Receptor
PDB id Resolution Class Description Source Keywords
1U9L 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR A NUSA- PROTEIN N INTERACTION ESCHERICHIA COLI ESCHERICHIA COLI NUSA PHAGE LAMBDA PROTEIN N REGULATION OF RNA BINDING TRANSCRIPTION ANTITERMINATION X-RAY CRYSTALLOGRAPHY RNA BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR THE INTERACTION OF ESCHERICHIA COLI NUSA WITH PROTEIN N OF PHAGE LAMBDA PROC.NATL.ACAD.SCI.USA V. 101 13762 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ASN ARG PRO ILE LEU SER LEU C:34;
 Valid;
 none;
 Kd = 3.5 nM
812.991 n/a O=C([...
AU A:1001;
 Invalid;
 none;
 submit data
196.967 Au [Au+]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1U9L 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR A NUSA- PROTEIN N INTERACTION ESCHERICHIA COLI ESCHERICHIA COLI NUSA PHAGE LAMBDA PROTEIN N REGULATION OF RNA BINDING TRANSCRIPTION ANTITERMINATION X-RAY CRYSTALLOGRAPHY RNA BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR THE INTERACTION OF ESCHERICHIA COLI NUSA WITH PROTEIN N OF PHAGE LAMBDA PROC.NATL.ACAD.SCI.USA V. 101 13762 2004
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 1U9L Kd = 3.5 nM ASN ARG PRO ILE LEU SER LEU n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 1U9L Kd = 3.5 nM ASN ARG PRO ILE LEU SER LEU n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 1U9L Kd = 3.5 nM ASN ARG PRO ILE LEU SER LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ASN ARG PRO ILE LEU SER LEU; Similar ligands found: 146
No: Ligand ECFP6 Tc MDL keys Tc
1 ASN ARG PRO ILE LEU SER LEU 1 1
2 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.610294 0.927536
3 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.555556 0.902778
4 SER HIS PRO ARG PRO ILE ARG VAL 0.553957 0.928571
5 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.537931 0.928571
6 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.533835 0.955224
7 SER PRO LYS ARG ILE ALA 0.53125 0.910448
8 CYS THR PRO SER ARG 0.528455 0.882353
9 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.52518 0.955882
10 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.524138 0.842857
11 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.521739 0.897059
12 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.518248 0.84507
13 SER ALA PRO ASP THR ARG PRO ALA 0.514925 0.885714
14 PHE ASN ARG PRO VAL 0.511628 0.882353
15 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.508065 0.895522
16 ALA MET ALA PRO ARG THR LEU LEU LEU 0.50365 0.835616
17 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.503356 0.780822
18 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.503311 0.871429
19 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.5 0.941176
20 LYS PRO VAL LEU ARG THR ALA 0.496296 0.897059
21 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.496296 0.791667
22 5JP PRO LYS ARG ILE ALA 0.492537 0.884058
23 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.490066 0.942029
24 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.48951 0.819444
25 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.489362 0.791667
26 SER ASP ILE LEU PHE PRO ALA ASP SER 0.489209 0.852941
27 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.489051 0.939394
28 ARG PRO LYS ARG ILE ALA 0.48855 0.865672
29 GLU LYS PRO SER SER SER 0.487395 0.791045
30 GLU ARG THR ILE PRO ILE THR ARG GLU 0.485294 0.926471
31 LEU ASN PHE PRO ILE SER PRO 0.481481 0.857143
32 ALA PRO ASP THR ARG PRO ALA PRO 0.481203 0.871429
33 ASP LEU THR ARG PRO 0.480315 0.940298
34 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.477941 0.852941
35 ASN LEU VAL PRO SER VAL ALA THR VAL 0.474074 0.880597
36 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.472 0.850746
37 SER SER TYR ARG ARG PRO VAL GLY ILE 0.467105 0.876712
38 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.466667 0.849315
39 ASN LEU VAL PRO THR VAL ALA THR VAL 0.466165 0.850746
40 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.465753 0.808219
41 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.464516 0.763158
42 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.463855 0.844156
43 VAL ARG SER ARG ARG ABA LEU ARG LEU 0.46281 0.761194
44 ASN LEU VAL PRO VAL VAL ALA THR VAL 0.462687 0.850746
45 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.460993 0.926471
46 ALA ARG MLZ SER ALA PRO ALA THR 0.459854 0.859155
47 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.458904 0.837838
48 ALA PRO ASP THR ARG PRO 0.458647 0.871429
49 DTY ILE ARG LEU LPD 0.453237 0.805556
50 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.452703 0.826667
51 THR PRO ARG ARG SER MLZ SER ALA 0.451852 0.847222
52 VAL MET ALA PRO ARG THR LEU PHE LEU 0.451613 0.813333
53 TYR PRO LYS ARG ILE ALA 0.451389 0.794521
54 VAL PRO LEU ARG PRO MET THR TYR 0.45098 0.805195
55 ARG PRO LYS PRO LEU VAL ASP PRO 0.450382 0.823529
56 PRO SER ILE ASP ARG SER THR LYS PRO 0.450331 0.927536
57 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.45 0.828947
58 ASN ARG LEU ILE LEU THR GLY 0.447154 0.69697
59 VAL ARG SER ARG ARG CYS LEU ARG LEU 0.446281 0.735294
60 SER LEU ILE PRO TPO PRO ASP LYS 0.445205 0.786667
61 LEU ASP PRO ARG 0.444444 0.878788
62 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.443709 0.813333
63 ASP ARG VAL TYR ILE HIS PRO PHE 0.443114 0.815789
64 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.44186 0.833333
65 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.441718 0.901408
66 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.440994 0.7875
67 SER ARG ASP HIS SER ARG THR PRO MET 0.440252 0.853333
68 LEU PRO PHE ASP ARG THR THR ILE MET 0.440252 0.864865
69 ARG ARG ARG GLU ARG SER PRO THR ARG 0.439716 0.897059
70 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.439189 0.819444
71 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.439189 0.802817
72 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.439189 0.861111
73 SER SER CYS PRO LEU SER LYS 0.438462 0.808824
74 PRO LYS ARG PRO THR THR LEU ASN LEU PHE 0.438272 0.887324
75 ARG SER ALA SEP GLU PRO SER LEU 0.437086 0.876712
76 ASN LEU VAL PRO GLN VAL ALA THR VAL 0.43662 0.850746
77 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.435714 0.757143
78 ASN LEU VAL PRO MET VAL ALA ALA VAL 0.435714 0.757143
79 DPN PRO DAR ILE NH2 0.435115 0.808824
80 GLU LEU PRO LEU VAL LYS ILE 0.433824 0.761194
81 ARG VAL ALA SER PRO THR SER GLY VAL 0.433566 0.940298
82 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.433121 0.885714
83 THR LYS PRO ARG 0.432203 0.776119
84 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.432099 0.853333
85 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.431953 0.818182
86 LYS LEU THR PRO LEU CYS VAL THR LEU 0.431655 0.797101
87 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.431507 0.897059
88 ARG THR PRO SEP LEU PRO THR 0.430556 0.813333
89 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.430464 0.863014
90 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.430464 0.911765
91 SER SER GLY LYS VAL PRO LEU SER 0.42963 0.850746
92 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.429379 0.822785
93 GLU PRO GLY GLY SER ARG 0.428571 0.880597
94 ASN LEU VAL PRO MET VAL ALA THR VAL 0.427586 0.802817
95 ACE ARG THR PRO SEP LEU PRO THR PIP 0.425676 0.772152
96 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.425373 0.823529
97 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.42515 0.84
98 SER SER GLY LYS VAL PRO LEU 0.424242 0.835821
99 GLN ASN TYR PRO ILE VAL GLN 0.423611 0.777778
100 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.423529 0.810811
101 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.422222 0.822785
102 PRO PRO LYS ARG ILE ALA 0.421429 0.838235
103 SER MET PRO GLU LEU SER PRO VAL LEU 0.42069 0.791667
104 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.419753 0.733333
105 ILE SER PRO ARG THR LEU ASP ALA TRP 0.41954 0.878378
106 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.419355 0.733333
107 LEU PRO PHE GLU ARG ALA THR ILE MET 0.419162 0.851351
108 ARG ARG ALA SEP ALA PRO LEU PRO 0.418919 0.8
109 SER VAL PRO ILE 0.418803 0.818182
110 HIS SER ILE THR TYR LEU LEU PRO VAL 0.41875 0.786667
111 ARG PRO GLY ASN PHE LEU GLN SER SER PRO 0.418182 0.914286
112 MET LEU LEU SER VAL PRO LEU LEU LEU GLY 0.41791 0.785714
113 LYS ARG ARG ARG HIS PRO SER GLY 0.417808 0.857143
114 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.416185 0.831169
115 SER PRO ARG LEU PRO LEU LEU GLU SER 0.416058 0.808824
116 SER PRO LEU ASP SER LEU TRP TRP ILE 0.415584 0.783784
117 3BY PRO LYS ARG ILE ALA 0.415493 0.805556
118 LEU PRO PRO GLU GLU ARG LEU ILE 0.415493 0.867647
119 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.414201 0.849315
120 ALA VAL PRO ILE ALA GLN 0.414062 0.787879
121 GLU SER ASP PRO ILE VAL ALA GLN TYR 0.414013 0.819444
122 LEU LEU CYS SER TPO PRO ASN GLY LEU 0.413793 0.797297
123 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.413174 0.842105
124 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.412903 0.885714
125 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.412121 0.914286
126 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.411765 0.830986
127 ARG VAL ALA SEP PRO THR SER GLY VAL 0.411765 0.863014
128 ASN ASP TRP LEU LEU PRO SER TYR 0.411043 0.766234
129 GLU GLU PRO THR VAL ILE LYS LYS TYR 0.410256 0.753425
130 LEU SER SER PRO VAL THR LYS SER PHE 0.409396 0.8
131 ALA ALA ARG KCR SER ALA PRO ALA 0.409396 0.869565
132 LEU PRO PHE ASP LYS SER THR ILE MET 0.408537 0.783784
133 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.408284 0.84
134 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.40625 0.771429
135 DMG PRO ARG ARG ARG SER ARG LYS PRO 0.406015 0.913043
136 PHE ASN PHE PRO GLN ILE THR 0.40411 0.802817
137 DPN PRO DAR DTH NH2 0.402985 0.811594
138 ARG SEP PRO VAL PHE SER 0.402597 0.810811
139 PRO ALA ILE ILE ASN ARG PRO GLN ASN 0.401408 0.867647
140 VAL SER GLN ASN TYR PRO ILE VAL GLN ASN 0.401316 0.819444
141 GLN ALA SER TPO PRO ARG NIT 0.401235 0.717647
142 PRO GLN ILE ILE ASN ARG PRO GLN ASN 0.4 0.867647
143 ASN SER THR LEU GLN 0.4 0.641791
144 DPN PRO ARG 0.4 0.764706
145 ARG PHE PRO LEU THR PHE GLY TRP 0.4 0.826667
146 HIS HIS ALA SER PRO ARG LYS 0.4 0.816901
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1U9L; Ligand: ASN ARG PRO ILE LEU SER LEU; Similar sites found: 36
This union binding pocket(no: 1) in the query (biounit: 1u9l.bio2) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1QMG APX 0.003037 0.46484 None
2 1GHE ACO 0.008826 0.43381 None
3 3ZLR X0B 0.01788 0.42453 None
4 1JQY A32 0.006212 0.42453 None
5 2QRD ATP 0.01195 0.42247 None
6 1U7T TDT 0.03763 0.42211 None
7 4H6U ACO 0.01297 0.41659 None
8 4TYO 39X 0.00989 0.41654 None
9 2GZ3 NAP 0.03459 0.41441 None
10 3RT4 LP5 0.04354 0.41351 None
11 5LYH 7B8 0.02614 0.40783 None
12 1LZR NAG NAG NAG NAG 0.02579 0.40475 None
13 4JEM C5P 0.01846 0.40288 None
14 4POW OP1 0.03463 0.40074 None
15 1HZP DAO 0.04135 0.41408 4.28571
16 3KPB SAM 0.00641 0.46062 5.71429
17 3Q9O NAD 0.01584 0.41718 5.71429
18 1N46 PFA 0.02065 0.41663 5.71429
19 1KUV CA5 0.03524 0.40473 5.71429
20 1XK9 P34 0.02128 0.41052 7.14286
21 2HFP NSI 0.02509 0.40856 7.14286
22 4ANP 3QI 0.02511 0.4048 8.57143
23 4L6T GAL NGA GAL BGC SIA 0.01157 0.40325 8.57143
24 1I36 NAP 0.01355 0.42652 10
25 2UUU PL3 0.04423 0.41955 10
26 2UUU FAD 0.03808 0.41955 10
27 4UUU SAM 0.02054 0.40835 10
28 3KC1 2T6 0.0138 0.40638 10
29 3B82 NAD 0.01939 0.41821 11.4286
30 4NVP 7CH 0.02003 0.40613 15.7143
31 1EM6 CP4 0.03347 0.44523 17.1429
32 1S4M LUM 0.0299 0.41282 17.1429
33 3CTY FAD 0.01637 0.43436 21.4286
34 4R33 TRP 0.01871 0.41535 21.4286
35 4R33 SAH 0.01871 0.41535 21.4286
36 2QTR NXX 0.03794 0.40319 21.4286
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