Receptor
PDB id Resolution Class Description Source Keywords
1SL5 1.8 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DC-SIGN CARBOHYDRATE RECOGNITION DOMAIN WITH LNFP III (DEXTRA L504). HOMO SAPIENS DC-SIGN C-TYPE LECTIN SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING AND TA PROPERTIES OF THE RECEPTORS DC-SIGN AND DC-SIGNR NAT.STRUCT.MOL.BIOL. V. 11 591 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:401;
A:402;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
40.078 Ca [Ca+2...
MG A:403;
 Part of Protein;
 none;
 submit data
24.305 Mg [Mg+2...
GAL NAG FUC GAL B:1;
 Valid;
 none;
 submit data
691.633 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2IT5 2.4 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DCSIGN-CRD WITH MAN6 HOMO SAPIENS C-TYPE LECTIN PROTEIN CARBOHYDRATE COMPLEX IMMUNE SYSTEM
Ref.: MULTIPLE MODES OF BINDING ENHANCE THE AFFINITY OF D FOR HIGH MANNOSE N-LINKED GLYCANS FOUND ON VIRAL GLYCOPROTEINS. J.BIOL.CHEM. V. 282 4202 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 1SL5 - GAL NAG FUC GAL n/a n/a
2 2IT5 - MAN MAN MAN n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 1SL5 - GAL NAG FUC GAL n/a n/a
2 2IT5 - MAN MAN MAN n/a n/a
3 1K9J - MAN MAN MAN NAG NAG n/a n/a
4 1SL4 - MAN MAN MAN MAN n/a n/a
5 2IT6 - MAN MAN n/a n/a
6 1K9I - MAN MAN MAN NAG NAG n/a n/a
7 6GHV Kd = 52 uM EZ8 C35 H48 Cl N6 O10 c1cc(ccc1C....
50% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 4N33 - GAL NAG n/a n/a
2 3P5I - NAG G6S n/a n/a
3 3P5H - BGC BGC n/a n/a
4 4N37 - MMA C7 H14 O6 CO[C@@H]1[....
5 4N34 - 2F8 C9 H17 N O6 CC(=O)N[C@....
6 3P5E - MAN C6 H12 O6 C([C@@H]1[....
7 6PWR - MAN NAG n/a n/a
8 6PWS Ki = 1.6 mM MMA C7 H14 O6 CO[C@@H]1[....
9 5G6U ic50 = 0.22 uM SGN C6 H13 N O11 S2 C([C@@H]1[....
10 5VYB - BMA MAN MAN MAN MAN MAN MAN n/a n/a
11 1SL5 - GAL NAG FUC GAL n/a n/a
12 2IT5 - MAN MAN MAN n/a n/a
13 6LFJ Kd = 140 uM MAN IPD MAN n/a n/a
14 1K9J - MAN MAN MAN NAG NAG n/a n/a
15 1SL4 - MAN MAN MAN MAN n/a n/a
16 2IT6 - MAN MAN n/a n/a
17 1K9I - MAN MAN MAN NAG NAG n/a n/a
18 6GHV Kd = 52 uM EZ8 C35 H48 Cl N6 O10 c1cc(ccc1C....
19 3VYK Kd = 0.000023 M MMA MAN NAG MAN NAG NAG n/a n/a
20 4KZV - GLC GLC n/a n/a
21 4ZRV - GLC U8V n/a n/a
22 5KTH - GLC GLC 6X7 6X7 n/a n/a
23 5KTI - GLC GLC 6X6 n/a n/a
24 2OX9 - NAG FUC GAL n/a n/a
25 4ZES Ki = 9.4 mM MMA C7 H14 O6 CO[C@@H]1[....
26 3WH2 - FLC C6 H5 O7 C(C(=O)[O-....
27 5JPV - GLC GAL n/a n/a
28 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
29 1SL6 - NDG FUC GAL n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GAL NAG FUC GAL; Similar ligands found: 100
No: Ligand ECFP6 Tc MDL keys Tc
1 GAL NAG FUC GAL 1 1
2 GAL NAG GAL FUC FUC 0.822785 0.978723
3 GLA NAG FUC GAL 0.694118 0.978723
4 NAG FUC GAL 0.679487 1
5 GLA NAG GAL FUC 0.666667 1
6 BGC GAL NAG GAL FUC FUC 0.663043 0.978723
7 GAL NAG GAL 0.65 0.978261
8 BGC FUC GAL NAG GAL 0.648352 1
9 GLC BGC FUC GAL 0.618421 0.73913
10 BGC FUC GAL 0.618421 0.73913
11 BGC FUC GAL NAG 0.617977 1
12 GAL NAG GAL NAG GAL 0.611765 0.958333
13 GAL NAG FUC GAL SIA 0.590909 0.884615
14 MAG GAL FUC FUC 0.569767 0.958333
15 MAG FUC GAL FUC 0.569767 0.958333
16 GLC GAL NAG GAL FUC GLA 0.555556 1
17 GAL NGA A2G 0.554217 0.958333
18 BGC GAL NAG GAL FUC 0.552083 1
19 NDG FUC GAL FUC 0.551724 0.978723
20 NAG GAL FUC FUC 0.551724 0.978723
21 GAL GLA 0.549296 0.717391
22 BMA MAN NAG 0.546512 0.978261
23 MAG FUC SGA 0.537634 0.692308
24 NAG GAL FUC GLA 0.532609 1
25 GAL FUC A2G 0.528736 1
26 BGC GAL NAG GAL 0.52809 0.978261
27 MAG FUC G4S 0.526882 0.692308
28 BGC FUC GAL FUC A2G 0.526316 0.978723
29 GAL FUC GAL 0.525 0.73913
30 NAG FUC 0.525 0.978261
31 BGC GAL GLA NGA GAL 0.521739 0.978261
32 MAG SGA FUC 0.521277 0.730159
33 BGC BGC BGC BGC BGC 0.513158 0.717391
34 BGC BGC BGC BGC BGC BGC 0.513158 0.717391
35 GLC BGC BGC BGC 0.513158 0.717391
36 BGC BGC BGC BGC BGC BGC BGC 0.513158 0.717391
37 BGC BGC BGC 0.513158 0.717391
38 NAG GAL FUC 0.511364 1
39 NAG GAL FUC FUC A2G 0.510204 0.938776
40 NAG FUC GAL FUC A2G 0.510204 0.938776
41 BGC GAL NGA GAL 0.505618 0.978261
42 GLC GAL NAG GAL FUC A2G 0.5 0.938776
43 NAG GAL FUC A2G 0.5 1
44 A2G GAL 0.5 0.978261
45 BGC GAL FUC A2G 0.489796 1
46 NAG GAL NAG GAL 0.48913 0.958333
47 NAG GAL NAG GAL NAG GAL 0.48913 0.938776
48 NAG GAL GAL 0.482759 0.978261
49 NAG GAL 0.481481 0.978261
50 MGC GAL 0.481481 0.978723
51 BGC GAL FUC GLA 0.477778 0.73913
52 NAG NON FUC GAL FUC 0.475728 0.836364
53 GAL NAG GAL FUC 0.474227 0.958333
54 GAL NAG GAL SIA 0.473214 0.867925
55 EAG RAM RAM GLC RAM NAG RAM RAM GLC RAM 0.466019 0.92
56 BGC GAL GLA NGA 0.463158 0.978261
57 BMA MAN MAN NAG GAL NAG 0.462264 0.958333
58 BGC GAL NAG 0.456522 0.978261
59 MAN NAG GAL 0.455556 0.978261
60 NDG GLA NAG GLC RAM 0.454545 0.938776
61 NDG NAG GLA NAG GLC RAM 0.454545 0.938776
62 BGC GAL FUC 0.453488 0.73913
63 GLC GAL BGC FUC 0.453488 0.73913
64 A2G MBN GAL 0.451613 0.9375
65 TVD GAL 0.445783 0.938776
66 C4W NAG FUC BMA MAN 0.445455 0.884615
67 MAG FUC GAL SIA 0.444444 0.849057
68 NDG GLA GLC NAG GLC RAM 0.442478 0.938776
69 C4W NAG FUC BMA 0.442308 0.884615
70 GCU BGC 0.439024 0.702128
71 MAN MAN M6P 0.438202 0.6
72 NAG NAG BMA MAN 0.435644 0.884615
73 BGC BGC BGC BGC 0.433333 0.717391
74 NAG FUC GAL SIA 0.432203 0.884615
75 NAG NAG BMA 0.431579 0.884615
76 NAG BMA 0.430233 0.88
77 BGC GAL NAG NAG GAL GAL 0.428571 0.958333
78 BGC GAL NGA 0.428571 0.978261
79 1GN ACY GAL 1GN BGC ACY GAL BGC 0.427184 0.958333
80 NAG GAL NAG 0.425532 0.958333
81 FUC GAL 0.425 0.717391
82 BMA MAN MAN 0.423529 0.717391
83 HSH A2G FUC 0.421569 0.836364
84 GAL A2G MBN 0.421053 0.918367
85 NAG GAL BGC GAL 0.421053 0.978261
86 LOG GAL 0.41573 0.789474
87 HSH GLA FUC 0.414894 0.648148
88 A2G SER GAL 0.414894 0.865385
89 BGC RAM BGC GAD 0.413462 0.7
90 A2G THR GAL 0.410526 0.901961
91 GAL GC2 0.410526 0.676923
92 SIA GAL NGA GAL 0.410256 0.884615
93 NAG NAG FUL BMA MAN MAN NAG GAL 0.409836 0.867925
94 BMA MAN MAN MAN 0.408602 0.744681
95 GAL FUC NGA 0.40625 0.918367
96 MAN MAN MAN NAG NAG 0.405941 0.958333
97 C4W NAG FUC BMA MAN NAG GAL 0.403361 0.793103
98 A2G GAL NAG 0.402062 0.958333
99 NAG NAG MAN MAN MAN 0.401869 0.958333
100 BGC GAL GLA 0.4 0.717391
Similar Ligands (3D)
Ligand no: 1; Ligand: GAL NAG FUC GAL; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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