Receptor
PDB id Resolution Class Description Source Keywords
1LR8 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE D-MYO- I NOSITOL HEXASULPHATE (INS6S) RATTUS NORVEGICUS CYSTINE-RICH D-MYO-INOSITOL HEXASULPHATE HORMONE/GROWTH FACTOR COMPLEX
Ref.: CRYSTAL STRUCTURES OF THE HEPARAN SULFATE-BINDING DOMAIN OF FOLLISTATIN: INSIGHTS INTO LIGAND BINDING. J.BIOL.CHEM. V. 278 39969 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
IHS A:30;
Valid;
none;
Kd = 10 nM
660.535 C6 H12 O24 S6 C1(C(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LR8 2.1 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN ANALOGUE D-MYO- I NOSITOL HEXASULPHATE (INS6S) RATTUS NORVEGICUS CYSTINE-RICH D-MYO-INOSITOL HEXASULPHATE HORMONE/GROWTH FACTOR COMPLEX
Ref.: CRYSTAL STRUCTURES OF THE HEPARAN SULFATE-BINDING DOMAIN OF FOLLISTATIN: INSIGHTS INTO LIGAND BINDING. J.BIOL.CHEM. V. 278 39969 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1LR8 Kd = 10 nM IHS C6 H12 O24 S6 C1(C(C(C(C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: IHS; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 IHS 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LR8; Ligand: IHS; Similar sites found: 18
This union binding pocket(no: 1) in the query (biounit: 1lr8.bio1) has 6 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4YEF 4CQ 0.0000952 0.50077 None
2 1VC9 ATP 0.00275 0.48762 None
3 4K49 HFQ 0.001391 0.47226 None
4 1Z0N BCD 0.0002272 0.43713 None
5 3UDG TMP 0.002313 0.41456 None
6 3F5O UOC COA 0.02558 0.41279 None
7 5EY0 GTP 0.0009787 0.40789 None
8 1U1B PAX 0.003977 0.47662 5.40541
9 4K4D HFQ 0.007502 0.44079 6.75676
10 1IWE IMP 0.02805 0.43987 6.75676
11 3KLL MAL 0.02043 0.42562 8.10811
12 4MBY BGC SIA GAL 0.003252 0.45594 9.45946
13 4POS NAG SIA GAL 0.004336 0.4289 9.45946
14 4LRJ ANP 0.01021 0.40823 9.45946
15 4M1U A2G MBG 0.0001718 0.48326 15.7143
16 4M1U MBG A2G 0.0007922 0.48326 15.7143
17 3UKR CKH 0.00357 0.45339 16.2162
18 3WXL ADP 0.000008876 0.45381 20.2703
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