Receptor
PDB id Resolution Class Description Source Keywords
1Z9O 1.9 Å NON-ENZYME: BINDING 1.9 ANGSTROM CRYSTAL STRUCTURE OF THE RAT VAP-A MSP HOMOLOGY COMPLEX WITH THE RAT ORP1 FFAT MOTIF RATTUS NORVEGICUS VAP-33 VAP-A VAP-B VAP-C VAPA VAPB VAPC VAP-33A SCS2FFAT MOTIF ER ENDOPLASMIC RETICULUM TARGETING IMMUNOGLOLIKE BETA SHEET MSP HOMOLOGY DOMAIN OSBP ORP OXYSTEROL PROTEIN PROTEIN BINDING-LIPID BINDING PROTEIN COMPLEX
Ref.: STRUCTURAL BASIS OF FFAT MOTIF-MEDIATED ER TARGETIN STRUCTURE V. 13 1035 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER GLU ASP GLU PHE TYR ASP ALA LEU SER G:473;
H:473;
I:473;
J:473;
K:473;
L:473;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
submit data
1069.07 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Z9O 1.9 Å NON-ENZYME: BINDING 1.9 ANGSTROM CRYSTAL STRUCTURE OF THE RAT VAP-A MSP HOMOLOGY COMPLEX WITH THE RAT ORP1 FFAT MOTIF RATTUS NORVEGICUS VAP-33 VAP-A VAP-B VAP-C VAPA VAPB VAPC VAP-33A SCS2FFAT MOTIF ER ENDOPLASMIC RETICULUM TARGETING IMMUNOGLOLIKE BETA SHEET MSP HOMOLOGY DOMAIN OSBP ORP OXYSTEROL PROTEIN PROTEIN BINDING-LIPID BINDING PROTEIN COMPLEX
Ref.: STRUCTURAL BASIS OF FFAT MOTIF-MEDIATED ER TARGETIN STRUCTURE V. 13 1035 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 1Z9O - SER GLU ASP GLU PHE TYR ASP ALA LEU SER n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 1Z9O - SER GLU ASP GLU PHE TYR ASP ALA LEU SER n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 272 families.
1 1Z9O - SER GLU ASP GLU PHE TYR ASP ALA LEU SER n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER GLU ASP GLU PHE TYR ASP ALA LEU SER; Similar ligands found: 185
No: Ligand ECFP6 Tc MDL keys Tc
1 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 1 1
2 ASP PHE GLU ASP TYR GLU PHE ASP 0.66055 0.843137
3 GLU LEU ASP LYS TYR ALA SER 0.649573 0.924528
4 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.614173 0.886792
5 ASP ALA ASP GLU TYR LEU 0.610619 0.862745
6 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.603053 0.925926
7 GLU ASN LEU TYR PHE GLN 0.598291 0.851852
8 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.590551 0.867925
9 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.588652 0.836066
10 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.578947 0.792453
11 ASP LEU TYR CYS TYR GLU GLN LEU ASN 0.568 0.890909
12 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.56 0.872727
13 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.555556 0.803279
14 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.55 0.716667
15 GLU THR LEU LEU ASP LEU ASP PHE LEU GLU 0.54386 0.764706
16 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.529412 0.87037
17 PHE LEU ALA TYR LYS 0.528926 0.849057
18 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.527027 0.786885
19 THR TYR PHE ALA VAL LEU MET VAL SER 0.525547 0.839286
20 THR ASN GLU PHE TYR ALA 0.52459 0.833333
21 ASP SEP TYR GLU VAL LEU ASP LEU 0.521739 0.79661
22 ALA GLU THR PHE TYR VAL ASP GLY 0.515873 0.884615
23 GLU VAL TYR GLU SER 0.512821 0.882353
24 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.510638 0.910714
25 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.510067 0.725806
26 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.507576 0.836364
27 GLU LEU ASP HOX TRP ALA SER 0.507246 0.783333
28 GLU GLN TYR LYS PHE TYR SER VAL 0.503876 0.875
29 GLU LEU ASP 1OL VAL GLU PHE 0.5 0.788462
30 GLY ASN TYR SER PHE TYR ALA LEU 0.496063 0.857143
31 THR ASN GLU PHE TYR PHE 0.495726 0.773585
32 LYS ALA LEU TYR ASN PHE ALA THR MET 0.492958 0.816667
33 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.492857 0.737705
34 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.492424 0.833333
35 PHE LEU SER TYR LYS 0.491935 0.907407
36 ALA ALA TRP LEU PHE GLU ALA 0.488889 0.701754
37 ASP ALA GLU PHE ARG HIS ASP SER 0.485507 0.606061
38 PHE TYR ARG ALA LEU MET 0.485294 0.730159
39 GLU LEU ASP LYS TRP ALA SER 0.485294 0.79661
40 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.484472 0.69863
41 THR ASN GLU PHE ALA PHE 0.483051 0.698113
42 GLU ASN GLN LYS GLU TYR PHE PHE 0.480315 0.767857
43 ASP ASP LEU TYR GLY 0.478632 0.849057
44 GLU LEU ASP ORN TRP ALA SER 0.478261 0.810345
45 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.475862 0.754098
46 ACE VAL PHE PHE ALA GLU ASP NH2 0.47541 0.764706
47 SER HIS PHE ASN GLU TYR GLU 0.475177 0.770492
48 CYS THR GLU LEU LYS LEU SER ASP TYR 0.47482 0.890909
49 ACE ASP ALA ASP GLU FTY LEU NH2 0.473282 0.655738
50 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.471831 0.770492
51 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.470588 0.629032
52 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.469799 0.762712
53 GLU THR PHE TYR VAL ASP GLY 0.469697 0.888889
54 GLU THR VAL ARG PHE GLN SER ASP 0.468531 0.75
55 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.468354 0.769231
56 ASP GLU LEU GLU ILE LYS ALA TYR 0.467153 0.818182
57 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.466667 0.851852
58 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.464789 0.844828
59 VAL ALA PHE ARG SER 0.464 0.677966
60 GLU ILE ILE ASN PHE GLU LYS LEU 0.463235 0.689655
61 MET PHE SER ILE ASP ASN ILE LEU ALA 0.460993 0.762712
62 THR TYR LYS PHE PHE GLU GLN 0.460938 0.803571
63 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.460938 0.803571
64 LEU GLU PHE GLN GLY 0.459016 0.740741
65 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.458065 0.701493
66 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.457143 0.842105
67 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.456954 0.707692
68 GLU LEU GLU LYS TRP ALA SER 0.455882 0.75
69 ALA TRP LEU PHE GLU ALA 0.455224 0.701754
70 GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA 0.455224 0.814815
71 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.455172 0.783333
72 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.453901 0.704918
73 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.453901 0.701493
74 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.453846 0.777778
75 PHE LEU GLU LYS 0.453782 0.735849
76 GLY LEU TYR ALA SER LYS LEU ALA 0.453125 0.854545
77 SER ILE ILE ASN PHE GLU LYS LEU 0.452555 0.789474
78 SER GLN TYR TYR TYR ASN SER LEU 0.452381 0.925926
79 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.451613 0.712121
80 GLU LEU ASP LYS TRP ALA ASN 0.45 0.693548
81 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.449367 0.727273
82 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.44898 0.656716
83 LYS LEU LEU PHE 0.447368 0.679245
84 PHE ARG TYR LEU GLY 0.44697 0.783333
85 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.446809 0.872727
86 SER GLU ILE GLU PHE ALA ARG LEU 0.446809 0.721311
87 GLU VAL ASN 1OL ALA GLU PHE 0.446809 0.745455
88 GLU ARG GLU SEP GLU PHE ASP ILE GLU ASP 0.446667 0.632353
89 THR PRO ASP TYR PHE LEU 0.445312 0.810345
90 GLU LEU ARG ARG LYS MET MET TYR MET 0.445255 0.707692
91 VAL ASN ASP ILE PHE GLU ALA ILE 0.445255 0.727273
92 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.444444 0.685714
93 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.443662 0.8
94 ASP PHE GLU GLU ILE 0.441667 0.730769
95 GLU LEU ASP HIS TRP ALA SER 0.441379 0.766667
96 TYR LEU ASP SER GLY ILE HIS SER GLY ALA 0.441379 0.75
97 ARG VAL LEU PHE GLU ALA MET 0.440559 0.615385
98 GLU GLU GLN GLU GLU TYR 0.440367 0.764706
99 GLU GLN ASP LYS TRP ALA SER 0.439716 0.721311
100 LYS VAL LEU PHE LEU ASP GLY 0.438462 0.759259
101 SER SER ILE GLU PHE ALA ARG LEU 0.4375 0.737705
102 ASP ASP MET GLY PHE GLY LEU PHE ASP 0.435484 0.773585
103 ASP ASP ASP MET GLY PHE GLY LEU PHE ASP 0.435484 0.773585
104 THR LYS ASN TYR LYS GLN PHE SER VAL 0.433824 0.892857
105 LYS GLN TRP ASP ASN TYR GLU PTR ILE TRP 0.433735 0.657143
106 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.433333 0.826923
107 PRO ALA TRP LEU PHE GLU ALA 0.433333 0.688525
108 ACE GLN LEU ASP ALA PHE 0.433071 0.716981
109 ACE PHE ALA TYR M3L SER NH2 0.432836 0.790323
110 PHE GLU ALA ASN GLY ASN LEU ILE 0.432624 0.736842
111 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.432624 0.725806
112 GLU ASN ASP LYS TRP ALA SER 0.432624 0.709677
113 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.431507 0.66129
114 GLU LEU ASP NRG TRP ALA SER 0.431373 0.626667
115 ASP PHE M3L THR ASP 0.430769 0.714286
116 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.430464 0.786885
117 THR ASN GLU TYR TYR VAL 0.429752 0.830189
118 THR ASN GLU TYR LYS VAL 0.429688 0.8
119 GLU ALA ASP LYS TRP GLN SER 0.429577 0.721311
120 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.429412 0.637681
121 GLU LEU ASP LYS TRP ALA GLY 0.428571 0.716667
122 THR PHE GLN ALA PSA LEU ARG GLU 0.428571 0.758065
123 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.427586 0.736842
124 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.427481 0.796296
125 ALA ARG THR GLU LEU TYR ARG SER LEU 0.426573 0.803279
126 PRO GLU SEP LEU GLU SER CYS PHE 0.426471 0.721311
127 SER LEU LYS ILE ASP ASN GLU ASP 0.426471 0.754386
128 THR ASN LEU TYR MET LEU 0.425373 0.775862
129 ACE ILE TYR GLU SER LEU 0.425197 0.886792
130 GLN TYR PHE MET TPO GLU PTR VAL ALA 0.425 0.731343
131 ASP SER LYS ASP VAL LYS GLU TRP TYR VAL ZN 0.424837 0.78125
132 PRO GLU GLY ASP PM3 GLU GLU VAL LEU 0.42446 0.7
133 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.423841 0.8
134 SER LEU PHE ASN THR VAL ALA THR LEU 0.423358 0.796296
135 SER LEU TYR ASN THR VAL ALA THR LEU 0.423358 0.851852
136 SER SER ARG LYS GLU TYR TYR ALA 0.423077 0.737705
137 SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.422819 0.844828
138 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.421429 0.872727
139 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.421053 0.71875
140 SER LEU TYR ASN THR ILE ALA THR LEU 0.42029 0.854545
141 SER LEU TYR ASN VAL VAL ALA THR LEU 0.42029 0.851852
142 SER ASP TYR GLN ARG LEU 0.419847 0.779661
143 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.41958 0.821429
144 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.419355 0.758065
145 PHE SER ALA PTR VAL SER GLU GLU ASP 0.419118 0.75
146 TYR ALA GLY SEP TPO ASP GLU ASN 0.418301 0.707692
147 ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG 0.41791 0.645161
148 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.417808 0.711864
149 GLU LEU LYS TPO GLU ARG TYR 0.417808 0.705882
150 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.417219 0.686567
151 SER LEU TYR LEU THR VAL ALA THR LEU 0.416667 0.865385
152 LEU SER PRO ASP SER PHE LEU ASN ASP 0.415929 0.75
153 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.414966 0.807018
154 GLU THR LEU LEU ASP LEU ASP PHE ASP PRO 0.414286 0.692308
155 SER LEU LEU LYS LYS LEU LEU ASP 0.413793 0.763636
156 GLY ASP GLU VAL LYS VAL PHE ARG 0.412587 0.645161
157 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.412162 0.75
158 SER GLN LEU LYS ASN ASN ALA LYS GLU ILE 0.411765 0.741379
159 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.411392 0.647059
160 GLY ASN PHE LEU GLN SER ARG 0.411348 0.725806
161 ACE GLN ALA ASP LEU PHE 0.410853 0.716981
162 PRO THR SER TYR ALA GLY ASP ASP SER GLY 0.410596 0.783333
163 GLU LEU ASN ARG LYS MET ILE TYR MET 0.410256 0.676471
164 ALA LEU ASP LYS TRP ALA SER 0.410072 0.79661
165 ARG GLN ALA ASN PHE LEU GLY LYS ILE ASN 0.409449 0.660714
166 LEU ALA ILE TYR SER 0.409449 0.846154
167 LYS ALA VAL TYR ASN PHE ALA THR MET 0.409396 0.816667
168 ALA PRO ALA TRP LEU PHE GLU ALA 0.408805 0.617647
169 SER ALA LYS ILE ASP ASN LEU ASP 0.408759 0.754386
170 SER LEU PHE ASN THR ILE ALA VAL LEU 0.408451 0.8
171 PRO PRO THR LEU HIS GLU LEU TYR ASP LEU 0.408284 0.695652
172 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.407895 0.707692
173 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.407143 0.814815
174 ALA LEU ASP LEU PHE 0.40708 0.705882
175 PCA PHE ARG HIS ASP SER GLY TYR GLU VAL 0.405714 0.735294
176 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.404908 0.723077
177 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.404762 0.807692
178 ARG GLU ASP GLN GLU THR ALA VAL 0.404762 0.735849
179 TYR ASP GLN ILE LEU 0.40458 0.811321
180 ALA VAL TYR ASN PHE ALA THR MET 0.402778 0.810345
181 PHE SER ALA PTR PRO SER GLU GLU ASP 0.402516 0.666667
182 THR LYS ASN TYR LYS GLN THR SER VAL 0.401408 0.842105
183 SER SER PHE TYR PRO SEP ALA GLU GLY 0.401316 0.661972
184 LYS ALA VAL TYR ASN LEU ALA THR MET 0.4 0.783333
185 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.4 0.65625
Similar Binding Sites (Proteins are less than 50% similar to leader)
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