Receptor
PDB id Resolution Class Description Source Keywords
1RJ9 1.9 Å NON-ENZYME: SIGNAL_HORMONE STRUCTURE OF THE HETERODIMER OF THE CONSERVED GTPASE DOMAINS SIGNAL RECOGNITION PARTICLE (FFH) AND ITS RECEPTOR (FTSY) THERMUS AQUATICUS SRP-GTPASE DOMAIN HETERODIMER NUCLEOTIDE TWINNING PROTEINCOMPLEX PROTEIN TRANSPORT
Ref.: SUBSTRATE TWINNING ACTIVATES THE SIGNAL RECOGNITION PARTICLE AND ITS RECEPTOR NATURE V. 427 215 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GCP A:500;
B:600;
Valid;
Valid;
none;
none;
submit data
521.208 C11 H18 N5 O13 P3 c1nc2...
MG A:501;
B:601;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1RJ9 1.9 Å NON-ENZYME: SIGNAL_HORMONE STRUCTURE OF THE HETERODIMER OF THE CONSERVED GTPASE DOMAINS SIGNAL RECOGNITION PARTICLE (FFH) AND ITS RECEPTOR (FTSY) THERMUS AQUATICUS SRP-GTPASE DOMAIN HETERODIMER NUCLEOTIDE TWINNING PROTEINCOMPLEX PROTEIN TRANSPORT
Ref.: SUBSTRATE TWINNING ACTIVATES THE SIGNAL RECOGNITION PARTICLE AND ITS RECEPTOR NATURE V. 427 215 2004
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GCP; Similar ligands found: 142
No: Ligand ECFP6 Tc MDL keys Tc
1 GCP 1 1
2 GP3 0.8375 0.948718
3 GDP 0.82716 0.973684
4 GNH 0.817073 0.961039
5 GP2 0.804878 0.987013
6 GTP 0.797619 0.973684
7 G1R 0.788235 0.961039
8 9GM 0.77907 0.948718
9 GNP 0.77907 0.948718
10 GSP 0.77907 0.925
11 G 0.765432 0.960526
12 5GP 0.765432 0.960526
13 G2P 0.758621 0.987013
14 GMV 0.755814 0.948718
15 G2R 0.736264 0.961538
16 Y9Z 0.715789 0.903614
17 GAV 0.703297 0.936709
18 G3A 0.701031 0.948718
19 GKE 0.697917 0.936709
20 GDC 0.697917 0.936709
21 GDD 0.697917 0.936709
22 ALF 5GP 0.696629 0.86747
23 G5P 0.693878 0.948718
24 GPG 0.691489 0.936709
25 GFB 0.690722 0.936709
26 GTG 0.690722 0.91358
27 GDR 0.690722 0.936709
28 GDP AF3 0.688172 0.86747
29 YGP 0.6875 0.879518
30 6CK 0.683673 0.91358
31 JB2 0.67 0.936709
32 GKD 0.67 0.936709
33 GDX 0.663366 0.948718
34 GPD 0.663366 0.925926
35 ALF GDP 0.652632 0.86747
36 GDP ALF 0.652632 0.86747
37 JB3 0.632075 0.925
38 GMP 0.62963 0.857143
39 NGD 0.626168 0.936709
40 G3D 0.610526 0.960526
41 2MD 0.609091 0.870588
42 G G 0.607843 0.924051
43 G4P 0.597938 0.960526
44 U2G 0.59633 0.91358
45 FEG 0.59633 0.880952
46 GDP 7MG 0.596154 0.888889
47 MGD 0.59292 0.870588
48 CAG 0.59292 0.860465
49 ZGP 0.590909 0.870588
50 0O2 0.59 0.960526
51 CG2 0.585586 0.91358
52 MD1 0.57265 0.892857
53 PGD 0.57265 0.902439
54 3GP 0.566667 0.922078
55 TPG 0.563025 0.842697
56 DBG 0.563025 0.925
57 FE9 0.550847 0.760417
58 ACP 0.548387 0.922078
59 GH3 0.54 0.973684
60 GCP G 0.538462 0.922078
61 A G 0.534483 0.911392
62 2GP 0.532609 0.935065
63 G4M 0.53125 0.860465
64 U A G G 0.529915 0.911392
65 GPX 0.529412 0.922078
66 DGI 0.525773 0.924051
67 G A A A 0.521368 0.9
68 IDP 0.520833 0.947368
69 DGT 0.52 0.924051
70 AKW 0.513043 0.869048
71 P1G 0.510417 0.873418
72 G1G 0.504132 0.902439
73 G1R G1R 0.5 0.901235
74 R5I 0.5 0.922078
75 BGO 0.5 0.901235
76 R7I 0.5 0.922078
77 PGD O 0.496 0.831461
78 G U 0.495726 0.878049
79 ACQ 0.494949 0.922078
80 P2G 0.489583 0.860759
81 GGM 0.487395 0.879518
82 MGP 0.485149 0.936709
83 6G0 0.480392 0.936709
84 6YZ 0.480392 0.922078
85 DGP 0.479167 0.911392
86 DG 0.479167 0.911392
87 GPC 0.47541 0.858824
88 G C 0.475 0.878049
89 4TC 0.470085 0.876543
90 IMP 0.46875 0.934211
91 GTA 0.464912 0.91358
92 G2Q 0.453704 0.961538
93 A2D 0.452632 0.871795
94 G G G C 0.452381 0.890244
95 G7M 0.44898 0.924051
96 AT4 0.44898 0.8625
97 APC G U 0.448 0.8875
98 SGP 0.444444 0.807229
99 BA3 0.443299 0.871795
100 G G G RPC 0.439024 0.853659
101 B4P 0.438776 0.871795
102 AP5 0.438776 0.871795
103 ADP 0.438776 0.896104
104 A G C C 0.4375 0.888889
105 ANP 0.436893 0.873418
106 G C C C 0.435115 0.901235
107 AN2 0.434343 0.884615
108 M33 0.43 0.860759
109 A12 0.428571 0.910256
110 AP2 0.428571 0.910256
111 A G U 0.427536 0.86747
112 35G 0.427184 0.909091
113 C2E 0.427184 0.897436
114 PCG 0.427184 0.909091
115 HEJ 0.425743 0.896104
116 ATP 0.425743 0.896104
117 5GP 5GP 0.423077 0.860759
118 G U34 0.422764 0.86747
119 AR6 0.421569 0.871795
120 AQP 0.421569 0.896104
121 5FA 0.421569 0.896104
122 APR 0.421569 0.871795
123 AGS 0.417476 0.851852
124 AD9 0.417476 0.873418
125 SAP 0.417476 0.851852
126 UP5 0.416667 0.851852
127 CA0 0.415842 0.873418
128 ATF 0.415094 0.8625
129 HFD 0.413462 0.851852
130 A G U U 0.412587 0.86747
131 A1R 0.409091 0.841463
132 01G 0.408696 0.880952
133 PRT 0.408696 0.934211
134 APC 0.407767 0.910256
135 DG DG 0.40708 0.86747
136 A4P 0.406504 0.848837
137 UCG 0.406015 0.888889
138 7DD 0.405941 0.883117
139 93A 0.405941 0.813953
140 6AD 0.40566 0.821429
141 ADX 0.401961 0.790698
142 AGO 0.401575 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1RJ9; Ligand: GCP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1rj9.bio1) has 55 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1RJ9; Ligand: GCP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1rj9.bio1) has 69 residues
No: Leader PDB Ligand Sequence Similarity
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