Receptor
PDB id Resolution Class Description Source Keywords
1QCO 1.9 Å EC: 3.7.1.2 CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE MUS MUSCULUS MIXED BETA SANDWICH ROLL HYDROLASE
Ref.: CRYSTAL STRUCTURE AND MECHANISM OF A CARBON-CARBON BOND HYDROLASE. STRUCTURE FOLD.DES. V. 7 1023 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AAE A:1010;
B:1011;
 Valid;
Valid;
 none;
none;
 submit data
102.089 C4 H6 O3 CC(=O...
CA A:1002;
B:1001;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
40.078 Ca [Ca+2...
FUM A:1008;
B:1009;
 Valid;
Valid;
 none;
none;
 submit data
116.072 C4 H4 O4 C(=C/...
NI A:1006;
B:1003;
B:1004;
B:1005;
B:1007;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
none;
 submit data
58.693 Ni [Ni+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HZY 1.35 Å EC: 3.7.1.2 MOUSE FUMARYLACETOACETATE HYDROLASE COMPLEXES WITH A TRANSITION-STATE MIMIC OF THE COMPLETE SUBSTRATE MUS MUSCULUS TRANSITION-STATE MIMICKING COMPLEX HYDROLASE
Ref.: SLOW-ONSET INHIBITION OF FUMARYLACETOACETATE HYDROLASE BY PHOSPHINATE MIMICS OF THE TETRAHEDRAL INTERMEDIATE: KINETICS, CRYSTAL STRUCTURE AND PHARMACOKINETICS. BIOCHEM.J. V. 402 251 2007
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2HZY Ki = 41 nM DHJ C7 H11 O7 P C(C[P@](=O....
2 1QCO - FUM C4 H4 O4 C(=C/C(=O)....
3 1HYO Ki = 84.8 uM HBU C5 H9 O5 P C[P@](=O)(....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2HZY Ki = 41 nM DHJ C7 H11 O7 P C(C[P@](=O....
2 1QCO - FUM C4 H4 O4 C(=C/C(=O)....
3 1HYO Ki = 84.8 uM HBU C5 H9 O5 P C[P@](=O)(....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2HZY Ki = 41 nM DHJ C7 H11 O7 P C(C[P@](=O....
2 1QCO - FUM C4 H4 O4 C(=C/C(=O)....
3 1HYO Ki = 84.8 uM HBU C5 H9 O5 P C[P@](=O)(....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: AAE; Similar ligands found: 9
No: Ligand ECFP6 Tc MDL keys Tc
1 AAE 1 1
2 P2D 0.6 0.625
3 MLA 0.6 0.631579
4 SHF 0.5 0.777778
5 6JN 0.473684 0.65
6 PPI 0.470588 0.625
7 PYR 0.411765 0.625
8 BUQ 0.4 0.6
9 BUA 0.4 0.611111
Ligand no: 2; Ligand: FUM; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 MAE 1 1
2 FUM 1 1
3 CCU 0.5625 1
4 GLV 0.5 0.666667
Similar Ligands (3D)
Ligand no: 1; Ligand: AAE; Similar ligands found: 602
No: Ligand Similarity coefficient
1 MLI 1.0000
2 DMG 0.9997
3 C5J 0.9992
4 MLM 0.9977
5 IVA 0.9950
6 3HL 0.9907
7 3HR 0.9857
8 IPU 0.9698
9 DTL 0.9686
10 PRO 0.9679
11 OXL 0.9657
12 3PY 0.9649
13 HV2 0.9628
14 THR 0.9586
15 IHG 0.9569
16 KIV 0.9560
17 VAL 0.9557
18 MAK 0.9556
19 BAL 0.9548
20 2PC 0.9523
21 DPR 0.9523
22 SER 0.9522
23 JBN 0.9521
24 ALO 0.9514
25 BU4 0.9511
26 DSN 0.9508
27 NMG 0.9501
28 PYC 0.9487
29 TFB 0.9483
30 BUB 0.9477
31 69O 0.9473
32 TZC 0.9472
33 PRS 0.9471
34 SIN 0.9471
35 3BB 0.9470
36 MPD 0.9463
37 24T 0.9460
38 BVC 0.9458
39 BMD 0.9457
40 MZ0 0.9451
41 MSF 0.9450
42 AOA 0.9445
43 FOA 0.9440
44 3OH 0.9438
45 MAE 0.9436
46 2HE 0.9432
47 S0H 0.9429
48 KG7 0.9428
49 DCL 0.9428
50 DXX 0.9427
51 CYS 0.9425
52 IQ0 0.9424
53 2KT 0.9423
54 CP 0.9411
55 SAR 0.9410
56 HDA 0.9410
57 TP5 0.9405
58 E60 0.9398
59 DBB 0.9383
60 273 0.9381
61 TB6 0.9380
62 C21 0.9380
63 EGD 0.9379
64 FUM 0.9378
65 ABU 0.9376
66 CHT 0.9375
67 NVI 0.9375
68 PAE 0.9374
69 265 0.9370
70 DTT 0.9370
71 23W 0.9366
72 MRY 0.9365
73 CEJ 0.9364
74 C2N 0.9362
75 SSN 0.9360
76 SAT 0.9358
77 AKB 0.9355
78 A3B 0.9350
79 PRI 0.9349
80 7VD 0.9349
81 T2C 0.9347
82 MTG 0.9344
83 HSE 0.9342
84 LEA 0.9339
85 284 0.9332
86 AMC 0.9331
87 1DU 0.9328
88 HCS 0.9326
89 ALQ 0.9325
90 TAU 0.9323
91 LER 0.9322
92 FBJ 0.9321
93 SMV 0.9321
94 MZW 0.9320
95 OXD 0.9320
96 JAB 0.9316
97 PUT 0.9314
98 192 0.9311
99 HX2 0.9304
100 JZ5 0.9303
101 DGY 0.9301
102 J1Z 0.9300
103 DCY 0.9295
104 2RA 0.9291
105 4MV 0.9291
106 FCN 0.9283
107 BAE 0.9283
108 PCT 0.9281
109 2EZ 0.9279
110 SLP 0.9278
111 FW5 0.9275
112 BXO 0.9274
113 A2Q 0.9274
114 M6W 0.9273
115 HVQ 0.9271
116 03W 0.9268
117 XAP 0.9260
118 HUI 0.9259
119 8X3 0.9259
120 LAC 0.9257
121 HSM 0.9253
122 ETX 0.9251
123 BVG 0.9248
124 ITU 0.9241
125 25T 0.9240
126 ABA 0.9230
127 1AC 0.9230
128 RCO 0.9228
129 HGY 0.9228
130 POA 0.9226
131 IDH 0.9225
132 GOL 0.9224
133 DE2 0.9223
134 HIU 0.9222
135 URA 0.9220
136 1SP 0.9215
137 DAL 0.9215
138 SYN 0.9214
139 4JU 0.9209
140 ETM 0.9209
141 ABN 0.9207
142 3CH 0.9203
143 ALA 0.9202
144 H95 0.9198
145 HAI 0.9196
146 54D 0.9195
147 MTD 0.9192
148 CRS 0.9190
149 1DH 0.9190
150 OXM 0.9190
151 CXL 0.9189
152 CYH 0.9189
153 DUC 0.9188
154 SMB 0.9185
155 DSS 0.9185
156 XBT 0.9184
157 39J 0.9179
158 APY 0.9179
159 OHG 0.9178
160 2OP 0.9177
161 2MH 0.9177
162 1DQ 0.9175
163 9YL 0.9174
164 6PC 0.9170
165 HPY 0.9167
166 HZP 0.9167
167 PCA 0.9163
168 HGQ 0.9161
169 HYN 0.9160
170 QSC 0.9159
171 UY7 0.9154
172 ILE 0.9152
173 HBS 0.9152
174 GBD 0.9150
175 OAA 0.9149
176 BEZ 0.9149
177 RP7 0.9149
178 7EX 0.9148
179 4HA 0.9146
180 BVF 0.9145
181 9X7 0.9144
182 HYP 0.9144
183 282 0.9142
184 HBR 0.9139
185 BEN 0.9138
186 BAM 0.9135
187 PPF 0.9134
188 LG5 0.9132
189 FJO 0.9132
190 M3T 0.9130
191 JZ7 0.9124
192 2IM 0.9122
193 5AC 0.9121
194 PY7 0.9120
195 1MR 0.9117
196 YCP 0.9117
197 LG3 0.9116
198 NBZ 0.9113
199 26D 0.9110
200 HBX 0.9110
201 CYT 0.9110
202 FPI 0.9108
203 NBN 0.9106
204 9CL 0.9100
205 HEW 0.9100
206 NCA 0.9100
207 8GF 0.9096
208 CSS 0.9091
209 ZBT 0.9091
210 NBE 0.9090
211 CIG 0.9090
212 THE 0.9089
213 PYF 0.9086
214 NIO 0.9084
215 60P 0.9082
216 PZA 0.9081
217 4H2 0.9080
218 BP9 0.9079
219 IPH 0.9076
220 TZL 0.9076
221 ODV 0.9076
222 OXQ 0.9072
223 PE9 0.9072
224 GAG 0.9071
225 B3R 0.9070
226 FLA 0.9066
227 NAK 0.9060
228 LLQ 0.9060
229 MRZ 0.9059
230 XPO 0.9059
231 A8C 0.9054
232 NTN 0.9053
233 RB5 0.9052
234 XYL 0.9052
235 DAB 0.9051
236 XRG 0.9045
237 VGL 0.9044
238 2HA 0.9043
239 93B 0.9038
240 L60 0.9037
241 V1L 0.9037
242 CRN 0.9036
243 GLY ALA 0.9035
244 AML 0.9033
245 TFS 0.9030
246 MLT 0.9029
247 LDU 0.9029
248 P7I 0.9027
249 RSF 0.9027
250 1CB 0.9025
251 PAH 0.9021
252 XIX 0.9020
253 DEN 0.9020
254 AC5 0.9019
255 IDM 0.9019
256 SGL 0.9019
257 PPV 0.9019
258 PYM 0.9018
259 FQI 0.9018
260 H3M 0.9015
261 BAQ 0.9014
262 OPE 0.9012
263 QFH 0.9012
264 BTL 0.9011
265 VAH 0.9010
266 UNU 0.9009
267 3CL 0.9008
268 GG6 0.9002
269 ECE 0.9002
270 GXE 0.9001
271 PLQ 0.9000
272 14J 0.9000
273 HE2 0.8997
274 HHQ 0.8994
275 UGC 0.8990
276 BZI 0.8990
277 JZ9 0.8989
278 PGA 0.8987
279 GXV 0.8987
280 IND 0.8980
281 LZ1 0.8980
282 6SP 0.8976
283 9A7 0.8976
284 1PT 0.8975
285 MEU 0.8973
286 PYJ 0.8973
287 MBN 0.8970
288 AC0 0.8970
289 DA1 0.8970
290 TEO 0.8969
291 LMR 0.8968
292 A20 0.8964
293 UYA 0.8963
294 XLS 0.8961
295 MPI 0.8960
296 40O 0.8960
297 BZF 0.8959
298 2RH 0.8957
299 3ZQ 0.8957
300 PBC 0.8956
301 TF4 0.8955
302 4JP 0.8955
303 1AB 0.8954
304 ISU 0.8952
305 PIS 0.8951
306 ATQ 0.8950
307 23B 0.8950
308 PCR 0.8950
309 FPN 0.8950
310 HQE 0.8950
311 0R1 0.8950
312 HY3 0.8949
313 IT2 0.8948
314 EFS 0.8944
315 0CT 0.8940
316 POP 0.8939
317 GBL 0.8937
318 BML 0.8935
319 TAY 0.8934
320 3SS 0.8934
321 NVA 0.8932
322 EDG 0.8932
323 OK7 0.8932
324 IOM 0.8932
325 GVH 0.8930
326 B24 0.8929
327 NIS 0.8928
328 ASP 0.8924
329 4CH 0.8923
330 280 0.8923
331 TH0 0.8923
332 3AP 0.8920
333 4AP 0.8920
334 2AP 0.8920
335 PXY 0.8920
336 MWM 0.8917
337 HRZ 0.8915
338 ASN 0.8914
339 CRD 0.8914
340 HY1 0.8913
341 MMU 0.8910
342 MCT 0.8910
343 MB3 0.8910
344 COM 0.8908
345 PKU 0.8904
346 3GR 0.8903
347 OXE 0.8902
348 BNS 0.8902
349 SS1 0.8902
350 VX 0.8902
351 ITN 0.8900
352 WOT 0.8900
353 LG4 0.8900
354 IZC 0.8895
355 4ZE 0.8893
356 285 0.8891
357 8CL 0.8891
358 9PO 0.8888
359 BUO 0.8886
360 SS2 0.8882
361 ICC 0.8881
362 3ZS 0.8881
363 HVK 0.8880
364 25R 0.8880
365 275 0.8877
366 XUL 0.8876
367 4SD 0.8876
368 13D 0.8874
369 LEU 0.8872
370 DYA 0.8871
371 TZE 0.8870
372 URF 0.8870
373 HLT 0.8868
374 COI 0.8865
375 TMZ 0.8862
376 GLV 0.8860
377 M58 0.8860
378 7WG 0.8859
379 FAN 0.8856
380 R2B 0.8855
381 LGA 0.8853
382 GLY 0.8850
383 4HO 0.8850
384 TMT 0.8850
385 5JC 0.8850
386 XYS 0.8848
387 CIZ 0.8848
388 DTU 0.8844
389 PXO 0.8842
390 URP 0.8841
391 CAQ 0.8840
392 HT4 0.8840
393 XBZ 0.8840
394 5Y9 0.8836
395 2AC 0.8834
396 TDR 0.8830
397 CMS 0.8828
398 C2A 0.8827
399 4HS 0.8826
400 RSO 0.8824
401 9SB 0.8824
402 51F 0.8822
403 TTO 0.8821
404 AKR 0.8820
405 2K4 0.8820
406 2YU 0.8820
407 BEW 0.8820
408 2CH 0.8820
409 AHR 0.8820
410 EHM 0.8820
411 NXA 0.8820
412 ETF 0.8819
413 HYA 0.8818
414 XYP 0.8812
415 5MI 0.8810
416 F60 0.8810
417 5H1 0.8810
418 2CO 0.8810
419 2MP 0.8805
420 FAH 0.8803
421 34A 0.8803
422 9A4 0.8802
423 FPY 0.8800
424 6AI 0.8800
425 14O 0.8800
426 5MB 0.8800
427 TM7 0.8800
428 PYD 0.8798
429 ICP 0.8798
430 XYD 0.8797
431 WBU 0.8794
432 ORN 0.8794
433 F3V 0.8793
434 3Q7 0.8792
435 TAR 0.8789
436 FEH 0.8788
437 YHO 0.8782
438 JZ0 0.8781
439 DAS 0.8781
440 1MC 0.8780
441 4CL 0.8780
442 5MH 0.8780
443 BZX 0.8780
444 HHN 0.8780
445 3MT 0.8780
446 2PN 0.8780
447 PAF 0.8778
448 43M 0.8778
449 YAN 0.8775
450 ICN 0.8775
451 4VP 0.8774
452 D2P 0.8773
453 2DR 0.8772
454 5UC 0.8771
455 4JN 0.8770
456 93Q 0.8769
457 SRT 0.8768
458 HBA 0.8767
459 CFI 0.8766
460 NIE 0.8763
461 FP2 0.8762
462 6M4 0.8761
463 ES9 0.8760
464 NIZ 0.8760
465 4JJ 0.8760
466 1AN 0.8757
467 2AF 0.8757
468 MET 0.8757
469 278 0.8755
470 MMZ 0.8755
471 JYD 0.8755
472 4MZ 0.8755
473 JZ2 0.8754
474 L89 0.8753
475 HTS 0.8752
476 938 0.8750
477 BHO 0.8746
478 R1X 0.8745
479 ISZ 0.8745
480 AMT 0.8743
481 76X 0.8742
482 GOA 0.8742
483 FMS 0.8741
484 11S 0.8740
485 PIH 0.8735
486 1DV 0.8735
487 HGW 0.8733
488 TLD 0.8731
489 H4N 0.8730
490 2MZ 0.8730
491 1MZ 0.8730
492 IMR 0.8729
493 HSL 0.8728
494 IUR 0.8724
495 1DJ 0.8724
496 4DX 0.8723
497 L3Q 0.8721
498 27Y 0.8720
499 MWJ 0.8720
500 6X8 0.8720
501 5MP 0.8719
502 92Z 0.8717
503 TLA 0.8717
504 8LG 0.8716
505 NPO 0.8716
506 2AI 0.8715
507 NMU 0.8713
508 40E 0.8712
509 MNN 0.8712
510 FK1 0.8710
511 HVB 0.8710
512 MR3 0.8706
513 47J 0.8705
514 HOW 0.8702
515 BR9 0.8700
516 JZ6 0.8696
517 F05 0.8694
518 JZ1 0.8694
519 PEL 0.8693
520 0RW 0.8691
521 XM0 0.8689
522 R3W 0.8685
523 9TY 0.8685
524 DQY 0.8684
525 FBA 0.8684
526 GLL 0.8684
527 MZY 0.8683
528 IOL 0.8683
529 6M9 0.8680
530 8NY 0.8680
531 PEA 0.8679
532 98J 0.8676
533 JAE 0.8675
534 3TR 0.8674
535 F9P 0.8671
536 0R0 0.8670
537 JZ3 0.8670
538 PYG 0.8670
539 1DW 0.8670
540 3MC 0.8661
541 LXC 0.8661
542 7CZ 0.8661
543 4XX 0.8661
544 0TR 0.8660
545 KSW 0.8660
546 1XX 0.8658
547 FBM 0.8658
548 4JO 0.8654
549 271 0.8653
550 ABV 0.8650
551 PHB 0.8650
552 4CS 0.8649
553 F50 0.8647
554 5KX 0.8643
555 KOJ 0.8641
556 SPA 0.8640
557 9EW 0.8640
558 4JM 0.8626
559 RIP 0.8626
560 DTI 0.8617
561 GLY GLY 0.8617
562 270 0.8615
563 AX7 0.8615
564 2A1 0.8615
565 GOJ 0.8614
566 QUZ 0.8613
567 RUU 0.8613
568 O7U 0.8611
569 Z82 0.8610
570 BYZ 0.8608
571 SNE 0.8604
572 Y8I 0.8602
573 MBD 0.8600
574 GMN 0.8600
575 4AX 0.8593
576 61G 0.8593
577 2C9 0.8590
578 CEE 0.8587
579 2MI 0.8583
580 7N0 0.8581
581 ES3 0.8580
582 FLM 0.8580
583 2MY 0.8580
584 717 0.8578
585 SAL 0.8577
586 CXF 0.8574
587 P92 0.8570
588 3FA 0.8570
589 NPY 0.8567
590 PBE 0.8567
591 PYZ 0.8562
592 3MH 0.8560
593 3CE 0.8560
594 SVN 0.8560
595 13P 0.8560
596 MGX 0.8547
597 4JL 0.8545
598 2CQ 0.8541
599 3U4 0.8539
600 4ZC 0.8530
601 1P3 0.8520
602 BXA 0.8515
Ligand no: 2; Ligand: FUM; Similar ligands found: 674
No: Ligand Similarity coefficient
1 HX2 1.0000
2 H95 1.0000
3 SIN 1.0000
4 4MV 0.9994
5 NMG 0.9994
6 SHF 0.9980
7 MLT 0.9849
8 2RH 0.9801
9 TEO 0.9795
10 OAA 0.9792
11 DQY 0.9775
12 LMR 0.9754
13 SSN 0.9737
14 OKG 0.9732
15 CMS 0.9731
16 CRN 0.9724
17 IOM 0.9724
18 OK7 0.9711
19 DYA 0.9705
20 ABU 0.9700
21 DAS 0.9693
22 COI 0.9681
23 GLY GLY 0.9679
24 UGC 0.9679
25 VKC 0.9674
26 MLI 0.9663
27 LEU 0.9660
28 ITN 0.9656
29 PG3 0.9655
30 LEA 0.9653
31 PGA 0.9650
32 ASP 0.9634
33 DAV 0.9618
34 GLU 0.9616
35 ASN 0.9612
36 NXA 0.9607
37 P2D 0.9601
38 HDA 0.9596
39 MLA 0.9593
40 SHO 0.9585
41 PRO 0.9582
42 JYD 0.9580
43 OEG 0.9572
44 X1S 0.9570
45 IZC 0.9561
46 6NA 0.9555
47 GUA 0.9546
48 4JU 0.9541
49 URP 0.9536
50 1GP 0.9535
51 SPA 0.9530
52 KIV 0.9522
53 40E 0.9519
54 TFB 0.9516
55 G3P 0.9516
56 IQ0 0.9500
57 2MH 0.9500
58 HTX 0.9493
59 9X7 0.9489
60 98J 0.9489
61 C21 0.9481
62 A8C 0.9473
63 HSE 0.9471
64 VAL 0.9469
65 IPU 0.9469
66 SD4 0.9464
67 THR 0.9463
68 GLN 0.9458
69 1KA 0.9449
70 3PP 0.9448
71 K34 0.9439
72 MAK 0.9439
73 HCS 0.9426
74 EOU 0.9422
75 BEN 0.9421
76 PCA 0.9418
77 FBJ 0.9415
78 GLL 0.9408
79 BUB 0.9394
80 2KT 0.9393
81 54D 0.9392
82 HYP 0.9386
83 URO 0.9384
84 THE 0.9384
85 282 0.9381
86 BEZ 0.9378
87 AAE 0.9378
88 MLM 0.9376
89 FPI 0.9376
90 3PY 0.9376
91 CFI 0.9375
92 ISZ 0.9375
93 DE5 0.9373
94 IVA 0.9371
95 DMG 0.9368
96 HE2 0.9367
97 PSE 0.9366
98 3SL 0.9365
99 AC0 0.9363
100 HZP 0.9363
101 QFH 0.9363
102 9YL 0.9359
103 SER 0.9358
104 PHU 0.9355
105 SRT 0.9354
106 NCA 0.9353
107 FOA 0.9351
108 PG0 0.9350
109 TP5 0.9345
110 NIZ 0.9344
111 BAM 0.9344
112 UNU 0.9339
113 T2C 0.9337
114 HSO 0.9337
115 49F 0.9336
116 FW5 0.9336
117 FQI 0.9332
118 ZBT 0.9329
119 HBA 0.9328
120 YIV 0.9327
121 DAB 0.9327
122 NIO 0.9320
123 C5J 0.9319
124 BNS 0.9318
125 AKG 0.9316
126 SMV 0.9315
127 S0H 0.9314
128 1DU 0.9312
129 RSO 0.9310
130 R2B 0.9310
131 273 0.9308
132 AKB 0.9308
133 BHO 0.9307
134 NVA 0.9304
135 PGH 0.9304
136 AL0 0.9301
137 PPR 0.9299
138 7WG 0.9299
139 69O 0.9298
140 TZC 0.9297
141 UYA 0.9294
142 TZL 0.9293
143 FBM 0.9293
144 G3H 0.9292
145 PBC 0.9292
146 265 0.9292
147 TLA 0.9291
148 ABN 0.9290
149 XBT 0.9289
150 BHH 0.9288
151 HSM 0.9288
152 6PC 0.9286
153 ETX 0.9285
154 PUT 0.9285
155 HL5 0.9285
156 NTN 0.9284
157 MEQ 0.9278
158 ACH 0.9276
159 IHG 0.9273
160 R67 0.9272
161 SPV 0.9272
162 HP6 0.9272
163 16D 0.9271
164 PYC 0.9270
165 PEP 0.9269
166 LTL 0.9266
167 JZ5 0.9265
168 A20 0.9264
169 QSC 0.9263
170 5XA 0.9263
171 BP9 0.9262
172 2PC 0.9261
173 14J 0.9260
174 SS2 0.9258
175 GP9 0.9258
176 M4T 0.9257
177 AC5 0.9257
178 M6W 0.9250
179 TPA 0.9248
180 TAR 0.9248
181 HIO 0.9243
182 0VT 0.9241
183 OGA 0.9235
184 4VP 0.9234
185 2CO 0.9233
186 OPE 0.9230
187 XAP 0.9229
188 PRS 0.9228
189 HIU 0.9228
190 4LR 0.9227
191 7N0 0.9226
192 HQE 0.9225
193 13P 0.9222
194 3SS 0.9222
195 4HA 0.9220
196 IXW 0.9220
197 DSN 0.9219
198 O8Y 0.9219
199 BE7 0.9218
200 PZI 0.9217
201 2RA 0.9215
202 PLQ 0.9214
203 AHB 0.9214
204 VGL 0.9213
205 FEH 0.9211
206 7VD 0.9210
207 JBN 0.9208
208 TIU 0.9208
209 9X6 0.9207
210 F9P 0.9204
211 M58 0.9204
212 FPY 0.9200
213 ILE 0.9200
214 NBN 0.9197
215 HBX 0.9197
216 2HG 0.9196
217 AMC 0.9193
218 YCP 0.9193
219 PE9 0.9193
220 SS1 0.9192
221 ALO 0.9192
222 1PT 0.9192
223 MRZ 0.9190
224 NBZ 0.9190
225 GZ3 0.9190
226 MRY 0.9188
227 NBE 0.9186
228 KMH 0.9185
229 DBB 0.9182
230 MZ0 0.9182
231 PZA 0.9181
232 C2B 0.9179
233 QY9 0.9179
234 DGY 0.9177
235 IDM 0.9177
236 AML 0.9176
237 DPR 0.9174
238 PAE 0.9174
239 4JL 0.9172
240 S2G 0.9171
241 CP 0.9169
242 SYN 0.9169
243 PYJ 0.9168
244 EHM 0.9167
245 1DV 0.9165
246 TB6 0.9164
247 VAH 0.9162
248 PIY 0.9162
249 PAC 0.9162
250 FPN 0.9161
251 FBA 0.9160
252 0V5 0.9159
253 PEQ 0.9159
254 JZ7 0.9156
255 GJZ 0.9154
256 UY7 0.9154
257 M3H 0.9152
258 B24 0.9149
259 129 0.9149
260 1SH 0.9149
261 3OL 0.9147
262 3HR 0.9146
263 CIZ 0.9146
264 DA1 0.9146
265 RBL 0.9145
266 PAH 0.9145
267 ABA 0.9143
268 2AS 0.9142
269 APY 0.9141
270 7A8 0.9140
271 HVQ 0.9140
272 FAN 0.9139
273 MUC 0.9138
274 3AB 0.9138
275 DCL 0.9136
276 CEJ 0.9134
277 53C 0.9133
278 JAB 0.9132
279 3HB 0.9131
280 I1E 0.9131
281 DGN 0.9130
282 PKU 0.9126
283 MPD 0.9126
284 MZW 0.9124
285 PIM 0.9120
286 ICF 0.9119
287 PIS 0.9117
288 KG7 0.9116
289 GLY ALA 0.9115
290 3OC 0.9115
291 DE2 0.9113
292 CXF 0.9113
293 CSS 0.9112
294 PMB 0.9110
295 7BC 0.9110
296 AG2 0.9110
297 3HL 0.9109
298 3OM 0.9108
299 1MR 0.9108
300 192 0.9107
301 XM0 0.9103
302 XRG 0.9103
303 CYX 0.9103
304 ORN 0.9102
305 ZGL 0.9099
306 HYA 0.9099
307 GGL 0.9097
308 2IT 0.9097
309 BXO 0.9096
310 LER 0.9094
311 R1X 0.9093
312 PCT 0.9092
313 MTD 0.9090
314 PHB 0.9089
315 23B 0.9087
316 PAB 0.9086
317 4CS 0.9085
318 ONL 0.9085
319 GAB 0.9084
320 IT2 0.9084
321 SAT 0.9084
322 WCE 0.9083
323 KVV 0.9082
324 9TY 0.9079
325 1SP 0.9078
326 DGL 0.9077
327 9ON 0.9077
328 OHG 0.9072
329 CYS 0.9072
330 BHL 0.9070
331 J9N 0.9069
332 BUA 0.9069
333 URS 0.9068
334 LLQ 0.9068
335 LDU 0.9064
336 FB2 0.9061
337 R9M 0.9060
338 23W 0.9059
339 NPO 0.9058
340 CCE 0.9054
341 ITU 0.9054
342 MEU 0.9054
343 URQ 0.9053
344 HV2 0.9052
345 1SA 0.9051
346 HY1 0.9050
347 7CL 0.9050
348 5HN 0.9050
349 HBD 0.9048
350 RB5 0.9048
351 XYL 0.9048
352 5FX 0.9046
353 J1Z 0.9046
354 MET 0.9045
355 SGL 0.9045
356 1DQ 0.9044
357 4P5 0.9044
358 3V4 0.9042
359 NLE 0.9040
360 IMR 0.9037
361 FLA 0.9037
362 OVV 0.9036
363 1Y6 0.9035
364 BZX 0.9033
365 HIS 0.9031
366 1DJ 0.9029
367 SKG 0.9029
368 FOC 0.9029
369 8GC 0.9028
370 MNN 0.9027
371 NVI 0.9026
372 NF3 0.9023
373 PLU 0.9022
374 3NT 0.9022
375 XUL 0.9022
376 HY3 0.9020
377 GG6 0.9019
378 BAL 0.9014
379 ROR 0.9013
380 2EH 0.9012
381 BMD 0.9009
382 XLS 0.9009
383 P72 0.9008
384 J9T 0.9004
385 K7M 0.9004
386 8K2 0.9003
387 SAR 0.9002
388 3HG 0.9000
389 3BZ 0.8997
390 DS0 0.8993
391 EDG 0.8992
392 BVG 0.8992
393 9J3 0.8991
394 PBZ 0.8991
395 SW7 0.8989
396 GOJ 0.8987
397 N6C 0.8987
398 SC2 0.8986
399 2HA 0.8985
400 JZ9 0.8984
401 SMB 0.8983
402 DXX 0.8982
403 FSG 0.8982
404 BRT 0.8981
405 PRI 0.8976
406 1P3 0.8976
407 1AB 0.8976
408 MXN 0.8975
409 IP8 0.8974
410 JAE 0.8970
411 0CT 0.8970
412 BZF 0.8969
413 KMT 0.8969
414 GAG 0.8968
415 MED 0.8967
416 HMH 0.8966
417 3S5 0.8965
418 BU4 0.8965
419 SHV 0.8963
420 51F 0.8962
421 AC6 0.8961
422 GPF 0.8959
423 8EW 0.8959
424 RNT 0.8959
425 GPJ 0.8958
426 826 0.8958
427 K6H 0.8958
428 9CL 0.8958
429 BZI 0.8957
430 4MA 0.8956
431 A3B 0.8951
432 DTL 0.8946
433 03W 0.8946
434 DEN 0.8945
435 BVC 0.8945
436 PPV 0.8945
437 PEA 0.8944
438 F60 0.8942
439 S8V 0.8939
440 2PN 0.8936
441 CHT 0.8936
442 HPV 0.8934
443 IND 0.8932
444 BUQ 0.8932
445 174 0.8932
446 069 0.8930
447 45L 0.8930
448 4ZA 0.8929
449 LZ1 0.8929
450 ABV 0.8928
451 NMJ 0.8927
452 PEL 0.8927
453 2K4 0.8922
454 FCN 0.8922
455 14O 0.8921
456 7MU 0.8921
457 PYF 0.8921
458 KOJ 0.8920
459 GBD 0.8919
460 717 0.8916
461 BAE 0.8915
462 LNO 0.8914
463 5H1 0.8913
464 GOL 0.8911
465 4WL 0.8911
466 QDK 0.8910
467 RSF 0.8910
468 M45 0.8909
469 4JP 0.8909
470 SEP 0.8906
471 ACA 0.8906
472 POA 0.8905
473 25T 0.8905
474 ODV 0.8904
475 TH7 0.8901
476 SME 0.8900
477 60P 0.8899
478 3QM 0.8897
479 OEM 0.8895
480 HUI 0.8895
481 6AI 0.8893
482 DTU 0.8891
483 C2N 0.8891
484 KVP 0.8891
485 CCD 0.8888
486 0R1 0.8887
487 OXQ 0.8887
488 DMV 0.8887
489 PY7 0.8886
490 HDH 0.8883
491 XPO 0.8883
492 2EZ 0.8883
493 5MI 0.8880
494 DHI 0.8879
495 POP 0.8879
496 TZE 0.8878
497 CEE 0.8876
498 271 0.8876
499 I4B 0.8876
500 Z82 0.8874
501 NM3 0.8873
502 GVH 0.8872
503 258 0.8870
504 39J 0.8869
505 3OH 0.8869
506 MPI 0.8866
507 I2M 0.8866
508 DCY 0.8865
509 CHH 0.8863
510 AX7 0.8863
511 2HE 0.8857
512 173 0.8856
513 NCT 0.8855
514 TAU 0.8855
515 SAL 0.8853
516 5MB 0.8853
517 NM2 0.8853
518 TH0 0.8852
519 HHI 0.8851
520 2CK 0.8844
521 4SD 0.8841
522 270 0.8840
523 EGD 0.8840
524 PAF 0.8834
525 FBW 0.8831
526 2MI 0.8831
527 MTG 0.8830
528 4SV 0.8820
529 QMP 0.8814
530 GVG 0.8814
531 VNJ 0.8813
532 INO 0.8811
533 3SK 0.8810
534 264 0.8810
535 G2H 0.8807
536 DIR 0.8806
537 4JT 0.8806
538 3U4 0.8804
539 DHB 0.8803
540 MSF 0.8802
541 4A3 0.8800
542 TYL 0.8799
543 11S 0.8797
544 ES6 0.8797
545 LYS 0.8796
546 2FT 0.8796
547 H8N 0.8796
548 SLP 0.8794
549 ICN 0.8793
550 3GR 0.8792
551 8X3 0.8792
552 HG3 0.8791
553 HGA 0.8791
554 8EZ 0.8791
555 RMN 0.8786
556 RBJ 0.8786
557 1DH 0.8784
558 3ID 0.8784
559 SMN 0.8784
560 FJO 0.8783
561 F05 0.8783
562 KPL 0.8782
563 4NC 0.8778
564 6M4 0.8777
565 BNF 0.8777
566 P9P 0.8776
567 FCR 0.8776
568 BE2 0.8776
569 9RW 0.8775
570 DMD 0.8775
571 2HO 0.8773
572 51R 0.8770
573 3HM 0.8769
574 ES9 0.8767
575 FHB 0.8763
576 3PG 0.8763
577 8OZ 0.8761
578 152 0.8760
579 A09 0.8760
580 NNO 0.8759
581 AT3 0.8755
582 OTR 0.8752
583 IHB 0.8752
584 ISU 0.8752
585 QSB 0.8747
586 PRA 0.8746
587 MYJ 0.8746
588 FK1 0.8745
589 1WD 0.8744
590 CHB 0.8744
591 TIH 0.8744
592 9TW 0.8743
593 P7I 0.8743
594 0OC 0.8741
595 AOA 0.8741
596 93K 0.8740
597 AAS 0.8739
598 AHR 0.8739
599 NPY 0.8738
600 MDN 0.8738
601 JB5 0.8735
602 2AL 0.8735
603 SAN 0.8734
604 QUZ 0.8734
605 TSU 0.8734
606 P92 0.8733
607 BTL 0.8732
608 7WV 0.8731
609 JKE 0.8731
610 H4N 0.8730
611 5AC 0.8726
612 DHS 0.8726
613 3BB 0.8726
614 COM 0.8726
615 PO6 0.8724
616 2PG 0.8724
617 IWT 0.8723
618 DAL DAL 0.8722
619 03V 0.8719
620 N4B 0.8719
621 HQJ 0.8717
622 WOT 0.8716
623 COU 0.8716
624 FBB 0.8716
625 SNE 0.8716
626 FBS 0.8716
627 2AQ 0.8712
628 3YP 0.8706
629 3AL 0.8701
630 1AC 0.8700
631 OCH 0.8699
632 6M9 0.8698
633 JLZ 0.8694
634 L5V 0.8693
635 K2T 0.8692
636 RUU 0.8691
637 DSS 0.8687
638 ES5 0.8684
639 YRL 0.8676
640 VX 0.8676
641 F4E 0.8672
642 HX4 0.8670
643 JFJ 0.8667
644 ETM 0.8664
645 4FA 0.8658
646 4J8 0.8655
647 4FS 0.8647
648 6TZ 0.8645
649 H42 0.8645
650 24T 0.8644
651 MPV 0.8640
652 C2A 0.8639
653 8NY 0.8637
654 E5X 0.8635
655 BZ3 0.8623
656 EFS 0.8613
657 HYN 0.8611
658 TCA 0.8610
659 4JM 0.8610
660 PC 0.8604
661 1P8 0.8603
662 5OB 0.8601
663 650 0.8599
664 AEF 0.8599
665 5WV 0.8595
666 CPZ 0.8593
667 MSE 0.8589
668 KKN 0.8571
669 3PF 0.8559
670 ANN 0.8553
671 MSR 0.8552
672 5XC 0.8530
673 261 0.8521
674 5QY 0.8521
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HZY; Ligand: DHJ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2hzy.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2HZY; Ligand: DHJ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2hzy.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
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