Receptor
PDB id Resolution Class Description Source Keywords
1ZY5 2 Å EC: 2.7.1.37 CRYSTAL STRUCTURE OF EIF2ALPHA PROTEIN KINASE GCN2: R794G HYPERACTIVATING MUTANT COMPLEXED WITH AMPPNP. SACCHAROMYCES CEREVISIAE TRANSLATION REGULATOR PROTEIN KINASE SIGNAL TRANSDUCTION ACID STARVATION STARVATION STRESS RESPONSE EIF2ALPHA KINATRANSFERASE
Ref.: STRUCTURAL BASIS FOR AUTOINHIBITION AND MUTATIONAL ACTIVATION OF EUKARYOTIC INITIATION FACTOR 2{ALPHA} KINASE GCN2 J.BIOL.CHEM. V. 280 29289 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:303;
B:304;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MG A:305;
B:306;
Invalid;
Invalid;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1ZY5 2 Å EC: 2.7.1.37 CRYSTAL STRUCTURE OF EIF2ALPHA PROTEIN KINASE GCN2: R794G HYPERACTIVATING MUTANT COMPLEXED WITH AMPPNP. SACCHAROMYCES CEREVISIAE TRANSLATION REGULATOR PROTEIN KINASE SIGNAL TRANSDUCTION ACID STARVATION STARVATION STRESS RESPONSE EIF2ALPHA KINATRANSFERASE
Ref.: STRUCTURAL BASIS FOR AUTOINHIBITION AND MUTATIONAL ACTIVATION OF EUKARYOTIC INITIATION FACTOR 2{ALPHA} KINASE GCN2 J.BIOL.CHEM. V. 280 29289 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 4G31 ic50 = 0.4 nM 0WH C24 H20 F3 N5 O Cn1cc(c2c1....
2 4X7H - 3Z2 C32 H26 N6 O5 CN1C(=C(C(....
3 4X7J ic50 = 41 nM 3Z1 C25 H22 F3 N5 O2 Cc1ccc(c(c....
4 4X7K ic50 = 4 nM 3Z3 C33 H27 F N6 O2 Cc1ccc(c(c....
5 4X7L ic50 = 9 nM 3Z4 C32 H27 N5 O2 S Cc1ccc(c(c....
6 4X7N ic50 = 6 nM 3Z5 C34 H28 N4 O2 Cc1ccc(c(c....
7 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1ZY5; Ligand: ANP; Similar sites found: 346
This union binding pocket(no: 1) in the query (biounit: 1zy5.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5C1P ADP 0.001207 0.44656 0.990099
2 2R85 AMP 0.01205 0.41168 1.32013
3 1YXM ADE 0.01765 0.40655 1.32013
4 1EHI ADP 0.001611 0.41896 1.65016
5 3BP1 GUN 0.02011 0.42005 1.72414
6 4WOP CTP 0.0025 0.42305 1.77778
7 4B1L FRU 0.01092 0.41793 1.81818
8 1W2D ADP 0.001516 0.44703 1.88679
9 2R7K AMZ 0.002993 0.43744 1.9802
10 4ME6 ADP 0.01449 0.40946 1.9802
11 1I7L ATP 0.0009846 0.4066 1.9802
12 5TG5 JW8 0.02322 0.40134 2.04082
13 3VPC ADP 0.0001998 0.44214 2.12766
14 4CS4 AXZ 0.01899 0.41546 2.18978
15 3AKK ADP 0.0002058 0.47598 2.31023
16 4LH7 1X8 0.0011 0.46083 2.31023
17 1GSA ADP 0.0007563 0.45672 2.31023
18 3WVR AMP 0.0006589 0.44362 2.31023
19 1M0W ANP 0.002757 0.4167 2.31023
20 2XZ9 PYR 0.01261 0.41297 2.31023
21 4MOB ADP 0.0137 0.41278 2.31023
22 2G30 ALA ALA PHE 0.0002358 0.45422 2.32558
23 5D9G GLU ASN LEU TYR PHE GLN 0.01169 0.40897 2.43902
24 4XYM A12 0.001567 0.42063 2.6087
25 5C4L 4XR 0.0001152 0.50691 2.64026
26 2PYW ADP 0.00001192 0.49379 2.64026
27 5C4L SIS 0.001926 0.44928 2.64026
28 4R78 AMP 0.002365 0.44298 2.64026
29 4RDL FUC GAL NDG FUC 0.004147 0.43934 2.64026
30 2CFM AMP 0.003777 0.42814 2.64026
31 4DFU QUE 0.007301 0.42386 2.64026
32 3DNT ATP 0.004734 0.42203 2.64026
33 3V4S ATP 0.001531 0.41062 2.64026
34 5GZ9 ANP 0.000107 0.49547 2.9703
35 4OUC 5ID 0.00003878 0.4949 2.9703
36 3UDZ ADP 0.000132 0.48464 2.9703
37 5KJW 53C 0.006618 0.43571 2.9703
38 4ZS4 ATP 0.0006925 0.43484 2.9703
39 5TDF ADP 0.003209 0.42441 2.9703
40 4OCV ANP 0.002134 0.41459 2.9703
41 1ZB6 GST 0.01497 0.40595 2.9703
42 3PDT ADP 0.0009917 0.44555 3.27273
43 3I0O ADP 0.001201 0.45184 3.30033
44 2QK4 ATP 0.0007601 0.42368 3.30033
45 4WOE ADP 0.01671 0.40825 3.30033
46 3VPB ADP 0.0003221 0.41819 3.57143
47 2CBT TH2 0.013 0.41123 3.57143
48 2PUL ACP 0.00004619 0.49982 3.63036
49 4CC6 L5Y 0.001415 0.45388 3.9604
50 2VQD AP2 0.000835 0.42648 3.9604
51 3Q8G PEE 0.01893 0.42181 3.9604
52 4U98 ACP 0.004243 0.41286 3.9604
53 3RE4 TO1 0.00002369 0.53301 4.26357
54 1ZP9 ATP 0.00001705 0.52553 4.26357
55 1ZTH ADP 0.000006634 0.50918 4.26357
56 4WW7 AMP 0.00001073 0.53864 4.27807
57 5MW8 ATP 0.0001856 0.48456 4.29043
58 1V8B NAD 0.02279 0.4051 4.29043
59 2IO8 ADP 0.0008422 0.40425 4.29043
60 1Y7P RIP 0.001338 0.44582 4.4843
61 2XG5 EC2 0.006954 0.42946 4.58716
62 2XG5 EC5 0.006954 0.42946 4.58716
63 3VOT ADP 0.0003214 0.44602 4.62046
64 2HGS ADP 0.002126 0.43623 4.62046
65 4GLW 0XT 0.00344 0.43502 4.62046
66 1IOW PHY 0.01276 0.41407 4.62046
67 5LXT ACP 0.001066 0.40954 4.6875
68 3ZJX BOG 0.00823 0.42355 4.84429
69 2VPQ ANP 0.0004941 0.46516 4.9505
70 3TDV GDP 0.0008111 0.43693 4.9505
71 5DZT AMP 0.001136 0.4658 5.28053
72 1AUX AGS 0.0003806 0.45208 5.61056
73 2BKK ADP 0.005317 0.40852 5.68182
74 3HAV ATP 0.00007172 0.44948 5.68562
75 4GYI ADP 0.0007171 0.45707 5.94059
76 5MRH Q9Z 0.001235 0.45678 5.94059
77 3X01 AMP 0.006544 0.4281 5.94059
78 2ET1 GLV 0.02104 0.40338 5.97015
79 2UYN 2KT 0.02038 0.40006 6.20155
80 3ORQ ADP 0.0004373 0.4372 6.27063
81 3VPD ANP 0.001498 0.44131 6.40569
82 3TII ANP 0.001304 0.41954 6.60066
83 1OBD ATP 0.006151 0.41369 6.60066
84 4UWH JXM 0.006125 0.40967 6.93069
85 2YW2 ATP 0.0005484 0.43263 7.26073
86 3K5I ADP 0.001283 0.41612 7.26073
87 2Z48 NGA 0.0101 0.40271 7.26073
88 5W2I I3P 0.0004803 0.41504 7.393
89 5W2I ADP 0.0004803 0.41504 7.393
90 4NG2 OHN 0.007898 0.41336 7.6087
91 5VZ0 ADP 0.0006853 0.44795 7.92079
92 5IQD RIO 0.00008529 0.5221 8.58086
93 5IQD GNP 0.00007975 0.5221 8.58086
94 4AZW ATP 0.0005956 0.45743 8.58086
95 4AZT LY2 0.0009338 0.45706 8.58086
96 5LRT ADP 0.01134 0.40609 8.58086
97 1E4E ADP 0.00758 0.40567 8.58086
98 1G51 AMO 0.01257 0.40689 8.91089
99 4IX4 ADP 0.0001395 0.48587 9.24092
100 4ZGP ADP 0.008192 0.40017 9.24092
101 2GQS ADP 0.006741 0.40394 9.2827
102 2GQS C2R 0.006292 0.40025 9.2827
103 2VDF OCT 0.008643 0.40532 9.48617
104 2IF8 ADP 0.0007434 0.47372 9.57096
105 2GQR ADP 0.007139 0.40283 9.70464
106 5M06 ADP 0.000001022 0.58093 9.78261
107 4LRJ ANP 0.0003781 0.45939 10.0592
108 3ETH ATP 0.0005303 0.46178 10.4225
109 1PK8 ATP 0.0008613 0.40416 10.4265
110 5I35 ANP 0.0001049 0.48404 10.5611
111 3PN1 IVH 0.001523 0.40504 10.8911
112 4CYI ATP 0.000006218 0.54683 11.5512
113 4O1P ANP 0.00000531 0.54439 11.5512
114 4XMF HSM 0.0001346 0.52092 11.9565
115 4OAV ACP 0.000007432 0.53495 13.2013
116 3Q60 ATP 0.0003446 0.46118 15.5116
117 1TQP ATP 0.00006861 0.44353 15.6028
118 4G17 0VN 0.0002318 0.46255 16.5016
119 4KBA 1QM 0.00005891 0.42504 16.5016
120 5W4W 9WG 0.0002441 0.42438 16.5016
121 4XH0 ADP 0.000002114 0.60629 16.8317
122 5CKW ANP 0.0002347 0.48561 17.1617
123 4Q5H ANP 0.00005174 0.48849 17.3077
124 4WOV 3SM 0.00001488 0.53522 17.4917
125 1Q8Y ADE 0.000001794 0.52657 17.4917
126 1Q8Y ADP 0.0003927 0.4656 17.4917
127 5C03 AGS 0.00000392 0.53464 17.8218
128 2CSN CKI 0.00001171 0.4599 18.1818
129 3VHE 42Q 0.000000818 0.46619 18.4818
130 5K2M ADP 0.003947 0.42565 20.7547
131 5U6C 7YS 0.00000005127 0.57059 22.1122
132 3PP0 03Q 0.0001638 0.41476 23.1023
133 4P5Z Q7M 0.000006086 0.40624 23.1023
134 2Y6O 1N1 0.00001064 0.48576 23.3677
135 4BKJ STI 0.0002661 0.41507 23.7624
136 4YMJ 4EJ 0.000000003378 0.75315 24.4224
137 4Y0X ADP 0.00001697 0.52563 24.7525
138 2PZI AXX 0.00004538 0.51273 24.7525
139 5JFS 6K0 0.000005282 0.58328 25.7426
140 4AT3 LTI 0.00003075 0.41955 25.7525
141 4XIZ LPP 0.01796 0.40581 27.1429
142 5N87 N66 0.000007874 0.41786 27.3927
143 4JR7 GNP 0.0000006468 0.56864 27.7228
144 3HMO STU 0.000004531 0.54446 27.7228
145 5TO8 7FM 0.000003445 0.40931 28.3688
146 4F9C 0SX 0.000002685 0.55453 28.7129
147 4FL3 ANP 0.000001745 0.51505 29.3729
148 3M2W L8I 0.0000251 0.52467 29.4314
149 2XVD AS6 0.00003299 0.52891 29.4702
150 3KMW ATP 0.0006588 0.44871 29.8893
151 4D2S DYK 0.00003853 0.51602 29.9296
152 4I94 ANP 0.00001259 0.5248 30.3333
153 5NKB 8ZT 0.0000004367 0.41683 30.6931
154 5MJA 7O3 0.00007187 0.49722 31.0231
155 4Y93 746 0.00003798 0.44199 31.0231
156 5DMZ ADP 0.0007421 0.43855 31.0231
157 2WU6 DKI 0.000004789 0.49244 31.3531
158 3GNI ATP 0.00002728 0.48131 31.6832
159 4EUU BX7 0.000004021 0.56741 32.0132
160 4IJP 1EH 0.000199 0.47891 32.0132
161 5T8O 76Z 0.0001929 0.44706 32.0132
162 3FHR P4O 0.0003205 0.4462 32.0132
163 4NFN 2KC 0.000004064 0.54655 32.3432
164 4XLI 1N1 0.00001731 0.51869 32.4627
165 3SRV S19 0.000002095 0.55929 32.491
166 4M69 ANP 0.000003466 0.55829 32.5879
167 4BTK DTQ 0.000005315 0.54437 32.6733
168 5LXC 7AA 0.000002958 0.54386 32.6733
169 4F4P 0SB 0.00000952 0.59035 32.967
170 2PVN P63 0.00000245 0.46532 33.2386
171 2QLU ADE 0.000105 0.51913 33.3333
172 5KO1 6UY 0.000002561 0.55544 33.5689
173 5JKG 6LF 0.00009217 0.52048 33.6634
174 3KRL KRL 0.00000336 0.50438 33.6634
175 3LXN MI1 0.0000003746 0.55359 33.9934
176 3VRY B43 0.000008321 0.46336 33.9934
177 4GJ3 0XP 0.000002037 0.58944 34.106
178 5HES 032 0.00002364 0.52308 34.3234
179 5EKO N17 0.0004075 0.46898 34.3234
180 3H9R TAK 0.00005241 0.46758 34.3234
181 1VJY 460 0.0000107 0.43052 34.3234
182 5HQ0 LZ9 0.000001657 0.52709 34.4371
183 3OFM 4B0 0.000000758 0.5568 34.5714
184 1U5R ATP 0.00000473 0.54364 34.6535
185 5EFQ ADP 0.00000424 0.534 34.6535
186 4CLI 5P8 0.000003143 0.5986 34.9835
187 4E1Z 0MX 0.0000005197 0.52795 35.0515
188 5FBN 5WF 0.00001479 0.55402 35.0554
189 1U59 STU 0.000001807 0.54947 35.1916
190 1BYG STU 0.000002029 0.55038 35.2518
191 3E7O 35F 0.0001102 0.50781 35.3135
192 5UR1 YY9 0.000001522 0.4499 35.3135
193 5UIU 8CG 0.000008041 0.55948 35.6037
194 4EWH T77 0.00001837 0.44173 35.6364
195 4CFU 2WC 0.0000009057 0.58331 35.6436
196 3PTG 932 0.000000941 0.53149 35.6436
197 3LXK MI1 0.000001132 0.48281 35.6436
198 4IDT T28 0.0001141 0.48243 35.6436
199 3TTI KBI 0.00004097 0.43557 35.6436
200 4AU8 Z3R 0.00002349 0.53319 35.8108
201 4BCQ TJF 0.000008929 0.55319 35.8804
202 4BCM T7Z 0.0000001204 0.55052 35.8804
203 4OH4 ANP 0.0000001311 0.59802 35.9736
204 4UAL 3FV 0.000002999 0.55545 35.9736
205 3GQI ACP 0.000004814 0.53189 35.9736
206 4BCN T9N 0.0000007358 0.59583 36
207 3PE2 E1B 0.000005581 0.58911 36.2018
208 3O0G 3O0 0.000005247 0.54164 36.3014
209 1UNH IXM 0.000006081 0.52104 36.3014
210 5LPZ ADP 0.000001062 0.55964 36.3036
211 4ASE AV9 0.00001076 0.54967 36.3036
212 3ORK AGS 0.00000585 0.47316 36.3036
213 4AG8 AXI 0.0000008116 0.43808 36.3036
214 5LMK 6ZK 0.000005198 0.54892 36.3636
215 2XMY CDK 0.000001631 0.63427 36.5772
216 3UIM ANP 0.000000135 0.59835 36.6337
217 4K33 ACP 0.000008644 0.53773 36.6337
218 4E93 GUI 0.000003483 0.43641 36.6337
219 5LPB ADP 0.000004103 0.56926 36.8243
220 3TXO 07U 0.00000181 0.5517 36.9637
221 2H8H H8H 0.000008018 0.53641 36.9637
222 2B9I ADP 0.00001809 0.50658 36.9637
223 4CSV STI 0.00002434 0.46217 37.0909
224 3TKI S25 0.00000007943 0.68856 37.2937
225 2HY0 306 0.000004426 0.55966 37.2937
226 2PVF ACP 0.000002956 0.55268 37.2937
227 5EOB 5QQ 0.0001305 0.52928 37.2937
228 3RI1 3RH 0.000002066 0.47843 37.2937
229 1Y57 MPZ 0.0000001172 0.54989 37.6238
230 3C1X CKK 0.0001478 0.44406 37.6238
231 5HX8 66P 0.00000007198 0.52995 37.7483
232 5LI9 ACP 0.000006501 0.51466 37.9538
233 4U0I 0LI 0.00008276 0.51367 37.9538
234 5LI1 ANP 0.000005719 0.49783 37.9538
235 4USF 6UI 0.000161 0.4894 37.9538
236 3GC8 B45 0.00006208 0.45963 37.9538
237 2HK5 1BM 0.00005029 0.50587 38.1481
238 1V0O INR 0.00002649 0.49035 38.1944
239 4DC2 ADE 0.00000007136 0.525 38.2838
240 4U44 3D9 0.00001836 0.52038 38.2838
241 4X7Q 3YR 0.00001225 0.51352 38.2838
242 5AX9 4KT 0.00004676 0.48887 38.2838
243 3PLS ANP 0.000002039 0.55981 38.5906
244 3ZRM ZRM 0.00000009749 0.60253 38.6139
245 3F7Z 34O 0.0000003396 0.57975 38.6139
246 5X8I SQZ 0.000002279 0.54493 38.6139
247 4NM5 ADP 0.0000003719 0.53227 38.6139
248 2JLD AG1 0.00000002485 0.49999 38.6139
249 4AUA 4AU 0.000009058 0.53114 38.9439
250 4LOO SB4 0.001032 0.43246 38.9439
251 4QTB 38Z 0.00002453 0.43136 38.9439
252 3NW7 LGV 0.00002401 0.55799 39.2739
253 3GC0 AMP 0.000001245 0.54964 39.2739
254 1CM8 ANP 0.00001809 0.51784 39.2739
255 4WNP 3RJ 0.0000007738 0.59482 39.3728
256 5USZ SKE 0.000003632 0.46408 39.4464
257 1K3A ACP 0.0000002051 0.58134 39.4649
258 3BU5 ATP 0.000001703 0.56641 39.604
259 4YZN 4K5 0.000001005 0.51687 39.7213
260 4H3P ANP 0.000002821 0.55664 39.934
261 5AWM ANP 0.00002529 0.53166 39.934
262 4H3Q ANP 0.00003157 0.46375 39.934
263 1JPA ANP 0.0000003081 0.42702 39.934
264 3EKK GS2 0.00000239 0.41737 39.934
265 4XV1 904 0.000005071 0.57442 40.0685
266 2X2M X2M 0.00001202 0.48648 40.264
267 4WNK 453 0.00002957 0.42989 40.264
268 5CEO 50D 0.0000295 0.5112 40.3333
269 3C0G 3AM 0.0000001572 0.62695 40.5941
270 4YZC STU 0.00001312 0.55969 40.5941
271 2OO8 RAJ 0.0004396 0.46548 40.5941
272 4L9I 8PR 0.00000182 0.562 40.9241
273 3CY2 MB9 0.000002 0.50336 40.9241
274 4L3L 5FI 0.000000003997 0.71443 41.2541
275 4Y8D 49J 0.000007684 0.52189 41.2541
276 2WEL K88 0.0000004043 0.51803 41.9142
277 4CQE CQE 0.00001624 0.48012 42.0863
278 3SXS PP2 0.00002018 0.48623 42.1642
279 2VN9 GVD 0.0000004402 0.54456 42.1927
280 5HVJ ANP 0.000003787 0.59278 42.2442
281 2VZ6 FEF 0.00002932 0.52153 42.2442
282 2V7O DRN 0.00000004442 0.58306 42.5743
283 5UKL SIX 0.0000217 0.53549 42.5743
284 4JDI ANP 0.000006769 0.50622 42.5743
285 3PVW QRX 0.00000143 0.48885 42.5743
286 4Y85 499 0.001351 0.4349 42.5743
287 4OTH DRN 0.0000001704 0.55474 42.9043
288 4I6H 1C8 0.00000445 0.53255 42.9043
289 5TA6 79D 0.0000001776 0.50107 42.9043
290 3KN5 ANP 0.0000006828 0.5629 43.2343
291 1XJD STU 0.000001215 0.54215 43.2343
292 4UX9 ANP 0.000007214 0.50577 43.5644
293 5VCV 1N1 0.000004264 0.48249 43.5644
294 2X4Z X4Z 0.00001532 0.55328 43.5811
295 2OFV 242 0.00000404 0.58256 43.6823
296 4YLL 4E3 0.000008447 0.54578 43.8944
297 3MVH WFE 0.00000001798 0.52018 43.8944
298 3DLS ADP 0.00006029 0.48776 43.8944
299 5IH9 6BF 0.0000124 0.41203 43.8944
300 2Z7R STU 0.0000005426 0.53689 44.2244
301 4NST ADP 0.000008826 0.53456 44.2244
302 4BFM ANP 0.000002092 0.52338 44.2244
303 3ALN ANP 0.00002456 0.48107 44.2244
304 3V8S 0HD 0.00000001741 0.6514 44.5545
305 4WB6 ATP 0.000001576 0.48617 44.5545
306 4FG8 ATP 0.00002433 0.48359 44.5545
307 1RE8 BD2 0.0000001127 0.67234 44.8845
308 2WQN ADP 0.0000004137 0.60744 44.8845
309 2QCS ANP 0.000001702 0.58469 44.8845
310 3FHI ANP 0.000003417 0.57068 44.8845
311 3IDB ANP 0.0000006361 0.5251 44.8845
312 4WB7 ATP 0.000004484 0.42333 44.8845
313 2YAK OSV 0.0000006266 0.61146 44.9123
314 2YAB AMP 0.000004092 0.5523 45.2145
315 5DBX ANP 0.00001012 0.51247 45.2145
316 4NW6 2NS 0.000001676 0.45052 45.2145
317 4QMN DB8 0.00000174 0.43045 45.2145
318 5H2U 1N1 0.0001974 0.46247 45.3184
319 5VC5 96M 0.000001073 0.4781 45.3287
320 2J7T 274 0.00008432 0.51161 45.3642
321 3SLS ANP 0.000000859 0.52752 45.5446
322 2R5T ANP 0.000002493 0.51442 45.5446
323 5A6N U7E 0.000001069 0.57844 45.583
324 2ZV2 609 0.00000905 0.55291 45.6376
325 1PHK ATP 0.000008386 0.53832 45.6376
326 5DA3 58V 0.000002556 0.57905 45.6604
327 5JZJ AN2 0.00001081 0.52775 45.7912
328 2XK9 XK9 0.00004133 0.5343 45.8746
329 4BHN BH9 0.00003621 0.47634 45.8746
330 3GGF GVD 0.000002824 0.56092 46.2046
331 5LVP ATP 0.000002095 0.54167 46.2046
332 4KS7 X4Z 0.000002266 0.50518 46.2329
333 4C2V YJA 0.00004355 0.52507 46.3158
334 3AQV TAK 0.000008795 0.53462 46.3768
335 3IGO ANP 0.0001329 0.44886 46.5347
336 5DH3 5BS 0.00005475 0.46817 46.8647
337 3DAK ANP 0.000001455 0.57398 46.8966
338 2RIO ADP 0.00001914 0.51675 47.1947
339 4C2W ANP 0.0000002908 0.56393 47.3118
340 5L8L ADP 0.000001178 0.59506 47.3684
341 5G1X ADP 0.00001627 0.51988 47.3684
342 5LXM ADP 0.000003883 0.54743 47.7032
343 3SXF BK5 0.000009563 0.56303 47.8548
344 5EYK 5U5 0.00000497 0.45845 48.1884
345 2WEI VGG 0.00004801 0.49158 49.1289
346 5UOX 8GY 0.00003392 0.46994 49.4465
Pocket No.: 2; Query (leader) PDB : 1ZY5; Ligand: ANP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1zy5.bio1) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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