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Receptor
PDB id Resolution Class Description Source Keywords
1PS9 2.2 Å EC: 1.3.1.34 THE CRYSTAL STRUCTURE AND REACTION MECHANISM OF E. COLI 2,4- COA REDUCTASE ESCHERICHIA COLI IRON-SULFUR TIM BARREL FLAVODOXIN FLAVIN ELECTRON TRANSFHYDRIDE TRANSFER OXIDOREDUCTASE
Ref.: THE CRYSTAL STRUCTURE AND REACTION MECHANISM OF ESC COLI 2,4-DIENOYL-COA REDUCTASE J.BIOL.CHEM. V. 278 37553 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:705;
A:706;
A:707;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
35.453 Cl [Cl-]
FAD A:701;
Valid;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
FMN A:702;
Valid;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
MDE A:704;
Valid;
none;
submit data
994.877 C33 H55 N7 O18 P3 S2 CCCCC...
NAP A:703;
Valid;
none;
submit data
743.405 C21 H28 N7 O17 P3 c1cc(...
SF4 A:700;
Part of Protein;
none;
submit data
351.64 Fe4 S4 [S]12...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1PS9 2.2 Å EC: 1.3.1.34 THE CRYSTAL STRUCTURE AND REACTION MECHANISM OF E. COLI 2,4- COA REDUCTASE ESCHERICHIA COLI IRON-SULFUR TIM BARREL FLAVODOXIN FLAVIN ELECTRON TRANSFHYDRIDE TRANSFER OXIDOREDUCTASE
Ref.: THE CRYSTAL STRUCTURE AND REACTION MECHANISM OF ESC COLI 2,4-DIENOYL-COA REDUCTASE J.BIOL.CHEM. V. 278 37553 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1PS9 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1PS9 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1PS9 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Ligand no: 2; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Ligand no: 3; Ligand: MDE; Similar ligands found: 23
No: Ligand ECFP6 Tc MDL keys Tc
1 MDE 1 1
2 RFC 0.567416 0.956522
3 SFC 0.567416 0.956522
4 8Z2 0.443299 0.989011
5 BCO 0.42246 0.956044
6 CO8 0.421875 0.978022
7 HDC 0.420513 0.978022
8 COO 0.420213 0.956044
9 UCC 0.419689 0.978022
10 ST9 0.419689 0.978022
11 MYA 0.419689 0.978022
12 5F9 0.419689 0.978022
13 DCC 0.419689 0.978022
14 MFK 0.419689 0.978022
15 HXC 0.418848 0.978022
16 1GZ 0.415789 0.945652
17 191 0.412698 0.908163
18 MRR 0.411168 0.978022
19 MRS 0.411168 0.978022
20 0ET 0.410256 0.956522
21 CS8 0.408163 0.967391
22 DAK 0.40201 0.925532
23 WCA 0.401015 0.935484
Ligand no: 4; Ligand: NAP; Similar ligands found: 123
No: Ligand ECFP6 Tc MDL keys Tc
1 NAP 1 1
2 NA0 0.881356 0.986301
3 TAP 0.872881 0.934211
4 NDO 0.840336 0.972603
5 NAD 0.811966 0.986111
6 N01 0.733871 0.958904
7 A3D 0.712 0.972603
8 NBP 0.707692 0.935065
9 NHD 0.68254 0.958904
10 NJP 0.661417 0.972973
11 NFD 0.658915 0.934211
12 NXX 0.619048 0.959459
13 DND 0.619048 0.959459
14 AMP NAD 0.606061 0.958904
15 ZID 0.605839 0.972603
16 NAQ 0.59854 0.922078
17 ATR 0.59292 0.917808
18 NAE 0.591241 0.946667
19 NDE 0.58042 0.986301
20 A22 0.571429 0.958904
21 NAJ 0.567164 0.986111
22 A2R 0.563025 0.932432
23 NDC 0.561644 0.922078
24 NA7 0.552846 0.907895
25 ODP 0.551471 0.935065
26 A2P 0.539823 0.930556
27 8ID 0.537313 0.910256
28 NPW 0.525547 0.8875
29 NZQ 0.521739 0.910256
30 CNA 0.521739 0.959459
31 NDP 0.514493 0.922078
32 PO4 PO4 A A A A PO4 0.503937 0.930556
33 1DG 0.503401 0.922078
34 DG1 0.503401 0.922078
35 TXP 0.5 0.922078
36 NMN AMP PO4 0.492958 0.921053
37 XNP 0.492958 0.875
38 25L 0.492308 0.958904
39 25A 0.492063 0.972222
40 NMN 0.486726 0.888889
41 NGD 0.485714 0.935065
42 9JJ 0.481707 0.8875
43 2AM 0.477876 0.891892
44 ADP 0.458333 0.945205
45 PAP 0.451613 0.931507
46 A2D 0.445378 0.945205
47 AN2 0.442623 0.932432
48 7L1 0.441558 0.777778
49 ADP PO3 0.44 0.944444
50 SAP 0.44 0.896104
51 AGS 0.44 0.896104
52 M33 0.439024 0.906667
53 AR6 AR6 0.438849 0.945205
54 BA3 0.438017 0.945205
55 OAD 0.43609 0.92
56 ADP BMA 0.43609 0.92
57 DQV 0.435714 0.958904
58 HEJ 0.435484 0.945205
59 ATP 0.435484 0.945205
60 OOB 0.435115 0.958904
61 B4P 0.434426 0.945205
62 AP5 0.434426 0.945205
63 GAP 0.433071 0.92
64 0WD 0.432432 0.922078
65 2A5 0.432 0.87013
66 5FA 0.432 0.945205
67 AQP 0.432 0.945205
68 AT4 0.430894 0.907895
69 00A 0.428571 0.909091
70 DAL AMP 0.427481 0.932432
71 CA0 0.427419 0.92
72 ADP ALF 0.426357 0.871795
73 ALF ADP 0.426357 0.871795
74 9X8 0.425373 0.871795
75 ACP 0.424 0.92
76 NAJ PZO 0.423841 0.897436
77 9SN 0.423358 0.897436
78 ADP VO4 0.423077 0.932432
79 VO4 ADP 0.423077 0.932432
80 WAQ 0.422222 0.884615
81 V3L 0.421875 0.945205
82 ACQ 0.421875 0.92
83 ADQ 0.421053 0.92
84 AR6 0.420635 0.918919
85 APR 0.420635 0.918919
86 ATP A A A 0.42029 0.958333
87 CO7 0.419753 0.786517
88 3OD 0.419118 0.92
89 1ZZ 0.419118 0.841463
90 DLL 0.41791 0.958904
91 AD9 0.417323 0.92
92 NAX 0.416667 0.875
93 OVE 0.416667 0.857143
94 MYR AMP 0.416058 0.841463
95 AV2 0.415385 0.868421
96 A3P 0.414634 0.944444
97 NNR 0.414414 0.72973
98 OMR 0.413793 0.831325
99 6YZ 0.412214 0.92
100 ANP 0.410853 0.92
101 A1R 0.410448 0.860759
102 ABM 0.409836 0.893333
103 A 0.408333 0.944444
104 AMP 0.408333 0.944444
105 SON 0.408 0.933333
106 PPS 0.407692 0.829268
107 5AL 0.407692 0.932432
108 NAI 0.406897 0.909091
109 7D3 0.406504 0.857143
110 ADX 0.404762 0.829268
111 ATF 0.40458 0.907895
112 3UK 0.404412 0.945946
113 TYR AMP 0.404255 0.921053
114 AMP DBH 0.404255 0.894737
115 139 0.402685 0.875
116 50T 0.401575 0.906667
117 SRP 0.401515 0.907895
118 A A 0.40146 0.972222
119 B5V 0.40146 0.933333
120 A3R 0.4 0.860759
121 3AM 0.4 0.90411
122 B5M 0.4 0.921053
123 FA5 0.4 0.933333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1PS9; Ligand: FMN; Similar sites found with APoc: 177
This union binding pocket(no: 1) in the query (biounit: 1ps9.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 3KLL MAL 1.19225
2 4Z87 5GP 1.52381
3 2OEM 1AE 1.69492
4 2Q8E OGA 1.70455
5 3KP6 SAL 1.98676
6 2YP9 SIA CMO 1.98807
7 5AHN IMP 2.04499
8 3DR4 G4M 2.04604
9 1ADO 13P 2.20386
10 1TV5 FMN 2.25734
11 5A5W GUO 2.37154
12 1ME8 RVP 2.38569
13 1LYX PGA 2.41935
14 4ORM 2V6 2.49377
15 4ORM FMN 2.49377
16 4ORM ORO 2.49377
17 1AL8 FMN 2.50696
18 1AL8 DHP 2.50696
19 5VJE GOS 2.51397
20 2GMH FAD 2.56849
21 1OVD ORO 2.57235
22 1OVD FMN 2.57235
23 4WZH FMN 2.59366
24 4FFG LBS 2.64228
25 1ZED PNP 2.68595
26 2Z6J FMN 2.71084
27 2Z6I FMN 2.71084
28 1SW0 PGA 2.82258
29 1OX5 1PR 2.88288
30 4HKP TKW 2.88462
31 2CUN 3PG 2.92683
32 2FJK 13P 2.95082
33 1UUO FMN 2.95699
34 1UUO BRF 2.95699
35 1UUO ORO 2.95699
36 3KO0 TFP 2.9703
37 1OFD AKG 2.98063
38 1OFD FMN 2.98063
39 2GJN NIS 3.04878
40 2GJN FMN 3.04878
41 5O0X FAD 3.09278
42 4EWN 0VR 3.16206
43 3OIX FMN 3.18841
44 1GXU 2HP 3.2967
45 2RDT FMN 3.35917
46 2RDT 2RD 3.35917
47 3W9Z FMN 3.41615
48 3K0T BGC 3.4965
49 4YMZ 13P 3.58566
50 3F9W SAH 3.61446
51 3EXS 5RP 3.61991
52 2FLI DX5 3.63636
53 4UP4 GAL NAG 3.74065
54 4XP7 FNR 3.75723
55 3MJY IJZ 3.75723
56 3MJY FMN 3.75723
57 6BFG FMN 3.7594
58 2ZRU FMN 3.80435
59 2QCD U5P 3.84615
60 1G51 AMP 3.87481
61 4XDA RIB 3.8835
62 1UI0 URA 3.90244
63 1P4C FMN 3.94737
64 1QDS PGA 3.98406
65 3QH2 3NM 4.0724
66 2NLI LAC 4.07609
67 2NLI FMN 4.07609
68 1Q6O LG6 4.16667
69 1U1J MET 4.17288
70 1W8S FBP 4.18251
71 3TW1 AHN 4.21941
72 3GAY P6T 4.33437
73 1KBI FMN 4.50098
74 1KBI PYR 4.50098
75 1JSH SIA GAL 4.54545
76 2Q8Z NUP 4.67836
77 1RJW ETF 4.71976
78 4N02 FNR 4.7619
79 6G47 SIA 4.78469
80 5XFV FMN 4.79042
81 5EYW PGA 4.81928
82 6DVH FMN 4.82234
83 5CSS G3P 4.86726
84 3TAO PGH 4.86891
85 3HP9 CF1 4.97925
86 3VKX T3 4.98084
87 1TB3 FMN 5.11364
88 3CTL S6P 5.19481
89 4UTU LRY 5.2161
90 4UTW RFW 5.2161
91 2YPI PGA 5.26316
92 1BO4 COA 5.35714
93 5TCI MLI 5.43478
94 4BI7 PGA 5.44747
95 1KBJ FMN 5.58252
96 6BVE PGA 5.71429
97 3TFC PEP 5.71429
98 1MO9 KPC 5.73614
99 2Y88 2ER 5.7377
100 2IL4 COA 5.82524
101 3L6C MLI 5.8997
102 1VHN FMN 5.97484
103 2F6U CIT 5.98291
104 1C3M MAN MAN 6.12245
105 1VKF CIT 6.38298
106 1GVF PGH 6.64336
107 4NAE 1GP 6.66667
108 1F76 FMN 6.84524
109 3OVR 5SP 7.01754
110 1CX9 NHP 7.0529
111 4IGH 1EA 7.25806
112 4IGH FMN 7.25806
113 4IGH ORO 7.25806
114 5GVH FMN 7.32484
115 1GTE FMN 7.45156
116 1GTE IUR 7.45156
117 3B0P FMN 7.71429
118 5W7B MYR 7.80142
119 4Q4K FMN 7.84314
120 2BTM PGA 7.93651
121 4Z0G 5GP 7.99031
122 4JEJ 1GP 8.19672
123 6BKA FMN 8.28877
124 1EP2 ORO 8.42912
125 1EP2 FMN 8.42912
126 5JIL 6KL 8.50515
127 1EIX BMQ 8.57143
128 4CW5 FMN 8.81057
129 3C3N FMN 8.97436
130 4JLS 3ZE 9.21053
131 2WCV FUC 9.28571
132 1PVN MZP 9.57447
133 1TRD PGH 9.6
134 1JOC ITP 9.6
135 1LSH PLD 10.5812
136 4Z7X 3CX 10.9244
137 1FDJ 2FP 11.2948
138 1FDJ 13P 11.2948
139 3HP8 SUC 11.8182
140 3NZ1 3NY 11.8774
141 4URX FK1 11.8919
142 6FA4 D1W 14.4509
143 4I9A NCN 14.5833
144 3BW2 FMN 15.4472
145 1LOJ U 20.6897
146 3AB4 THR 20.7865
147 1DBT U5P 24.6862
148 4M5P FMN 26.2899
149 4TMC HBA 27.5434
150 4TMC FMN 27.5434
151 4QNW FMN 28.5714
152 2HSA FMN 28.607
153 4JIQ 1L5 29.1777
154 4JIQ FMN 29.1777
155 1ICP FMN 30.5851
156 1OYB HBA 30.75
157 1OYB FMN 30.75
158 4RNV HBA 30.75
159 1DJN FMN 36.0656
160 5OCS FMN 41.5094
161 3HF3 FMN 41.8338
162 2Q3R FMN 42.2043
163 2H8Z FMN 43.1755
164 2H8Z 8CM 43.1755
165 2Q3O FMN 43.734
166 3KRU FMN 44.0233
167 3ATY FMN 44.3272
168 2R14 FMN 44.5623
169 2R14 TXD 44.5623
170 1VYP TNF 44.7802
171 1VYP FMN 44.7802
172 1Z44 FMN 45.2663
173 1Z48 FMN 45.2663
174 1Z42 FMN 45.2663
175 1Z41 FMN 45.2663
176 4A3U FMN 45.5307
177 2GOU FMN 46.8493
Pocket No.: 2; Query (leader) PDB : 1PS9; Ligand: MDE; Similar sites found with APoc: 1
This union binding pocket(no: 2) in the query (biounit: 1ps9.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 5N0L ILE 6.28931
Pocket No.: 3; Query (leader) PDB : 1PS9; Ligand: NAP; Similar sites found with APoc: 772
This union binding pocket(no: 3) in the query (biounit: 1ps9.bio1) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 5UAV TFB 1.24224
2 5UAV NDP 1.24224
3 1GZ4 ATP 1.27042
4 4EDF UPG 1.417
5 2GK6 ADP 1.44231
6 4PIV NDP 1.51515
7 4XYB NDP 1.53453
8 1O0S NAI 1.65289
9 1K3T BRZ 1.67131
10 6A3J NAI 1.70732
11 6A3J SOE 1.70732
12 5TUF TDC 1.71149
13 5TUF FAD 1.71149
14 1PN0 IPH 1.80451
15 1PN0 FAD 1.80451
16 4ZGS NAD 1.81347
17 5KOX FAD 1.89076
18 5KOX RFP 1.89076
19 3UCL NAP 1.91972
20 3UCL CYH 1.91972
21 3UCL FAD 1.91972
22 2C7G ODP 1.97368
23 2C7G FAD 1.97368
24 4W6Z 8ID 2.01729
25 1Y8Q ATP 2.02312
26 5UAO FAD 2.03327
27 2DKH 3HB 2.03443
28 2DKH FAD 2.03443
29 4K5S FAD 2.05224
30 4K5S PM0 2.05224
31 1ZH8 NAP 2.05882
32 2GJP MAL 2.06186
33 5M67 NAD 2.08768
34 5M67 ADE 2.08768
35 5M67 3D1 2.08768
36 5HSA FAS 2.11161
37 2WET FAD 2.15264
38 4ISS TAR 2.17391
39 1SC6 NAD 2.22772
40 2YY7 NAD 2.24359
41 3VPH NAD 2.25806
42 3VPH OXM 2.25806
43 5N0J FAD 2.2792
44 3NJ4 NAD 2.29885
45 3NJ4 AFX 2.29885
46 4B4U NAP 2.31023
47 4MIG G3F 2.31481
48 4XQC 13D 2.31579
49 4XQC NAD 2.31579
50 4XFR CIT 2.34192
51 4YAC NAI 2.3569
52 4MP8 NAD 2.35988
53 4MP8 MLI 2.35988
54 3NYC FAD 2.3622
55 3NYC IAR 2.3622
56 5NUE NAD 2.40964
57 5NUF NAD 2.40964
58 1F8F NAD 2.42588
59 2GZ3 NAP 2.45902
60 1YQD NAP 2.45902
61 4MAF ADX 2.47525
62 1VJT NAD 2.48447
63 4HXY NDP 2.51142
64 1P1C SAH 2.51256
65 5FI3 NAP 2.52101
66 1LCF OXL 2.53353
67 4CJX NAP 2.53353
68 5O4J PJL 2.55474
69 5O4J 9KH 2.55474
70 5O4J SAH 2.55474
71 1GPE FAD 2.55537
72 2GKS ADP 2.5641
73 2GMH FAD 2.56849
74 4TXI FAD 2.60163
75 3IHG FAD 2.61682
76 4Y9D NAI 2.62295
77 5C9P FUC 2.62467
78 2O4C NAD 2.63158
79 5X9D 80F 2.63158
80 3ULK NDP 2.64766
81 1FEC FAD 2.65306
82 1BZL GCG 2.6749
83 1BZL FAD 2.6749
84 2JHP SAH 2.68256
85 1PZG A3D 2.71903
86 1X87 NAD 2.72232
87 5BRT FAD 2.73038
88 5BRT CH9 2.73038
89 1SOW NAD 2.7439
90 3HB5 NAP 2.75229
91 1NAA 6FA 2.77264
92 1NAA ABL 2.77264
93 1H2B NAJ 2.78552
94 3ORF NAD 2.78884
95 2QRK AMP 2.79188
96 4NBU NAI 2.8
97 1KJ8 GAR 2.8133
98 1EZ4 NAD 2.83019
99 2D2I NAP 2.83159
100 3O9Z AKG 2.88462
101 3O9Z NAD 2.88462
102 5E9W SAH 2.88462
103 6C4T NA7 2.88889
104 5J7X FAD 2.91439
105 3VYW SAM 2.92208
106 1U3U BNF 2.94118
107 1U3U NAD 2.94118
108 6C4M NAP 2.95359
109 3NT6 FAD 2.96167
110 3NTA FAD 2.96167
111 1YQZ FAD 2.96804
112 1YJQ NAP 2.9703
113 1J0X NAD 3.01205
114 3ABI NAD 3.0137
115 2A8X FAD 3.01724
116 1YKJ FAD 3.04569
117 1YKJ PHB 3.04569
118 5E4R NAP 3.06122
119 5Z21 NAI 3.07263
120 5H81 NAP 3.08483
121 1FK8 NAD 3.11284
122 4U8P FDA 3.11891
123 4U8P UDP 3.11891
124 3ICC NAP 3.13725
125 2VTD LKM 3.14607
126 3L9W AMP 3.1477
127 3L9W GSH 3.1477
128 5UR0 NAD 3.15186
129 1LDN NAD 3.16456
130 1QO8 FAD 3.18021
131 1NVM NAD 3.20513
132 1D1T NAD 3.21716
133 4OOE NDP 3.21782
134 4OOE FOM 3.21782
135 2BRY FAD 3.21932
136 1DLJ NAI 3.23383
137 1DLJ UGA 3.23383
138 2C29 NAP 3.2641
139 6ER9 NAP 3.27869
140 6ER9 FAD 3.27869
141 3OND ADN 3.27869
142 3OND NAD 3.27869
143 2NVK FAD 3.27869
144 3WBF API 3.27869
145 3WBF NAP 3.27869
146 2NVK NAP 3.27869
147 1HDR NAD 3.27869
148 4XB2 HSE 3.28358
149 4XB2 NDP 3.28358
150 3E1T FAD 3.32031
151 5JCM ISD 3.32594
152 5JCM NAD 3.32594
153 5JCM FAD 3.32594
154 5H6S HDH 3.3264
155 5K0A FAD 3.33333
156 1LDM NAD 3.34347
157 1B8U NAD 3.34347
158 2AQJ TRP 3.34572
159 2AQJ FAD 3.34572
160 4EUE NAI 3.34928
161 1BW9 NAD 3.37079
162 1BXG NAD 3.37079
163 2IZ1 ATR 3.37553
164 1C1X NAD 3.38028
165 1H82 GZZ 3.38983
166 1H82 FAD 3.38983
167 1YKF NAP 3.40909
168 4KQW NAP 3.42857
169 1U7T TDT 3.44828
170 1U7T NAD 3.44828
171 5JWC FAD 3.45489
172 3A06 NDP 3.45745
173 3AYI HCI 3.46741
174 3AYI FAD 3.46741
175 1E1M NAP 3.47826
176 1E1M FAD 3.47826
177 1PJS NAD 3.50109
178 1CF2 NAP 3.56083
179 4L8V NAP 3.56083
180 6FP4 FAD 3.57675
181 6FP4 E1T 3.57675
182 5Y77 FAD 3.59408
183 1J49 NAD 3.6036
184 1DSS NAD 3.6036
185 6A0S NDP 3.61446
186 6A0S HSE 3.61446
187 3WMX NAD 3.63128
188 2VVL FAD 3.63636
189 2VVM FAD 3.63636
190 1MV8 NAD 3.66972
191 1MUU NAD 3.66972
192 5Z75 NAD 3.66972
193 5TUK FAD 3.67647
194 3FPZ AHZ 3.68098
195 5MZI FAD 3.68764
196 5MZI FYK 3.68764
197 4YCA NDP 3.7415
198 3CGB FAD 3.75
199 1RM0 D6P 3.75235
200 1RM0 NAI 3.75235
201 1P0F NAP 3.75335
202 2B4R NAD 3.76812
203 2B4R AES 3.76812
204 5ZI2 NAD 3.76812
205 5ZI2 ADP 3.76812
206 4FWE FAD 3.76884
207 4IV9 FAD 3.7702
208 2Z3Y F2N 3.77644
209 2R4J 13P 3.79242
210 2R4J FAD 3.79242
211 4B63 NAP 3.79242
212 4B63 ORN 3.79242
213 4B63 FAD 3.79242
214 2DC1 NAD 3.81356
215 3B1J NAD 3.83481
216 3B20 NAD 3.83481
217 2WPF WPF 3.83838
218 2WPF FAD 3.83838
219 5X20 NAD 3.84615
220 5O42 NAD 3.87481
221 5O42 BGC 3.87481
222 5O42 9JW 3.87481
223 1KEW NAD 3.87812
224 1KEW TYD 3.87812
225 1HYH NAD 3.8835
226 5WGR FAD 3.89805
227 3CIF NAD 3.89972
228 3CIF G3H 3.89972
229 1V6A TRE 3.91566
230 1CER NAD 3.92749
231 5BUK FAD 4
232 1CDO NAD 4.01069
233 2FR1 NDP 4.02385
234 2PV7 NAD 4.02685
235 2DFV NAD 4.03458
236 1P77 ATR 4.04412
237 3H9E NAD 4.04624
238 2IXB A2G 4.05405
239 2IXB NAD 4.05405
240 6F5W KG1 4.06504
241 3QH2 3NM 4.0724
242 1KNR FAD 4.07407
243 1I8T FAD 4.08719
244 3GMB FAD 4.09639
245 3ITJ CIT 4.14201
246 3ITJ FAD 4.14201
247 4XDY NAI 4.14201
248 1GQ2 NAP 4.14414
249 5KKA 6V0 4.16667
250 2AG8 NAP 4.18251
251 1RYI GOA 4.18848
252 1RYI FAD 4.18848
253 3CMC NAD 4.19162
254 1GUZ NAD 4.19355
255 1Q9I TEO 4.20315
256 1Q9I FAD 4.20315
257 4IDC 1XX 4.21687
258 4IDC NDP 4.21687
259 1HDG NAD 4.21687
260 4YKG NAD 4.22265
261 4YKG FAD 4.22265
262 2ZXI FAD 4.23862
263 5XVH NAP 4.24837
264 3H5N ATP 4.24929
265 1KEV NDP 4.2735
266 3OZ2 FAD 4.28212
267 3GFB NAD 4.28571
268 2FZW NAD 4.28954
269 2F1K NAP 4.30108
270 3F8D FAD 4.33437
271 1COY FAD 4.33925
272 1COY AND 4.33925
273 1OMO NAD 4.34783
274 2A92 NAI 4.36137
275 1ELI PYC 4.37018
276 1LLU NAD 4.38596
277 5Y8L HUI 4.40678
278 5Y8L NAD 4.40678
279 4Z24 FAD 4.44785
280 3QVP FAD 4.45969
281 5AOV NAP 4.46429
282 5LD5 NAD 4.46927
283 5HXI FAD 4.48549
284 5HXI 5HN 4.48549
285 4ZRN UPG 4.48718
286 1X14 NAD 4.48878
287 2CVZ NDP 4.49827
288 3BAZ NAP 4.5045
289 4AT0 FAD 4.5098
290 1C3X 8IG 4.51128
291 4RDI ATP 4.51389
292 4RDH AMP 4.51389
293 1UXG FUM 4.53074
294 1UXG NAD 4.53074
295 3HDY FAD 4.53401
296 3HDY FDA 4.53401
297 3HDY GDU 4.53401
298 6AIN FAD 4.54545
299 1RP0 AHZ 4.57746
300 1OC2 NAD 4.5977
301 1OC2 TDX 4.5977
302 3NKS FAD 4.61216
303 4MO2 FAD 4.61957
304 4MO2 FDA 4.61957
305 1WDK NAD 4.61997
306 5FEU NAP 4.61997
307 5BJX NAD 4.64481
308 5BJX UDP 4.64481
309 1RSG FAD 4.65116
310 5YU3 PRO 4.65116
311 5YU3 NAD 4.65116
312 2E5V FAD 4.66102
313 4D7E FAD 4.662
314 2YYY NAP 4.66472
315 5ZYN FAD 4.67091
316 1YY5 FAD 4.67836
317 1Q0H NDP 4.6798
318 4USR FAD 4.70914
319 4USQ FAD 4.70914
320 4D79 ATP 4.71014
321 4CP8 MLI 4.72279
322 1JA9 NDP 4.74453
323 4UP3 NDP 4.77707
324 4UP3 FAD 4.77707
325 4X9M FAD 4.78469
326 4KOA NDP 4.8048
327 2I3G NAP 4.82955
328 1WP4 NDP 4.84429
329 4C3Y FAD 4.90566
330 4C3Y ANB 4.90566
331 3I9U DTU 4.94297
332 5DN9 NAD 4.94506
333 3S5W FAD 4.9676
334 3S5W NAP 4.9676
335 5VKT NAP 4.97238
336 5W3K 9TY 5
337 5W3K NDP 5
338 1XG5 NAP 5.01792
339 2IID PHE 5.02008
340 2IID FAD 5.02008
341 3AD8 PYC 5.05051
342 3AD8 FAD 5.05051
343 3AD8 NAD 5.05051
344 4REP FAD 5.05051
345 3VOZ 04A 5.07937
346 2DBZ NAP 5.08982
347 4EIP FAD 5.10018
348 4EIP K2C 5.10018
349 5EZ7 FAD 5.10204
350 4CNK FAD 5.11509
351 2NXE SAM 5.11811
352 4ZVV GN0 5.12048
353 4ZVV NAD 5.12048
354 9LDB NAD 5.12048
355 9LDT NAD 5.12048
356 6C4N NAP 5.12249
357 3AXB PRO 5.13393
358 3AXB FAD 5.13393
359 4M52 FAD 5.15021
360 4M52 M52 5.15021
361 2XVF FAD 5.17241
362 5YB7 FAD 5.17241
363 5YB7 ORN 5.17241
364 5HS2 CTP 5.17241
365 4OM8 NAD 5.17799
366 4BJZ FAD 5.18868
367 4BJZ P3A 5.18868
368 1JAY NAP 5.18868
369 3FG2 FAD 5.19802
370 6F7L FAD 5.20362
371 2NU8 COA 5.20833
372 2HQM FAD 5.21921
373 1LUA NAP 5.22648
374 2IVD FAD 5.23013
375 1C0I BE2 5.23416
376 1C0I FAD 5.23416
377 3QJ4 FAD 5.26316
378 4JDR FAD 5.27426
379 3AB1 FAD 5.27778
380 4AP3 NAP 5.28233
381 4AP3 FAD 5.28233
382 2VHW NAI 5.30504
383 3K7M FAD 5.33643
384 5MQ6 NDP 5.34351
385 2RGO FAD 5.36513
386 5X68 FAD 5.37084
387 6H3O FAD 5.37634
388 2XVE FAD 5.38793
389 5I39 FAD 5.39216
390 2BGM NAJ 5.39568
391 1BDB NAD 5.41516
392 2B9W FAD 5.42453
393 5KMS NAD 5.4321
394 5KMS FAD 5.4321
395 2VYN NAD 5.43807
396 1QH8 HCA 5.43933
397 3VZS CAA 5.44747
398 3VZS NAP 5.44747
399 1GAD NAD 5.45455
400 3DXY SAM 5.50459
401 5Z20 NAI 5.50725
402 5GSN NAP 5.51876
403 5GSN MMZ 5.51876
404 5GSN FAD 5.51876
405 5GZ6 7C3 5.52147
406 5GZ6 NDP 5.52147
407 5YAP NAI 5.52632
408 5YAP 8S0 5.52632
409 1KOL NAD 5.52764
410 2XVM SAH 5.52764
411 5T9F TYR 5.53506
412 5T9F NAP 5.53506
413 5JGL SAM 5.53633
414 2RHO GDP 5.53846
415 1SAY PYR 5.54017
416 1UWK NAD 5.56553
417 1UWK URO 5.56553
418 4DPL NAP 5.57103
419 2B5W NAP 5.60224
420 1PL6 572 5.61798
421 1PL6 NAD 5.61798
422 5A96 GTP 5.62249
423 5BVA FAD 5.62347
424 5WXU FLC 5.63674
425 3GF4 FAD 5.64103
426 3GF4 UPG 5.64103
427 1A5Z NAD 5.64263
428 3SQP FAD 5.64854
429 1YS4 NAP 5.64972
430 5N6C NAD 5.66667
431 3UOY FAD 5.68807
432 3UOY NAP 5.68807
433 2G5C NAD 5.69395
434 3ZV6 NAD 5.69395
435 5FJN FAD 5.70175
436 5FJN BE2 5.70175
437 1X7D ORN 5.71429
438 1X7D NAD 5.71429
439 5Z2L NDP 5.71429
440 2RGJ FAD 5.72139
441 2JB2 PHE 5.72597
442 2JB2 FAD 5.72597
443 5GUD NDP 5.73248
444 1MO9 KPC 5.73614
445 1MO9 FAD 5.73614
446 4YNU FAD 5.77933
447 4YNU LGC 5.77933
448 4J36 1HR 5.78313
449 4J36 FAD 5.78313
450 2Q1S NAI 5.83554
451 4USI AKG 5.84416
452 1HKU NAD 5.86592
453 2JHF NAD 5.88235
454 4AF0 MOA 5.93525
455 5AHO TLA 5.95238
456 6AA8 NAD 5.96026
457 2RGH FAD 5.96125
458 4NTC FAD 5.97015
459 5D4V SAH 5.97015
460 6CEP OXM 5.98802
461 6CEP NAD 5.98802
462 3ETG GLU 5.98802
463 3ETG GTP 5.98802
464 3ETG NDP 5.98802
465 1JNR FAD 6
466 1G0N NDP 6.00707
467 1G0N PHH 6.00707
468 3NTD FAD 6.0177
469 3QFA FAD 6.03448
470 3SJU NDP 6.09319
471 5EOW FAD 6.11028
472 5JY6 NAD 6.17978
473 2YG3 FAD 6.18102
474 5ZBC FAD 6.20843
475 2GSD NAD 6.21891
476 1E7S NAP 6.23053
477 3OJO NAD 6.2645
478 1LTH NAD 6.26959
479 1O6Z NAD 6.27063
480 1L1E SAH 6.27178
481 1NYT NAP 6.27306
482 3OA2 NAD 6.28931
483 4HA6 FAD 6.29921
484 5MDH NAD 6.30631
485 3LZW NAP 6.3253
486 3LZW FAD 6.3253
487 6GAS FAD 6.34441
488 4OPC PGT 6.40177
489 4OPC FDA 6.40177
490 6F97 FAD 6.40301
491 4YSX FAD 6.41026
492 3Q9T FAY 6.41248
493 4GUT FAD 6.45161
494 5XWV NDP 6.45161
495 5XWV 8H6 6.45161
496 2CUL FAD 6.46552
497 5KVS NAP 6.49351
498 5G6U TRP 6.51341
499 5OCM NAP 6.52921
500 5O9F NAD 6.53409
501 5O9F 9ON 6.53409
502 1KYQ NAD 6.56934
503 3CTY FAD 6.58307
504 1REO FAD 6.58436
505 5V2L ATP 6.58683
506 6GAR FAD 6.59026
507 4DSG UDP 6.61157
508 4DSG FAD 6.61157
509 2NAD NAD 6.61578
510 3ICR FAD 6.63265
511 3ICS FAD 6.63265
512 3ICT ADP 6.63265
513 3ICS ADP 6.63265
514 3ICT FAD 6.63265
515 1V8B NAD 6.68058
516 5EB4 FAD 6.76692
517 4TM3 FAD 6.77201
518 6F3N ADN 6.77966
519 6F3N NAD 6.77966
520 5U5G NAP 6.77966
521 5AYV KPL 6.79612
522 5AYV NAP 6.79612
523 2CDC XYP 6.8306
524 2CDC XYS 6.8306
525 2CDC NAP 6.8306
526 1T26 NAI 6.8323
527 1T26 GBD 6.8323
528 5TSU CYS 6.87204
529 4Z0H NAD 6.88623
530 3TWO NDP 6.89655
531 6F3M NAD 6.95652
532 1TDF NAP 6.96203
533 1TDF FAD 6.96203
534 5TWB FAD 6.97674
535 3G5S FAD 6.99774
536 2QA1 FAD 7
537 1VQW FAD 7.00219
538 4RSL FAD 7.00447
539 5OVK NDP 7.03125
540 3WLE NAD 7.03812
541 5MBX FAD 7.04225
542 5MBX SP5 7.04225
543 5J5Z FAD 7.05645
544 2WSB NAD 7.08661
545 1FL2 FAD 7.09677
546 2GV8 FAD 7.15884
547 2GVC FAD 7.15884
548 2GV8 NDP 7.15884
549 5VE5 GSH 7.1618
550 5Z2F NAP 7.16981
551 4RQU NAD 7.2
552 3KIH GDL 7.2165
553 4KWI 1TJ 7.22433
554 4KWI NAP 7.22433
555 3A4V PYR 7.25552
556 3A4V NAD 7.25552
557 4MOP 2H5 7.26698
558 4EA7 COA 7.27273
559 4EA7 JB2 7.27273
560 3GDN FAD 7.29367
561 3GDN HBX 7.29367
562 1V59 FAD 7.32218
563 1V59 NAD 7.32218
564 1ZBQ NAD 7.33945
565 5CAE COA 7.34177
566 5CAE SIN 7.34177
567 4ZCC FAD 7.44048
568 4ZCC NAI 7.44048
569 4GKV NAD 7.44048
570 1GTE FAD 7.45156
571 5K4W THR 7.47664
572 5K4W NAI 7.47664
573 1J5P NAD 7.50988
574 5TTJ FAD 7.55102
575 2DT5 NAD 7.58294
576 5TVI O8N 7.6087
577 5OFW 9TW 7.62332
578 2VOH CIT 7.64331
579 2C5A NAD 7.65171
580 2C5A GDC 7.65171
581 1E3W NAD 7.66284
582 2ZJ1 NAD 7.67677
583 2ZJ1 ARJ 7.67677
584 1E6W NAD 7.69231
585 3FWN ATR 7.70833
586 3L4S NAD 7.7381
587 3L4S 3PG 7.7381
588 1GV0 NAD 7.74194
589 4D3F NAP 7.74194
590 1R37 NAD 7.78098
591 3WV8 ATP 7.79817
592 4FN4 NAD 7.87402
593 1GR0 NAD 7.90191
594 1U1I NAD 7.90816
595 5GT9 NAP 7.98479
596 4RPL FAD 8.02005
597 4RPL 3UC 8.02005
598 1HPG BOC ALA ALA PRO GLU 8.02139
599 3LKF PC 8.02676
600 1D4D FAD 8.04196
601 4CQM NAP 8.04598
602 5TS5 FAD 8.05785
603 3HAD NAD 8.11688
604 3RGG AIR 8.1761
605 5TOW ADN 8.35381
606 5TOW NAI 8.35381
607 4PLG NAI 8.38323
608 4PLG OXM 8.38323
609 3KB6 NAD 8.38323
610 4E13 NAD 8.48057
611 2AHR NAP 8.49421
612 3X0V FAD 8.50277
613 4R5M NAP 8.51064
614 3OID NDP 8.52713
615 2Y6Q FAD 8.54271
616 2Y6Q I7T 8.54271
617 5JE8 NAD 8.60927
618 5N2I NAP 8.62069
619 3WGT FAD 8.64553
620 3WGT QSC 8.64553
621 3K5I AIR 8.68486
622 4O0L NDP 8.72727
623 4J56 FAD 8.77193
624 4NTD FAD 8.82353
625 1QB7 ADE 8.8983
626 4HZ0 1AV 8.92019
627 3ZNN FAD 8.93372
628 3ZNN 4WL 8.93372
629 1EDO NAP 9.01639
630 2EV9 SKM 9.12547
631 2EV9 NAP 9.12547
632 4II2 ATP 9.20245
633 1EBF NAD 9.21788
634 3GGO ENO 9.23567
635 3GGO NAI 9.23567
636 1I36 NAP 9.4697
637 2CDU FAD 9.51327
638 2CDU ADP 9.51327
639 4D42 W0I 9.57447
640 4D42 NAP 9.57447
641 1F8G NAD 9.63542
642 3B1F NAD 9.65517
643 2RH4 EMO 9.74729
644 2VT3 ATP 9.76744
645 5ZZ6 NAD 10.0962
646 5ZZ6 ADP 10.0962
647 2HK9 NAP 10.1818
648 2HK9 ATR 10.1818
649 3GUZ PAF 10.2273
650 3H8V ATP 10.274
651 3RNM FAD 10.3448
652 1E3I CXF 10.3723
653 4TSK NDP 10.5714
654 3LXD FAD 10.6024
655 1GET FAD 10.6667
656 1GET NAP 10.6667
657 5OJL TXP 10.7383
658 3FPF MTA 10.7383
659 3FPF TNA 10.7383
660 3QWI CUE 10.7407
661 3QWI NAP 10.7407
662 6FHO FAD 10.7769
663 4JK3 NAD 10.8108
664 2F5Z FAD 10.9375
665 5G3U FDA 11.1111
666 5G3U ITW 11.1111
667 4J4H NAI 11.1969
668 4J4H 1J1 11.1969
669 4YT4 FE9 11.2
670 2HJR APR 11.2805
671 1LVL NAD 11.3264
672 1LVL FAD 11.3264
673 2QHS OCA 11.3924
674 1LSS NAD 11.4286
675 3V1Y NAD 11.5727
676 5NII FAD 11.6505
677 2HMT NAI 11.8056
678 1C3V NDP 11.8367
679 5OC1 FAD 11.8584
680 1F06 NDP 11.875
681 1F06 2NP 11.875
682 5FFF NAP 12.0623
683 5THQ NDP 12.1324
684 4D04 NAP 12.1771
685 4D04 FAD 12.1771
686 2C3H GLC GLC 12.2449
687 2GAG NAD 12.381
688 2GAG FAD 12.381
689 2GAG FOA 12.381
690 5L95 AMP 12.5
691 1XPJ TLA 12.6984
692 4PLT OXM 12.9909
693 4PLT NAI 12.9909
694 6CI9 NAP 13.1274
695 2NPX NAD 13.1991
696 2NPX FAD 13.1991
697 3KIF GDL 13.2075
698 5N53 8NB 13.3333
699 4JNA FAD 13.5294
700 1NVT NAP 13.9373
701 4E5N NAD 13.9394
702 4BVA T3 14.0299
703 4BVA NDP 14.0299
704 1E6E FAD 14.0625
705 1Q1R FAD 14.3852
706 6FA4 D1W 14.4509
707 5VN0 NAI 14.4788
708 5VN0 FAD 14.4788
709 3LAD FAD 14.7059
710 5U8U FAD 14.7609
711 3CGD FAD 14.7917
712 3CGD COA 14.7917
713 3CGD NAD 14.7917
714 2RAB NAD 14.9028
715 2RAB FAD 14.9028
716 5J60 FAD 15
717 1NM5 NAD 15.1042
718 2OOR NAD 15.1042
719 1L7E NAI 15.1042
720 1NM5 NAP 15.1042
721 2GN4 UD1 15.407
722 4YRY FAD 15.812
723 4YRY NAD 15.812
724 2VMG MBG 15.9236
725 5YEC ATP 15.9664
726 3T31 FAD 16.2471
727 3T31 DCQ 16.2471
728 4NEC SAH 16.2879
729 1RM4 NDP 16.3205
730 1VI2 NAD 16.3333
731 3QV1 NAD 16.6172
732 2YVF NAD 16.6667
733 2YVF FAD 16.6667
734 2YVJ NAI 16.6667
735 5EIN NAP 16.6667
736 2YVJ FAD 16.6667
737 1NPD NAD 17.0139
738 4BV6 FAD 17.2414
739 1ZK7 FAD 17.3448
740 5NMX NAP 17.4118
741 5NMX FAD 17.4118
742 1I2B USQ 18.3168
743 1I2B NAD 18.3168
744 1I2B UPG