Receptor
PDB id Resolution Class Description Source Keywords
1YIM 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPL COMPOUND 4 HOMO SAPIENS NUCLEAR RECEPTOR TRANSCRIPTION FACTOR ER-ALPHA ANTAGONISTHORMONE-GROWTH FACTOR RECEPTOR COMPLEX
Ref.: ESTROGEN RECEPTOR LIGANDS. PART 10: CHROMANES: OLD FOR NEW SERAMS. BIOORG.MED.CHEM.LETT. V. 15 1675 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CM4 A:600;
Valid;
none;
ic50 = 1.5 nM
445.55 C28 H31 N O4 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2QE4 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A BENZOPYRAN AGONIST HOMO SAPIENS NUCLEAR RECEPTOR LIGAND-BINDING DOMAIN ALTERNATIVE SPLICING DNA-BINDING LIPID-BINDING METAL-BINDING NUCLEAR PROTEIN PHOSPHORYLATION POLYMORPHISM STEROID- BINDING TRANSCRIPTION TRANSCRIPTION REGULATION ZINC ZINC-FINGER
Ref.: BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR BETA AGONISTS (SERBAS). PART 4: FUNCTIONALIZATION OF THE BENZOPYRAN A-RING. BIOORG.MED.CHEM.LETT. V. 17 5082 2007
Members (50)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
2 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
3 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
4 5FQT ic50 = 160 nM 7QN C23 H27 N O3 Cc1c(ccc2c....
5 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
6 5FQV ic50 = 610 nM VQI C23 H27 N O3 Cc1cc2c(cc....
7 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
8 5FQR ic50 = 26 nM QHG C22 H25 N O3 CC(C)CN1CC....
9 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
10 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
11 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
12 5U2B - 6WV C24 H29 N O C[C@]12CC[....
13 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
14 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
15 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
16 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
17 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
18 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
19 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
20 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
21 5AK2 ic50 = 0.0039 uM 85Z C26 H19 F O5 Cc1cc(ccc1....
22 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
23 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
24 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
25 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
26 5TN9 - 7EC C31 H32 Br N O6 S c1cc(ccc1C....
27 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
28 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
29 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
30 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
31 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
32 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
33 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
34 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
35 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
36 5TNB - 7EB C28 H28 Br N O6 S CN(C)CCOc1....
37 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
38 5T92 ic50 = 16 nM 77W C25 H22 F N O3 C[C@]1(c2c....
39 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
40 5AAU ic50 = 13.8 uM XBR C20 H19 Cl N2 O2 c1ccc2c(c1....
41 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
42 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
43 5FQP ic50 = 19 nM GQD C23 H27 N O3 C[C@@H]1Cc....
44 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
45 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
46 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
47 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
48 5FQS ic50 = 44 nM J0W C23 H27 N O3 CC(C)CN1CC....
49 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
50 5ACC ic50 = 0.676 nM KE9 C25 H25 F3 N2 O2 C[C@@H]1Cc....
70% Homology Family (62)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
2 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
3 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
4 5FQT ic50 = 160 nM 7QN C23 H27 N O3 Cc1c(ccc2c....
5 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
6 5FQV ic50 = 610 nM VQI C23 H27 N O3 Cc1cc2c(cc....
7 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
8 5FQR ic50 = 26 nM QHG C22 H25 N O3 CC(C)CN1CC....
9 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
10 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
11 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
12 5U2B - 6WV C24 H29 N O C[C@]12CC[....
13 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
14 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
15 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
16 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
17 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
18 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
19 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
20 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
21 5AK2 ic50 = 0.0039 uM 85Z C26 H19 F O5 Cc1cc(ccc1....
22 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
23 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
24 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
25 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
26 5TN9 - 7EC C31 H32 Br N O6 S c1cc(ccc1C....
27 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
28 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
29 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
30 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
31 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
32 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
33 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
34 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
35 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
36 5TNB - 7EB C28 H28 Br N O6 S CN(C)CCOc1....
37 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
38 5T92 ic50 = 16 nM 77W C25 H22 F N O3 C[C@]1(c2c....
39 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
40 5AAU ic50 = 13.8 uM XBR C20 H19 Cl N2 O2 c1ccc2c(c1....
41 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
42 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
43 5FQP ic50 = 19 nM GQD C23 H27 N O3 C[C@@H]1Cc....
44 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
45 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
46 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
47 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
48 5FQS ic50 = 44 nM J0W C23 H27 N O3 CC(C)CN1CC....
49 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
50 5ACC ic50 = 0.676 nM KE9 C25 H25 F3 N2 O2 C[C@@H]1Cc....
51 2JJ3 Kd = 0.281 uM JJ3 C20 H22 O4 COCc1cc(cc....
52 2Z4B Ki = 0.44 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
53 5TOA - EST C18 H24 O2 C[C@]12CC[....
54 1QKM - GEN C15 H10 O5 c1cc(ccc1C....
55 2GIU ic50 = 1.5 nM FBR C17 H19 Br O2 CCCC[C@@]1....
56 1QKN - RAL C28 H27 N O4 S c1cc(ccc1c....
57 1U9E ic50 = 5.7 nM 397 C14 H10 O3 c1cc(ccc1c....
58 1U3Q ic50 = 3.5 nM 272 C13 H9 N O4 c1cc2c(cc1....
59 2I0G Ki = 0.19 nM I0G C18 H18 O3 c1cc(ccc1[....
60 1HJ1 - PMB C6 H5 Hg O3 S c1cc(ccc1S....
61 2FSZ - OHT C26 H29 N O2 CC/C(=C(c1....
62 2NV7 ic50 = 5 nM 555 C17 H13 N O2 c1ccc2c(c1....
50% Homology Family (77)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 3ERT - OHT C26 H29 N O2 CC/C(=C(c1....
2 1YIM ic50 = 1.5 nM CM4 C28 H31 N O4 C[C@@H]1c2....
3 1XP6 ic50 = 0.4 nM AIU C28 H31 N O4 S C[C@@H]1CN....
4 5FQT ic50 = 160 nM 7QN C23 H27 N O3 Cc1c(ccc2c....
5 4IW6 - 1GU C18 H15 F3 N2 O2 C=CCCn1c(c....
6 5FQV ic50 = 610 nM VQI C23 H27 N O3 Cc1cc2c(cc....
7 4IW8 - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
8 5FQR ic50 = 26 nM QHG C22 H25 N O3 CC(C)CN1CC....
9 2IOG ic50 = 8 nM IOG C33 H39 N3 O3 C[C@H](CCc....
10 1GWQ Kd = 76 nM LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
11 4IVW - 1GJ C21 H15 F3 N2 O2 c1ccc(cc1)....
12 5U2B - 6WV C24 H29 N O C[C@]12CC[....
13 4IUI - 1GQ C18 H17 F3 N2 O2 CCCCn1c2c(....
14 1XQC ic50 = 63 nM AEJ C29 H33 N3 O c1ccc(cc1)....
15 1UOM ic50 = 19 nM PTI C28 H32 N2 O2 c1ccc(cc1)....
16 1XP1 ic50 = 0.5 nM AIH C28 H31 N O4 S C[C@H]1CN(....
17 2QXS - RAL C28 H27 N O4 S c1cc(ccc1c....
18 2Q70 Ki = 8.3 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
19 2R6W Ki = 0.44 nM LLB C29 H29 N O4 S CC1CCN(CC1....
20 2QE4 Ki = 0.28 nM JJ3 C20 H22 O4 COCc1cc(cc....
21 5AK2 ic50 = 0.0039 uM 85Z C26 H19 F O5 Cc1cc(ccc1....
22 1XP9 ic50 = 1.3 nM AIJ C27 H29 N O4 S C[C@@H](CO....
23 4IV4 - 1GS C18 H17 F3 N2 O2 CC(C)Cn1c(....
24 2IOK ic50 = 1 nM IOK C26 H26 N2 O2 C[C@H](CCc....
25 3OSA - KN3 C19 H17 F3 N2 O2 CC(=CCn1c2....
26 5TN9 - 7EC C31 H32 Br N O6 S c1cc(ccc1C....
27 3UUC - 0D1 C14 H10 Cl2 O2 c1cc(ccc1C....
28 1GWR Kd = 250 nM ASN ALA LEU LEU ARG TYR LEU LEU ASP n/a n/a
29 4PP6 - LYS ILE LEU HIS ARG LEU LEU GLN ASP n/a n/a
30 2OUZ - C3D C28 H31 N O2 c1ccc(cc1)....
31 3OS9 - KN1 C17 H13 F3 N2 O2 C=CCn1c2c(....
32 1XPC ic50 = 1.7 nM AIT C27 H29 N O4 S C[C@H](COc....
33 2R6Y Ki = 0.32 nM LLC C27 H25 N O4 S c1cc(ccc1c....
34 4IU7 - 1GM C16 H13 F3 N2 O2 CCn1c(c2cc....
35 2POG Ki = 0.29 nM WST C18 H18 O3 c1cc(c2c(c....
36 5TNB - 7EB C28 H28 Br N O6 S CN(C)CCOc1....
37 1SJ0 ic50 = 0.8 nM E4D C27 H29 N O4 S c1cc(ccc1[....
38 5T92 ic50 = 16 nM 77W C25 H22 F N O3 C[C@]1(c2c....
39 3DT3 - 369 C23 H18 O4 Cc1cc2cc(c....
40 5AAU ic50 = 13.8 uM XBR C20 H19 Cl N2 O2 c1ccc2c(c1....
41 4IV2 - 1GR C18 H17 F3 N2 O2 CC(C)Cn1c2....
42 4IWC - 1GV C18 H16 O2 S Cc1cc(ccc1....
43 5FQP ic50 = 19 nM GQD C23 H27 N O3 C[C@@H]1Cc....
44 1YIN ic50 = 1.4 nM CM3 C29 H32 F N O4 C[C@@H]1c2....
45 4IVY - 1GT C18 H15 F3 N2 O2 C=CCCn1c2c....
46 2AYR Ki = 0.52 nM L4G C30 H31 N O5 S CS(=O)(=O)....
47 4IWF - 15Q C13 H9 Cl F N O3 c1cc(c(cc1....
48 5FQS ic50 = 44 nM J0W C23 H27 N O3 CC(C)CN1CC....
49 1QKT Kd = 0.92 nM EST C18 H24 O2 C[C@]12CC[....
50 5ACC ic50 = 0.676 nM KE9 C25 H25 F3 N2 O2 C[C@@H]1Cc....
51 1G5Y - REA C20 H28 O2 CC1=C(C(CC....
52 3PCU - LX8 C21 H24 O5 CC(=O)OC(C....
53 1FBY Kd = 1.5 nM REA C20 H28 O2 CC1=C(C(CC....
54 4N5G ic50 = 14.5 uM K09 C23 H23 F N4 CC1=C(c2cc....
55 2PJL ic50 = 190 nM 047 C23 H28 N2 Cc1ccc(cc1....
56 2JJ3 Kd = 0.281 uM JJ3 C20 H22 O4 COCc1cc(cc....
57 2Z4B Ki = 0.44 nM DC8 C18 H16 F2 O3 c1cc(ccc1[....
58 5TOA - EST C18 H24 O2 C[C@]12CC[....
59 1QKM - GEN C15 H10 O5 c1cc(ccc1C....
60 2GIU ic50 = 1.5 nM FBR C17 H19 Br O2 CCCC[C@@]1....
61 1QKN - RAL C28 H27 N O4 S c1cc(ccc1c....
62 1U9E ic50 = 5.7 nM 397 C14 H10 O3 c1cc(ccc1c....
63 1U3Q ic50 = 3.5 nM 272 C13 H9 N O4 c1cc2c(cc1....
64 2I0G Ki = 0.19 nM I0G C18 H18 O3 c1cc(ccc1[....
65 1HJ1 - PMB C6 H5 Hg O3 S c1cc(ccc1S....
66 2FSZ - OHT C26 H29 N O2 CC/C(=C(c1....
67 2NV7 ic50 = 5 nM 555 C17 H13 N O2 c1ccc2c(c1....
68 3FS1 - MYR C14 H28 O2 CCCCCCCCCC....
69 2ZAS ic50 = 13.9 nM 1OH C15 H16 O CC(C)(c1cc....
70 2EWP ic50 = 0.079 uM TXF C27 H31 N O3 CN(C)CCOc1....
71 1S9P - DES C18 H20 O2 CC/C(=C(/C....
72 2E2R Kd = 5.5 nM 2OH C15 H16 O2 CC(C)(c1cc....
73 2P7Z Kd = 0.262 uM OHT C26 H29 N O2 CC/C(=C(c1....
74 2GPU - OHT C26 H29 N O2 CC/C(=C(c1....
75 2P7A Kd = 0.788 uM 43M C7 H7 Cl O Cc1cc(ccc1....
76 2P7G Kd = 0.297 uM 2OH C15 H16 O2 CC(C)(c1cc....
77 1S9Q - OHT C26 H29 N O2 CC/C(=C(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: CM4; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 CM4 1 1
2 CM3 0.610526 0.87037
3 E4D 0.525773 0.851852
4 AIH 0.460784 0.827586
5 AIU 0.460784 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2QE4; Ligand: JJ3; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2qe4.bio1) has 55 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2QE4; Ligand: JJ3; Similar sites found: 165
This union binding pocket(no: 2) in the query (biounit: 2qe4.bio1) has 60 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1L0I PSR 0.01512 0.44565 None
2 5V4R MGT 0.0224 0.44198 None
3 4XPL ACO 0.006928 0.4386 None
4 3RET SAL 0.01494 0.42898 None
5 3RET PYR 0.01494 0.42898 None
6 1DTL BEP 0.02515 0.42077 None
7 4UA3 COA 0.02288 0.40731 None
8 4XBT 3ZQ 0.04943 0.40524 None
9 5KO1 6UY 0.01497 0.42547 1.20968
10 3L1N PLM 0.03483 0.42439 1.54639
11 3EHH ADP 0.03953 0.4174 1.83486
12 1J78 OLA 0.004745 0.46738 2.41935
13 4V3I ASP LEU THR ARG PRO 0.02739 0.43605 2.41935
14 2WDA L42 0.02813 0.43433 2.41935
15 5LB3 ADP 0.03278 0.42191 2.41935
16 2CNT COA 0.01247 0.40633 2.5
17 2GBB CIT 0.04309 0.41913 2.5641
18 4H07 IPH 0.01165 0.40062 2.5974
19 4NSQ COA 0.02732 0.40927 2.63158
20 1RL4 BL5 0.007119 0.44027 2.65957
21 4DOL PLM 0.01183 0.4272 2.76498
22 5LX9 OLB 0.002476 0.46885 2.82258
23 2OBM ADP 0.02492 0.43435 2.82258
24 2WH8 II2 0.04894 0.41224 2.82258
25 3SHZ 5CO 0.04793 0.40924 2.82258
26 3RDE OYP 0.01752 0.40733 2.82258
27 5K53 STE 0.03098 0.40103 2.82258
28 4NB5 2JT 0.002726 0.4546 2.92398
29 3KO0 TFP 0.009717 0.44383 2.9703
30 1CM0 COA 0.04563 0.40396 2.97619
31 3IA4 MTX 0.002421 0.46934 3.08642
32 3OTH CLJ 0.03675 0.40012 3.22581
33 4WQ2 3SU 0.04106 0.40048 3.46821
34 1SBR VIB 0.00583 0.46802 3.5
35 3HP9 CF1 0.01348 0.45431 3.62903
36 4PPF FLC 0.01499 0.44233 3.62903
37 4WZ6 ATP 0.0354 0.42619 3.62903
38 4MRP GSH 0.03023 0.42607 3.62903
39 3LL5 IP8 0.03448 0.42511 3.62903
40 4DHY S41 0.01352 0.40727 3.62903
41 1EWF PC1 0.003378 0.40065 3.62903
42 3AQT RCO 0.01251 0.44645 3.67347
43 2C1P FNZ 0.04319 0.4117 3.68664
44 5E5U MLI 0.01138 0.46275 4.0201
45 5T96 79J 0.04007 0.41988 4.03226
46 2FDW D3G 0.04625 0.41361 4.03226
47 3B6C SDN 0.001399 0.50264 4.2735
48 5KOD IAC 0.005023 0.48431 4.43548
49 4ZXF 4S7 0.007083 0.43141 4.43548
50 4Y7E BMA BMA BMA 0.01637 0.41919 4.43548
51 3MAN BMA BMA MAN 0.034 0.41553 4.43548
52 4QC6 30N 0.0235 0.4015 4.46927
53 4QVX 3CQ 0.01546 0.41254 4.79042
54 3G4Q MCH 0.01644 0.43047 4.79452
55 3R9V DXC 0.0258 0.43304 4.83871
56 1YC4 43P 0.03507 0.41316 4.83871
57 2ZPA ACO 0.01691 0.40804 4.83871
58 4AVB ACO 0.01715 0.40271 4.83871
59 1DQE BOM 0.02515 0.40535 5.10949
60 5HCN DAO 0.01427 0.44625 5.24194
61 4BNU 9KQ 0.004367 0.43482 5.24194
62 3HW5 AMP 0.03875 0.42351 5.64516
63 1XMY ROL 0.0439 0.41487 5.64516
64 1XMU ROF 0.04454 0.40451 5.64516
65 3VVY ET 0.01023 0.41005 5.6701
66 4WGF HX2 0.03763 0.40744 5.85366
67 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.003398 0.40865 6.12245
68 3N7S 3N7 0.006978 0.47024 6.25
69 5UGW GSH 0.002159 0.48255 6.28571
70 2QJY UQ2 0.04802 0.41645 6.41711
71 2WPX ACO 0.01917 0.41385 6.45161
72 1W2D ADP 0.0416 0.41259 6.45161
73 4EIL FOL 0.03209 0.41189 6.45161
74 4ELG 52J 0.007465 0.42137 6.62651
75 4AG9 COA 0.003127 0.4728 6.66667
76 3I6B KDO 0.02355 0.434 6.66667
77 3IX9 MTX 0.02424 0.41184 6.84211
78 1JJ7 ADP 0.03133 0.42425 6.85484
79 3TDC 0EU 0.000008112 0.65326 7.25806
80 3OGN 3OG 0.02114 0.41792 7.25806
81 5B25 4QJ 0.04348 0.40207 7.25806
82 1TV5 N8E 0.00002263 0.61576 7.66129
83 1OW4 2AN 0.03651 0.41223 7.75194
84 4R38 RBF 0.02268 0.40749 7.85714
85 2RH1 CAU 0.007557 0.43675 8.06452
86 4KVL PLM 0.01533 0.40999 8.06452
87 5HTX ADP 0.0474 0.4095 8.06452
88 2PRG BRL 0.00004443 0.5458 8.87097
89 2HFP NSI 0.001658 0.45053 8.87097
90 3FUR Z12 0.00003381 0.4334 8.87097
91 4YSX E23 0.02281 0.43479 8.97436
92 5OCA 9QZ 0.0006265 0.54146 9.52381
93 5K52 OCD 0.01213 0.41743 9.67742
94 2VWA PTY 0.004434 0.47742 9.90099
95 4EJ1 FOL 0.01894 0.42033 10.4478
96 4INW 1EY 0.03691 0.40279 10.7143
97 1XPJ TLA 0.009117 0.48428 11.1111
98 5APK 76E 0.0006829 0.4543 11.2903
99 5APJ 76E 0.003866 0.42034 11.2903
100 5IXK 6EW 0.006893 0.43196 12.2807
101 4ZOM 4Q3 0.0000002023 0.53536 12.4444
102 3PXP MYR 0.01606 0.41756 12.9032
103 3SP6 IL2 0.00001973 0.55717 13.3065
104 3FEI CTM 0.0002564 0.48664 13.3065
105 2NPA MMB 0.0004196 0.48498 13.3065
106 1K7L 544 0.0002667 0.47833 13.3065
107 2P54 735 0.003029 0.43288 13.3065
108 3KDU NKS 0.000631 0.40014 13.3065
109 5CHR 4NC 0.02329 0.4262 15.3285
110 3UP3 XCA 0.00353 0.43589 16.0494
111 5CX6 CDP 0.04886 0.41741 16.5323
112 5N8V KZZ 0.04345 0.41512 17.3913
113 4HBM 0Y7 0.02316 0.41282 18.3333
114 4I67 G G G RPC 0.0008186 0.50377 18.3908
115 5LWY OLB 0.009728 0.43852 18.6916
116 3JZB 4HY 0.0007372 0.45292 20.9677
117 2XCM ADP 0.04882 0.40243 21.6216
118 4OAS 2SW 0.0213 0.42107 22.9167
119 1N46 PFA 0.001838 0.44223 22.9839
120 3BEJ MUF 0.0001583 0.50016 25.2101
121 3W54 RNB 0.01429 0.42316 27.0161
122 2AX9 BHM 0.000000000301 0.65057 31.4516
123 3V49 PK0 0.00000001773 0.45357 31.4516
124 5HCV 60R 0.000000003229 0.72956 33.0645
125 2A3I C0R 0.000000003826 0.71757 33.0645
126 4S15 4D8 0.008716 0.4241 33.0645
127 5TWO 7MV 0.00005798 0.52958 33.3333
128 4UDB CV7 0.000000005801 0.68615 33.4677
129 5L7G 6QE 0.0000000003741 0.47281 33.4677
130 2R40 EPH 0.00002778 0.51225 36.1217
131 2R40 20E 0.0009735 0.45741 36.1217
132 4DK7 0KS 0.0002172 0.50726 36.4372
133 3OKI OKI 0.0009371 0.42041 38.1974
134 3DCT 064 0.0001834 0.48915 38.2979
135 5LGA 6VH 0.00006497 0.47619 38.3064
136 4Q0A 4OA 0.001908 0.46203 38.3064
137 3L0E G58 0.0001392 0.48672 38.7097
138 3RUU 37G 0.0003949 0.46422 39.3013
139 5ICK FEZ 0.003333 0.45041 39.3013
140 3KMR EQN 0.00001797 0.55912 39.9194
141 3KMZ EQO 0.00002494 0.51834 39.9194
142 4OIV XX9 0.001075 0.42049 40.2655
143 5K13 6Q7 0.00006229 0.52321 40.6504
144 4P6X HCY 0.0000001328 0.41132 41.129
145 3RY9 1CA 0.000000008837 0.72662 41.5323
146 4P6W MOF 0.0000003725 0.61929 41.9355
147 1RDT L79 0.0000005676 0.62403 42.1488
148 1RDT 570 0.0002108 0.4865 42.1488
149 3FAL LO2 0.00003234 0.40386 42.1488
150 1M2Z DEX 0.00000009426 0.66069 42.3387
151 5G5W R8C 0.000000024 0.64608 42.3387
152 1M2Z BOG 0.01126 0.46021 42.3387
153 3BQD DAY 0.00000002401 0.43516 42.3387
154 1NHZ 486 0.0004075 0.41599 42.3387
155 4LSJ LSJ 0.00000001396 0.43693 42.7419
156 2Q1H AS4 0.000000001933 0.74923 43.5484
157 5UFS 1TA 0.00000001857 0.67832 43.5484
158 3GN8 DEX 0.00000004048 0.67794 43.5484
159 4E2J MOF 0.00000003389 0.66647 43.5484
160 3H0A 9RA 0.0000004342 0.40456 43.8596
161 1SR7 MOF 0.000000006903 0.49092 44.7581
162 4OAR 2S0 0.000000003465 0.44777 44.7581
163 5NTW 98N 0.003522 0.4195 45
164 2O4J VD4 0.002439 0.43404 47.9839
165 3VRV YSD 0.0003124 0.41033 47.9839
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