-->
Receptor
PDB id Resolution Class Description Source Keywords
1US4 1.75 Å NON-ENZYME: SIGNAL_HORMONE PUTATIVE GLUR0 LIGAND BINDING CORE WITH L-GLUTAMATE THERMUS THERMOPHILUS RECEPTOR MEMBRANE PROTEIN GLUTAMATE RECEPTOR GLUR0 L-GLURIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI STRUGENOMICS
Ref.: STRUCTURE OF THE THERMUS THERMOPHILUS PUTATIVE PERI GLUTAMATE/GLUTAMINE-BINDING PROTEIN ACTA CRYSTALLOGR.,SECT.D V. 60 1846 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1314;
Invalid;
none;
submit data
62.068 C2 H6 O2 C(CO)...
GLU A:1313;
Valid;
none;
submit data
147.129 C5 H9 N O4 C(CC(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1US5 1.5 Å NON-ENZYME: SIGNAL_HORMONE PUTATIVE GLUR0 LIGAND BINDING CORE WITH L-GLUTAMATE THERMUS THERMOPHILUS RECEPTOR MEMBRANE PROTEIN GLUTAMATE RECEPTOR GLUR0 L-GLUTAMATE RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI STRUCTURAL GENOMICS
Ref.: STRUCTURE OF THE THERMUS THERMOPHILUS PUTATIVE PERIPLASMIC GLUTAMATE/GLUTAMINE-BINDING PROTEIN ACTA CRYSTALLOGR.,SECT.D V. 60 1846 2004
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1US5 - GLU C5 H9 N O4 C(CC(=O)O)....
2 1US4 - GLU C5 H9 N O4 C(CC(=O)O)....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1US5 - GLU C5 H9 N O4 C(CC(=O)O)....
2 1US4 - GLU C5 H9 N O4 C(CC(=O)O)....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1US5 - GLU C5 H9 N O4 C(CC(=O)O)....
2 1US4 - GLU C5 H9 N O4 C(CC(=O)O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLU; Similar ligands found: 53
No: Ligand ECFP6 Tc MDL keys Tc
1 GGL 1 1
2 GLU 1 1
3 DGL 1 1
4 DGN 0.62963 0.821429
5 GLN 0.62963 0.821429
6 ONL 0.586207 0.821429
7 UN1 0.566667 0.96
8 11C 0.566667 0.96
9 HCS 0.555556 0.714286
10 NPI 0.53125 0.923077
11 HGA 0.53125 0.666667
12 HSE 0.518519 0.758621
13 DAB 0.518519 0.666667
14 MEQ 0.515152 0.71875
15 3O3 0.513514 0.727273
16 NVA 0.5 0.740741
17 API 0.5 0.884615
18 DAS 0.481481 0.846154
19 ASP 0.481481 0.846154
20 TNA 0.463415 0.685714
21 DBB 0.461538 0.692308
22 ABA 0.461538 0.692308
23 DSN 0.461538 0.655172
24 SER 0.461538 0.655172
25 RGP 0.459459 0.648649
26 ORN 0.451613 0.689655
27 HOZ 0.451613 0.666667
28 AE5 0.447368 0.727273
29 DCY 0.444444 0.642857
30 C2N 0.444444 0.666667
31 CYS 0.444444 0.642857
32 NLE 0.4375 0.689655
33 2HG 0.433333 0.653846
34 S2G 0.433333 0.653846
35 ASN 0.428571 0.677419
36 26P 0.428571 0.857143
37 3GC 0.425 0.705882
38 DLY 0.424242 0.666667
39 MED 0.424242 0.625
40 MET 0.424242 0.625
41 MSE 0.424242 0.606061
42 BIX 0.418605 0.631579
43 MF3 0.416667 0.625
44 CBH 0.414634 0.774194
45 DHH 0.411765 0.851852
46 LYS 0.411765 0.645161
47 SHR 0.409091 0.774194
48 2NP 0.405405 0.71875
49 AS2 0.4 0.84
50 5OY 0.4 0.648649
51 ONH 0.4 0.611111
52 2JJ 0.4 0.648649
53 LEU 0.4 0.642857
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1US5; Ligand: GLU; Similar sites found with APoc: 188
This union binding pocket(no: 1) in the query (biounit: 1us5.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 6BKL RIM None
2 6BKK 308 None
3 3B6O TMP 1.21457
4 4REP FAD 1.27389
5 1RP0 AHZ 1.40845
6 1F0X FAD 1.59236
7 1AKY AP5 1.81818
8 2JB2 FAD 1.91083
9 2JB2 PHE 1.91083
10 2Q8M AMP 1.91083
11 2WET FAD 1.91083
12 4XDY NAI 1.91083
13 4RVU NDP 1.91083
14 3JZ4 NAP 1.91083
15 3CTY FAD 1.91083
16 1H5R G1P 2.04778
17 1R0X ATP 2.0979
18 2CZL TLA 2.20588
19 1PVN MZP 2.2293
20 2Q7V FAD 2.2293
21 5J5R 6G1 2.2293
22 5J5R IMP 2.2293
23 4Q4K FMN 2.2293
24 3TWO NDP 2.2293
25 1TOI HCI 2.2293
26 4RKC PMP 2.2293
27 1GPM CIT 2.2293
28 4YJK URA 2.38095
29 6GNA FAD 2.43056
30 2WTX UDP 2.53165
31 2WTX VDO 2.53165
32 2HK9 NAP 2.54545
33 3NYC FAD 2.54777
34 3NYC IAR 2.54777
35 5E4R NAP 2.54777
36 4YKG FAD 2.54777
37 3RNM FAD 2.54777
38 2JDU MFU 2.6087
39 1I1N SAH 2.65487
40 4YAG NAI 2.76817
41 1XKQ NDP 2.85714
42 2IID PHE 2.86624
43 2IID FAD 2.86624
44 5A1S FLC 2.86624
45 1JBW TMF 2.86624
46 1JBW ACQ 2.86624
47 4UMJ BFQ 3.04054
48 1MJH ATP 3.08642
49 1UKG MMA 3.1746
50 1Q8S MAN MMA 3.1746
51 2GND MAN 3.1746
52 4Z87 5GP 3.18471
53 2C6Q NDP 3.18471
54 4Z0G 5GP 3.18471
55 2C6Q IMP 3.18471
56 2C7G ODP 3.18471
57 2C7G FAD 3.18471
58 3QJ4 FAD 3.18471
59 4R74 F6P 3.18471
60 2Z6J FMN 3.18471
61 2A8X FAD 3.18471
62 4M52 FAD 3.18471
63 4IV9 FAD 3.18471
64 4PIV 2W4 3.18471
65 4PIV NDP 3.18471
66 5K4W NAI 3.18471
67 2B3D FAD 3.43137
68 5ZZO FLC 3.48259
69 1CT9 GLN 3.50318
70 2BLE 5GP 3.50318
71 3QF7 ANP 3.50318
72 4YMU ATP 3.75
73 4AF0 IMP 3.82166
74 2UUU PL3 3.82166
75 1FEC FAD 3.82166
76 2E5V FAD 3.82166
77 1U2Z SAH 3.82166
78 3QKT ANP 3.82166
79 1JQ3 AAT 4.05405
80 3HGM ATP 4.08163
81 5T63 ALA ALA ALA ALA 4.14013
82 4PPF FLC 4.14013
83 1QM5 GLC GLC GLC PO4 SGC GLC 4.14013
84 2IV3 UDP 4.14013
85 4G86 BNT 4.22535
86 5YRF GLC GLC 4.22535
87 5MB4 NAG 4.4586
88 2RGO FAD 4.4586
89 2YPO PHE 4.4586
90 2F5Z FAD 4.6875
91 4X7R 3YW 4.77707
92 4X7R NTO 4.77707
93 2UZ1 TPP 4.77707
94 2HIM ASN 4.77707
95 4X7R UDP 4.77707
96 2BVL GLC 4.77707
97 2BVL UDP 4.77707
98 1NVM NAD 4.77707
99 5AYV NAP 4.85437
100 4XT8 TMQ 5.03876
101 3AB4 THR 5.05618
102 3LAD FAD 5.09554
103 4GKV NAD 5.09554
104 4NZ6 DLY 5.11182
105 4KFU ACP 5.18868
106 5XDT MB3 5.19481
107 2UVO NDG 5.26316
108 4AML GYU 5.26316
109 2WZF BGC 5.41401
110 3K7M FAD 5.41401
111 1RQJ RIS 5.41401
112 1KKR 2AS 5.41401
113 4YRY FAD 5.43478
114 5IFS ADP 5.48523
115 6BWL NAD 5.4878
116 4CNE SAH 5.61798
117 1RRC ADP 5.64784
118 3NUG NAD 5.66802
119 4Z24 FAD 5.73248
120 3FPZ AHZ 5.73248
121 2ZRU FMN 5.73248
122 1M26 GAL A2G 6.01504
123 2GJN NIS 6.05096
124 6APL C5P 6.05096
125 6D5X ATP 6.12245
126 2BOI MFU 6.19469
127 3WLE NAD 6.45161
128 2PZM NAD 6.6879
129 2PZM UDP 6.6879
130 4JB1 FAD 6.6879
131 4JB1 NAP 6.6879
132 6DNT NAD 6.6879
133 1IDA 0PO 7.07071
134 1QF9 ADP 7.2165
135 1QF9 ALF 7.2165
136 1QF9 C5P 7.2165
137 4GUT FAD 7.25806
138 3RGG AIR 7.54717
139 5BWD FUM 7.64331
140 2VVL FAD 7.64331
141 2RAB FAD 7.64331
142 2IVD FAD 7.64331
143 5A5W GUO 7.90514
144 3KO0 TFP 7.92079
145 1F2U ATP 8.05369
146 1SQL GUN 8.21918
147 4CNK FAD 8.28025
148 5ECP ATP 8.52018
149 5ECP JAA 8.52018
150 3VBK COA 8.78049
151 1VDC FAD 8.9172
152 1Z83 AP5 9.18367
153 3GDN HBX 9.23567
154 3QFA FAD 9.48276
155 4B7X NAP 9.55414
156 4YSX FAD 9.61539
157 5FUS DAO 9.7561
158 2NZ2 ASP 9.87261
159 5UAO FAD 10.1911
160 3WGT FAD 10.1911
161 5VN0 FAD 10.1911
162 4X8O AP5 10.2804
163 5AHN IMP 10.4294
164 1BZL FAD 10.5096
165 2WPF WPF 10.828
166 2WPF FAD 10.828
167 4TQK NAG 11.1465
168 3AD8 NAD 11.33
169 1IXI 2HP 11.465
170 4LFL TG6 11.7284
171 1K7T NAG GAL 11.828
172 1K7U NAG NAG 11.828
173 1ZFJ IMP 12.1019
174 5AHM IMP 12.75
175 1E1M NAP 13.0573
176 1E1M FAD 13.0573
177 1E6E FAD 13.0573
178 1G8S MET 13.913
179 6FP4 FAD 14.0127
180 6FP4 E1T 14.0127
181 4J56 FAD 14.0351
182 1SVM ATP 15.2866
183 3CR3 ADP 15.7025
184 5EZ7 FAD 15.9236
185 5Y6Q MCN 16.6667
186 4IXH IMP 24.5223
187 2BES RES 26.1628
188 1NVT NAP 27.5261
APoc FAQ
Feedback