Receptor
PDB id Resolution Class Description Source Keywords
1qkt 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL HOMO SAPIENS NUCLEAR RECEPTOR AGONISM ANTAGONISM STEROID STRUCTURAL PROTEOMICS IN EUROPE SPINE STRUCTURAL GENOMICS
Ref.: CRYSTAL STRUCTURE OF A MUTANT HERALPHA LIGAND- BIND DOMAIN REVEALS KEY STRUCTURAL FEATURES FOR THE MECH PARTIAL AGONISM J.BIOL.CHEM. V. 276 15059 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data Chemaxon Viewer Molecular Weight (Da) Formula SMILES
EST A:600;
Valid;
none;
Kd = 0.92 nM
272.382 C18 H24 O2 C[C@]...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2QE4 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST HOMO SAPIENS NUCLEAR RECEPTOR LIGAND-BINDING DOMAIN ALTERNATIVE SPLICING DNA-BINDING LIPID-BINDING METAL-BINDING NUCLEAR PROTEIN PHOSPHORYLATION POLYMORPHISM STEROID- BINDING TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER
Ref.: BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR BETA AGONISTS (SERBAS). PART 4: FUNCTIONALIZATION OF THE BENZOPYRAN A-RING. BIOORG.MED.CHEM.LETT. V. 17 5082 2007
Members (38)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 195 families.
1 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
2 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
3 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
4 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
5 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
6 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
7 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
8 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
9 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
10 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
11 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
12 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
13 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
14 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
15 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
16 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
17 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
18 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
19 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
20 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
21 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
22 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
23 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
24 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
25 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
26 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
27 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
28 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
29 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
30 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
31 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
32 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
33 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
34 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
35 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
36 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
37 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
38 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
70% Homology Family (49)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 168 families.
1 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
2 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
3 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
4 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
5 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
6 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
7 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
8 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
9 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
10 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
11 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
12 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
13 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
14 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
15 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
16 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
17 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
18 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
19 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
20 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
21 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
22 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
23 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
24 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
25 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
26 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
27 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
28 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
29 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
30 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
31 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
32 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
33 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
34 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
35 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
36 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
37 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
38 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
39 1QKN - RAL C28 H27 N O4 S c1cc(ccc1c....
40 1HJ1 - PMB C6 H5 Hg O3 S c1cc(ccc1S....
41 1QKM - GEN C15 H10 O5 c1cc(ccc1C....
42 2GIU ic50 = 1.5 nM FBR C17 H19 Br O2 CCCC[C@@]1....
43 1U9E ic50 = 5.7 nM 397 C14 H10 O3 c1cc(ccc1c....
44 2JJ3 Kd = 0.281 uM JJ3 C20 H22 O4 COCc1cc(cc....
45 1U3Q ic50 = 3.5 nM 272 C13 H9 N O4 c1cc2c(cc1....
46 2Z4B Ki = 0.44 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
47 2I0G Ki = 0.19 nM I0G C18 H18 O3 c1cc(ccc1[....
48 2FSZ - OHT C26 H29 N O2 CC/C(=C(c1....
49 2NV7 ic50 = 5 nM 555 C17 H13 N O2 c1ccc2c(c1....
50% Homology Family (64)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 140 families.
1 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
2 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
3 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
4 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
5 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
6 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
7 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
8 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
9 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
10 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
11 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
12 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
13 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
14 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
15 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
16 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
17 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
18 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
19 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
20 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
21 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
22 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
23 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
24 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
25 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
26 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
27 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
28 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
29 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
30 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
31 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
32 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
33 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
34 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
35 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
36 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
37 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
38 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
39 1QKN - RAL C28 H27 N O4 S c1cc(ccc1c....
40 1HJ1 - PMB C6 H5 Hg O3 S c1cc(ccc1S....
41 1QKM - GEN C15 H10 O5 c1cc(ccc1C....
42 2GIU ic50 = 1.5 nM FBR C17 H19 Br O2 CCCC[C@@]1....
43 2EWP ic50 = 0.079 uM TXF C27 H31 N O3 CN(C)CCOc1....
44 1S9P - DES C18 H20 O2 CC/C(=C(/C....
45 2E2R Kd = 5.5 nM 2OH C15 H16 O2 CC(C)(c1cc....
46 2P7Z Kd = 0.262 uM OHT C26 H29 N O2 CC/C(=C(c1....
47 2ZAS ic50 = 13.9 nM 1OH C15 H16 O CC(C)(c1cc....
48 2GPU - OHT C26 H29 N O2 CC/C(=C(c1....
49 2P7A Kd = 0.788 uM 43M C7 H7 Cl O Cc1cc(ccc1....
50 2P7G Kd = 0.297 uM 2OH C15 H16 O2 CC(C)(c1cc....
51 1S9Q - OHT C26 H29 N O2 CC/C(=C(c1....
52 1U9E ic50 = 5.7 nM 397 C14 H10 O3 c1cc(ccc1c....
53 2JJ3 Kd = 0.281 uM JJ3 C20 H22 O4 COCc1cc(cc....
54 1U3Q ic50 = 3.5 nM 272 C13 H9 N O4 c1cc2c(cc1....
55 2Z4B Ki = 0.44 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
56 2I0G Ki = 0.19 nM I0G C18 H18 O3 c1cc(ccc1[....
57 2FSZ - OHT C26 H29 N O2 CC/C(=C(c1....
58 2NV7 ic50 = 5 nM 555 C17 H13 N O2 c1ccc2c(c1....
59 2PJL ic50 = 190 nM 047 C23 H28 N2 Cc1ccc(cc1....
60 3PCU - LX8 C21 H24 O5 CC(=O)OC(C....
61 1FBY Kd = 1.5 nM REA C20 H28 O2 CC1=C(C(CC....
62 4N5G ic50 = 14.5 uM K09 C23 H23 F N4 CC1=C(c2cc....
63 1G5Y - REA C20 H28 O2 CC1=C(C(CC....
64 3FS1 - MYR C14 H28 O2 CCCCCCCCCC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: EST; Similar ligands found: 9
No: Ligand ECFP6 Tc MDL keys Tc
1 EST 1 1
2 ECS 0.626866 0.916667
3 ESL 0.614286 0.916667
4 ESZ 0.597222 0.837838
5 ESM 0.597222 0.868421
6 HE7 0.547619 0.846154
7 E2B 0.467391 0.688889
8 EED 0.451219 0.785714
9 EZT 0.412371 0.825
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 2QE4; Ligand: JJ3; Similar sites found: 282
This union binding pocket (no: 1) in the query (biounit: 2qe4.bio1) has 36 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 2QE4 JJ3 3.391e-20 1
2 2I0G I0G 9.659e-15 0.80592
3 2Q1H AS4 4.242e-11 0.68321
4 2AX9 BHM 8.075e-10 0.66313
5 2B1Z 17M 6.591e-13 0.65247
6 1U3R 338 2.425e-12 0.58189
7 1SR7 MOF 1.54e-09 0.57777
8 3VHU SNL 1.635e-10 0.56948
9 2BJ4 OHT 5.298e-13 0.55017
10 2YJD YJD 6.799e-12 0.5417
11 3V49 PK0 8.001e-09 0.52936
12 4MG8 27J 1.203e-12 0.52888
13 4OKX 198 7.081e-09 0.52289
14 3OLL EST 4.652e-12 0.52078
15 2QZO KN1 8.331e-12 0.5148
16 4MGB XDH 2.258e-12 0.50808
17 4J24 EST 5.85e-12 0.50301
18 1YYE 196 3.154e-10 0.50242
19 3MNP DEX 4.288e-07 0.50002
20 4OHA HFT 8.309e-09 0.49802
21 2Q7J TES 3.97e-10 0.49337
22 4POJ 2VP 2.314e-07 0.48935
23 4OAR 2S0 9.375e-09 0.48692
24 2A3I C0R 1.025e-08 0.48234
25 4MG7 27H 2.65e-11 0.47872
26 4J26 EST 2.618e-11 0.47827
27 4M8E 29V 8.153e-08 0.47726
28 4OKW 198 1.154e-07 0.46659
29 2GIU FBR 7.555e-05 0.46635
30 3L3X DHT 2.952e-09 0.46001
31 4E2J MOF 9.461e-08 0.45954
32 4CSJ NN7 1.865e-07 0.45864
33 2QA8 GEN 4.67e-11 0.4578
34 3BQD DAY 3.624e-07 0.45477
35 1NHZ 486 1.183e-07 0.45406
36 1M2Z DEX 3.565e-07 0.45098
37 1T5Z DHT 3.959e-09 0.45079
38 3FAL LO2 3.29e-05 0.44708
39 1FBY REA 1.369e-05 0.44622
40 4P6W MOF 1.032e-06 0.44487
41 3UUD EST 2.118e-11 0.44333
42 3RY9 1CA 2.677e-08 0.44199
43 3KFC 61X 7.413e-05 0.44184
44 2AO6 R18 4.23e-09 0.44143
45 3GN8 DEX 1.217e-07 0.44022
46 1T65 DHT 3.133e-09 0.44009
47 1T74 DHT 3.33e-09 0.43942
48 1T79 DHT 4.168e-09 0.43865
49 3L3Z DHT 4.712e-09 0.43763
50 3UUA 0CZ 1.243e-10 0.43612
51 2JF9 OHT 0.0003943 0.43549
52 4QJR PIZ 2.634e-05 0.43526
53 2E2R 2OH 0.00101 0.43509
54 1DKF BMS 7.154e-06 0.43487
55 3PLZ 470 2.147e-05 0.43381
56 1RDT L79 9.572e-07 0.43378
57 1T73 DHT 8.77e-09 0.43081
58 2HC4 VDX 0.0001108 0.42564
59 4DM8 REA 1.535e-05 0.42327
60 3KDU NKS 0.0006207 0.42245
61 3VRV YSD 0.0006256 0.42233
62 4FHH 0U3 0.0002314 0.42181
63 1YMT DR9 1.506e-05 0.42078
64 1YP0 PEF 2.111e-06 0.41906
65 1T7F DHT 3.247e-08 0.41871
66 3UU7 2OH 1.108e-10 0.41823
67 1T7M DHT 4.722e-08 0.41707
68 1ZDU P3A 2.394e-05 0.41651
69 1T7R DHT 1.532e-08 0.41615
70 1FCY 564 6.329e-05 0.41497
71 3H0A 9RA 6.958e-06 0.41393
72 3B1M KRC 0.001299 0.41097
73 3KMZ EQO 2.883e-05 0.41021
74 4P6X HCY 1.414e-06 0.40979
75 3GZ9 D32 0.001984 0.40884
76 1YUC EPH 1.602e-05 0.40861
77 1DB1 VDX 0.0008421 0.40852
78 2HFP NSI 0.00131 0.40681
79 1FCZ 156 8.11e-05 0.40388
80 2P4Y C03 0.003091 0.40384
81 4WLB 3QQ 0.000922 0.40274
82 1FM9 9CR 8.283e-06 0.40094
83 3OKI OKI 0.001952 0.4005
84 4LSJ LSJ 0.0052 0.40004
85 1DKF OLA 3.785e-06 0.39701
86 3FAL REA 4.658e-06 0.39491
87 3G9E RO7 0.001079 0.39417
88 3LMP CEK 0.00184 0.39244
89 1ZDT PEF 0.0001045 0.38877
90 2O4J VD4 0.000589 0.3878
91 3KMR EQN 5.481e-05 0.38709
92 3BEJ MUF 2.991e-05 0.38641
93 1XAP TTB 2.7e-05 0.38477
94 2R40 EPH 0.0001713 0.38229
95 4O2C ACE 0.01969 0.38066
96 3RUU 37G 0.0008188 0.37966
97 1OSH FEX 0.003593 0.37931
98 3DCT 064 0.0002506 0.3785
99 1T76 DHT 5.565e-08 0.37775
100 4DK7 0KS 0.0002076 0.37756
101 4MGA 27L 3.29e-10 0.37659
102 3G08 FEE 0.01868 0.37597
103 4MG9 27K 5.826e-10 0.37486
104 3SP6 IL2 2.478e-05 0.37469
105 3L0E G58 0.001153 0.37458
106 1FM4 DXC 0.01546 0.37442
107 3JZB 4HY 0.008647 0.37377
108 1M13 HYF 0.001074 0.37238
109 1Y4L SVR 0.0448 0.37218
110 1FM9 570 0.001036 0.37211
111 1G2N EPH 0.0001734 0.37143
112 4MGD 27N 1.232e-07 0.37007
113 4KCF FMN 0.01108 0.36946
114 3FEI CTM 0.0006635 0.36574
115 1RDT 570 0.0004393 0.36488
116 1N46 PFA 0.003928 0.36282
117 2H26 6UL 0.04902 0.36112
118 3QCP FAD 0.002354 0.35926
119 4OAS 2SW 0.008867 0.35888
120 2E3N 6CM 0.02402 0.35744
121 1ONQ SLF 0.002812 0.35726
122 4QRS GLU 0.04126 0.35599
123 2P54 735 0.001292 0.35569
124 4HBM 0Y7 0.009966 0.3547
125 3T58 FAD 0.006912 0.35449
126 3FS1 MYR 3.948e-05 0.35401
127 4QC6 30N 0.001589 0.35317
128 1K7L 544 0.002043 0.35267
129 4QRT GLU 0.04126 0.35182
130 4KVX ACO 0.009132 0.35096
131 4HW3 19G 0.001517 0.35028
132 3BZF VAL 0.04872 0.349
133 2NPA MMB 0.00113 0.34655
134 4IBF 1D5 0.001962 0.34512
135 1OQC FAD 0.008324 0.34481
136 4G43 ILE 0.03025 0.34463
137 1XKK FMM 0.04302 0.3444
138 4BVN P32 0.01175 0.34409
139 3GYT DL4 0.005856 0.34292
140 2R40 20E 0.009864 0.3429
141 4IEH 1E9 0.007125 0.34289
142 3L9R L9Q 0.02607 0.34028
143 1JR8 FAD 0.009422 0.34015
144 3PWU ILE 0.02296 0.33984
145 1TMC GLU 0.04568 0.33952
146 3QKD HI0 0.03225 0.33912
147 3NJQ NJQ 0.003315 0.338
148 3NMH PYV 0.01308 0.33741
149 1S7Q ALA 0.04336 0.33718
150 1IYK MYA 0.04014 0.33711
151 3L0L HC3 0.01223 0.33559
152 3GWL FAD 0.02473 0.33444
153 1PZL MYR 0.0008744 0.33425
154 3LDW ZOL 0.02161 0.33424
155 4H07 IPH 0.02943 0.33418
156 2BCG GER 0.001321 0.33392
157 1YC4 43P 0.001169 0.33375
158 2PRG BRL 0.001413 0.33341
159 1N83 CLR 0.01451 0.3332
160 4RC8 STE 0.01057 0.33259
161 4RC7 PL3 0.003402 0.33248
162 1BII ARG 0.04966 0.33226
163 1NRL SRL 0.002757 0.33105
164 4O4Z N2O 0.01829 0.331
165 4Q0A 4OA 0.01522 0.33058
166 3R1V AZB 0.03556 0.33018
167 4I67 G 0.0006722 0.32989
168 1N4H REA 0.02296 0.32946
169 1HG4 LPP 0.009643 0.3285
170 3UP3 XCA 0.02686 0.32845
171 4EES FMN 0.03308 0.32788
172 4MW0 392 0.02589 0.32773
173 2HJ3 FAD 0.01895 0.32724
174 4F7E 0SH 0.01285 0.32662
175 3GKJ HC3 0.02955 0.32487
176 4Q0A GLY 0.0004289 0.32394
177 3KDJ A8S 0.01668 0.32391
178 3C8Z 5CA 0.04154 0.32347
179 2AEL SAZ 0.02375 0.32339
180 3ET1 ET1 0.004683 0.3233
181 4EKQ NPO 0.0419 0.32257
182 3FEA ACE 0.004474 0.32174
183 1KVO OAP 0.02719 0.32154
184 1DQE BOM 0.0219 0.32142
185 4GBD MCF 0.02744 0.32116
186 3GFZ FMN 0.01078 0.31982
187 2P1C GG3 0.017 0.31967
188 4LWU 20U 0.006756 0.31965
189 3H0A D30 0.01515 0.31924
190 3AHQ FAD 0.04353 0.31899
191 1YRE COA 0.02425 0.31864
192 3JUQ AKD 0.03254 0.3186
193 3R9C ECL 0.04553 0.31806
194 4O1Z MXM 0.03883 0.31768
195 4EJ1 FOL 0.009228 0.31765
196 3HR1 PF9 0.04212 0.3168
197 4HIA FMN 0.04987 0.31674
198 3JRS A8S 0.02792 0.31642
199 1OSV CHC 0.01142 0.31632
200 3RDE OYP 0.04182 0.31623
201 1JNQ EGT 0.01536 0.31594
202 1G27 BB1 0.04517 0.31507
203 1S17 GNR 0.01651 0.31436
204 1OKC CXT 0.01735 0.31385
205 4O6M C5P 0.02823 0.31359
206 3GWN FAD 0.02188 0.31353
207 3M6P BB2 0.0433 0.31329
208 1S8G DAO 0.004236 0.31297
209 2HW2 RFP 0.03904 0.31265
210 3G5K BB2 0.02853 0.31179
211 3LLI FAD 0.04775 0.31145
212 3HY9 098 0.0402 0.31132
213 4WLB SER 0.0006716 0.31114
214 2W90 6PG 0.01968 0.31109
215 4FH7 TBP 0.01387 0.3103
216 2RH1 CAU 0.02542 0.3103
217 4JE7 BB2 0.04051 0.30992
218 3JRX S1A 0.03589 0.30973
219 3OGN 3OG 0.004367 0.30972
220 2O5L MNR 0.0421 0.3084
221 1NQ7 HIS 0.0001972 0.30834
222 2WPX ACO 0.03477 0.30812
223 3ETG GTP 0.01183 0.30808
224 3B6C SDN 0.03754 0.30804
225 1TMX HGX 0.01147 0.30751
226 1NQ7 ARL 0.02223 0.30711
227 1X0P FAD 0.04028 0.30657
228 4L77 CNL 0.02975 0.30549
229 2WOR 2AN 0.04751 0.30495
230 3SE5 ANP 0.02921 0.30454
231 1KUK PCA 0.0497 0.30402
232 1XDS SAM 0.04815 0.30399
233 4NY3 PRO 0.0006104 0.30235
234 1M2Z BOG 0.003729 0.29873
235 4BTB PRO 0.002209 0.29834
236 1JGL EST 0.01657 0.2979
237 3QYY C2E 0.04452 0.29729
238 4TU4 37N 0.04435 0.29639
239 4MA6 28E 0.01637 0.29619
240 1XN0 ROL 0.03023 0.29551
241 3GXO MQA 0.03752 0.29489
242 4U0S ADP 0.0456 0.29489
243 3TL1 JRO 0.02166 0.29409
244 1W9O ASN 0.01951 0.29396
245 4DOL PLM 0.03433 0.29335
246 3WJO IPE 0.02997 0.29075
247 3RLF MAL 0.005066 0.29022
248 1N7F ALA 0.03995 0.29001
249 3AQT RCO 0.00617 0.28822
250 1ALW ISA 0.02111 0.28654
251 1L0I PSR 0.0451 0.28581
252 4OB0 PBC 0.03217 0.28411
253 3FS1 ALA 0.0002228 0.28407
254 4RHP PEF 0.02269 0.28394
255 3HP9 CF1 0.01039 0.28247
256 3V1S 0LH 0.0156 0.28204
257 3R9V DXC 0.005401 0.28203
258 3I6B KDO 0.02993 0.28167
259 4OB1 BUB 0.0111 0.28113
260 1GVE CIT 0.01444 0.28055
261 1O6U PLM 0.04999 0.28053
262 3P2H MTA 0.007108 0.27992
263 2W3L DRO 0.04773 0.27784
264 2UW1 GVM 0.04457 0.27679
265 2BP1 FLC 0.01431 0.27677
266 2WHL MAN 0.02322 0.27549
267 3ETG GWD 0.005433 0.27475
268 4UYF 73B 0.04328 0.27463
269 3MAN BMA 0.03999 0.27461
270 3TDC 0EU 0.0003348 0.27401
271 1HBK COA 0.01813 0.27327
272 3SXU ASP 0.001192 0.26927
273 2XN3 ID8 0.04558 0.26902
274 3O01 DXC 0.0009929 0.26865
275 3F33 PFL 0.005547 0.2671
276 1TV5 N8E 0.0424 0.26689
277 3RV5 DXC 0.01055 0.26537
278 4QEK GLC 0.02049 0.26522
279 2BHW XAT 0.04055 0.26337
280 4MRP GSH 0.03681 0.26273
281 2CIX CEJ 0.01789 0.26008
282 2BHW NEX 0.02758 0.25741
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