Receptor
PDB id Resolution Class Description Source Keywords
1qhc 1.7 Å EC: 3.1.27.5 CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'- PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'- P HOSPHATE BOS TAURUS HYDROLASE RIBONUCLEASE ENDONUCLEASE NUCLEOTIDE INHIBITOR
Ref.: TOWARD RATIONAL DESIGN OF RIBONUCLEASE INHIBITORS: HIGH-RESOLUTION CRYSTAL STRUCTURE OF A RIBONUCLEASE A COMPLEX WITH A POTENT 3',5'-PYROPHOSPHATE-LINKED DINUCLEOTIDE INHIBITOR. BIOCHEMISTRY V. 38 10287 1999
Ligand Information
Ligand Validity Binding Data Ligand Warnings Chemaxon Viewer Molecular Weight (Da) Formula SMILES
PUA Valid Ki = 27 nM none 797.348
C19 H27 N7 O20 P4
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)O[C@H]4C[C@@H](O[C@@H]4COP(=O)(O)O)N5C=CC(=O)NC5=O)OP(=O)(O)O)O)N
90% Homology Family

The Class containing this family consists of a total of 5 families.

Leader:    1U1B     STRUCTURE OF BOVINE PANCREATIC RIBONUCLEASE A IN COMPLEX WITH 3'-PHOSPHOTHYMIDINE (3'-5')-PYROPHOSPHATE ADENOSINE 3 '-PHOSPHATE
No: PDB id Binding Data Representative ligand
1 1Z6D Ki = 4.6 mM IMP
2 1O0H Ki = 1.2 uM ADP
3 1W4O Ki = 5.85 uM UA3
4 1RNN - C5P
5 1JVU - C2P
6 3D7B Ki = 203 uM U4S
7 3FL1 - CGP
8 2XOG Ki = 370 uM SFB
9 3D6Q Ki = 172 uM U3S
10 3JW1 - U5P
11 3EV6 - RSF
12 2W5I Ki = 4.7 uM ATP
13 3D8Y Ki = 396 uM T3S
14 1W4P Ki = 18 uM UM3
15 3D6O Ki = 77 uM U1S
16 1AFL Ki = 520 nM ATR
17 3EV3 - TBU
18 3LXO Kd = 15 uM T3P
19 3RID - CGP
20 1O0O Ki = 8 uM A2P
21 1RPF - C3P
22 3D6P Ki = 179 uM U2S
23 1RPG - CPA
24 4G8V Ki = 1.6 uM 0EY
25 1RNC - 5GP
26 1WBU - WBU
27 1ROB - C2P
28 1W4Q Ki = 5.5 uM UMF
29 4G8Y Ki = 25.8 uM 0FT
30 1O0F Ki = 5 uM A3P
31 1JN4 Ki = 11.3 uM 139
32 1O0N Ki = 82 uM U3P
33 3EV4 - ETF
34 1RCA - CGP
35 1AFK Ki = 240 nM PAP
36 1RND - DGP
37 2XOI Ki = 370 uM SFB
38 1EOW - U2G
39 4RSK Kd = 47.4 uM U3P
40 1RCN - A T A A
41 1RNM - C5P
42 2W5K Ki = 12 uM NDP
43 2G8R Ki = 103 uM N3E
44 1U1B Kd = 16 nM PAX
45 1QHC Ki = 27 nM PUA
46 3FL0 - CGP
47 1F0V - C G
48 2W5L Ki = 63 uM NAP
49 1RUV - TBU
50 1O0M Ki = 7.1 uM U2P
51 2QCA - DGP
52 1Z6S Ki = 63 uM AMP
53 3EV5 - TMO
54 4G90 Ki = 30.8 uM 0G0
55 2W5G Ki = 0.86 uM ATP
56 3D8Z Ki = 423 uM TXS
57 1EOS - U2G
More Information
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