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Receptor
PDB id Resolution Class Description Source Keywords
1YUC 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BO PHOSPHOLIPID AND A FRAGMENT OF HUMAN SHP HOMO SAPIENS LIVER RECEPTOR HOMOLOGUE 1; NUCLEAR RECEPTOR LIGAND BINDING LRH-1; PHOSPHOLIPID; SHP; SMALL HETERODIMER PARTNER TRANSCREGULATION
Ref.: MODULATION OF HUMAN NUCLEAR RECEPTOR LRH-1 ACTIVITY PHOSPHOLIPIDS AND SHP NAT.STRUCT.MOL.BIOL. V. 12 357 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EPH A:1001;
B:1002;
Valid;
Valid;
none;
none;
submit data
709.933 C39 H68 N O8 P CCCC=...
GOL A:5001;
B:5002;
B:5003;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YUC 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BO PHOSPHOLIPID AND A FRAGMENT OF HUMAN SHP HOMO SAPIENS LIVER RECEPTOR HOMOLOGUE 1; NUCLEAR RECEPTOR LIGAND BINDING LRH-1; PHOSPHOLIPID; SHP; SMALL HETERODIMER PARTNER TRANSCREGULATION
Ref.: MODULATION OF HUMAN NUCLEAR RECEPTOR LRH-1 ACTIVITY PHOSPHOLIPIDS AND SHP NAT.STRUCT.MOL.BIOL. V. 12 357 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 1YUC - EPH C39 H68 N O8 P CCCC=CCC=C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 1YUC - EPH C39 H68 N O8 P CCCC=CCC=C....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1YUC - EPH C39 H68 N O8 P CCCC=CCC=C....
2 1YMT - DR9 C40 H75 O10 P CCCCCCCCC=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: EPH; Similar ligands found: 77
No: Ligand ECFP6 Tc MDL keys Tc
1 EPH 1 1
2 GP7 0.847059 1
3 L9Q 0.752941 1
4 LOP 0.752941 1
5 6OU 0.752941 1
6 PEK 0.741573 1
7 ZPE 0.715909 1
8 PSC 0.673684 0.79661
9 8PE 0.647059 0.980769
10 PEV 0.647059 0.980769
11 PTY 0.647059 0.980769
12 PEH 0.647059 0.980769
13 PEF 0.647059 0.980769
14 9PE 0.639535 0.980769
15 PCW 0.634409 0.79661
16 P50 0.610526 0.924528
17 D3D 0.595745 0.830189
18 PGW 0.595745 0.830189
19 PGV 0.589474 0.830189
20 DR9 0.589474 0.830189
21 P6L 0.583333 0.830189
22 DLP 0.58 0.728814
23 OZ2 0.57732 0.830189
24 D21 0.566667 0.792453
25 T7X 0.563107 0.711864
26 B7N 0.555556 0.711864
27 PLD 0.537634 0.779661
28 HGX 0.537634 0.779661
29 PC7 0.537634 0.779661
30 HGP 0.537634 0.779661
31 6PL 0.537634 0.779661
32 LIO 0.537634 0.779661
33 PEE 0.532609 0.962264
34 POV 0.53 0.728814
35 L9R 0.53 0.728814
36 PIE 0.519608 0.666667
37 XP5 0.516129 0.779661
38 CD4 0.51087 0.807692
39 P5S 0.505263 0.888889
40 P3A 0.504854 0.796296
41 LHG 0.5 0.811321
42 PGT 0.5 0.811321
43 PCK 0.480769 0.741935
44 CN3 0.47 0.807692
45 6PH 0.466667 0.773585
46 LPP 0.466667 0.773585
47 3PH 0.466667 0.773585
48 F57 0.466667 0.773585
49 7PH 0.466667 0.773585
50 PII 0.464646 0.694915
51 3PE 0.463918 0.867925
52 PSF 0.463158 0.888889
53 PX8 0.461538 0.754717
54 7P9 0.461538 0.773585
55 PX2 0.461538 0.754717
56 44G 0.457447 0.811321
57 PIZ 0.451923 0.694915
58 42H 0.45098 0.830508
59 CN6 0.45 0.807692
60 PGK 0.447619 0.767857
61 PD7 0.444444 0.773585
62 CDL 0.443299 0.735849
63 IP9 0.442308 0.694915
64 MC3 0.44 0.711864
65 PC1 0.44 0.711864
66 PCF 0.44 0.711864
67 DGG 0.435185 0.767857
68 PIF 0.427184 0.683333
69 S12 0.427184 0.888889
70 M7U 0.424242 0.773585
71 44E 0.422222 0.773585
72 8ND 0.419355 0.716981
73 PDK 0.418803 0.819672
74 NKP 0.416667 0.792453
75 52N 0.415094 0.683333
76 PIO 0.415094 0.683333
77 AGA 0.401961 0.777778
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: 276
This union binding pocket(no: 1) in the query (biounit: 1yuc.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 2WOR 2AN None
2 4V1F BQ1 None
3 5NNT DPV None
4 3AQT RCO None
5 5KAU RHQ None
6 4DOL PLM None
7 4RYV ZEA None
8 4RJD TFP None
9 1SBR VIB None
10 3QIN P1Y None
11 2RKN LP3 None
12 4QGE 35O 1.56863
13 3W54 RNB 1.56863
14 4K55 H6P 1.6129
15 4G86 BNT 1.96078
16 3X01 AMP 1.96078
17 3KO0 TFP 1.9802
18 5CHR 4NC 2.18978
19 1DQE BOM 2.18978
20 2HHP FLC 2.35294
21 1ZED PNP 2.35294
22 3LXI CAM 2.35294
23 1ON3 DXX 2.35294
24 1TV5 N8E 2.35294
25 1Z41 FMN 2.35294
26 1ZPD CIT 2.35294
27 1J78 OLA 2.35294
28 3W5N RAM 2.35294
29 1J1R ADE 2.35294
30 4IA6 EIC 2.35294
31 5G57 6M5 2.35294
32 2BHW NEX 2.58621
33 2BHW XAT 2.58621
34 5UC4 83S 2.72727
35 3O01 DXC 2.7451
36 2BP1 FLC 2.7451
37 3ZQE DXC 2.7451
38 1ZGA HMK 2.7451
39 3HSS MLA 2.7451
40 5KLP IHP 2.7451
41 5Z3I ADE 2.7451
42 4Y9J UCC 2.7451
43 5HCN DAO 2.7451
44 1I0B PEL 2.7451
45 1YKD CMP 2.7451
46 2PX6 DH9 2.7451
47 6BMM OLB 2.7451
48 2Q1A 2KT 2.7451
49 1XZ3 ICF 2.87356
50 4DOO DAO 2.92683
51 4WKI 3PW 2.97872
52 3KYQ DPV 3.01508
53 1FX8 BOG 3.13725
54 1XMY ROL 3.13725
55 2UW1 GVM 3.13725
56 1FCH TYR GLN SER LYS LEU 3.13725
57 2PNC CLU 3.13725
58 4NV0 MG7 3.13725
59 6CGN DA 3.13725
60 4EIL FOL 3.13725
61 4O4Z N2O 3.24675
62 3RV5 DXC 3.37079
63 3A76 SPD 3.40909
64 4WGF HX2 3.41463
65 5UGW GSH 3.42857
66 5OKL PAM 3.52941
67 3HYW DCQ 3.52941
68 1GVE CIT 3.52941
69 2HFK E4H 3.52941
70 5OLK DTP 3.52941
71 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 3.52941
72 1UDY CS8 3.52941
73 3HP9 CF1 3.52941
74 3F3E LEU 3.52941
75 5AZC PGT 3.52941
76 5UC9 MYR 3.53982
77 1ZEI CRS 3.77358
78 3JRS A8S 3.84615
79 5M37 9SZ 3.91304
80 6A0S NDP 3.92157
81 3ETG GWD 3.92157
82 5KOD IAC 3.92157
83 2RH1 CLR 3.92157
84 5IUY BOG 3.92157
85 3G58 988 3.92157
86 4X8D AVI 3.92157
87 3UNG ADP 3.92157
88 5K53 STE 3.92157
89 3AI3 SOL 3.92157
90 3G4G D71 3.92157
91 2RH1 CAU 3.92157
92 3TKY N7I 3.92157
93 2O5L MNR 3.92157
94 3KDJ A8S 3.9604
95 1QFT HSM 4
96 1RL4 BL5 4.25532
97 3ZUY TCH 4.31373
98 3LGG CFE 4.31373
99 2XXP DSL 4.31373
100 5XJ7 87O 4.47761
101 1HBK MYR 4.49438
102 3B99 U51 4.70588
103 4MRP GSH 4.70588
104 5OSW DIU 4.70588
105 4O08 PO6 4.70588
106 5A4W QCT 4.71698
107 1P6O HPY 4.96894
108 2HZL PYR 5.09804
109 5B25 4QJ 5.09804
110 6BE0 IHP 5.09804
111 5CX6 CDP 5.09804
112 2D09 FLV 5.09804
113 5MOB A8S 5.17241
114 4RC8 STE 5.40541
115 4DS8 A8S 5.4902
116 6H8S FSZ 5.4902
117 5OCA 9QZ 5.55556
118 5MWE TCE 5.71429
119 4ZGM 32M 5.7377
120 3BRE C2E 5.88235
121 4OKD GLC GLC GLC 5.88235
122 3R9V DXC 5.88235
123 3RLF MAL 5.88235
124 3BJC WAN 5.88235
125 6BR8 6OU 5.95238
126 6BR8 PGV 5.95238
127 5V4R MGT 6.17284
128 5LX9 OLB 6.27451
129 6MVU K4V 6.27451
130 4DXJ 0M9 6.27451
131 6D28 NEC 6.27451
132 5ZQ4 AMP 6.27451
133 2XMY CDK 6.27451
134 4NTO 1PW 6.28019
135 4OIC A8S 6.28019
136 2GBB CIT 6.41026
137 5C9J DAO 6.66667
138 4URX FK1 6.66667
139 3EYK EYK 6.97674
140 4DE3 DN8 7.05882
141 5W3Y IHP 7.05882
142 5CQG 55C 7.05882
143 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 7.11297
144 4RHP PEF 7.23404
145 3GQT UFO 7.45098
146 2PSJ CEI 7.45098
147 5Y02 MXN 7.47664
148 5Y02 HBX 7.47664
149 4WCX MET 7.84314
150 3WUR O4B 8.18713
151 4XCP PLM 8.23529
152 2GWH PCI 8.23529
153 1T9D 1MM 8.23529
154 5WKC PXD 8.23529
155 2BCG GER 8.25243
156 2XN5 FUN 8.62745
157 2JFN UMA 8.62745
158 4DD8 BAT 8.65385
159 5N8V KZZ 8.69565
160 5N26 CPT 8.79121
161 1KUK PCA LYS TRP 8.86699
162 6BVK EAV 8.98204
163 6BVM EBV 8.98204
164 6D5H FV7 8.98204
165 5KD8 TNR 9.01961
166 2CB8 MYA 9.1954
167 3TDC 0EU 9.41177
168 1XVB 3BR 9.41177
169 3BZ3 YAM 9.41177
170 2NNQ T4B 9.92366
171 4INW 1EY 10
172 4V2O CLQ 10.9756
173 5IM3 DTP 10.9804
174 6CB2 OLC 11.3725
175 6BR9 PGV 11.7647
176 2YLD CMO 11.811
177 3VVY ET 11.8557
178 3N7S 3N7 12.5
179 3SAO DBH 12.5
180 3WFD AXO 12.549
181 2D5X L35 13.0137
182 1NF8 BOG 13.0435
183 1AUA BOG 13.3333
184 6FBA D48 13.7255
185 5C1M OLC 14.4
186 5C1M CLR 14.4
187 5LWY OLB 14.9533
188 3RUG DB6 15.1515
189 6GMN F4E 15.3846
190 6EOP F15 16.0784
191 5W7B MYR 16.3121
192 3RMK BML 16.8675
193 1DTL BEP 17.3913
194 3TL1 JRO 17.6101
195 3WBG 2AN 19.6078
196 4AIG FLX 19.9005
197 1YC4 43P 20
198 5TVI MYR 20.6522
199 5TVI O8N 20.6522
200 5M36 9SZ 21.0526
201 3RY9 1CA 21.2
202 4E2J MOF 21.6
203 2Y69 CHD 21.6495
204 3GN8 DEX 21.6867
205 2VWA PTY 21.7822
206 5HZ9 5M8 22.2222
207 3BQD DAY 22.3529
208 5XNA SHV 22.4638
209 4P6X HCY 23.5294
210 4P6W MOF 23.8095
211 5Z84 CHD 24.7059
212 5W97 CHD 24.7059
213 5ZCO CHD 24.7059
214 3KDU NKS 25.098
215 3SP6 IL2 25.098
216 3ET1 ET1 25.098
217 4OGQ UMQ 26.4706
218 4OGQ 7PH 26.4706
219 2HFP NSI 27.0588
220 3FUR Z12 27.0588
221 1M2Z BOG 27.8431
222 1M2Z DEX 27.8431
223 4LSJ LSJ 28.2353
224 5G5W R8C 29.0196
225 1NHZ 486 29.0196
226 5NTW 98N 29.4118
227 1SR7 MOF 29.8039
228 4OAR 2S0 29.8039
229 5APK 76E 30.1961
230 6ESN BWE 30.1961
231 5NTP 98E 31.0924
232 5IXK 6EW 31.5789
233 2AX9 BHM 31.7647
234 3V49 PK0 31.7647
235 3RET PYR 32.6733
236 3RET SAL 32.6733
237 4DK7 0KS 32.7935
238 3KFC 61X 33.5968
239 4S15 4D8 33.7255
240 5UC1 486 34.2342
241 3IPQ 965 34.902
242 1M13 HYF 34.902
243 5E7V M7E 35.2941
244 5LGA 6VH 35.2941
245 3KMR EQN 36.8627
246 3KMZ EQO 36.8627
247 3VRV YSD 37.6471
248 5K13 6Q7 38.2114
249 2I0G I0G 38.8235
250 1YYE 196 38.8235
251 5WGD EST 40
252 5DXE EST 40
253 5DX3 EST 40
254 5DXG EST 40
255 4MGD 27N 40
256 4MG9 27K 40
257 4MG7 27H 40
258 4TUZ 36J 40
259 4MG8 27J 40
260 4MGB XDH 40
261 5WGQ EST 40
262 4MGA 27L 40
263 5HYR EST 40
264 5ICK FEZ 40.1747
265 3UUD EST 40.6375
266 3UU7 2OH 40.6375
267 3UUA 0CZ 40.6375
268 4TV1 36M 40.6375
269 3OLL EST 41.6667
270 1BRW URA 42.8571
271 2R40 EPH 44.3137
272 4DM8 REA 45.4902
273 1U3R 338 48.1328
274 4J24 EST 48.3333
275 2YJD YJD 48.3333
276 4J26 EST 48.3333
277 2Q1H AS4 50
Pocket No.: 2; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: 89
This union binding pocket(no: 2) in the query (biounit: 1yuc.bio2) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 4KPM BEN None
2 4U0S ADP 0.784314
3 5V3Y 5V8 1.96078
4 4RQL SNE 1.96078
5 3GXO MQA 1.96078
6 4RW3 PLM 2.35294
7 4RW3 SHV 2.35294
8 1MRH FMC 2.35294
9 6B04 C6J 2.35294
10 1Z42 FMN 2.35294
11 4FE3 U5P 2.35294
12 1EWF PC1 2.7451
13 2FDW D3G 2.7451
14 4Y9J FAD 2.7451
15 5MIL DUP 2.9703
16 5BVT PAM 2.98507
17 5KBE IPH 3.05677
18 2YIV YIV 3.13725
19 2CIX CEJ 3.13725
20 2QES ADE 3.13725
21 1XM4 PIL 3.13725
22 1VJ7 GPX 3.13725
23 3B6C SDN 3.4188
24 4F06 PHB 3.52941
25 4X6F 3XU 3.80952
26 4JZX 476 3.92157
27 4JZB P2H 3.92157
28 3E70 GDP 3.92157
29 4LOC OXM 3.92157
30 1JX6 AI2 3.92157
31 5WL1 D3D 4.0404
32 5WL1 CUY 4.0404
33 3D78 NBB 4.20168
34 5A5D 5LC 4.31373
35 3NJQ NJQ 4.66321
36 5OSW AE4 4.70588
37 1A05 IPM 5.09804
38 6C0B PAM 5.09804
39 1QVJ RP5 5.09804
40 5JO1 6LM 5.4902
41 3BMQ AX5 5.4902
42 3IX9 MTX 5.78947
43 2OZ5 7XY 5.88235
44 1KPG 16A 5.88235
45 5CX8 RP3 6.27451
46 1MID LAP 6.59341
47 5C9J STE 6.66667
48 4I90 CHT 6.66667
49 2JC9 ADN 7.02703
50 6DIO CIT 7.05882
51 3L9R L9R 7.14286
52 3L9R L9Q 7.14286
53 2VDY HCY 7.45098
54 4XNV BUR 7.45098
55 1IXE CIT 7.45098
56 4YMU ARG 7.5
57 3KU0 ADE 7.56972
58 4F4S EFO 7.89474
59 2XEM SSV 8
60 4V3I ASP LEU THR ARG PRO 8.23529
61 4AIA ADK 8.51064
62 2VVM PRO 8.62745
63 2XN3 ID8 8.62745
64 6BVI EC4 8.98204
65 2IDO TMP 9.63855
66 2NW9 FT6 9.80392
67 5A07 GDP 9.80392
68 3NB0 G6P 10.5882
69 3NMV PYV 11.236
70 3G08 FEE 15.1515
71 3SCM LGN 15.9184
72 3PMD 11A 16.9935
73 3HF3 FMN 17.6471
74 5ZCO PEK 24.7059
75 1K7L 544 25.098
76 2NPA MMB 25.098
77 2P54 735 25.098
78 3FEI CTM 25.098
79 2PRG BRL 27.0588
80 3G9E RO7 27.0588
81 5TWO 7MV 27.0588
82 6FX0 E9T 33.7255
83 5A86 D7E 34.902
84 4Q0A 4OA 35.2941
85 3L0E G58 36.3636
86 3BEJ MUF 38.6555
87 3DCT 064 39.1489
88 3RUU 37G 40.1747
89 4OIV XX9 41.1504
Pocket No.: 3; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: 27
This union binding pocket(no: 3) in the query (biounit: 1yuc.bio4) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 3IS2 FAD 1.2987
2 3Q8G PEE 1.56863
3 5LI9 ACP 1.96078
4 1XQP 8HG 1.96078
5 4EKQ NPO 2.6738
6 1XMU ROF 3.13725
7 4DO1 ANN 3.13725
8 2OWZ CIT 3.52941
9 4MNS 2AX 3.77358
10 2CHT TSA 3.93701
11 4ARE FLC 4.31373
12 5J32 IPM 4.31373
13 5FQ0 FLC 4.38596
14 2QCX PF1 4.56274
15 2E7F C2F 4.70588
16 2GJ3 FAD 5
17 1R55 097 6.07477
18 2VOT NHV 6.27451
19 3ROE THM 6.79245
20 6BVJ EAS 7.18563
21 5DMZ ADP 7.84314
22 3QPB URA 8.23529
23 6D59 FVJ 8.98204
24 1U25 IHS 10.9804
25 2ZO9 MLI 11.7647
26 4I4S LAT 14.3836
27 4OGQ 1O2 26.4706
Pocket No.: 4; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: 35
This union binding pocket(no: 4) in the query (biounit: 1yuc.bio4) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 1N8V BDD None
2 4B52 RDF 1.56863
3 1DGH NDP 2.35294
4 4ETZ C2E 2.35294
5 6EYT NDG 2.35294
6 6BMS PLM 2.7451
7 5OM2 DXT 2.7451
8 1QW9 KHP 2.7451
9 4OB6 S2T 2.7451
10 6C1R EFD 2.7451
11 1ND4 KAN 2.7451
12 5UR6 8KM 2.76243
13 1DMH MCT 3.13725
14 2C3Q GTX 3.23887
15 5VRH OLB 3.52941
16 2X3J ATP 3.92157
17 5VOP C2F 3.92157
18 5EE7 5MV 4.31373
19 5K52 OCD 4.70588
20 4WVO 3UZ 5.4902
21 5EW9 5VC 5.88235
22 4KCF FMN 5.88235
23 5M8T 0TR 7.45098
24 3VMG 9CA 7.82609
25 6CS8 F9Y 7.84314
26 4D1J DGJ 8.23529
27 2Q8G AZX 8.62745
28 6D5V FVY 8.98204
29 6D5M FW4 8.98204
30 8CAT NDP 9.41177
31 4LA7 A1O 10.3627
32 5JNN 6LM 10.5263
33 4YSX E23 15.4255
34 5JM8 ATP 18.0392
35 1H0A I3P 18.9873
Pocket No.: 5; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1yuc.bio3) has 26 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1YUC; Ligand: EPH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 1yuc.bio3) has 28 residues
No: Leader PDB Ligand Sequence Similarity
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