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Receptor
PDB id Resolution Class Description Source Keywords
1Z6T 2.21 Å NON-ENZYME: CELL_CYCLE STRUCTURE OF THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 BOUND TO ADP HOMO SAPIENS APAF-1 CASPASE ACTIVATION ADP NUCLEOTIDE BINDING CARD APOPTOSIS
Ref.: STRUCTURE OF THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 BOUND TO ADP NATURE V. 434 926 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ADP A:900;
B:901;
C:902;
D:903;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
427.201 C10 H15 N5 O10 P2 c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Z6T 2.21 Å NON-ENZYME: CELL_CYCLE STRUCTURE OF THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 BOUND TO ADP HOMO SAPIENS APAF-1 CASPASE ACTIVATION ADP NUCLEOTIDE BINDING CARD APOPTOSIS
Ref.: STRUCTURE OF THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 BOUND TO ADP NATURE V. 434 926 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 24 families.
1 1Z6T - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 17 families.
1 1Z6T - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 1Z6T - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ADP; Similar ligands found: 452
No: Ligand ECFP6 Tc MDL keys Tc
1 ADP 1 1
2 HEJ 0.9 1
3 ATP 0.9 1
4 A2D 0.895522 0.971831
5 5FA 0.887324 1
6 AQP 0.887324 1
7 AP5 0.884058 0.971831
8 B4P 0.884058 0.971831
9 BA3 0.869565 0.971831
10 AN2 0.84507 0.985915
11 AT4 0.84507 0.958904
12 M33 0.833333 0.958333
13 ACQ 0.826667 0.972222
14 A 0.823529 0.971429
15 AMP 0.823529 0.971429
16 ACP 0.821918 0.972222
17 6YZ 0.818182 0.972222
18 APR 0.810811 0.971831
19 AR6 0.810811 0.971831
20 ANP 0.802632 0.972222
21 SAP 0.8 0.945946
22 AGS 0.8 0.945946
23 AD9 0.8 0.972222
24 ADX 0.783784 0.873418
25 CA0 0.783784 0.945205
26 TAT 0.779221 0.958904
27 T99 0.779221 0.958904
28 50T 0.773333 0.958333
29 ABM 0.763889 0.917808
30 APC 0.763158 0.958904
31 PRX 0.763158 0.893333
32 ATF 0.759494 0.958904
33 A22 0.753086 0.985915
34 AP2 0.743243 0.958904
35 A12 0.743243 0.958904
36 SRA 0.736111 0.918919
37 ADQ 0.73494 0.945205
38 25L 0.732558 0.985915
39 5AL 0.725 0.931507
40 2A5 0.717949 0.918919
41 A1R 0.714286 0.907895
42 AU1 0.714286 0.972222
43 A3R 0.714286 0.907895
44 ATR 0.708861 0.971429
45 ADP PO3 0.708861 0.943662
46 PAP 0.708861 0.985714
47 SRP 0.707317 0.906667
48 7D3 0.706667 0.905405
49 25A 0.702381 0.971831
50 9X8 0.697674 0.92
51 OAD 0.697674 0.945205
52 RBY 0.6875 0.932432
53 ADV 0.6875 0.932432
54 00A 0.686047 0.883117
55 OOB 0.682353 0.931507
56 5SV 0.682353 0.848101
57 8QN 0.682353 0.931507
58 3OD 0.681818 0.945205
59 BIS 0.681818 0.933333
60 ALF ADP 0.674699 0.87013
61 ADP ALF 0.674699 0.87013
62 AMO 0.674419 0.932432
63 4AD 0.674419 0.92
64 PAJ 0.674419 0.884615
65 GAP 0.670732 0.893333
66 MAP 0.670588 0.945946
67 AHX 0.666667 0.896104
68 VO4 ADP 0.666667 0.931507
69 DLL 0.666667 0.931507
70 ADP VO4 0.666667 0.931507
71 PTJ 0.662921 0.896104
72 3UK 0.659091 0.918919
73 SON 0.658228 0.932432
74 LMS 0.653333 0.82716
75 LAD 0.651685 0.860759
76 WAQ 0.651685 0.883117
77 B5V 0.651685 0.906667
78 PR8 0.651685 0.85
79 ITT 0.65 0.943662
80 7D4 0.65 0.905405
81 G5P 0.648936 0.921053
82 XYA 0.647059 0.84507
83 ADN 0.647059 0.84507
84 RAB 0.647059 0.84507
85 1ZZ 0.644444 0.839506
86 ME8 0.644444 0.839506
87 FYA 0.644444 0.905405
88 NB8 0.644444 0.896104
89 TXA 0.644444 0.932432
90 6AD 0.642857 0.909091
91 ADP BMA 0.640449 0.918919
92 G3A 0.638298 0.921053
93 DAL AMP 0.632184 0.905405
94 AFH 0.631579 0.884615
95 9SN 0.630435 0.871795
96 9ZA 0.625 0.907895
97 DQV 0.625 0.958333
98 9ZD 0.625 0.907895
99 GTA 0.625 0.886076
100 YAP 0.623656 0.894737
101 B5M 0.623656 0.894737
102 FA5 0.623656 0.906667
103 B5Y 0.623656 0.894737
104 UP5 0.622449 0.92
105 HFD 0.619048 0.945946
106 XAH 0.617021 0.839506
107 AV2 0.616279 0.917808
108 AOC 0.615385 0.821918
109 48N 0.612245 0.896104
110 4UV 0.610526 0.894737
111 6V0 0.606061 0.896104
112 NAI 0.606061 0.907895
113 DND 0.606061 0.932432
114 NAX 0.606061 0.873418
115 NXX 0.606061 0.932432
116 TXD 0.606061 0.907895
117 5N5 0.605634 0.819444
118 5AS 0.604938 0.77907
119 A4P 0.60396 0.843373
120 DAT 0.60241 0.905405
121 A2R 0.602273 0.985915
122 TXE 0.6 0.907895
123 OMR 0.6 0.851852
124 4UU 0.597938 0.894737
125 GA7 0.597938 0.906667
126 A A 0.597826 0.944444
127 A4D 0.597222 0.819444
128 5CD 0.597222 0.805556
129 AP0 0.594059 0.896104
130 4TC 0.594059 0.896104
131 A3P 0.592593 0.971429
132 T5A 0.592233 0.841463
133 139 0.592233 0.873418
134 7D5 0.592105 0.878378
135 ATP A A A 0.589474 0.930556
136 LAQ 0.585859 0.839506
137 MYR AMP 0.585106 0.817073
138 F2R 0.580952 0.864198
139 YLP 0.58 0.819277
140 UPA 0.578431 0.907895
141 7DD 0.578313 0.985714
142 3AM 0.576923 0.929577
143 ADJ 0.576923 0.851852
144 COD 0.575472 0.811765
145 NAD 0.575472 0.931507
146 3AT 0.574713 0.971831
147 JB6 0.574468 0.883117
148 4UW 0.574257 0.860759
149 EP4 0.573333 0.753247
150 A2P 0.573171 0.957143
151 CNA 0.571429 0.932432
152 TYM 0.568627 0.906667
153 PPS 0.568182 0.873418
154 DTA 0.565789 0.786667
155 M2T 0.565789 0.734177
156 AR6 AR6 0.565657 0.917808
157 A3D 0.564815 0.918919
158 80F 0.564815 0.841463
159 3DH 0.564103 0.773333
160 G5A 0.563218 0.77907
161 YLB 0.563107 0.819277
162 YLC 0.563107 0.839506
163 AMP DBH 0.561224 0.893333
164 TYR AMP 0.561224 0.87013
165 MTA 0.558442 0.773333
166 DTP 0.556818 0.905405
167 AHZ 0.554455 0.817073
168 NA7 0.553191 0.958904
169 IOT 0.552381 0.831325
170 ZAS 0.55 0.766234
171 7MD 0.55 0.8625
172 ARG AMP 0.55 0.829268
173 IMO 0.548781 0.929577
174 YLA 0.54717 0.819277
175 NAE 0.544643 0.894737
176 TAD 0.544554 0.884615
177 A5A 0.544444 0.807229
178 2AM 0.544304 0.943662
179 TSB 0.543478 0.819277
180 6RE 0.54321 0.759494
181 AYB 0.542056 0.809524
182 NAQ 0.539823 0.871795
183 V3L 0.539326 0.971831
184 SSA 0.538462 0.8
185 AF3 ADP 3PG 0.538462 0.8375
186 ZID 0.535088 0.918919
187 LPA AMP 0.533981 0.817073
188 52H 0.532609 0.77907
189 VMS 0.532609 0.788235
190 54H 0.532609 0.788235
191 BTX 0.53211 0.841463
192 A3N 0.53012 0.786667
193 J7C 0.53012 0.769231
194 5X8 0.528736 0.763158
195 BT5 0.527273 0.831325
196 8X1 0.526882 0.752809
197 5CA 0.526882 0.8
198 53H 0.526882 0.77907
199 ARU 0.526316 0.860759
200 EAD 0.525862 0.873418
201 RGT 0.525253 0.958904
202 OVE 0.52439 0.905405
203 S4M 0.52381 0.666667
204 7DT 0.522727 0.985714
205 GDP 0.522222 0.92
206 DDS 0.522222 0.878378
207 AVV 0.521277 0.896104
208 NDE 0.521008 0.932432
209 7MC 0.518868 0.841463
210 DSH 0.518072 0.725
211 MAO 0.517647 0.759036
212 NSS 0.515789 0.8
213 DSZ 0.515789 0.8
214 LSS 0.515789 0.761364
215 P5A 0.515464 0.744444
216 DZD 0.513514 0.884615
217 NVA LMS 0.510417 0.752809
218 9K8 0.510204 0.714286
219 12D 0.509615 0.785714
220 M24 0.508772 0.85
221 YLY 0.508772 0.809524
222 P1H 0.508333 0.851852
223 5AD 0.506849 0.746479
224 GJV 0.505882 0.75
225 LEU LMS 0.505155 0.752809
226 AMP NAD 0.504505 0.905405
227 4TA 0.504505 0.807229
228 G A A A 0.504505 0.871795
229 NAJ PZO 0.504425 0.848101
230 GSU 0.5 0.77907
231 128 0.5 0.776471
232 KAA 0.5 0.752809
233 71V 0.5 0.907895
234 A3G 0.5 0.8
235 NDC 0.5 0.871795
236 7D7 0.5 0.743243
237 N0B 0.495726 0.819277
238 NJP 0.495495 0.945946
239 ODP 0.495495 0.909091
240 2SA 0.494624 0.932432
241 6C6 0.494505 0.881579
242 SFG 0.494382 0.75
243 0WD 0.491071 0.921053
244 YSA 0.490196 0.77907
245 PO4 PO4 A A A A PO4 0.489796 0.902778
246 SAM 0.48913 0.690476
247 6IA 0.48913 0.8375
248 A7D 0.488636 0.776316
249 6FA 0.488 0.841463
250 FB0 0.487805 0.804598
251 NAJ PYZ 0.487179 0.807229
252 A5D 0.483516 0.786667
253 IDP 0.483516 0.918919
254 SA8 0.483516 0.707317
255 PGS 0.483146 0.883117
256 MHZ 0.483146 0.697674
257 DA 0.482353 0.878378
258 D5M 0.482353 0.878378
259 NEC 0.482353 0.746667
260 NIA 0.481928 0.822785
261 Y3J 0.480519 0.726027
262 8PZ 0.480392 0.8
263 FAD 0.480315 0.851852
264 FAS 0.480315 0.851852
265 FDA 0.48 0.833333
266 N6P 0.479592 0.915493
267 GGZ 0.479167 0.825
268 U A 0.478261 0.907895
269 SAH 0.478261 0.74359
270 SAI 0.478261 0.734177
271 A G 0.477876 0.883117
272 NPW 0.477477 0.886076
273 NDP 0.477477 0.921053
274 AAM 0.476744 0.971429
275 C2R 0.47561 0.90411
276 AMZ 0.47561 0.916667
277 A A A 0.474747 0.905405
278 GTP 0.473684 0.92
279 U A G G 0.473684 0.883117
280 SMM 0.473684 0.686047
281 NZQ 0.473214 0.909091
282 TXP 0.473214 0.921053
283 A3S 0.47191 0.810811
284 SFD 0.46875 0.734043
285 AIR 0.468354 0.901408
286 AAT 0.468085 0.707317
287 EEM 0.468085 0.690476
288 J7V 0.466667 0.833333
289 Z5A 0.466667 0.77907
290 7C5 0.466667 0.818182
291 62F 0.465649 0.8625
292 HDV 0.463158 0.893333
293 FAY 0.462121 0.8625
294 A3T 0.461538 0.821918
295 ETB 0.461538 0.833333
296 DCA 0.461538 0.823529
297 A6D 0.46 0.722892
298 A U 0.459459 0.87013
299 GEK 0.459184 0.7375
300 6K6 0.459184 0.930556
301 RFL 0.458647 0.821429
302 NAP 0.458333 0.945205
303 S7M 0.458333 0.690476
304 4YB 0.457944 0.761364
305 WSA 0.454545 0.788235
306 TAP 0.454545 0.907895
307 FNK 0.454545 0.804598
308 COA 0.453782 0.823529
309 0T1 0.453782 0.823529
310 101 0.453488 0.878378
311 XNP 0.452174 0.873418
312 NA0 0.45082 0.932432
313 7RP 0.448276 0.928571
314 GP3 0.446809 0.921053
315 TM1 0.446602 0.77381
316 APU 0.446429 0.894737
317 PUA 0.445378 0.884615
318 V1N 0.443396 0.917808
319 7RA 0.443182 0.957747
320 COS 0.442623 0.804598
321 AMX 0.442623 0.833333
322 30N 0.442623 0.752688
323 CAO 0.442623 0.795455
324 QQY 0.44186 0.815789
325 ACK 0.44186 0.861111
326 649 0.441441 0.744444
327 0UM 0.44 0.698795
328 NHD 0.439655 0.905405
329 CMX 0.439024 0.823529
330 SCO 0.439024 0.823529
331 GCP 0.438776 0.896104
332 8BR 0.438202 0.906667
333 GNH 0.4375 0.907895
334 8Q2 0.4375 0.772727
335 3AD 0.4375 0.805556
336 NVA 2AD 0.43617 0.759494
337 62X 0.435644 0.666667
338 FCX 0.435484 0.795455
339 ACO 0.435484 0.795455
340 FAM 0.435484 0.804598
341 9JJ 0.434783 0.8625
342 GNP 0.434343 0.896104
343 9GM 0.434343 0.896104
344 NMX 0.433071 0.76087
345 MGP 0.43299 0.884615
346 26A 0.432099 0.763158
347 HAX 0.432 0.804598
348 K15 0.431373 0.682353
349 DG1 0.430894 0.921053
350 1DG 0.430894 0.921053
351 QQX 0.430233 0.805195
352 2VA 0.430108 0.8
353 S8M 0.43 0.759494
354 2MC 0.429688 0.769231
355 6G0 0.428571 0.884615
356 P5F 0.428571 0.823529
357 FYN 0.428571 0.823529
358 3KK 0.428571 0.804598
359 A C A C 0.428571 0.848101
360 7L1 0.427419 0.795455
361 FAI 0.426966 0.916667
362 RMB 0.426966 0.873239
363 AS 0.426966 0.833333
364 1RB 0.425287 0.885714
365 CA6 0.425197 0.729167
366 SOP 0.425197 0.804598
367 OXK 0.425197 0.804598
368 MCD 0.425197 0.804598
369 COK 0.425197 0.804598
370 G1R 0.424242 0.907895
371 SXZ 0.423077 0.710843
372 CC5 0.423077 0.816901
373 F2N 0.422535 0.813953
374 EO7 0.422222 0.788235
375 ANZ 0.422018 0.8
376 1VU 0.421875 0.795455
377 CMC 0.421875 0.804598
378 CO6 0.421875 0.804598
379 ZDA 0.421053 0.864865
380 GKE 0.420561 0.884615
381 GDC 0.420561 0.884615
382 GDD 0.420561 0.884615
383 NFD 0.420168 0.883117
384 GSP 0.42 0.873418
385 D3Y 0.42 0.789474
386 MC4 0.419847 0.76087
387 3D1 0.419753 0.773333
388 3L1 0.419753 0.773333
389 FA9 0.41958 0.864198
390 5GP 0.419355 0.906667
391 G 0.419355 0.906667
392 KB1 0.419048 0.698795
393 CAJ 0.418605 0.804598
394 SCD 0.418605 0.823529
395 CMP 0.417582 0.901408
396 2BA 0.417582 0.915493
397 SO8 0.416667 0.789474
398 VRT 0.416667 0.769231
399 N01 0.416667 0.905405
400 IVC 0.415385 0.813953
401 1HE 0.415385 0.786517
402 A1S 0.415385 0.804598
403 BCO 0.415385 0.804598
404 3HC 0.415385 0.813953
405 MLC 0.415385 0.804598
406 NMN AMP PO4 0.415254 0.87013
407 2FA 0.414634 0.813333
408 MGO 0.414141 0.860759
409 3NZ 0.413462 0.782051
410 COO 0.412214 0.804598
411 MCA 0.412214 0.795455
412 YE1 0.412214 0.813953
413 CAA 0.412214 0.813953
414 GAV 0.411765 0.884615
415 PRT 0.411215 0.931507
416 JLN 0.411111 0.890411
417 P2P 0.411111 0.902778
418 ZZB 0.410256 0.77381
419 SP1 0.409091 0.842105
420 RP1 0.409091 0.842105
421 2CP 0.409091 0.795455
422 SCA 0.409091 0.804598
423 103 0.409091 0.837838
424 PAX 0.408 0.829268
425 FAD NBT 0.407143 0.75
426 COW 0.406015 0.795455
427 3CP 0.406015 0.804598
428 IRC 0.406015 0.813953
429 BYC 0.406015 0.804598
430 CA8 0.406015 0.729167
431 1GZ 0.406015 0.795455
432 COF 0.406015 0.786517
433 HGG 0.406015 0.804598
434 2KQ 0.406015 0.786517
435 G2P 0.405941 0.884615
436 SLU 0.404959 0.770115
437 U A C C 0.404959 0.858974
438 RBZ 0.404494 0.849315
439 1CZ 0.404412 0.795455
440 FAQ 0.402985 0.804598
441 BCA 0.402985 0.795455
442 4CA 0.402985 0.795455
443 MTP 0.402439 0.730769
444 8OD 0.402062 0.945205
445 CO7 0.401515 0.804598
446 GRA 0.4 0.804598
447 G2R 0.4 0.884615
448 ENQ 0.4 0.916667
449 CNV FAD 0.4 0.8
450 GMV 0.4 0.896104
451 HXC 0.4 0.786517
452 HF7 0.4 0.893333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1Z6T; Ligand: ADP; Similar sites found with APoc: 703
This union binding pocket(no: 1) in the query (biounit: 1z6t.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 4XB4 45D 0.507614
2 1XKV ATP 1.13422
3 1WDT GTP 1.18443
4 5MZN ADP 1.18443
5 4WOP CTP 1.33333
6 1OYY AGS 1.33843
7 1DAK DPU 1.33929
8 1DAK ADP 1.33929
9 3RC3 ANP 1.35364
10 2ZJ5 ADP 1.35364
11 2J5V PCA 1.3624
12 1D2E GDP 1.51134
13 5LTJ BEF 1.52284
14 5LTJ ADP 1.52284
15 5H7J GCP 1.52284
16 1G7S GDP 1.52284
17 2X7I CIT 1.62338
18 1XP8 AGS 1.63934
19 3WMX THR 1.67598
20 1XMV ADP 1.68539
21 4R43 GDP 1.69205
22 4KVA GTP 1.69903
23 1W5T ANP 1.69903
24 1W5T ADP 1.69903
25 3DC4 ADP 1.74419
26 1FNN ADP 1.79949
27 4ZKD GDP 1.80361
28 3ZL8 ADP 1.83066
29 4PFO ADP 1.86125
30 1IHU ADP 1.86757
31 1IHU AF3 1.86757
32 4X8O AP5 1.86916
33 3CV2 OXL 1.8797
34 4YJ1 ADP 1.95122
35 2C9O ADP 1.97368
36 1SVK ALF GDP 1.983
37 3BER AMP 2.00803
38 1G41 ADP 2.02703
39 4IOK ADP 2.03046
40 4IOK XPO 2.03046
41 1D8C GLV 2.03046
42 1OS1 ATP 2.03704
43 1OS1 PYR 2.03704
44 3PQC GDP 2.05128
45 5Y6N ADP 2.05479
46 5HR5 ADP 2.07156
47 1Z06 GNP 2.1164
48 2NCD ADP 2.14286
49 5W7Q GDP 2.14477
50 3IIJ ADP 2.22222
51 1BH2 GSP 2.22222
52 1H65 GDP 2.22222
53 5M04 GDP 2.22222
54 2WOJ ADP ALF 2.25989
55 3ZS9 ADP ALF 2.25989
56 5H7K GDP 2.267
57 2QEN ADP 2.28571
58 3WYA GDP 2.30415
59 6CS8 F9Y 2.31023
60 4OHY ANP 2.32019
61 4TMK T5A 2.34742
62 4V0K GDP 2.36686
63 4B47 GDP 2.36887
64 2ZPA ADP 2.3845
65 1NST A3P 2.46154
66 1D5C GDP 2.46914
67 3BD9 A3P 2.5
68 5X80 SAL 2.5
69 1MKY GDP 2.50569
70 5ZB0 ADP 2.52525
71 5ZB0 TYD 2.52525
72 1P7T PYR 2.53807
73 4J0Q GDP 2.54042
74 2XTZ GSP 2.54237
75 4AG5 ADP 2.55102
76 1T8U UAP SGN IDS SGN 2.57353
77 1T8U A3P 2.57353
78 5KSZ GCP 2.59434
79 2O0J ADP 2.5974
80 4JLV ADP 2.60223
81 1OIV GDP 2.6178
82 1OIX GDP 2.6178
83 2AWN ADP 2.62467
84 1RJ9 GCP 2.63158
85 3HU3 AGS 2.65849
86 3P4X ADP 2.66344
87 3DEF GDP 2.67176
88 3FKQ ATP 2.68097
89 5HCN GCP 2.68199
90 5FHD ADP ALF 2.70728
91 4YS0 ADP 2.70728
92 5FTB ANP 2.70728
93 2XAU ADP 2.70728
94 4YMU ATP 2.72727
95 4NU0 AP5 2.76498
96 4HSE ADP 2.77078
97 3B8I OXL 2.78746
98 5H4S RAM 2.8169
99 4LX0 BEF GDP 2.82486
100 4KFU ACP 2.83019
101 3IO3 ADP 2.87356
102 2FAH GDP 2.87648
103 1KK1 GNP 2.87648
104 2OBM ADP 2.88184
105 1TQ4 GDP 2.90557
106 2RGX AP5 2.91262
107 3CX8 GSP 2.95567
108 3Q85 GNP 2.95858
109 3ITJ CIT 2.95858
110 6A20 ADP 2.97483
111 1RRC ADP 2.99003
112 1WF3 GNP 2.99003
113 3Q72 GNP 3.01205
114 6B4K ANP 3.02326
115 1G6O ADP 3.0303
116 2ZPT A3P 3.05085
117 3REF GDP 3.09278
118 3MD0 GDP 3.09859
119 5ZXD ATP 3.11355
120 1VKJ A3P 3.15789
121 1HTW ADP 3.16456
122 1V8K ANP 3.17073
123 4TMZ GSP 3.18841
124 4GOX A3P 3.19489
125 2BIF SIN 3.19829
126 2BIF ANP 3.19829
127 5I0H ADP BEF 3.21489
128 5XDR ADP 3.21489
129 1SKQ GDP 3.21839
130 2WPF WPF 3.23232
131 2WPF FAD 3.23232
132 3TMK T5A 3.24074
133 3EC1 GDP 3.25203
134 4ZNL BEF ADP 3.28467
135 1IN4 ADP 3.29341
136 5GOE GDP 3.31754
137 1JI0 ATP 3.33333
138 3T34 GDP 3.33333
139 2Z5F A3P 3.3557
140 2FNA ADP 3.36134
141 2OFW ADX 3.36538
142 5IFS ADP 3.37553
143 1YTM ATP 3.38346
144 4PJ3 ANP 3.38409
145 5TSH ADP 3.40136
146 5TSH ANP 3.40136
147 6G14 G4P 3.40136
148 4GBM A3P 3.40557
149 5GVR LMR 3.4188
150 5ZBR ANP 3.46667
151 3B7G ANP 3.47826
152 5J1J ANP 3.50877
153 1R27 MGD 3.51562
154 2CHG ANP 3.53982
155 1F5N GNP 3.5533
156 4LC1 GDP 3.56083
157 2ZTS ADP 3.58566
158 2I4I AMP 3.59712
159 5BN3 ADP 3.60577
160 4P4T GDP 3.61111
161 2WKQ GTP 3.61446
162 5WRJ A3P 3.63036
163 2B8W ALF 5GP 3.65854
164 3DKP ADP 3.67347
165 1M2O GNP 3.68421
166 1SVM ATP 3.71353
167 1CR1 TTP 3.71622
168 4LPS GDP 3.71901
169 1LVK MNT BEF 3.7225
170 2ZR9 DTP 3.72493
171 1QHG ATP 3.72928
172 6AIC AMP 3.73832
173 4Z7X 3CX 3.78151
174 3RWO GDP 3.78378
175 3TBK ANP 3.78378
176 5H68 AGS 3.82353
177 4Y4V DAL 3.83481
178 2Y65 ADP 3.83562
179 1KY3 GDP 3.84615
180 4UCI ADN 3.85542
181 1VG0 GDP 3.86473
182 1VG8 GNP 3.86473
183 2BCG GDP 3.8835
184 2GK6 ADP 3.89171
185 1P72 ADP 3.89171
186 1VHT BA3 3.89171
187 6FAA ADP 3.89171
188 4NE2 SH2 3.89222
189 4NE2 ADP 3.89222
190 5W76 GDP 3.8961
191 4IHQ ADP 3.89864
192 2PEZ DAT 3.91061
193 2PEZ GGZ 3.91061
194 4ZDJ UTP 3.91823
195 3NHB ADP 3.92157
196 3W5J GDP 3.92157
197 1J78 OLA 3.93013
198 4U5X GNP 3.93258
199 1X1R GDP 3.93258
200 1K6M AGS 3.93519
201 4LYA ATP 3.9356
202 3KJI ADP 3.93701
203 1GOJ ADP 3.94366
204 1S8F GDP 3.9548
205 2CDN ADP 3.9801
206 2HT6 GDP 4.02299
207 2GKS ADP 4.0293
208 4YLG GDP 4.04624
209 1H74 ADP 4.05405
210 4RC8 STE 4.05405
211 4ZG4 VO4 ADP 4.06091
212 5VHC BEF ADP 4.06091
213 4RD0 GDP 4.06091
214 4RZ3 ADP 4.0678
215 1FQK GDP 4.08163
216 1G3M PCQ 4.08163
217 1G3M A3P 4.08163
218 5URY PAM 4.10959
219 4DDY DN6 4.18251
220 5M7P ADP 4.18502
221 1R0X ATP 4.1958
222 2QZ4 ADP 4.19847
223 5K53 STE 4.19847
224 1E2K TMC 4.22961
225 2WHX ADP 4.23012
226 1DAR GDP 4.23012
227 5UQW GDP 4.2328
228 5OCG GNP 4.2328
229 5JCP GDP ALF 4.29594
230 1T5C ADP 4.29799
231 4OKS 2T9 4.31034
232 3ZQ6 ADP ALF 4.32099
233 1VG1 GDP 4.32432
234 1YZN GNP 4.32432
235 1VG9 GDP 4.32432
236 5DI3 GNP 4.32432
237 2ZE7 DST 4.34783
238 2ZE7 AMP 4.34783
239 2XT3 ADP 4.36047
240 2OZE AGS 4.36242
241 1JJV ATP 4.36893
242 4KBF AMP 4.38356
243 1GWN GTP 4.39024
244 3BFX A3P 4.39189
245 1GXU 2HP 4.3956
246 5WC2 ADP 4.39815
247 3H4S ADP 4.40415
248 4FRZ ADP 4.40415
249 5G3Y ADP 4.42478
250 4LJ9 ACP 4.42478
251 3VX3 ADP 4.43548
252 5NM7 GLY 4.51128
253 3T1O GDP 4.54545
254 5E5U MLI 4.54545
255 3ZFD ANP 4.5584
256 2DPY ADP 4.56621
257 5Z69 AGS 4.56989
258 2VVG ADP 4.57143
259 5L3W GDP 4.57516
260 1YRB GDP 4.58015
261 3R7F CP 4.60526
262 1S3G AP5 4.60829
263 6FA4 GNP 4.62428
264 5VGR GDP 4.64037
265 1NY5 ADP 4.65116
266 4TTQ ATP 4.65116
267 3EWA ANP 4.65839
268 5U32 GDP 4.66102
269 5WDR GNP 4.67836
270 2GWH A3P 4.69799
271 2A5J GDP 4.71204
272 1YVD GNP 4.73373
273 3RAB GNP 4.73373
274 4TL6 ANP 4.73773
275 5BQ5 ADP BEF 4.7619
276 4R2I ANP 4.7619
277 3FWY ADP 4.77707
278 1ZD9 GDP 4.78723
279 4R98 GNH 4.79705
280 2D2F ADP 4.8
281 2A9K GDP 4.81283
282 5WLB GNP 4.81928
283 4FCW ADP 4.82315
284 2F3R G5P 4.83092
285 2BME GNP 4.83871
286 4M9Q GNP 4.84582
287 4E03 ADP 4.85437
288 4URX FK1 4.86486
289 3AQ4 GDP 4.8913
290 1M7B GTP 4.8913
291 2QQ0 THM 4.8913
292 2QQ0 ANP 4.8913
293 2QQ0 ADP 4.8913
294 2QQ0 TMP 4.8913
295 4UXH T5A 4.8913
296 2IS6 ADP 4.90694
297 3BFV ADP 4.90694
298 2XZ9 PYR 4.93827
299 3FYH ADP 4.96894
300 1ZCB GDP 4.97238
301 5XKT GNP 5
302 3QKT ANP 5.01475
303 4IDN GNP 5.03282
304 4MKF AP5 5.06912
305 4MKG AP5 5.06912
306 2EFE GNH 5.07614
307 5EP2 AZU 5.07812
308 4DKX GDP 5.09259
309 5K5Z ANP 5.09554
310 5XC5 GTP 5.11364
311 1UAD GNP 5.14286
312 3T12 GDP ALF 5.14706
313 3COB ADP 5.14905
314 5LB3 ADP 5.16854
315 1Z0A GDP 5.17241
316 4WZ6 ATP 5.17241
317 2HJ4 PNZ 5.18518
318 1FP6 ADP 5.19031
319 1M7G ADX 5.21327
320 1M7G ADP 5.21327
321 1M7G AV2 5.21327
322 1XX6 ADP 5.2356
323 2YOH WMJ 5.2381
324 4QOS ADP 5.28302
325 5KUT GDP 5.29101
326 4GOJ GNP 5.29101
327 1R2Q GNP 5.29412
328 1Z08 GNP 5.29412
329 1W7J ADP BEF 5.29801
330 4D81 ADP 5.30035
331 1BZL GCG 5.34979
332 1U8Z GDP 5.35714
333 3MJH GTP 5.35714
334 3VPB ADP 5.35714
335 2G77 GDP 5.36585
336 2VB6 ADP BEF 5.36913
337 3Q9L ATP 5.38462
338 6D5J GNP 5.38922
339 6D59 GNP 5.38922
340 6D55 GNP 5.38922
341 6BVM GNP 5.38922
342 6D5L GNP 5.38922
343 6BVI GNP 5.38922
344 6BVJ GNP 5.38922
345 6D5V GNP 5.38922
346 6D56 GNP 5.38922
347 6BVL GNP 5.38922
348 6BVK GNP 5.38922
349 6D5E GNP 5.38922
350 6D5G GNP 5.38922
351 6D5H GNP 5.38922
352 6D5M GNP 5.38922
353 5KDO GDP 5.40541
354 1X6V ADP 5.41455
355 4A4Z ANP 5.41455
356 1CLU DBG 5.42169
357 1WQ1 GDP 5.42169
358 1O3Y GTP 5.42169
359 1WQ1 AF3 5.42169
360 1NVV GNP 5.42169
361 4PPF FLC 5.42857
362 4WZA ADP 5.43478
363 4WZA ACP 5.43478
364 1AKY AP5 5.45455
365 5OEC GDP 5.46448
366 1RE0 GDP 5.4878
367 1FZQ GDP 5.52486
368 5O74 GDP 5.55556
369 1UJ2 ADP 5.55556
370 1UJ2 C5P 5.55556
371 6AU6 GDP 5.57029
372 4NON GDP 5.58376
373 1T9D P22 5.613
374 6B8B ADP 5.62249
375 3SAO DBH 5.625
376 4XGU ADP 5.66038
377 1OXV ANP 5.66572
378 2ODE ALF GDP 5.67376
379 5CK5 GDP 5.6962
380 3NKV GNP 5.71429
381 2A5F GTP 5.71429
382 2ZFI ADP 5.7377
383 3B5J 12D 5.76132
384 1ION ADP 5.76132
385 2JAQ DCP 5.85366
386 5O2T GSP 5.88235
387 2BVE PH5 5.88235
388 1G3Q ADP 5.90717
389 4KAX GTP 5.91716
390 2O66 FLC 5.92593
391 1QF5 RPL 6.03248
392 1QF5 GDP 6.03248
393 2GDJ ANP 6.06061
394 3TK1 GDP 6.09137
395 1R6B ADP 6.09137
396 5FG3 GDP 6.09137
397 4YDS ATP 6.14035
398 2Y8E GNP 6.14525
399 3A4M ADP 6.15385
400 1SVI GDP 6.15385
401 3N5C GDP 6.17284
402 1TAD GDP 6.17284
403 1TAD ALF 6.17284
404 4DCT GDP 6.26058
405 2CHT TSA 6.29921
406 2FZH DH1 6.31068
407 3U6B GDP 6.34518
408 5JBQ GDP 6.34518
409 4P3Y GDP 6.34518
410 4G5G GDP 6.34518
411 4PC3 GDP 6.34518
412 3U6K GDP 6.34518
413 1D8T GDP 6.36132
414 2BVN GNP 6.36132
415 2VOH CIT 6.36943
416 1S9D GDP 6.40394
417 1UKZ ADP 6.40394
418 1B7T ADP 6.41026
419 2FFQ GSP 6.43275
420 2W58 ADP 6.43564
421 3QVV A3P 6.44068
422 3QVV 3QV 6.44068
423 1G16 GDP 6.47059
424 1YZQ GNP 6.47059
425 1SQ5 ADP 6.49351
426 1KK8 BEF ADP 6.49351
427 1YQT ADP 6.50558
428 5Z2M GTP 6.52174
429 5YV5 ADP 6.52985
430 5JCZ GDP 6.54912
431 2PZE ATP 6.55022
432 1WA5 GTP 6.59898
433 2BEK ATP 6.61479
434 2C77 GNP 6.66667
435 2C78 GNP 6.66667
436 1QF9 ADP 6.70103
437 1QF9 C5P 6.70103
438 1QF9 ALF 6.70103
439 1Z0F GDP 6.70391
440 3WXM GTP 6.71141
441 3DDC GNP 6.74847
442 3RLF ANP 6.80934
443 3VMF GTP 6.81818
444 4PX9 ADP 6.84932
445 4BFW ZVW 6.91824
446 2EW1 GNP 6.96517
447 3A1S GDP 6.97674
448 2IXE ATP 7.01107
449 4H1V GNP 7.04607
450 2JLR ANP 7.09534
451 1CS4 GSP 7.11111
452 5E95 GDP 7.2165
453 4WEI GLC GAL 7.22022
454 1L2T ATP 7.23404
455 5IRN ADP 7.2758
456 5X40 ACP 7.2758
457 2FSH ANP 7.2758
458 1BG2 ADP 7.38462
459 5AVF TAU 7.393
460 3BOS CDP 7.43802
461 2HCJ GDP 7.46269
462 1OFH ADP 7.47126
463 5UIV ADP 7.48899
464 4Q1A UDP 7.5
465 4Q1A 2XZ 7.5
466 4ZI2 GNP 7.5188
467 1Q19 SSC 7.55467
468 3LRE ADP 7.60563
469 3DZD ADP 7.6087
470 2ORV 4TA 7.69231
471 3AB3 GDP 7.72358
472 1G6H ADP 7.7821
473 3FVQ ATP 7.79944
474 1PUJ GNP 7.80142
475 2RCN GDP 7.82123
476 3PCR GTP 7.84314
477 1RYH GNP 7.88177
478 5AK0 8V1 7.88462
479 4HI0 GDP 8.0402
480 3CPJ GDP 8.07175
481 4QRH 0O2 8.09524
482 5IRR GSP 8.11688
483 2GJ8 ALF GDP 8.13953
484 6DEF GCP 8.18414
485 4NCN GTP 8.3151
486 1E96 GTP 8.33333
487 5LLB 6YZ 8.36502
488 1YZG GDP 8.37989
489 2FH5 GTP 8.41121
490 3AB4 THR 8.42697
491 2CBZ ATP 8.43882
492 1JJ7 ADP 8.46154
493 2J0V GDP 8.49057
494 4BQS K2Q 8.52273
495 4BQS ADP 8.52273
496 4BAS GNP 8.54271
497 3SBD GNP 8.55615
498 1ZJ6 G3D 8.55615
499 1LVG ADP 8.58586
500 1MH1 GNP 8.60215
501 1KSH GDP 8.60215
502 3KUD GDP 8.64198
503 5TB5 GDP 8.66667
504 4UTG ANP 8.67052
505 1Z83 AP5 8.67347
506 1G4U GDP 8.69565
507 5TAR GDP 8.78378
508 1NJF ADP 8.8
509 1NJF AGS 8.8
510 1D2N ANP 8.82353
511 2CJW GDP 8.85417
512 1I4D GDP 8.92857
513 5MLJ 9ST 8.92857
514 2GCO GNP 8.95522
515 2GCN GDP 8.95522
516 2FJU GSP 8.98876
517 3UIE ANP 9
518 5L3V GDP 9.0301
519 5L3S GNP 9.0604
520 5L3S G 9.0604
521 1HE1 GDP 9.09091
522 1OE0 TTP 9.13043
523 1W4R TTP 9.23077
524 5MVR ADP 9.25926
525 5UWH GNP 9.2827
526 5DHF GNP 9.2827
527 5UWO GNP 9.2827
528 5UWT GNP 9.2827
529 5UWU GNP 9.2827
530 6CIT GNP 9.2827
531 5DIF GNP 9.2827
532 5UWP GNP 9.2827
533 5UWS GNP 9.2827
534 5DI9 GNP 9.2827
535 5UWQ GNP 9.2827
536 5UWI GNP 9.2827
537 5UWJ GNP 9.2827
538 5UWR GNP 9.2827
539 5UWW GNP 9.2827
540 1NN5 2DT 9.30233
541 1NN5 ANP 9.30233
542 2PL3 ADP 9.32203
543 1OW3 GDP 9.32642
544 4U00 ADP 9.42623
545 4HDO GNP 9.58084
546 3X1Z GNP 9.58084
547 4HDQ GNP 9.58084
548 5IRC GDP 9.67742
549 3FB4 AP5 9.72222
550 5HPY GDP 9.72973
551 6BCB GSP 9.72973
552 4D0N GDP 9.72973
553 3LXR GDP 9.72973
554 6BCA GSP 9.72973
555 3E70 GDP 9.7561
556 1KMQ GNP 9.78261
557 1CXZ GSP 9.89011
558 5YT0 GDP 9.89011
559 3H86 AP5 9.89583
560 4QM7 GTP 9.94152
561 3SFV GDP 9.94475
562 3GJ7 GDP 9.95475
563 3GJ0 GDP 9.95475
564 4XOI GTP 10
565 2D7D ADP 10
566 2X77 GDP 10.0529
567 1F9V ADP 10.0865
568 3IUY AMP 10.0877
569 4KVG GTP 10.119
570 1ZUI SKM 10.119
571 1ZIN AP5 10.1382
572 1U0J ADP 10.1523
573 1TX4 ALF GDP 10.1695
574 1GUA GNP 10.1796
575 4HAT GNP 10.1852
576 1IBR GNP 10.1852
577 3GJX GTP 10.1852
578 3CNL GNP 10.3053
579 3DOE GTP 10.4167
580 1MR3 G3D 10.4972
581 1NRJ GTP 10.5505
582 3EZ2 ADP 10.5528
583 2Q2Y ADP 10.6267
584 2Q2Y MKR 10.6267
585 1KAO GDP 10.7784
586 1KO8 6PG 10.8571
587 5J1S ATP 10.9155
588 2HF9 GSP 11.0619
589 1F6B GDP 11.1111
590 5EXT ADP 11.1538
591 2WJG GDP 11.1702
592 2W2X GSP 11.2903
593 2CK3 ADP 11.3971
594 1W0J ADP BEF 11.3971
595 2V7Q ADP 11.3971
596 2CK3 ANP 11.3971
597 1W0J ADP 11.3971
598 2V7Q ATP 11.3971
599 1F2U ATP 11.4094
600 2XTN GTP 11.5385
601 3CH5 GDP 11.5385
602 5WRI A3P 11.5625
603 4D0G GTP 11.5942
604 1EK0 GNP 11.7647
605 3B9Q MLI 11.9205
606 5L3R GCP 11.9454
607 1DS6 GDP 11.9792
608 2GMV UN8 12.16
609 1NHX PEP 12.16
610 1NHX FTB 12.16
611 2GMV PEP 12.16
612 4JX1 CAH 12.3894
613 2UZI GTP 12.5
614 2F9L GDP 12.5628
615 3K0T BGC 12.5874
616 5BXQ GDP 12.5984
617 4LHW GNP 12.6437
618 3QBT GNP 12.6437
619 3TNF GNP 12.6437
620 2WJH GDP 12.6506
621 2WJH FLC 12.6506
622 6BC0 GSP 12.6667
623 5W75 SUC 12.7551
624 5W75 GDP 12.7551
625 1NF3 GNP 13.3333
626 5G41 AP5 13.4529
627 6C90 ADP 13.4615
628 4IEE AGS 13.4694
629 4DID GDP 13.4715
630 4K81 GTP 13.5659
631 2ZEJ GDP 13.587
632 2NGR GDP 13.6126
633 1GRN GDP 13.6126
634 1A4R GNH 13.6126
635 1A4R GDP 13.6126
636 4ITR GDP 13.6126
637 2WMO GTP 13.6842
638 1B0U ATP 13.7405
639 5H67 ATP 13.75
640 2KIN ADP 13.8655
641 3NOJ PYR 13.8655
642 4V03 ADP 14.0078
643 2QG6 NMN 14.0704
644 6CRK GDP 14.0845
645 1GP2 GDP 14.0845
646 1ZC3 GNP 14.1593
647 2OG2 MLI 14.2061
648 4YC7 GNP 14.3646
649 3M1I GTP 14.6119
650 3WYF GTP 14.6119
651 1LFD GNP 14.9425
652 5N69 ADP 15.0754
653 4XTR ATP 15.2174
654 4XVU ATP 15.2174
655 4XTR ADP 15.2174
656 1Y63 ADP 15.2174
657 1Z0J GTP 15.2542
658 5KSP GDP 15.2632
659 3QXC ATP 15.2893
660 2W83 GTP 15.5844
661 5SZH GNP 15.7635
662 2J59 GTP 16.0714
663 3E5H GNP 16.2921
664 2QTV GNP 16.3265
665 3T5G GDP 16.5746
666 5KK4 44E 16.6667
667 3TKL GTP 16.8367
668 6BSX GDP 16.8539
669 6BSX E7S 16.8539
670 2HV8 GTP 17.1875
671 1UPT GTP 17.5439
672 1TU3 GNP 17.7215
673 1Z2A GDP 17.8571
674 3GJ4 GDP 18.1818
675 3GJ3 GDP 18.1818
676 3WYG GTP 18.4211
677 2C5L GTP 18.8034
678 2WIC GNP 19.1011
679 5EE5 GTP 19.2982
680 3GJ8 GDP 19.5652
681 4OI4 ATP 19.8675
682 3GJ5 GDP 20.5882
683 1R4A GNP 21.2121
684 4XSH GSP 21.4612
685 2QN6 GDP 21.5054
686 3WY9 GDP 21.875
687 2OM2 GDP 22.2222
688 5UPK GNP 22.9167
689 4CVN ADP 23.5602
690 1Z0K GTP 24.6377
691 3BC1 GNP 25.4237
692 1QHH ATP 26.087
693 2D7C GTP 26.1905
694 1FQJ GDP 26.1905
695 4C4P GNP 27.1028
696 1G7C 5GP 27.6596
697 3QF7 ANP 28
698 1Y3A GDP 31.25
699 1GOT GDP 32.8767
700 3ZIA ADP 34.4262
701 3ZIA ATP 34.4262
702 1J2J GTP 42.2222
703 5LEF GTP 42.4242
Pocket No.: 2; Query (leader) PDB : 1Z6T; Ligand: ADP; Similar sites found with APoc: 19
This union binding pocket(no: 2) in the query (biounit: 1z6t.bio3) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 3N2O AG2 1.69205
2 4KVL PLM 1.86125
3 1VBH PEP 2.19966
4 4B5W PYR 3.125
5 2ALG DAO 3.26087
6 1AQU A3P 3.367
7 3L6C MLI 3.83481
8 2WCU FUC 4.02685
9 4A34 FUL 4.08163
10 1NXJ TLA 4.37158
11 1RGE 2GP 5.20833
12 6AC9 ANP 5.67568
13 2XOC ADE 6.89655
14 5XCZ GLC BGC 6.98324
15 5V8E CIT 8.09062
16 2ZX2 RAM 8.20513
17 2VWT PYR 10.8614
18 2CB8 MYA 13.7931
19 4NTO 1PW 16.9082
Pocket No.: 3; Query (leader) PDB : 1Z6T; Ligand: ADP; Similar sites found with APoc: 4
This union binding pocket(no: 3) in the query (biounit: 1z6t.bio2) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 1X8J A3P 2.849
2 4D42 NAP 5.31915
3 4D42 W0I 5.31915
4 4AF5 CIT 17.8947
Pocket No.: 4; Query (leader) PDB : 1Z6T; Ligand: ADP; Similar sites found with APoc: 10
This union binding pocket(no: 4) in the query (biounit: 1z6t.bio4) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 1KC7 PPR 1.18443
2 4JD3 COA 1.69972
3 4JD3 PLM 1.69972
4 3MGB PAP 4.38871
5 4WBD ADP 4.62107
6 5OSW DIU 4.63122
7 1KZL CRM 4.80769
8 5A89 FMN 5.76923
9 5A89 ADP 5.76923
10 1HE1 AF3 9.09091
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