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Receptor
PDB id Resolution Class Description Source Keywords
1SL4 1.55 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DC-SIGN CARBOHYDRATE RECOGNITION DOMAIN COMPLEXED WITH MAN4 HOMO SAPIENS DC-SIGN C-TYPE LECTIN SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING AND TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN AND DC-SIGNR NAT.STRUCT.MOL.BIOL. V. 11 591 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:405;
A:406;
A:407;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
MAN MAN MAN MAN A:1;
Valid;
none;
submit data
666.579 n/a O(CC1...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1SL4 1.55 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF DC-SIGN CARBOHYDRATE RECOGNITION DOMAIN COMPLEXED WITH MAN4 HOMO SAPIENS DC-SIGN C-TYPE LECTIN SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR DISTINCT LIGAND-BINDING AND TARGETING PROPERTIES OF THE RECEPTORS DC-SIGN AND DC-SIGNR NAT.STRUCT.MOL.BIOL. V. 11 591 2004
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 1SL4 - MAN MAN MAN MAN n/a n/a
2 2IT6 - MAN MAN n/a n/a
3 1K9I - NAG MAN MAN MAN NAG n/a n/a
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 1SL5 - GAL NAG GAL FUC n/a n/a
2 2IT5 - MAN MAN MAN n/a n/a
3 1K9J - NAG MAN MAN MAN NAG n/a n/a
4 1SL4 - MAN MAN MAN MAN n/a n/a
5 2IT6 - MAN MAN n/a n/a
6 1K9I - NAG MAN MAN MAN NAG n/a n/a
50% Homology Family (25)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 3P5I - G6S NAG n/a n/a
2 3P5H - BGC BGC n/a n/a
3 4N37 - MMA C7 H14 O6 CO[C@@H]1[....
4 4N34 - 2F8 C9 H17 N O6 CC(=O)N[C@....
5 3P5E - MAN C6 H12 O6 C([C@@H]1[....
6 3P5D - MAN C6 H12 O6 C([C@@H]1[....
7 5G6U ic50 = 0.22 uM YJM C6 H13 N O11 S2 C([C@@H]1[....
8 5VYB - MAN MAN MAN BMA MAN MAN MAN n/a n/a
9 1SL5 - GAL NAG GAL FUC n/a n/a
10 2IT5 - MAN MAN MAN n/a n/a
11 1K9J - NAG MAN MAN MAN NAG n/a n/a
12 1SL4 - MAN MAN MAN MAN n/a n/a
13 2IT6 - MAN MAN n/a n/a
14 1K9I - NAG MAN MAN MAN NAG n/a n/a
15 3VYK Kd = 0.00003 M MMA MAN NAG MAN NAG NAG n/a n/a
16 4KZV - TRE C12 H22 O11 C([C@@H]1[....
17 4ZRV - 4RS C16 H28 O12 CCCC(=O)OC....
18 5KTH - TRE 6X7 6X7 n/a n/a
19 5KTI - TRE 6X6 n/a n/a
20 2OX9 - GAL NAG FUC n/a n/a
21 4ZES Ki = 9.4 mM MMA C7 H14 O6 CO[C@@H]1[....
22 3WH2 - FLC C6 H5 O7 C(C(=O)[O-....
23 5JPV - LBT C12 H22 O11 C([C@@H]1[....
24 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
25 1SL6 - GAL NDG FUC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MAN MAN MAN MAN; Similar ligands found: 167
No: Ligand ECFP6 Tc MDL keys Tc
1 MAN MAN MAN MAN 1 1
2 MAN MAN BMA MAN 1 1
3 M5S 0.852459 1
4 MAN BMA MAN MAN MAN 0.852459 1
5 MAN MAN MAN BMA MAN 0.80303 1
6 MAN BMA MAN 0.754098 1
7 GLC GLC GLC GLC BGC 0.736842 1
8 BMA MAN MAN 0.736842 1
9 GLC GLC GLC 0.736842 1
10 MAN MAN MAN 0.736842 1
11 GLC GLC GLC GLC GLC BGC 0.736842 1
12 GLC GLC 0.732143 1
13 GLA GLC 0.732143 1
14 GAL GAL 0.732143 1
15 BGC GLC 0.732143 1
16 BMA MAN 0.732143 1
17 GLC BGC 0.732143 1
18 BGC GLA 0.732143 1
19 MLB 0.732143 1
20 GAL GLC 0.732143 1
21 MAN MAN 0.732143 1
22 GLA BGC 0.732143 1
23 MAN BMA 0.732143 1
24 GLA BMA 0.732143 1
25 LAK 0.732143 1
26 BMA GLA 0.732143 1
27 MAN MMA MAN 0.703125 0.942857
28 MAN MAN MAN BMA MAN MAN MAN 0.675325 0.942857
29 WZ3 0.611111 0.916667
30 MAN MAN MAN MAN MAN MAN MAN 0.61039 1
31 GLC GLC GLC BGC 0.591549 1
32 NAG BMA MAN MAN MAN MAN MAN 0.589744 0.868421
33 FUB AHR AHR 0.583333 0.857143
34 AHR AHR AHR AHR AHR AHR 0.583333 0.857143
35 BMA NAG MAN MAN MAN MAN MAN MAN MAN 0.561798 0.733333
36 FUB AHR 0.559322 0.857143
37 AHR AHR 0.559322 0.857143
38 BMA MAN MAN MAN MAN 0.546667 1
39 BMA BMA GLA BMA BMA 0.540541 1
40 GLC BGC BGC BGC BGC BGC BGC 0.530303 1
41 BGC BGC BGC GLC BGC BGC 0.530303 1
42 1GN ACY GAL ACY 1GN BGC GAL BGC 0.528736 0.6875
43 ACY 1GN GAL 1GN BGC ACY GAL BGC 0.528736 0.6875
44 AML MAN MAN MAN MAN MAN MAN MAN MAN 0.528736 0.825
45 NAG NAG BMA MAN MAN 0.52809 0.6875
46 M5G 0.525773 0.6875
47 LB2 0.52381 1
48 M3M 0.52381 1
49 NGR 0.52381 1
50 MAN GLC 0.52381 1
51 BMA NGT MAN MAN 0.523256 0.66
52 GLA GAL GAL 0.521739 1
53 GAL GAL SO4 0.513889 0.66
54 NAG BMA MAN MAN MAN MAN 0.511364 0.733333
55 MAN MMA 0.507692 0.942857
56 BGC BGC BGC BGC BGC BGC BGC BGC 0.493151 1
57 M13 0.484848 0.942857
58 GAL MBG 0.484848 0.942857
59 MDM 0.484848 0.942857
60 WZ5 0.483516 0.702128
61 P3M 0.48 0.767442
62 CBI 0.476923 1
63 GLA GLA 0.476923 1
64 GLC GAL 0.476923 1
65 BGC GAL 0.476923 1
66 BGC BMA 0.476923 1
67 LAT 0.476923 1
68 CBK 0.476923 1
69 MAB 0.476923 1
70 GAL BGC 0.476923 1
71 BMA GAL 0.476923 1
72 N9S 0.476923 1
73 MAL 0.476923 1
74 B2G 0.476923 1
75 GLA GAL 0.476923 1
76 LBT 0.476923 1
77 BQZ 0.47541 0.909091
78 NAG NAG BMA MAN MAN MAN MAN MAN MAN MAN 0.470588 0.6875
79 NAG BMA MAN MAN MAN MAN MAN MAN MAN 0.469388 0.673469
80 MAN MAN MAN GLC 0.466667 1
81 OPM MAN MAN 0.4625 0.804878
82 BMA MAN MAN MAN 0.452055 1
83 BGC BGC BGC BGC 0.449275 1
84 CE6 0.449275 1
85 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.449275 1
86 MAN BMA BMA BMA BMA 0.449275 1
87 BMA MAN BMA 0.449275 1
88 MT7 0.449275 1
89 MAN MAN BMA BMA BMA BMA 0.449275 1
90 MAN BMA BMA 0.449275 1
91 MLR 0.449275 1
92 GLC BGC BGC BGC BGC 0.449275 1
93 BGC GLC GLC 0.449275 1
94 DXI 0.449275 1
95 BGC BGC BGC BGC BGC 0.449275 1
96 GLC BGC GLC 0.449275 1
97 BMA BMA BMA BMA BMA 0.449275 1
98 GLA GAL BGC 0.449275 1
99 GLC BGC BGC BGC 0.449275 1
100 CEY 0.449275 1
101 BGC GLC GLC GLC GLC GLC GLC 0.449275 1
102 B4G 0.449275 1
103 CE5 0.449275 1
104 GLC BGC BGC 0.449275 1
105 GLC GLC BGC 0.449275 1
106 CTT 0.449275 1
107 BMA BMA BMA BMA BMA BMA 0.449275 1
108 BGC BGC BGC 0.449275 1
109 GLC GLC GLC GLC GLC 0.449275 1
110 CEX 0.449275 1
111 BGC BGC GLC 0.449275 1
112 GLC GAL GAL 0.449275 1
113 GLC BGC BGC BGC BGC BGC 0.449275 1
114 BGC BGC BGC GLC 0.449275 1
115 CT3 0.449275 1
116 CE8 0.449275 1
117 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.449275 1
118 GAL GAL GAL 0.449275 1
119 BGC GLC GLC GLC GLC 0.449275 1
120 MTT 0.449275 1
121 MAN BMA BMA BMA BMA BMA 0.449275 1
122 CTR 0.449275 1
123 BGC BGC BGC BGC BGC BGC 0.449275 1
124 BMA BMA BMA 0.449275 1
125 BGC GLC GLC GLC 0.449275 1
126 GLA GAL GLC 0.449275 1
127 KDO MAN MAN MAN MAN MAN 0.446602 0.868421
128 NAG MAN MAN 0.440476 0.733333
129 2M4 0.439394 1
130 NAG NAG BMA MAN MAN MAN MAN 0.433962 0.634615
131 STW 0.43038 0.891892
132 MAN MAN MAN MAN MAN MAN MAN MAN 0.430108 0.846154
133 GAL FUC 0.428571 0.941176
134 CGC 0.424658 0.941176
135 TRE 0.423729 1
136 GAL BGC NAG GAL 0.423529 0.733333
137 6SA 0.423077 0.733333
138 GLA EGA 0.422535 0.942857
139 GAL BGC BGC XYS 0.421687 0.942857
140 NAG MAN MAN MAN NAG GAL NAG GAL 0.42 0.673469
141 MAN BMA NAG NAG MAN NAG GAL GAL 0.42 0.673469
142 GLA GAL NAG 0.419753 0.733333
143 MAN BMA NAG 0.419753 0.733333
144 NAG A2G GAL 0.418605 0.6875
145 RAF 0.417722 0.891892
146 BMA BMA MAN 0.416667 1
147 MAN MAN BMA 0.416667 1
148 IAB 0.414141 0.733333
149 6PZ BGC GAL 1GN 1GN ACY GAL GAL ACY BGC 0.413223 0.611111
150 BGC BGC XYS BGC 0.411765 0.942857
151 BMA Z4Y NAG 0.411111 0.717391
152 MAN MNM 0.410959 0.702128
153 NAG MAN BMA MAN NAG GAL 0.41 0.6875
154 XYS BGC BGC XYS BGC XYS BGC BGC BGC 0.409091 0.942857
155 XYS BGC BGC BGC BGC XYS BGC BGC BGC 0.409091 0.942857
156 BGC BGC BGC XYS BGC BGC 0.409091 0.942857
157 U63 0.408451 0.891892
158 XYT 0.407895 0.767442
159 FUC GLA GLA 0.402597 0.970588
160 GLA GAL FUC 0.402597 0.970588
161 GAL GAL FUC 0.402597 0.970588
162 GLA GLA FUC 0.402597 0.970588
163 FUC GAL GLA 0.402597 0.970588
164 GAL NAG GAL GLC 0.402299 0.733333
165 BGC GAL NAG GAL 0.402299 0.733333
166 NAG MAN BMA NDG MAN NAG GAL 0.4 0.673469
167 T6P 0.4 0.767442
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1SL4; Ligand: MAN MAN MAN MAN; Similar sites found with APoc: 28
This union binding pocket(no: 1) in the query (biounit: 1sl4.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 1TMM APC None
2 1TMM HHR None
3 3ZZQ TRP None
4 5YW5 ADE 1.93548
5 3LOO B4P 3.22581
6 4G9N NGA 3.4965
7 4OWK NGA 4.51613
8 1KNM LAT 4.61538
9 1PVC ILE SER GLU VAL 5.16129
10 3CV2 COA 5.80645
11 1B4P GPS 6.45161
12 5C79 PBU 7.33333
13 4OUJ LBT 7.74194
14 4YEF 4CQ 8.98876
15 4B2D SER 9.03226
16 2XG5 EC5 10.9677
17 2XG5 EC2 10.9677
18 5ETR 5RW 11.6129
19 5ETR APC 11.6129
20 2YIP YIO 13.0435
21 4AKB GAL 23.8095
22 1PWB GLC GLC 29.6774
23 1PWB GLC 29.6774
24 2GGX NPJ 29.6774
25 4BC5 5FX 30.3226
26 4DN8 BMA 34.1936
27 1G1T SIA GAL MAG FUC 35.4839
28 3PAK MAN 37.8378
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