8651
910 JRO 0.8651
911 KJU 0.8646
912 STZ 0.8646
913 2BX 0.8645
914 WCU 0.8645
915 IL5 0.8644
916 7MX 0.8644
917 M01 0.8639
918 DX2 0.8634
919 G30 0.8634
920 EZL 0.8633
921 2UB 0.8633
922 PAU 0.8632
923 5QY 0.8632
924 CDJ 0.8632
925 M6P 0.8631
926 QMS 0.8631
927 IBP 0.8630
928 258 0.8630
929 W8L 0.8630
930 2KU 0.8627
931 GVG 0.8627
932 650 0.8626
933 8MO 0.8625
934 DNF 0.8623
935 4JC 0.8621
936 LDC 0.8620
937 GJB 0.8620
938 A3M 0.8620
939 XYS XYS 0.8618
940 DHB 0.8617
941 HLP 0.8615
942 KDG 0.8613
943 39O 0.8613
944 GA2 0.8613
945 HHR 0.8611
946 GDL 0.8610
947 27M 0.8605
948 JLZ 0.8605
949 SG3 0.8602
950 H2W 0.8602
951 MS9 0.8601
952 WS6 0.8601
953 L21 0.8599
954 6J9 0.8599
955 D48 0.8599
956 93K 0.8596
957 HAR 0.8595
958 272 0.8592
959 CHB 0.8592
960 NE1 0.8592
961 JGY 0.8586
962 NIF 0.8585
963 3PF 0.8585
964 3AD 0.8584
965 8HH 0.8584
966 UFO 0.8582
967 BM3 0.8581
968 J9T 0.8580
969 HHV 0.8579
970 BMZ 0.8576
971 DI6 0.8571
972 LFQ 0.8570
973 M3W 0.8568
974 AX3 0.8566
975 F31 0.8565
976 GZL 0.8563
977 4KL 0.8559
978 IHB 0.8558
979 3N0 0.8557
980 KBZ 0.8556
981 CMU 0.8554
982 64Z 0.8553
983 7FZ 0.8553
984 NNO 0.8550
985 FHB 0.8549
986 GLU 0.8548
987 VNL 0.8544
988 VGS 0.8538
989 JF5 0.8530
990 XYP XYS 0.8524
991 069 0.8510
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1YVM; Ligand: TMG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1yvm.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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