Receptor
PDB id Resolution Class Description Source Keywords
1Z0K 1.92 Å NON-ENZYME: TRANSPORT STRUCTURE OF GTP-BOUND RAB4Q67L GTPASE IN COMPLEX WITH THE CENTRAL RAB BINDING DOMAIN OF RABENOSYN-5 HOMO SAPIENS RAB GTPASES RAB4 RABENOSYN EFFECTOR COMPLEX VESICULAR TRAFFICKING PROTEIN TRANSPORT
Ref.: STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASE RECOGNITION BY RABENOSYN-5. NATURE V. 436 415 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GTP A:1200;
C:2200;
Valid;
Valid;
none;
none;
submit data
523.18 C10 H16 N5 O14 P3 c1nc2...
MES D:1001;
Invalid;
none;
submit data
195.237 C6 H13 N O4 S C1COC...
MG A:1201;
C:2201;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Z0K 1.92 Å NON-ENZYME: TRANSPORT STRUCTURE OF GTP-BOUND RAB4Q67L GTPASE IN COMPLEX WITH THE CENTRAL RAB BINDING DOMAIN OF RABENOSYN-5 HOMO SAPIENS RAB GTPASES RAB4 RABENOSYN EFFECTOR COMPLEX VESICULAR TRAFFICKING PROTEIN TRANSPORT
Ref.: STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASE RECOGNITION BY RABENOSYN-5. NATURE V. 436 415 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1Z0K - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 175 families.
1 1Z0K - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 149 families.
1 1Z0K - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GTP; Similar ligands found: 156
No: Ligand ECFP6 Tc MDL keys Tc
1 GTP 1 1
2 GP3 0.921053 0.973684
3 GDP 0.909091 1
4 GSP 0.853659 0.948718
5 GNH 0.82716 0.986667
6 G1R 0.819277 0.986667
7 GAV 0.811765 0.961039
8 9GM 0.809524 0.973684
9 GNP 0.809524 0.973684
10 GCP 0.797619 0.973684
11 5GP 0.797468 0.986486
12 G 0.797468 0.986486
13 GMV 0.764706 0.973684
14 G2R 0.764045 0.961039
15 G5P 0.755319 0.973684
16 GTG 0.752688 0.936709
17 G2P 0.747126 0.961039
18 G3A 0.744681 0.973684
19 GDD 0.741935 0.961039
20 GDC 0.741935 0.961039
21 GKE 0.741935 0.961039
22 0O2 0.736264 0.986486
23 GP2 0.729412 0.961039
24 6CK 0.726316 0.936709
25 Y9Z 0.723404 0.902439
26 GPG 0.717391 0.961039
27 GFB 0.715789 0.961039
28 GDR 0.715789 0.961039
29 GPD 0.704082 0.925
30 GKD 0.693878 0.961039
31 JB2 0.693878 0.961039
32 GDX 0.686869 0.973684
33 ALF 5GP 0.685393 0.888889
34 GH3 0.681319 0.973333
35 YGP 0.677083 0.901235
36 G3D 0.67033 0.986486
37 GDP AF3 0.659574 0.888889
38 ALF GDP 0.659574 0.888889
39 GDP ALF 0.659574 0.888889
40 DGT 0.659341 0.923077
41 GMP 0.658228 0.88
42 G4P 0.655914 0.986486
43 JB3 0.653846 0.948718
44 NGD 0.647619 0.961039
45 CAG 0.642202 0.880952
46 2MD 0.62963 0.891566
47 MGP 0.619565 0.961039
48 U2G 0.616822 0.936709
49 6G0 0.612903 0.961039
50 MGD 0.612613 0.891566
51 TPG 0.608696 0.840909
52 CG2 0.605505 0.936709
53 GDP 7MG 0.601942 0.911392
54 FEG 0.601852 0.879518
55 G G 0.598039 0.948052
56 ZGP 0.59633 0.869048
57 PGD 0.591304 0.925
58 MD1 0.591304 0.891566
59 3GP 0.590909 0.946667
60 GPX 0.581633 0.946667
61 DGI 0.580645 0.923077
62 IDP 0.576087 0.972973
63 DBG 0.567797 0.948718
64 2GP 0.555556 0.96
65 FE9 0.555556 0.776596
66 G4M 0.547619 0.880952
67 BGO 0.544643 0.924051
68 GCP G 0.543689 0.921053
69 ATP 0.537634 0.92
70 HEJ 0.537634 0.92
71 G1G 0.533898 0.925
72 AQP 0.531915 0.92
73 5FA 0.531915 0.92
74 A G 0.525862 0.935065
75 G A A A 0.525862 0.923077
76 U A G G 0.521368 0.935065
77 HFD 0.520833 0.873418
78 R5I 0.520408 0.946667
79 R7I 0.520408 0.946667
80 01G 0.518868 0.902439
81 P2G 0.510638 0.883117
82 ITT 0.510638 0.868421
83 AKW 0.504348 0.890244
84 GGM 0.504274 0.901235
85 G1R G1R 0.504065 0.924051
86 DGP 0.5 0.910256
87 PGD O 0.5 0.850575
88 MGO 0.5 0.864198
89 DG 0.5 0.910256
90 P1G 0.5 0.871795
91 GTA 0.495495 0.936709
92 PRT 0.490741 0.959459
93 B4P 0.489362 0.894737
94 AP5 0.489362 0.894737
95 IMP 0.489362 0.959459
96 G U 0.487179 0.9
97 7DT 0.484536 0.906667
98 GPC 0.479339 0.879518
99 G C 0.478992 0.9
100 BA3 0.478723 0.894737
101 ADP 0.473684 0.92
102 G2Q 0.471698 0.961039
103 6YZ 0.470588 0.896104
104 G7M 0.46875 0.948052
105 C1Z 0.462963 0.986486
106 25L 0.458716 0.907895
107 A2D 0.457447 0.894737
108 RGT 0.45045 0.909091
109 AGS 0.45 0.873418
110 SAP 0.45 0.873418
111 SGP 0.44898 0.82716
112 A4P 0.445378 0.869048
113 G G G RPC 0.442623 0.875
114 ANP 0.441176 0.896104
115 ACQ 0.441176 0.896104
116 8GT 0.441176 0.875
117 APC G U 0.44 0.886076
118 AT4 0.438776 0.884615
119 G U34 0.438017 0.888889
120 6AD 0.436893 0.841463
121 G G G C 0.433071 0.9125
122 UP5 0.432203 0.873418
123 PCG 0.431373 0.933333
124 C2E 0.431373 0.921053
125 35G 0.431373 0.933333
126 A G C C 0.429688 0.911392
127 T99 0.427184 0.884615
128 5GP 5GP 0.427184 0.883117
129 TAT 0.427184 0.884615
130 AR6 0.425743 0.894737
131 APR 0.425743 0.894737
132 7DD 0.424242 0.906667
133 AN2 0.424242 0.907895
134 DG DG 0.423423 0.865854
135 AD9 0.421569 0.896104
136 M33 0.42 0.883117
137 7D4 0.42 0.835443
138 UCG 0.419847 0.911392
139 HDV 0.419048 0.825
140 H6Y 0.419048 0.946667
141 G C C C 0.416667 0.924051
142 ACP 0.415842 0.896104
143 T5A 0.414634 0.802326
144 A1R 0.412844 0.839506
145 ADQ 0.412844 0.871795
146 MGQ 0.412844 0.935897
147 A3R 0.412844 0.839506
148 MGT 0.411215 0.823529
149 A G U 0.410072 0.888889
150 93A 0.41 0.833333
151 A22 0.407407 0.907895
152 CA0 0.405941 0.896104
153 ATF 0.40566 0.884615
154 AGO 0.404762 0.888889
155 MGV 0.401786 0.890244
156 CGP 0.4 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1Z0K; Ligand: GTP; Similar sites found with APoc: 86
This union binding pocket(no: 1) in the query (biounit: 1z0k.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 1GOJ ADP 1.74419
2 2QN6 GDP 7.24638
3 4RD0 GDP 7.24638
4 2C77 GNP 7.24638
5 2C78 GNP 7.24638
6 5W75 GDP 7.24638
7 4DCT GDP 7.55814
8 5W7Q GDP 8.69565
9 3EC1 GDP 8.69565
10 3U6B GDP 8.72093
11 4P3Y GDP 8.72093
12 2BVN GNP 8.72093
13 3U6K GDP 8.72093
14 1YRB GDP 13.0435
15 5KUT GDP 13.9535
16 3WY9 GDP 14.4928
17 1SKQ GDP 14.4928
18 5CK5 GDP 15.942
19 5W76 GDP 15.942
20 3VMF GTP 18.8406
21 1WDT GTP 18.8406
22 3WXM GTP 20.2899
23 1UPT GTP 21.0526
24 4J0Q GDP 25
25 1KK1 GNP 25
26 4TMZ GSP 29.0698
27 5FG3 GDP 30.2326
28 3CX8 GSP 30.814
29 2A5F GTP 31.3953
30 3PCR GTP 32.0988
31 4KAX GTP 32.5444
32 4NCN GTP 32.5581
33 2J59 GTP 33.1325
34 2W83 GTP 33.3333
35 4LC1 GDP 33.3333
36 3N5C GDP 33.3333
37 5DI3 GNP 33.7209
38 4M9Q GNP 33.7209
39 5YT0 GDP 34.3023
40 4BAS GNP 34.8837
41 2FH5 GTP 36.6279
42 4U5X GNP 36.6279
43 5EE5 GTP 39.1813
44 4ZI2 GNP 39.5349
45 4GOJ GNP 39.5349
46 1FZQ GDP 39.779
47 3REF GDP 40.6977
48 1KSH GDP 41.2791
49 3DOE GTP 41.8605
50 4YC7 GNP 43.0233
51 1A4R GNH 43.6047
52 1A4R GDP 43.6047
53 5UPK GNP 43.6047
54 1GRN GDP 43.6047
55 2WMO GTP 43.6047
56 1NF3 GNP 44.186
57 1M7B GTP 44.7674
58 1GWN GTP 44.7674
59 2HT6 GDP 45.3488
60 5IRC GDP 45.3488
61 3Q72 GNP 45.7831
62 4XSH GSP 45.9302
63 5JCP GDP ALF 45.9302
64 1TX4 ALF GDP 45.9302
65 5HPY GDP 45.9302
66 1I4D GDP 46.5116
67 2J0V GDP 46.5116
68 6BCB GSP 46.5116
69 6BCA GSP 46.5116
70 4D0N GDP 46.5116
71 1KMQ GNP 46.5116
72 1CXZ GSP 46.5116
73 4XOI GTP 46.5116
74 3LXR GDP 46.5116
75 2W2X GSP 46.5116
76 3SBD GNP 46.5116
77 6BC0 GSP 46.5116
78 1MH1 GNP 47.093
79 1E96 GTP 47.093
80 2FJU GSP 47.093
81 5UQW GDP 47.093
82 2GCO GNP 47.6744
83 2GCN GDP 47.6744
84 5TB5 GDP 48.1081
85 5TAR GDP 48.1081
86 2WKQ GTP 48.2558
87 3E5H GNP 50
Pocket No.: 2; Query (leader) PDB : 1Z0K; Ligand: GTP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1z0k.bio2) has 24 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback