Receptor
PDB id Resolution Class Description Source Keywords
1LR8 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE D-MYO- I NOSITOL HEXASULPHATE (INS6S) RATTUS NORVEGICUS CYSTINE-RICH D-MYO-INOSITOL HEXASULPHATE HORMONE/GROWTH FACTOR COMPLEX
Ref.: CRYSTAL STRUCTURES OF THE HEPARAN SULFATE-BINDING DOMAIN OF FOLLISTATIN: INSIGHTS INTO LIGAND BINDING. J.BIOL.CHEM. V. 278 39969 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
IHS A:30;
Valid;
none;
Kd = 10 nM
660.535 C6 H12 O24 S6 C1(C(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LR8 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE D-MYO- I NOSITOL HEXASULPHATE (INS6S) RATTUS NORVEGICUS CYSTINE-RICH D-MYO-INOSITOL HEXASULPHATE HORMONE/GROWTH FACTOR COMPLEX
Ref.: CRYSTAL STRUCTURES OF THE HEPARAN SULFATE-BINDING DOMAIN OF FOLLISTATIN: INSIGHTS INTO LIGAND BINDING. J.BIOL.CHEM. V. 278 39969 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: IHS; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 IHS 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LR8; Ligand: IHS; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lr8.bio1) has 6 residues
No: Leader PDB Ligand Sequence Similarity
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