Receptor
PDB id Resolution Class Description Source Keywords
1OLM 1.95 Å EC: 2.-.-.- SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED V ITAMIN E AND CHOLESTEROL BIOSYNTHESIS HOMO SAPIENS LIPID-BINDING PROTEIN CHOLESTEROL BIOSYNTHESIS OXIDIZED VITAMIN E LIPID-BINDING TRANSPORT TRANSCRIPTION REGULATION ACTIVATOR
Ref.: SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS J.MOL.BIOL. V. 332 759 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
VTQ A:1322;
C:1323;
E:1398;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
446.706 C29 H50 O3 CC1=C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1OLM 1.95 Å EC: 2.-.-.- SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED V ITAMIN E AND CHOLESTEROL BIOSYNTHESIS HOMO SAPIENS LIPID-BINDING PROTEIN CHOLESTEROL BIOSYNTHESIS OXIDIZED VITAMIN E LIPID-BINDING TRANSPORT TRANSCRIPTION REGULATION ACTIVATOR
Ref.: SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS J.MOL.BIOL. V. 332 759 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 236 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 211 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 166 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: VTQ; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 VTQ 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found: 159
This union binding pocket(no: 1) in the query (biounit: 1olm.bio3) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4RJD TFP 0.01861 0.41794 None
2 2C1Q BTN 0.008424 0.41146 None
3 4V3I ASP LEU THR ARG PRO 0.005189 0.45151 1.55642
4 2HHP FLC 0.0009305 0.47528 1.73697
5 2VWA PTY 0.001026 0.49199 1.9802
6 2Q8H TF4 0.007145 0.42326 1.98511
7 4OPC FDA 0.04173 0.40197 1.98511
8 4OKD GLC GLC GLC 0.02586 0.41715 2.23325
9 5N87 N66 0.004063 0.40985 2.23642
10 1YYE 196 0.01478 0.40706 2.23881
11 2R5V HHH 0.002353 0.44971 2.2409
12 5C3R HMU 0.01343 0.40219 2.33236
13 5C3R AKG 0.01343 0.40219 2.33236
14 4BCS BTN 0.003438 0.43316 2.4
15 5V4R MGT 0.004903 0.45154 2.46914
16 2AXR ABL 0.02637 0.41045 2.48139
17 4J24 EST 0.006372 0.42861 2.5
18 4J26 EST 0.007258 0.42585 2.5
19 3RDO BTN 0.004264 0.43284 2.61438
20 3TDV GDP 0.01036 0.40736 2.61438
21 1ULE GLA GAL NAG 0.01942 0.40206 2.66667
22 1XMY ROL 0.02349 0.40842 2.76382
23 3TDC 0EU 0.001407 0.49583 2.88714
24 3NNT DQA 0.01289 0.41762 2.89855
25 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 0.03417 0.40876 2.92887
26 3B00 16A 0.02827 0.40045 2.94118
27 3OPT AKG 0.02944 0.40869 2.94906
28 2WW2 SWA 0.02841 0.41222 2.97767
29 3OYW TDG 0.01174 0.42851 2.98507
30 1GZW GAL BGC 0.01478 0.42195 2.98507
31 3FW3 ETS 0.01947 0.40863 3.00752
32 1ZZ7 S0H 0.02398 0.41211 3.0303
33 3ZJQ NCA 0.02318 0.40323 3.07692
34 4FE2 AIR 0.02626 0.40208 3.13725
35 3G58 988 0.01572 0.41329 3.14961
36 4CNO 9PY 0.02639 0.41279 3.1746
37 3JUQ AJD 0.007364 0.40133 3.24324
38 4I90 CHT 0.01011 0.42754 3.30033
39 5AZC PGT 0.0301 0.40185 3.33333
40 2HZQ STR 0.00462 0.45001 3.44828
41 1TV5 N8E 0.005203 0.45302 3.47395
42 4N14 WR7 0.02642 0.4189 3.50318
43 4URG C2E 0.02132 0.41532 3.59281
44 4JH6 FCN 0.009528 0.42859 3.62319
45 3MPB FRU 0.01071 0.41376 3.65854
46 1K12 FUC 0.02429 0.40275 3.79747
47 4RW3 IPD 0.03181 0.4016 3.97022
48 2ET1 GLV 0.03433 0.40482 3.9801
49 2WA4 069 0.0005772 0.47942 4.01146
50 2XUM OGA 0.02281 0.41084 4.01146
51 3P3N AKG 0.02806 0.40566 4.01146
52 3AQT RCO 0.0278 0.41225 4.08163
53 1TMX HGX 0.007476 0.40403 4.09556
54 2ZZV LAC 0.03378 0.40314 4.15512
55 2BP1 FLC 0.02986 0.41381 4.16667
56 4JZR 4JR 0.03133 0.40194 4.16667
57 2GQS C2R 0.01011 0.41495 4.21941
58 3B6C SDN 0.03635 0.40249 4.2735
59 3E2M E2M 0.002999 0.40575 4.32432
60 4QDF 30Q 0.004652 0.42704 4.35897
61 3TL1 JRO 0.008052 0.43713 4.40252
62 4Z28 BTN 0.005396 0.43655 4.47761
63 4OCT AKG 0.02382 0.40421 4.5045
64 5T7I LAT NAG GAL 0.03192 0.40621 4.51613
65 1I0B PEL 0.002988 0.46421 4.51807
66 1GVE CIT 0.04121 0.40262 4.58716
67 5BYZ 4WE 0.002858 0.41088 4.5977
68 1SN0 T44 0.01035 0.41832 4.61538
69 1EYE PMM 0.02088 0.40337 4.64286
70 5LX9 OLB 0.01728 0.40381 4.71464
71 1I82 BGC BGC 0.01585 0.42244 4.7619
72 4DE9 VTP 0.002143 0.41584 4.8951
73 1OBD ATP 0.01687 0.40792 4.90196
74 2AGC DAO 0.03318 0.40065 4.93827
75 5HCN DAO 0.008584 0.43567 4.98084
76 1RTW MP5 0.03007 0.40689 5
77 2C91 TLA 0.03403 0.40316 5.02959
78 1GT4 UNA 0.006593 0.41997 5.03145
79 4MG8 27J 0.002547 0.4435 5.09804
80 4MGA 27L 0.01488 0.42377 5.09804
81 3FUR Z12 0.003527 0.42284 5.14706
82 3UUA 0CZ 0.002638 0.45207 5.17928
83 4QCK ASD 0.003487 0.437 5.18135
84 2WDQ CBE 0.03574 0.4036 5.21739
85 4DK7 0KS 0.008796 0.40725 5.26316
86 4EVQ PHB 0.01968 0.4084 5.33333
87 4QVX 3CQ 0.00852 0.40159 5.38922
88 2XIB DFU 0.0107 0.41377 5.45906
89 2ARC ARA 0.004081 0.44746 5.4878
90 3RV5 DXC 0.003877 0.4179 5.61798
91 3IX9 MTX 0.01402 0.41187 5.78947
92 4J8T DOG 0.02293 0.40137 5.83942
93 4IAW LIZ 0.01084 0.4214 5.85106
94 3RGA LSB 0.001698 0.44741 6.00707
95 1NSZ GLC 0.02377 0.40815 6.05187
96 1EPB REA 0.001016 0.45779 6.09756
97 2GN2 C5P 0.0426 0.40434 6.14035
98 4EKV BTN 0.004347 0.43671 6.28931
99 3P9T TCL 0.01466 0.41482 6.39269
100 1NF8 BOG 0.01669 0.42522 6.76329
101 4QM9 CYS 0.0364 0.4016 6.93642
102 5U98 1KX 0.01882 0.40058 7.07071
103 5UC9 MYR 0.014 0.40818 7.07965
104 5L2J 70E 0.004359 0.43289 7.14286
105 5L2J 6UL 0.004063 0.43289 7.14286
106 5D3X 4IP 0.01856 0.4126 7.18563
107 1EWF PC1 0.00008473 0.41122 7.19603
108 1OGZ EQU 0.006431 0.42841 7.2
109 3L1N PLM 0.02125 0.4149 7.2165
110 4ME6 ADP 0.02436 0.4114 7.25389
111 3KFF XBT 0.01747 0.4194 7.40741
112 3KFF ZBT 0.01747 0.4194 7.40741
113 5FS0 5JC 0.03364 0.40034 7.58294
114 1T36 ORN 0.03601 0.40271 7.69231
115 1H2M OGA 0.03425 0.40078 7.69231
116 1QFT HSM 0.004097 0.42961 8
117 3FAL REA 0.01256 0.41045 8.26446
118 4MA6 28E 0.01771 0.41908 8.28025
119 3WG3 A2G GAL NAG FUC 0.008204 0.43921 8.42697
120 3PG7 PTY 0.0002128 0.43362 8.59375
121 4UCC ZKW 0.009755 0.43336 8.933
122 4A7W GTP 0.02877 0.41546 9.16667
123 2OVD DAO 0.03066 0.40875 9.34066
124 2Z77 NCA 0.02377 0.41231 9.35252
125 1XVB 3BR 0.02837 0.40038 9.41177
126 5MOB A8S 0.02182 0.40614 9.48276
127 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 0.0109 0.43574 9.52381
128 3RY9 1CA 0.008272 0.41182 9.6
129 1H2K OGA 0.03091 0.4032 9.7561
130 1N5S ADL 0.008374 0.41512 9.82143
131 1ZOY UQ1 0.03605 0.40178 9.92064
132 1XX4 BAM 0.04529 0.40843 9.96169
133 4JNJ BTN 0.008288 0.41908 10.4348
134 4DOL PLM 0.007567 0.41359 11.0599
135 2OMN IPH 0.03011 0.40229 11.0599
136 3G08 FEE 0.009153 0.41121 11.1111
137 3OKI OKI 0.00886 0.40391 11.1588
138 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.01599 0.40155 11.4035
139 2JDR L20 0.01599 0.40155 11.4035
140 4J7Q B7N 0.004344 0.40868 11.7117
141 3N7S 3N7 0.02189 0.41994 12.1739
142 4MA7 P2Z 0.009653 0.4157 12.2807
143 4GGZ BTN 0.001119 0.46541 13.0435
144 4O4Z N2O 0.03648 0.4129 13.6364
145 4WVW SLT 0.001819 0.44966 13.8889
146 5OCA 9QZ 0.001047 0.49193 16.6667
147 5AIG VPR 0.02681 0.40545 16.8
148 3KO0 TFP 0.006116 0.43838 16.8317
149 4XCP PLM 0.01329 0.42992 17.0588
150 3KYQ DPV 0.01559 0.42201 18.0905
151 2QCX PF1 0.01619 0.42366 20.9125
152 3HX3 RET 0.0005966 0.40415 29.1139
153 4XBT FLC 0.009465 0.41632 29.6774
154 3SAO NKN 0.002029 0.45775 33.75
155 1BHX ASP PHE GLU GLU ILE 0.009515 0.42423 40
156 3Q8G PEE 0.00005738 0.50506 44.375
157 1AUA BOG 0.000633 0.49511 44.5946
158 1R5L VIV 0.0009168 0.43235 45.8015
159 3W68 VIV 0.001016 0.41006 45.8647
Pocket No.: 2; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found: 19
This union binding pocket(no: 2) in the query (biounit: 1olm.bio1) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2FAH MLA 0.03399 0.40274 1.73697
2 2Y3S TIR 0.009393 0.40137 2.23325
3 3LXI CAM 0.03478 0.40319 2.72953
4 1XM4 PIL 0.02147 0.40143 2.76382
5 2OVW CBI 0.03668 0.40098 2.97767
6 1WBI BTN 0.01099 0.4118 3.10078
7 5J32 IPM 0.03208 0.404 3.72208
8 2Y0I AKG 0.02775 0.40821 3.97727
9 5ML3 DL3 0.003613 0.417 4.02685
10 3FRQ ERY 0.008342 0.40054 4.10256
11 2GQS ADP 0.008096 0.41436 4.21941
12 4CPH LH4 0.004106 0.43212 4.51128
13 3T50 FMN 0.004341 0.41946 4.6875
14 2QZO KN1 0.008239 0.40708 5.03876
15 2YG2 S1P 0.009957 0.40026 5.23256
16 5FPX GLY SER SER HIS HIS HIS HIS HIS 0.009703 0.40391 6.19469
17 1DZK PRZ 0.006393 0.41913 8.28025
18 2WMC MGP 0.03493 0.4053 8.98876
19 3G4Q MCH 0.01553 0.40831 13.6986
Pocket No.: 3; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found: 13
This union binding pocket(no: 3) in the query (biounit: 1olm.bio2) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4UDB CV7 0.003446 0.40137 1.83824
2 4ZOM 4Q3 0.0008095 0.40174 2.66667
3 5A61 3PO 0.01784 0.40245 3.22581
4 4EAX S12 0.01731 0.41669 4.16667
5 1OW4 2AN 0.00549 0.43156 4.65116
6 2QYK NPV 0.0259 0.40616 4.77612
7 2VFK AMP 0.04409 0.40187 4.87805
8 3ZGJ RMN 0.01585 0.41732 5.66038
9 5U9J GER 0.02673 0.40135 5.91716
10 2UZ2 BTN 0.009966 0.40715 6.15385
11 1Y9Q MED 0.006202 0.43993 6.77083
12 1PU7 39A 0.0235 0.40374 7.33945
13 2V5E SCR 0.01236 0.42003 35.6436
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