Receptor
PDB id Resolution Class Description Source Keywords
1LSH 1.9 Å NON-ENZYME: BINDING LIPID-PROTEIN INTERACTIONS IN LIPOVITELLIN ICHTHYOMYZON UNICUSPIS LIPOVITELLIN VITELLOGENIN LIPOPROTEIN PLASMA APOLIPOPROTE APOLIPOPROTEIN B APOB MICROSOMAL TRIGLYCERIDE TRANSFER PR BOUNDARY LIPID PHOSPHOLIPID STRUCTURE LIPID BINDING PROTEIN
Ref.: LIPID-PROTEIN INTERACTIONS IN LIPOVITELLIN. BIOCHEMISTRY V. 41 9398 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PLD A:2001;
A:2002;
A:2004;
A:2005;
A:2006;
A:2007;
B:2003;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
submit data
875.313 C50 H101 N O8 P CCCCC...
UPL A:2008;
A:2009;
A:2011;
A:2012;
A:2013;
A:2014;
A:2015;
A:2017;
A:2018;
A:2019;
A:2020;
A:2022;
A:2024;
A:2025;
A:2026;
A:2029;
A:2030;
A:2032;
A:2034;
A:2035;
A:2036;
A:2037;
A:2038;
A:2039;
A:2040;
A:2041;
A:2042;
A:2047;
A:2048;
A:2050;
B:2010;
B:2016;
B:2021;
B:2023;
B:2027;
B:2028;
B:2031;
B:2033;
B:2043;
B:2044;
B:2045;
B:2046;
B:2049;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
478.92 C34 H70 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LSH 1.9 Å NON-ENZYME: BINDING LIPID-PROTEIN INTERACTIONS IN LIPOVITELLIN ICHTHYOMYZON UNICUSPIS LIPOVITELLIN VITELLOGENIN LIPOPROTEIN PLASMA APOLIPOPROTE APOLIPOPROTEIN B APOB MICROSOMAL TRIGLYCERIDE TRANSFER PR BOUNDARY LIPID PHOSPHOLIPID STRUCTURE LIPID BINDING PROTEIN
Ref.: LIPID-PROTEIN INTERACTIONS IN LIPOVITELLIN. BIOCHEMISTRY V. 41 9398 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 1LSH - PLD C50 H101 N O8 P CCCCCCCCCC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 1LSH - PLD C50 H101 N O8 P CCCCCCCCCC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 272 families.
1 1LSH - PLD C50 H101 N O8 P CCCCCCCCCC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLD; Similar ligands found: 82
No: Ligand ECFP6 Tc MDL keys Tc
1 LIO 1 1
2 HGX 1 1
3 HGP 1 1
4 6PL 1 1
5 PC7 1 1
6 PLD 1 1
7 XP5 0.935484 1
8 PCW 0.871429 0.981481
9 PCK 0.847222 0.946429
10 PTY 0.80303 0.793103
11 PEH 0.80303 0.793103
12 8PE 0.80303 0.793103
13 PEV 0.80303 0.793103
14 PEF 0.80303 0.793103
15 PSC 0.792208 0.981481
16 9PE 0.791045 0.793103
17 PEE 0.764706 0.810345
18 CD4 0.735294 0.727273
19 PC1 0.732394 0.924528
20 PCF 0.732394 0.924528
21 MC3 0.732394 0.924528
22 PGT 0.714286 0.701754
23 LHG 0.714286 0.701754
24 LOP 0.706667 0.779661
25 L9Q 0.706667 0.779661
26 P5S 0.694444 0.745763
27 LAP 0.685714 0.963636
28 LPC 0.685714 0.963636
29 LP3 0.685714 0.963636
30 3PH 0.681818 0.727273
31 6PH 0.681818 0.727273
32 7PH 0.681818 0.727273
33 LPP 0.681818 0.727273
34 7P9 0.671642 0.727273
35 PX2 0.671642 0.773585
36 ZPE 0.666667 0.779661
37 CN3 0.657895 0.727273
38 L9R 0.65 0.907407
39 GP7 0.638554 0.779661
40 PEK 0.634146 0.779661
41 PGW 0.632911 0.689655
42 PII 0.631579 0.655738
43 CN6 0.631579 0.727273
44 PD7 0.626866 0.727273
45 DR9 0.625 0.689655
46 PGV 0.625 0.689655
47 P6L 0.617284 0.689655
48 PGK 0.617284 0.666667
49 PIF 0.615385 0.645161
50 44G 0.611111 0.701754
51 OZ2 0.609756 0.689655
52 CDL 0.608108 0.722222
53 42H 0.607595 0.946429
54 PIZ 0.604938 0.655738
55 M7U 0.6 0.727273
56 DGG 0.595238 0.666667
57 PSF 0.594595 0.745763
58 PIO 0.592593 0.645161
59 52N 0.592593 0.645161
60 IP9 0.592593 0.655738
61 3PE 0.592105 0.754386
62 DLP 0.574713 0.907407
63 44E 0.573529 0.727273
64 B7N 0.564706 0.645161
65 8ND 0.56338 0.614035
66 PC5 0.56 0.824561
67 PDK 0.55914 0.777778
68 AGA 0.544304 0.701754
69 EPH 0.537634 0.779661
70 3PC 0.531646 0.90566
71 PIE 0.522727 0.629032
72 P3A 0.505618 0.689655
73 T7X 0.505376 0.645161
74 OPC 0.472527 0.963636
75 LPE 0.467532 0.909091
76 NKN 0.452055 0.696429
77 CN5 0.451219 0.745455
78 SPU 0.445783 0.803279
79 3XU 0.44086 0.809524
80 OCB 0.438356 0.796296
81 S12 0.41573 0.716667
82 NKP 0.402439 0.684211
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lsh.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1lsh.bio1) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1lsh.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1lsh.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1lsh.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: 138
This union binding pocket(no: 6) in the query (biounit: 1lsh.bio1) has 30 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4L77 CNL 0.01415 0.42688 1.25628
2 5LUN OGA 0.0007899 0.48132 2.19436
3 1I1E DM2 0.03482 0.40598 2.19436
4 2C5S AMP 0.03303 0.40325 2.50784
5 4KBA 1QM 0.005058 0.44551 2.71903
6 2VDF OCT 0.00005042 0.54537 2.7668
7 3PUN FUC GAL NDG FUC 0.03302 0.40917 2.8481
8 4NV7 COA 0.001547 0.42001 2.88462
9 2IU8 PLM 0.001578 0.43604 2.94118
10 4RQL SNE 0.0197 0.42089 2.94118
11 2G30 ALA ALA PHE 0.0001465 0.54139 3.10078
12 2Z5Y HRM 0.002116 0.46502 3.1348
13 5MRH Q9Z 0.01377 0.42303 3.1348
14 1OJJ GLC GAL 0.03114 0.40458 3.1348
15 2IVD ACJ 0.005802 0.43339 3.2197
16 3ZF8 GDP 0.01711 0.41406 3.27869
17 2GTF P1R 0.0001333 0.41998 3.33333
18 1ZNY GDP 0.009226 0.43674 3.38164
19 4CJN QNZ 0.01372 0.43595 3.44828
20 3ZGJ RMN 0.03345 0.40295 3.44828
21 1K0E TRP 0.02073 0.40259 3.44828
22 3KYF 5GP 5GP 0.001814 0.46317 3.4632
23 3A16 PXO 0.001381 0.46429 3.48525
24 3GD9 GLC BGC BGC BGC 0.006182 0.43204 3.54223
25 5FPE 3TR 0.00564 0.45553 3.61757
26 3QSB 743 0.01948 0.4112 3.76176
27 2NZ2 CIR 0.03899 0.40334 3.76176
28 1RYD GLC 0.00307 0.46974 3.87597
29 4NOS ITU 0.03428 0.4024 4.07523
30 2EB5 OXL 0.03879 0.40658 4.11985
31 1QH5 GSH 0.02167 0.42013 4.23077
32 4MVK ACE VAL PHE PHE ALA GLU ASP NH2 0.006178 0.40159 4.25532
33 4XMF HSM 0.002173 0.46985 4.34783
34 3NZ1 3NY 0.01432 0.42068 4.38871
35 1H3F TYE 0.003137 0.46999 4.39815
36 2YKL NLD 0.01059 0.42052 4.62963
37 2CYB TYR 0.04972 0.40192 4.64396
38 2IF8 ADP 0.0162 0.42374 4.6832
39 5KJW 53C 0.0007518 0.49889 4.68384
40 5D9G GLU ASN LEU TYR PHE GLN 0.00167 0.47032 4.87805
41 3JQ3 ADP 0.007299 0.43275 4.91803
42 4ZTD ALA GLY ALA GLY ALA 0.01593 0.42958 5.01567
43 3VKX T3 0.01554 0.4203 5.01567
44 3CBC DBS 0.0004898 0.52027 5.05051
45 4GGL CJC 0.01451 0.41009 5.11628
46 4DXD 9PC 0.002322 0.43233 5.30303
47 1FHX 4IP 0.02199 0.41668 5.42636
48 4FE2 AIR 0.01125 0.42328 5.4902
49 3TAY MN0 0.001488 0.42688 5.52147
50 3QXV MTX 0.001877 0.4442 5.55556
51 5L2R MLA 0.003803 0.46201 5.64263
52 2VFT SOR 0.01149 0.42281 5.64263
53 4FFG 0U8 0.02683 0.40851 5.64263
54 5LXB 7A9 0.03141 0.41 5.78512
55 4DSU BZI 0.00005996 0.55805 5.82011
56 5CHR 4NC 0.0437 0.40098 5.83942
57 5F7J ADE 0.02736 0.41333 5.9375
58 3ZJX BOG 0.005932 0.45117 6.22837
59 2QHS OCA 0.02449 0.40616 6.32911
60 1OFL NGK GCD 0.0003103 0.51243 6.44491
61 5EWK P34 0.03503 0.40761 6.5
62 2WZ5 MET 0.00005894 0.54252 6.53595
63 4URX HXY 0.01766 0.43395 6.58307
64 4EMV 0R9 0.005078 0.42074 6.63717
65 5FWJ MMK 0.01951 0.41517 6.89655
66 5T8U LPA 0.01543 0.41245 6.89655
67 5H9P TD2 0.009263 0.43665 6.96203
68 1QKQ MAN 0.0009326 0.48455 7.04225
69 2QHV OC9 0.01477 0.42145 7.14286
70 2OVW CBI 0.0362 0.40507 7.21003
71 1HXD BTN 0.008015 0.40856 7.47664
72 3H0L ADP 0.005293 0.44449 7.53138
73 2QZ3 XYP XYP XYP 0.001095 0.44289 7.56757
74 4WOE ADP 0.02284 0.4166 7.68156
75 4U60 SIA GAL NGA 0.04921 0.40002 7.85714
76 2CM4 RCL 0.01063 0.40016 8
77 4ZU4 4TG 0.006201 0.424 8.10811
78 4MOB ADP 0.001621 0.48172 8.13253
79 4NG2 OHN 0.007019 0.40497 8.15217
80 1KDK DHT 0.008681 0.40104 8.47458
81 3EFS BTN 0.007648 0.41272 8.58369
82 5W10 CMP 0.005362 0.41968 8.71795
83 1SZO CAX 0.0194 0.42069 8.94942
84 4WCX MET 0.0009603 0.49685 8.95833
85 5A7Y SAH 0.02135 0.40918 8.97436
86 2WOR 2AN 0.02241 0.41863 9
87 1TT8 PHB 0.001989 0.41866 9.14634
88 1UYY BGC BGC 0.002264 0.46904 9.16031
89 3NKS ACJ 0.00407 0.4326 9.22432
90 4YVN EBS 0.006961 0.44571 9.40439
91 5F6U 5VK 0.0008149 0.49706 9.55414
92 3HCH RSM 0.03625 0.40674 9.58904
93 5DYO FLU 0.01057 0.43742 9.90566
94 5TV6 PML 0.03765 0.40027 10
95 2CJU PHX 0.022 0.42155 10.0313
96 5X7Q GLC GLC GLC GLC GLC 0.02172 0.41242 10.0313
97 5H9Y BGC BGC BGC BGC 0.003219 0.44156 10.1351
98 4TW7 37K 0.00479 0.40333 10.1562
99 5CLO NS8 0.03226 0.40876 10.1695
100 2PFC PLM 0.02701 0.4004 10.3825
101 3PNA CMP 0.02146 0.41301 10.3896
102 3QRC SCR 0.002857 0.47758 10.828
103 5H2U 1N1 0.004125 0.42847 10.8614
104 2XG5 EC5 0.02565 0.40592 11.0092
105 2XG5 EC2 0.02565 0.40592 11.0092
106 5J75 6GQ 0.0006154 0.47604 11.3636
107 4RT1 C2E 0.005384 0.42689 11.6071
108 5VNF VAL THR SER VAL VAL 0.01919 0.41555 12.1019
109 4LO2 GAL BGC 0.03715 0.40463 12.2449
110 1SN0 T44 0.004457 0.43903 12.3077
111 1Y7P RIP 0.001195 0.46347 12.5561
112 1KGI T4A 0.0004432 0.45205 12.5984
113 3KYG 5GP 5GP 0.005491 0.41921 12.7753
114 3ACL 3F1 0.001103 0.45922 12.8378
115 2AZ5 307 0.004602 0.42629 12.8378
116 4RYV ZEA 0.0003837 0.49708 13.5484
117 5FUI APY 0.0001846 0.50655 13.6364
118 4IEN GDP 0.003457 0.43593 14.1104
119 5TVF CGQ 0.0101 0.42153 14.1176
120 5L83 ASP TRP GLU ILE VAL 0.02462 0.4024 14.2857
121 5N2D 8J8 0.00398 0.42551 14.5833
122 3DZ6 PUT 0.02347 0.42377 14.9254
123 1I7M CG 0.01454 0.41764 14.9254
124 2R09 4IP 0.008058 0.43986 14.9856
125 1P0Z FLC 0.04314 0.40467 16.0305
126 5HWV MBN 0.008595 0.43837 16.9231
127 5J8O 6GZ 0.001681 0.45063 16.9355
128 5N2F 8HW 0.001446 0.43411 16.9355
129 3RF4 FUN 0.007511 0.44148 17.2414
130 4KAX 4IP 0.0218 0.41687 19.5266
131 4LOO SB4 0.003592 0.43124 20.6897
132 4K55 H6P 0.006326 0.45322 20.9677
133 3AJH BL3 0.002291 0.43631 22.1774
134 4L4V 1VY 0.01086 0.41253 23.2323
135 5XLY C2E 0.004171 0.42825 24.812
136 4IAW LIZ 0.002152 0.45945 30.8511
137 2QL9 CIT 0.001616 0.48455 30.9278
138 3IWD M2T 0.0155 0.42476 35.4839
Pocket No.: 7; Query (leader) PDB : 1LSH; Ligand: PLD; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 1lsh.bio1) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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