Receptor
PDB id Resolution Class Description Source Keywords
1SL4 1.55 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DC-SIGN CARBOHYDRATE RECOGNITION DOMAIN COMPLEXED WITH MAN4 HOMO SAPIENS DC-SIGN C-TYPE LECTIN SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING AND TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN AND DC-SIGNR NAT.STRUCT.MOL.BIOL. V. 11 591 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:405;
A:406;
A:407;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
MAN MAN MAN MAN A:1;
Valid;
none;
submit data
666.579 n/a O(C1O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1SL4 1.55 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DC-SIGN CARBOHYDRATE RECOGNITION DOMAIN COMPLEXED WITH MAN4 HOMO SAPIENS DC-SIGN C-TYPE LECTIN SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING AND TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN AND DC-SIGNR NAT.STRUCT.MOL.BIOL. V. 11 591 2004
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 1SL4 - MAN MAN MAN MAN n/a n/a
2 2IT6 - MAN MAN n/a n/a
3 1K9I - NAG MAN MAN MAN NAG n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 1SL5 - GAL NAG GAL FUC n/a n/a
2 2IT5 - MAN MAN MAN n/a n/a
3 1K9J - NAG MAN MAN MAN NAG n/a n/a
4 1SL4 - MAN MAN MAN MAN n/a n/a
5 2IT6 - MAN MAN n/a n/a
6 1K9I - NAG MAN MAN MAN NAG n/a n/a
7 1SL6 - GAL NDG FUC n/a n/a
50% Homology Family (22)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 272 families.
1 3P5I - G6S NAG n/a n/a
2 3P5H - BGC BGC n/a n/a
3 3P7H - MAL C12 H22 O11 C([C@@H]1[....
4 5VYB - MAN MAN MAN BMA MAN MAN MAN n/a n/a
5 1SL5 - GAL NAG GAL FUC n/a n/a
6 2IT5 - MAN MAN MAN n/a n/a
7 1K9J - NAG MAN MAN MAN NAG n/a n/a
8 1SL4 - MAN MAN MAN MAN n/a n/a
9 2IT6 - MAN MAN n/a n/a
10 1K9I - NAG MAN MAN MAN NAG n/a n/a
11 3VYK Kd = 0.00003 M MMA MAN NAG MAN NAG NAG n/a n/a
12 4KZV - TRE C12 H22 O11 C([C@@H]1[....
13 4ZRV - 4RS C16 H28 O12 CCCC(=O)OC....
14 5KTH - TRE 6X7 6X7 n/a n/a
15 5KTI - TRE 6X6 n/a n/a
16 2OX9 - GAL NAG FUC n/a n/a
17 4ZES Ki = 9.4 mM MMA C7 H14 O6 CO[C@@H]1[....
18 3WH2 - FLC C6 H5 O7 C(C(=O)[O-....
19 5JPV - LBT C12 H22 O11 C([C@@H]1[....
20 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
21 1SL6 - GAL NDG FUC n/a n/a
22 5M62 - BGC C6 H12 O6 C([C@@H]1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MAN MAN MAN MAN; Similar ligands found: 177
No: Ligand ECFP6 Tc MDL keys Tc
1 MAN MAN BMA MAN 1 1
2 MAN MAN MAN MAN 1 1
3 MAN BMA MAN MAN MAN 0.852459 1
4 M5S 0.852459 1
5 MAN MAN MAN BMA MAN 0.80303 1
6 MAN MAN MAN 0.736842 1
7 GLC GLC GLC GLC GLC BGC 0.736842 1
8 GLC GLC GLC 0.736842 1
9 GLC GLC GLC GLC BGC 0.736842 1
10 MLB 0.732143 1
11 GLA BGC 0.732143 1
12 MAN BMA 0.732143 1
13 BMA GLA 0.732143 1
14 GLA GLC 0.732143 1
15 GAL GAL 0.732143 1
16 GLA BMA 0.732143 1
17 BGC GLA 0.732143 1
18 LAK 0.732143 1
19 GLC GLC GLC GLC 0.730159 1
20 MAN MMA MAN 0.703125 0.942857
21 MAN MAN MAN BMA MAN MAN MAN 0.675325 0.942857
22 GLC GLC GLC GLC GLC GLC 0.656716 1
23 NAG BMA MAN MAN MAN MAN 0.625 0.733333
24 WZ3 0.611111 0.916667
25 GLC GLC GLC BGC 0.591549 1
26 NAG BMA MAN MAN MAN MAN MAN 0.589744 0.868421
27 FUB AHR AHR 0.583333 0.857143
28 AHR AHR AHR 0.583333 0.857143
29 BMA NAG MAN MAN MAN MAN MAN MAN MAN 0.561798 0.733333
30 AHR AHR 0.559322 0.857143
31 FUB AHR 0.559322 0.857143
32 BMA BMA GLA BMA BMA 0.540541 1
33 MAN H1M MAN 0.533333 0.868421
34 GLC BGC BGC BGC BGC BGC BGC 0.530303 1
35 BGC BGC BGC GLC BGC BGC 0.530303 1
36 BGC BGC BGC BGC BGC 0.530303 1
37 GLC BGC BGC BGC 0.530303 1
38 BGC BGC BGC 0.530303 1
39 BGC BGC BGC ASO BGC BGC ASO 0.530303 1
40 1GN ACY GAL ACY 1GN BGC GAL BGC 0.528736 0.6875
41 AML MAN MAN MAN MAN MAN MAN MAN MAN 0.528736 0.825
42 ACY 1GN GAL 1GN BGC ACY GAL BGC 0.528736 0.6875
43 NAG NAG BMA MAN MAN 0.52809 0.6875
44 MAN MAN NAG MAN NAG 0.52809 0.6875
45 M5G 0.525773 0.6875
46 LB2 0.52381 1
47 M3M 0.52381 1
48 MAN GLC 0.52381 1
49 BMA NGT MAN MAN 0.523256 0.66
50 GLA GAL BGC 0.521739 1
51 GLA GAL GAL 0.521739 1
52 GAL GAL SO4 0.521127 0.702128
53 MAN MMA 0.507692 0.942857
54 BGC BGC BGC BGC BGC BGC BGC BGC 0.493151 1
55 BGC BGC BGC BGC 0.493151 1
56 BMA BMA MAN 0.492537 0.970588
57 M13 0.484848 0.942857
58 MDM 0.484848 0.942857
59 GAL MBG 0.484848 0.942857
60 WZ5 0.483516 0.702128
61 P3M 0.48 0.767442
62 BGC BMA 0.476923 1
63 GLC GAL 0.476923 1
64 LBT 0.476923 1
65 GLC BGC 0.476923 1
66 GLA GAL 0.476923 1
67 MAB 0.476923 1
68 BMA BMA 0.476923 1
69 BGC GAL 0.476923 1
70 LAT 0.476923 1
71 N9S 0.476923 1
72 CBI 0.476923 1
73 GLA GLA 0.476923 1
74 BGC GLC 0.476923 1
75 B2G 0.476923 1
76 GAL GLC 0.476923 1
77 CBK 0.476923 1
78 GAL BGC 0.476923 1
79 MAL 0.476923 1
80 BMA GAL 0.476923 1
81 MAL MAL 0.476923 0.970588
82 NAG NAG BMA MAN MAN MAN MAN MAN MAN MAN 0.470588 0.6875
83 NAG BMA MAN MAN MAN MAN MAN MAN MAN 0.469388 0.673469
84 MAN MAN MAN GLC 0.466667 1
85 BMA BMA BMA BMA BMA BMA MAN 0.464789 0.970588
86 MAN BMA BMA BMA BMA BMA 0.464789 0.970588
87 BGC BGC GLC 0.464789 1
88 OPM MAN MAN 0.4625 0.804878
89 BMA MAN MAN 0.458333 1
90 GLC GAL GAL 0.449275 1
91 MAN MAN BMA BMA BMA BMA 0.449275 1
92 GLC BGC GLC 0.449275 1
93 BGC GLC GLC GLC GLC 0.449275 1
94 GLA GAL GLC 0.449275 1
95 GLC BGC BGC BGC BGC BGC 0.449275 1
96 MAN BMA BMA 0.449275 1
97 BGC GLC GLC 0.449275 1
98 CEY 0.449275 1
99 DXI 0.449275 1
100 BMA BMA BMA BMA BMA 0.449275 1
101 MLR 0.449275 1
102 CEX 0.449275 1
103 CTT 0.449275 1
104 B4G 0.449275 1
105 GLC GLC GLC GLC GLC GLC GLC 0.449275 1
106 GLC GLC BGC 0.449275 1
107 CTR 0.449275 1
108 BMA BMA BMA 0.449275 1
109 GLC GLC GLC GLC GLC 0.449275 1
110 CT3 0.449275 1
111 GLC GLC BGC GLC GLC GLC GLC 0.449275 1
112 GLC BGC BGC 0.449275 1
113 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.449275 1
114 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.449275 1
115 GLC BGC BGC BGC BGC 0.449275 1
116 BMA MAN BMA 0.449275 1
117 CE5 0.449275 1
118 MTT 0.449275 1
119 BGC GLC GLC GLC 0.449275 1
120 CE8 0.449275 1
121 BGC GLC GLC GLC GLC GLC GLC 0.449275 1
122 BMA BMA BMA BMA BMA BMA 0.449275 1
123 GAL GAL GAL 0.449275 1
124 MAN BMA BMA BMA BMA 0.449275 1
125 BGC BGC BGC GLC 0.449275 1
126 BGC BGC BGC BGC BGC BGC 0.449275 1
127 GLC GLC GLC GLC GLC GLC GLC GLC 0.449275 1
128 MT7 0.449275 1
129 CE6 0.449275 1
130 KDO MAN MAN MAN MAN MAN 0.446602 0.868421
131 NAG MAN BMA 0.440476 0.733333
132 NAG MAN MAN 0.440476 0.733333
133 2M4 0.439394 1
134 MAN MAN 0.439394 1
135 BGC BGC 0.439394 1
136 NAG NAG BMA MAN MAN MAN MAN 0.433962 0.634615
137 NAG MAN GAL MAN MAN NAG GAL 0.431579 0.6875
138 MAN MAN MAN MAN MAN MAN MAN MAN 0.430108 0.846154
139 GAL FUC 0.428571 0.941176
140 CGC 0.424658 0.941176
141 TRE 0.423729 1
142 GAL BGC NAG GAL 0.423529 0.733333
143 6SA 0.423077 0.733333
144 GLA EGA 0.422535 0.942857
145 GLC BGC BGC BGC XYS BGC XYS XYS 0.422222 0.916667
146 GAL BGC BGC XYS 0.421687 0.942857
147 NAG MAN GAL BMA NDG MAN NAG GAL 0.42 0.673469
148 NAG MAN GAL BMA NAG MAN NAG GAL 0.42 0.673469
149 NAG MAN MAN MAN NAG GAL NAG GAL 0.42 0.673469
150 MAN BMA NAG NAG MAN NAG GAL GAL 0.42 0.673469
151 NAG GAL GAL 0.419753 0.733333
152 GLA GAL NAG 0.419753 0.733333
153 MAN BMA NAG 0.419753 0.733333
154 GLC GLC BGC XYS BGC XYS 0.418605 0.942857
155 RAF 0.417722 0.891892
156 FRU GLC GLA 0.417722 0.891892
157 MAN MAN BMA 0.416667 1
158 IAB 0.414141 0.733333
159 6PZ ACY ACY BGC GAL 1GN 1GN ACY GAL GAL ACY BGC 0.413223 0.611111
160 ACY ACY 6PZ BGC GAL 1GN ACY 1GN GAL GAL ACY BGC 0.413223 0.611111
161 BGC BGC XYS BGC 0.411765 0.942857
162 6PZ BGC GAL 1GN 1GN ACY GAL GAL ACY BGC 0.409836 0.611111
163 AXR BXY BXY BXX 0.409639 0.789474
164 BGC BGC BGC XYS BGC BGC 0.409091 0.942857
165 XYS BGC BGC BGC BGC XYS BGC BGC BGC 0.409091 0.942857
166 XYS BGC BGC XYS BGC XYS BGC BGC BGC 0.409091 0.942857
167 U63 0.408451 0.891892
168 GLA GLA FUC 0.402597 0.970588
169 FUC GAL GLA 0.402597 0.970588
170 GLA GAL FUC 0.402597 0.970588
171 FUC GLA GLA 0.402597 0.970588
172 GAL GAL FUC 0.402597 0.970588
173 GAL NAG GAL BGC 0.402299 0.733333
174 LAT NAG GAL 0.402299 0.733333
175 BGC GAL NAG GAL 0.402299 0.733333
176 NAG MAN BMA NDG MAN NAG GAL 0.4 0.673469
177 T6P 0.4 0.767442
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1SL4; Ligand: MAN MAN MAN MAN; Similar sites found: 18
This union binding pocket(no: 1) in the query (biounit: 1sl4.bio1) has 26 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1TMM HHR 0.01588 0.41168 None
2 1TMM APC 0.01678 0.41156 None
3 4G9N NGA 0.01531 0.40022 3.4965
4 4OWK NGA 0.01311 0.40117 4.51613
5 3CV2 COA 0.0138 0.40428 5.80645
6 5C79 PBU 0.01846 0.40769 7.33333
7 4OUJ LBT 0.01017 0.41553 7.74194
8 4B2D SER 0.01256 0.41325 9.03226
9 2XG5 EC2 0.003198 0.44543 10.9677
10 2XG5 EC5 0.003198 0.44543 10.9677
11 2YIP YIO 0.007985 0.41722 13.0435
12 1PWB GLC GLC 0.000000002338 0.82114 29.6774
13 1PWB GLC 0.000000003191 0.80693 29.6774
14 2GGX NPJ 0.000001565 0.61598 29.6774
15 4BC5 5FX 0.01245 0.40718 30.3226
16 4DN8 BMA 0.00000007203 0.72342 34.1936
17 1G1T SIA GAL MAG FUC 0.00001942 0.56653 35.4839
18 2VUZ NAG BMA NAG MAN MAN NAG NAG 0.00000121 0.62229 45.7364
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