Receptor
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M6P A:200;
B:200;
Valid;
Valid;
none;
none;
Kd = 8 uM
260.136 C6 H13 O9 P C([C@...
MN A:199;
B:199;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M6P; Similar ligands found: 52
No: Ligand ECFP6 Tc MDL keys Tc
1 M6P 1 1
2 BG6 1 1
3 G6P 1 1
4 M6D 1 1
5 BGP 1 1
6 A6P 1 1
7 RP5 0.8 0.902439
8 HSX 0.8 0.902439
9 ABF 0.8 0.902439
10 AHG 0.621622 0.795455
11 GLP 0.590909 0.829787
12 4R1 0.590909 0.829787
13 RF5 0.571429 0.8
14 50A 0.571429 0.8
15 4QY 0.55102 0.75
16 BMX 0.55102 0.75
17 16G 0.55102 0.75
18 GRF 0.547619 0.692308
19 NNG 0.530612 0.75
20 1FT 0.517857 0.847826
21 FDQ 0.511111 0.777778
22 G16 0.5 0.951219
23 PRP 0.5 0.880952
24 T6P 0.470588 0.906977
25 D6G 0.468085 0.951219
26 P3M 0.466667 0.906977
27 GLA 0.461538 0.675
28 GIV 0.461538 0.675
29 WOO 0.461538 0.675
30 GLC 0.461538 0.675
31 ALL 0.461538 0.675
32 BGC 0.461538 0.675
33 GXL 0.461538 0.675
34 GAL 0.461538 0.675
35 BMA 0.461538 0.675
36 MAN 0.461538 0.675
37 GLA BGC 0.45098 0.674419
38 BGC GLA 0.45098 0.674419
39 GLA BMA 0.45098 0.674419
40 LAK 0.45098 0.674419
41 GAL GAL 0.45098 0.674419
42 BMA GLA 0.45098 0.674419
43 MAN BMA 0.45098 0.674419
44 GLA GLC 0.45098 0.674419
45 MLB 0.45098 0.674419
46 N 0.444444 0.777778
47 PPC 0.442308 0.822222
48 GLC GLC GLC 0.433962 0.674419
49 MAN MAN MAN 0.433962 0.674419
50 GLC GLC GLC GLC BGC 0.433962 0.674419
51 GLC GLC GLC GLC GLC BGC 0.433962 0.674419
52 GLC GLC 0.423077 0.707317
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found: 50
This union binding pocket(no: 1) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4ZU4 4TG 0.005937 0.42839 1.35135
2 4P5Z Q7M 0.04868 0.40551 1.97368
3 3AIH BMA MAN MAN 0.000003486 0.58045 2.41935
4 2JF4 VDM 0.01109 0.42381 2.63158
5 2A4W BLM 0.008857 0.43634 2.89855
6 3Q60 ATP 0.0143 0.40914 3.28947
7 1GP6 SIN 0.0252 0.40824 3.28947
8 1GP6 DH2 0.0252 0.40824 3.28947
9 3T7V MD0 0.002264 0.43633 3.94737
10 4KYS VIB 0.01185 0.40141 3.94737
11 1AJS PLA 0.03304 0.40061 3.94737
12 4IGH FMN 0.01879 0.44762 4.60526
13 4IGH ORO 0.01879 0.44762 4.60526
14 4IGH 1EA 0.01879 0.44762 4.60526
15 4X5S AZM 0.003818 0.43269 4.60526
16 1UMZ BGC BGC XYS BGC XYS GAL 0.008148 0.41207 4.60526
17 1TLL FMN 0.02056 0.41142 4.60526
18 1DMY AZM 0.01214 0.40608 5.26316
19 1GQG DCD 0.02661 0.40249 5.26316
20 1PZ1 NAP 0.04066 0.40115 5.26316
21 4Q0L V14 0.01078 0.42758 5.92105
22 1W3T 3GR 0.008329 0.41366 5.92105
23 4C2V YJA 0.02807 0.411 5.92105
24 3MF2 AMP 0.02765 0.40318 5.92105
25 4H2V AMP 0.0269 0.40224 5.92105
26 5EYK 5U5 0.03684 0.40219 5.92105
27 1NN5 ANP 0.04486 0.40121 5.92105
28 3ML5 AZM 0.007962 0.40108 5.92105
29 5OO5 UUA 0.008109 0.42157 6.45161
30 5GQF GAL NAG 0.01101 0.41277 6.57895
31 3CU0 UDP 0.02183 0.40356 6.57895
32 4COQ SAN 0.004149 0.43072 7.23684
33 1HDC CBO 0.01894 0.40848 7.23684
34 4IOK ADP 0.03504 0.40334 7.23684
35 4TMK T5A 0.0459 0.40288 7.23684
36 2CJ9 SSA 0.01946 0.40612 7.89474
37 4MLO PAM 0.01862 0.40131 7.89474
38 5D48 L96 0.03455 0.40236 8.55263
39 4PSB GA3 0.009384 0.44128 9.21053
40 2X4Z X4Z 0.03098 0.41325 9.21053
41 5W4W 9WG 0.02219 0.40968 10.5263
42 4P7X YCP 0.01044 0.41804 11.1842
43 4P7X AKG 0.01044 0.41804 11.1842
44 4N8I COA 0.03337 0.40316 11.1842
45 2VUT NAD 0.0213 0.41061 14.4737
46 3W7T BMA 0.02648 0.40416 14.4737
47 4XQM MAN 0.0000002032 0.51637 21.2766
48 5IH1 GDP 0.02899 0.42742 22.3684
49 5IH1 6BQ 0.02899 0.42742 22.3684
50 1SZ0 M6P 0.000006714 0.50619 34.2105
Pocket No.: 2; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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