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Receptor
PDB id Resolution Class Description Source Keywords
1RG9 2.5 Å EC: 2.5.1.6 S-ADENOSYLMETHIONINE SYNTHETASE COMPLEXED WITH SAM AND PPNP ESCHERICHIA COLI S-ADENOSYLMETHIONINE SYNTHETASE; METHIONINE ADENOSYLTRANSFERTRANSFERASE
Ref.: CRYSTAL STRUCTURE OF THE S-ADENOSYLMETHIONINE SYNTH TERNARY COMPLEX: A NOVEL CATALYTIC MECHANISM OF S-ADENOSYLMETHIONINE SYNTHESIS FROM ATP AND MET. BIOCHEMISTRY V. 43 1821 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
K A:386;
B:486;
C:586;
D:686;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
39.098 K [K+]
MG A:387;
A:388;
B:487;
B:488;
C:588;
C:687;
D:587;
D:688;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
PPK A:384;
B:484;
C:584;
D:684;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
256.97 H6 N O9 P3 N(P(=...
SAM A:385;
B:485;
C:585;
C:685;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1P7L 2.5 Å EC: 2.5.1.6 S-ADENOSYLMETHIONINE SYNTHETASE COMPLEXED WITH AMPPNP AND ME ESCHERICHIA COLI S-ADENOSYLMETHIONINE SYNTHETASE AMPPNP SAM TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF THE S-ADENOSYLMETHIONINE SYNTH TERNARY COMPLEX: A NOVEL CATALYTIC MECHANISM OF S-ADENOSYLMETHIONINE SYNTHESIS FROM ATP AND MET. BIOCHEMISTRY V. 43 1821 2004
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1P7L - MET C5 H11 N O2 S CSCC[C@@H]....
2 1RG9 - PPK H6 N O9 P3 N(P(=O)(O)....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1P7L - MET C5 H11 N O2 S CSCC[C@@H]....
2 1RG9 - PPK H6 N O9 P3 N(P(=O)(O)....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1P7L - MET C5 H11 N O2 S CSCC[C@@H]....
2 1RG9 - PPK H6 N O9 P3 N(P(=O)(O)....
3 5A1G - PPK H6 N O9 P3 N(P(=O)(O)....
4 5A19 - PPK H6 N O9 P3 N(P(=O)(O)....
5 5A1I - SAM C15 H22 N6 O5 S C[S@@+](CC....
6 5UGH ic50 = 420 uM 8AJ C20 H19 Cl N4 CN(C)CCc1n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PPK; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 PPK 1 1
2 2PN 0.473684 0.9
3 PPV 0.473684 0.7
4 PIS 0.409091 0.617647
Ligand no: 2; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1P7L; Ligand: ANP; Similar sites found with APoc: 27
This union binding pocket(no: 1) in the query (biounit: 1p7l.bio1) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 4K55 H6P None
2 2PYW SR1 1.30548
3 3WUD GLC GAL 2.20588
4 4GNC ASO 2.34114
5 1Z6K OAA 2.38908
6 5G3R NAG 2.55682
7 2BMR 3NT 2.61097
8 2PCU ASP 2.62295
9 2ED4 NAD 2.68456
10 6B2W AG2 3.3033
11 3LGG CFE 3.39426
12 1LNX URI 3.7037
13 1DCP HBI 3.84615
14 1A05 IPM 3.91061
15 2CJ9 SSA 3.91645
16 1WHT BZS 3.92157
17 5N0F 7K2 4.14365
18 4JX1 CAH 4.42478
19 4JX1 CAM 4.42478
20 5CKS GAL 4.5584
21 2G2Y MLI 4.87013
22 3SQG COM 6.52742
23 1A78 TDG 6.71642
24 5N1Q COM 7.27969
25 1C1L GAL BGC 8.75912
26 2CHT TSA 14.1732
27 1SLT NDG GAL 19.403
Pocket No.: 2; Query (leader) PDB : 1P7L; Ligand: PPK; Similar sites found with APoc: 20
This union binding pocket(no: 2) in the query (biounit: 1p7l.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 4K55 H6P None
2 2PYW SR1 1.30548
3 4CIB 7UZ 2.08877
4 2XVL PXN 2.34987
5 1Z6K OAA 2.38908
6 5G3R NAG 2.55682
7 2ED4 NAD 2.68456
8 4UEC MGT 2.71739
9 3W6X HZP 3.05677
10 1DCP HBI 3.84615
11 1A05 IPM 3.91061
12 4JX1 CAM 4.42478
13 4JX1 CAH 4.42478
14 5CKS GAL 4.5584
15 2G2Y MLI 4.87013
16 1CBK ROI 6.25
17 1YRO UDP 6.50407
18 1XKD ICT 6.78851
19 1GXS DKA 8.14815
20 1SLT NDG GAL 19.403
Pocket No.: 3; Query (leader) PDB : 1P7L; Ligand: MET; Similar sites found with APoc: 21
This union binding pocket(no: 3) in the query (biounit: 1p7l.bio1) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 2PYW SR1 1.30548
2 3WUD GLC GAL 2.20588
3 4GNC ASO 2.34114
4 1Z6K OAA 2.38908
5 5G3R NAG 2.55682
6 2BMR 3NT 2.61097
7 2ED4 NAD 2.68456
8 1H70 CIR 3.52941
9 3G5N PB2 3.65535
10 1DCP HBI 3.84615
11 1A05 IPM 3.91061
12 5N0F 7K2 4.14365
13 4JX1 CAH 4.42478
14 4JX1 CAM 4.42478
15 5AEW BNL 4.78723
16 2G2Y MLI 4.87013
17 4QM9 CYS 5.20231
18 3SQG COM 6.52742
19 5N1Q COM 7.27969
20 1C1L GAL BGC 8.75912
21 1SLT NDG GAL 19.403
Pocket No.: 4; Query (leader) PDB : 1P7L; Ligand: PPK; Similar sites found with APoc: 14
This union binding pocket(no: 4) in the query (biounit: 1p7l.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 2DKD NG1 1.56658
2 3WUD GLC GAL 2.20588
3 4GNC ASO 2.34114
4 1A0T SUC 3.13316
5 6B2W AG2 3.3033
6 3LGG CFE 3.39426
7 5JQ1 ZPF 3.44828
8 1OH2 SUC 3.91645
9 1WHT BZS 3.92157
10 5VIT MLI 4.0404
11 2HAW 2PN 4.20712
12 2CI5 HCS 4.22535
13 3O03 GCO 5.15464
14 1A78 TDG 6.71642
Pocket No.: 5; Query (leader) PDB : 1P7L; Ligand: SAM; Similar sites found with APoc: 26
This union binding pocket(no: 5) in the query (biounit: 1p7l.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 4K55 H6P None
2 2DKD NG1 1.56658
3 3WUD GLC GAL 2.20588
4 4GNC ASO 2.34114
5 1Z6K OAA 2.38908
6 5G3R NAG 2.55682
7 2ED4 NAD 2.68456
8 1A0T SUC 3.13316
9 6B2W AG2 3.3033
10 3LGG CFE 3.39426
11 5JQ1 ZPF 3.44828
12 1DCP HBI 3.84615
13 1A05 IPM 3.91061
14 1OH2 SUC 3.91645
15 1WHT BZS 3.92157
16 5VIT MLI 4.0404
17 2HAW 2PN 4.20712
18 2CI5 HCS 4.22535
19 4JX1 CAH 4.42478
20 4JX1 CAM 4.42478
21 5CKS GAL 4.5584
22 2G2Y MLI 4.87013
23 3O03 GCO 5.15464
24 1YRO UDP 6.50407
25 1A78 TDG 6.71642
26 1SLT NDG GAL 19.403
Pocket No.: 6; Query (leader) PDB : 1P7L; Ligand: SAM; Similar sites found with APoc: 8
This union binding pocket(no: 6) in the query (biounit: 1p7l.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 2PYW SR1 1.30548
2 4CIB 7UZ 2.08877
3 2XVL PXN 2.34987
4 4UEC MGT 2.71739
5 3W6X HZP 3.05677
6 1CBK ROI 6.25
7 1XKD ICT 6.78851
8 1GXS DKA 8.14815
Pocket No.: 7; Query (leader) PDB : 1P7L; Ligand: MET; Similar sites found with APoc: 8
This union binding pocket(no: 7) in the query (biounit: 1p7l.bio1) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 4CU1 H4B 2.34987
2 2PCU ASP 2.62295
3 4UEC MGT 2.71739
4 5CKS GAL 4.5584
5 3NV3 GAL NAG MAN 5.07246
6 6GH9 MIX 6.30137
7 1YRO UDP 6.50407
8 1I7A FLC 9.00901
Pocket No.: 8; Query (leader) PDB : 1P7L; Ligand: ANP; Similar sites found with APoc: 8
This union binding pocket(no: 8) in the query (biounit: 1p7l.bio1) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 4CIB 7UZ 2.08877
2 4UEC MGT 2.71739
3 3W6X HZP 3.05677
4 1Y7P RIP 4.4843
5 5AEW BNL 4.78723
6 6GH9 MIX 6.30137
7 1YRO UDP 6.50407
8 1GXS DKA 8.14815
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