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Receptor
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M6P A:200;
B:200;
Valid;
Valid;
none;
none;
Kd = 8 uM
260.136 C6 H13 O9 P C([C@...
MN A:199;
B:199;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M6P; Similar ligands found: 61
No: Ligand ECFP6 Tc MDL keys Tc
1 M6D 1 1
2 BG6 1 1
3 G6P 1 1
4 A6P 1 1
5 BGP 1 1
6 M6P 1 1
7 RP5 0.8 0.902439
8 ABF 0.8 0.902439
9 HSX 0.8 0.902439
10 AHG 0.621622 0.795455
11 GLP 0.590909 0.829787
12 4R1 0.590909 0.829787
13 50A 0.571429 0.8
14 RF5 0.571429 0.8
15 16G 0.55102 0.75
16 4QY 0.55102 0.75
17 BMX 0.55102 0.75
18 EMZ 0.55 0.636364
19 GRF 0.547619 0.692308
20 NNG 0.530612 0.75
21 XYT 0.527273 0.906977
22 1FT 0.517857 0.847826
23 FDQ 0.511111 0.777778
24 G16 0.5 0.951219
25 PRP 0.5 0.880952
26 RI2 0.5 0.857143
27 T6P 0.470588 0.906977
28 D6G 0.468085 0.951219
29 P3M 0.466667 0.906977
30 GIV 0.461538 0.675
31 GLC 0.461538 0.675
32 ALL 0.461538 0.675
33 GXL 0.461538 0.675
34 GAL 0.461538 0.675
35 BMA 0.461538 0.675
36 BGC 0.461538 0.675
37 WOO 0.461538 0.675
38 GLA 0.461538 0.675
39 MAN 0.461538 0.675
40 LAK 0.45098 0.674419
41 GLA BGC 0.45098 0.674419
42 MAN MAN 0.45098 0.674419
43 GLC GLC 0.45098 0.674419
44 BGC GLC 0.45098 0.674419
45 MAN BMA 0.45098 0.674419
46 GAL GLC 0.45098 0.674419
47 BMA MAN 0.45098 0.674419
48 BMA GLA 0.45098 0.674419
49 GLA GLC 0.45098 0.674419
50 GLC BGC 0.45098 0.674419
51 GLA BMA 0.45098 0.674419
52 MLB 0.45098 0.674419
53 BGC GLA 0.45098 0.674419
54 GAL GAL 0.45098 0.674419
55 N 0.444444 0.777778
56 PPC 0.442308 0.822222
57 GLC GLC GLC GLC GLC BGC 0.433962 0.674419
58 GLC GLC GLC 0.433962 0.674419
59 MAN MAN MAN 0.433962 0.674419
60 BMA MAN MAN 0.433962 0.674419
61 GLC GLC GLC GLC BGC 0.433962 0.674419
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: 99
This union binding pocket(no: 1) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 2CB3 MLD None
2 5VX9 FUC GAL NAG GAL BGC None
3 3I8T LBT 1.31579
4 4ZU4 4TG 1.35135
5 4P5Z Q7M 1.97368
6 3AIH BMA MAN MAN 2.41935
7 2JF4 VDM 2.63158
8 3A4V NAD 2.63158
9 3A4V PYR 2.63158
10 4EWH T77 2.63158
11 4IJR NDP 2.63158
12 2A4W BLM 2.89855
13 3MPB FRU 3.28947
14 2YCH ATP 3.28947
15 3Q60 ATP 3.28947
16 1GP6 DH2 3.28947
17 1GP6 SIN 3.28947
18 3ZKK XYP XYP XYP XYP 3.28947
19 6DW2 HD4 3.28947
20 3T7V MD0 3.94737
21 3QP8 HL0 3.94737
22 4G7A AZM 3.94737
23 4KYS VIB 3.94737
24 1AJS PLA 3.94737
25 4X5S AZM 4.60526
26 4YGF AZM 4.60526
27 3FW3 ETS 4.60526
28 1TLL FMN 4.60526
29 4CPZ ZMR 4.60526
30 4RYV ZEA 4.60526
31 1VBJ NAP 4.60526
32 1UMZ BGC BGC XYS BGC XYS GAL 4.60526
33 5Y1G NAD 5.26316
34 3E85 BSU 5.26316
35 3W25 XYP XYP 5.26316
36 4ZCC FAD 5.26316
37 1DMY AZM 5.26316
38 1LBF 137 5.26316
39 1GQG DCD 5.26316
40 2Y6O 1N1 5.26316
41 1PZ1 NAP 5.26316
42 4IE6 UN9 5.92105
43 1RV0 NDG 5.92105
44 3M3E GAL A2G NPO 5.92105
45 1W3T 3GR 5.92105
46 4C2V YJA 5.92105
47 4H2X G5A 5.92105
48 3MF2 AMP 5.92105
49 4H2V AMP 5.92105
50 5EYK 5U5 5.92105
51 1NN5 ANP 5.92105
52 1NN5 2DT 5.92105
53 5OO5 UUA 6.45161
54 4WUP 3UF 6.57895
55 5GQF GAL NAG 6.57895
56 3CU0 UDP 6.57895
57 2PGJ N1C 6.57895
58 4COQ SAN 7.23684
59 5DRB 5FJ 7.23684
60 2YG2 S1P 7.23684
61 2V54 TYD 7.23684
62 3PFG TLO 7.23684
63 3PFG SAM 7.23684
64 4YZ5 SLT 7.23684
65 1HDC CBO 7.23684
66 2WA4 069 7.23684
67 4IOK ADP 7.23684
68 4TMK T5A 7.23684
69 3W8X FTK 7.89474
70 5E2N V14 7.89474
71 2CJ9 SSA 7.89474
72 4MLO PAM 7.89474
73 3WUC GLC GAL 8.0292
74 1TYU GLA MAN RAM TYV GLA MAN RAM TYV 8.55263
75 5D48 L96 8.55263
76 4PSB GA3 9.21053
77 5XVG 8FX 9.21053
78 4LIT AKG 9.21053
79 3TMK T5A 9.86842
80 1MFD GLA MMA ABE 9.86842
81 5W4W 9WG 10.5263
82 1IOW ADP 10.5263
83 4P7X AKG 11.1842
84 4P7X YCP 11.1842
85 4N8I COA 11.1842
86 3L9R L9R 11.2245
87 4FG8 ATP 11.8421
88 4GFD 0YB 12.5
89 6D61 4AA 13.8158
90 2VUT NAD 14.4737
91 4WHZ 3NL 15.1316
92 3TTI KBI 15.1316
93 4M1U A2G MBG 15.7143
94 1H5T DAU 17.1053
95 3PP0 03Q 21.0526
96 4XQM MAN 21.2766
97 5IH1 6BQ 22.3684
98 5IH1 GDP 22.3684
99 1SZ0 M6P 34.2105
Pocket No.: 2; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: 25
This union binding pocket(no: 2) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 2XMY CDK None
2 2G30 ALA ALA PHE None
3 3A28 NAD None
4 3SJU NDP 1.97368
5 4ASE AV9 2.63158
6 1QIN GIP 3.28947
7 1E3W NAD 4.60526
8 5Y1G AKB 5.26316
9 5BVE 4VG 5.26316
10 5Y72 DST 5.26316
11 1AFS NAP 5.26316
12 4WW8 VD9 5.92105
13 3KRB NAP 5.92105
14 6FE1 V14 6.57895
15 1YKD CMP 6.57895
16 5GUD NDP 7.23684
17 2VZR GCU 7.87402
18 4B2Z P5S 8.55263
19 5ZM4 AKG 8.55263
20 4WVW SLT 9.02778
21 6BS6 GLC GLC GLC 9.21053
22 6CBN OZY 13.8158
23 4IPH 1FJ 13.8211
24 5KK4 44E 16.6667
25 5X7Q GLC GLC GLC GLC 18.4211
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