Receptor
PDB id Resolution Class Description Source Keywords
1LAH 2.06 Å NON-ENZYME: TRANSPORT STRUCTURAL BASES FOR MULTIPLE LIGAND SPECIFICITY OF THE PERI LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN SALMONELLA TYPHIMURIUM AMINO ACID TRANSPORT
Ref.: STRUCTURAL BASIS FOR MULTIPLE LIGAND SPECIFICITY OF PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING P J.BIOL.CHEM. V. 269 26323 1994
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ORN E:240;
Valid;
none;
Kd = 30 nM
132.161 C5 H12 N2 O2 C(C[C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6MLE 1.86 Å NON-ENZYME: TRANSPORT CRYSTAL STRUCTURE OF THE PERIPLASMIC LYSINE-, ARGININE-, ORN BINDING PROTEIN (LAO) FROM SALMONELLA TYPHIMURIUM COMPLEXEDA RGININE SALMONELLA TYPHIMURIUM (STRAIN LT2 / SATCC 700720) PERIPLASMIC BINDING PROTEIN LAO THERMODYNAMICS PROTEIN LICOMPLEX PROTEIN BINDING
Ref.: THE INTERPLAY OF PROTEIN-LIGAND AND WATER-MEDIATED INTERACTIONS SHAPE AFFINITY AND SELECTIVITY IN THE BINDING PROTEIN. FEBS J. V. 287 763 2020
Members (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 232 families.
1 6MLA Kd = 42 uM ARG C6 H15 N4 O2 C(C[C@@H](....
2 1LAG Kd = 500 nM HIS C6 H10 N3 O2 c1c([nH+]c....
3 6MLI Kd = 3700 uM HIS C6 H10 N3 O2 c1c([nH+]c....
4 6MLO Kd = 0.8 uM ARG C6 H15 N4 O2 C(C[C@@H](....
5 6MLN Kd = 29 nM ARG C6 H15 N4 O2 C(C[C@@H](....
6 6ML9 Kd = 5 uM ARG C6 H15 N4 O2 C(C[C@@H](....
7 6MKW Kd = 17 uM HIS C6 H10 N3 O2 c1c([nH+]c....
8 6MLG Kd = 9 uM ARG C6 H15 N4 O2 C(C[C@@H](....
9 6MLP Kd = 200 uM HIS C6 H10 N3 O2 c1c([nH+]c....
10 1LST - LYS C6 H15 N2 O2 C(CC[NH3+]....
11 1LAF Kd = 14 nM ARG C6 H15 N4 O2 C(C[C@@H](....
12 5OWF Kd = 1.59 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
13 6MKU Kd = 70 nM ARG C6 H15 N4 O2 C(C[C@@H](....
14 6MLJ Kd = 55 nM ARG C6 H15 N4 O2 C(C[C@@H](....
15 6MLE Kd = 1 nM ARG C6 H15 N4 O2 C(C[C@@H](....
16 1LAH Kd = 30 nM ORN C5 H12 N2 O2 C(C[C@@H](....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 197 families.
1 6MLA Kd = 42 uM ARG C6 H15 N4 O2 C(C[C@@H](....
2 1LAG Kd = 500 nM HIS C6 H10 N3 O2 c1c([nH+]c....
3 6MLI Kd = 3700 uM HIS C6 H10 N3 O2 c1c([nH+]c....
4 6MLO Kd = 0.8 uM ARG C6 H15 N4 O2 C(C[C@@H](....
5 6MLN Kd = 29 nM ARG C6 H15 N4 O2 C(C[C@@H](....
6 6ML9 Kd = 5 uM ARG C6 H15 N4 O2 C(C[C@@H](....
7 6MKW Kd = 17 uM HIS C6 H10 N3 O2 c1c([nH+]c....
8 6MLG Kd = 9 uM ARG C6 H15 N4 O2 C(C[C@@H](....
9 6MLP Kd = 200 uM HIS C6 H10 N3 O2 c1c([nH+]c....
10 1LST - LYS C6 H15 N2 O2 C(CC[NH3+]....
11 1LAF Kd = 14 nM ARG C6 H15 N4 O2 C(C[C@@H](....
12 5OWF Kd = 1.59 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
13 6MKU Kd = 70 nM ARG C6 H15 N4 O2 C(C[C@@H](....
14 6MLJ Kd = 55 nM ARG C6 H15 N4 O2 C(C[C@@H](....
15 6MLE Kd = 1 nM ARG C6 H15 N4 O2 C(C[C@@H](....
16 1LAH Kd = 30 nM ORN C5 H12 N2 O2 C(C[C@@H](....
17 1HSL Kd = 0.064 uM HIS C6 H10 N3 O2 c1c([nH+]c....
18 1HPB Kd = 0.03 uM HIS C6 H10 N3 O2 c1c([nH+]c....
50% Homology Family (46)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 165 families.
1 1WDN Kd = 0.5 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
2 6MLA Kd = 42 uM ARG C6 H15 N4 O2 C(C[C@@H](....
3 1LAG Kd = 500 nM HIS C6 H10 N3 O2 c1c([nH+]c....
4 6MLI Kd = 3700 uM HIS C6 H10 N3 O2 c1c([nH+]c....
5 6MLO Kd = 0.8 uM ARG C6 H15 N4 O2 C(C[C@@H](....
6 6MLN Kd = 29 nM ARG C6 H15 N4 O2 C(C[C@@H](....
7 6ML9 Kd = 5 uM ARG C6 H15 N4 O2 C(C[C@@H](....
8 6MKW Kd = 17 uM HIS C6 H10 N3 O2 c1c([nH+]c....
9 6MLG Kd = 9 uM ARG C6 H15 N4 O2 C(C[C@@H](....
10 6MLP Kd = 200 uM HIS C6 H10 N3 O2 c1c([nH+]c....
11 1LST - LYS C6 H15 N2 O2 C(CC[NH3+]....
12 1LAF Kd = 14 nM ARG C6 H15 N4 O2 C(C[C@@H](....
13 5OWF Kd = 1.59 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
14 6MKU Kd = 70 nM ARG C6 H15 N4 O2 C(C[C@@H](....
15 6MLJ Kd = 55 nM ARG C6 H15 N4 O2 C(C[C@@H](....
16 6MLE Kd = 1 nM ARG C6 H15 N4 O2 C(C[C@@H](....
17 1LAH Kd = 30 nM ORN C5 H12 N2 O2 C(C[C@@H](....
18 6A8S Kd = 0.000000064 M CYS C3 H7 N O2 S C([C@@H](C....
19 6A80 Kd = 0.000000064 M CYS C3 H7 N O2 S C([C@@H](C....
20 6AA1 - CIT C6 H8 O7 C(C(=O)O)C....
21 5OT8 Kd = 52 uM 6DB C9 H18 N4 O4 [H]/N=C(/N....
22 5OT9 Kd = 84.4 uM AOZ C9 H13 N3 O4 CC(C(=O)O)....
23 5OTC Kd = 23 uM AQK C7 H14 N2 O4 C(C[C@@H](....
24 4POW Kd = 0.58 uM OP1 C11 H18 N4 O5 [H]/N=C(N)....
25 5ITO Kd = 68.9 uM 6DB C9 H18 N4 O4 [H]/N=C(/N....
26 5ITP Kd = 9.9 uM 6DB C9 H18 N4 O4 [H]/N=C(/N....
27 4POX Kd = 3.7 uM 2W2 C11 H20 N4 O6 [H]/N=C(/N....
28 5OTA Kd = 4.4 uM AQQ C8 H16 N2 O4 C[C@H](C(=....
29 4PP0 - OP1 C11 H18 N4 O5 [H]/N=C(N)....
30 6SVF - ARG C6 H15 N4 O2 C(C[C@@H](....
31 6Q3U - ARG C6 H15 N4 O2 C(C[C@@H](....
32 2Y7I - ARG C6 H15 N4 O2 C(C[C@@H](....
33 4G4P Kd = 0.13 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
34 2PVU Kd = 0.49 uM LYS C6 H15 N2 O2 C(CC[NH3+]....
35 2Q2C Kd = 0.42 uM HIS C6 H10 N3 O2 c1c([nH+]c....
36 4YMX Kd = 79 nM ARG C6 H15 N4 O2 C(C[C@@H](....
37 2PYY Kd = 0.000023 M GLU C5 H9 N O4 C(CC(=O)O)....
38 1HSL Kd = 0.064 uM HIS C6 H10 N3 O2 c1c([nH+]c....
39 1HPB Kd = 0.03 uM HIS C6 H10 N3 O2 c1c([nH+]c....
40 3VVF - ARG C6 H15 N4 O2 C(C[C@@H](....
41 3VVD - ORN C5 H12 N2 O2 C(C[C@@H](....
42 5L9O Kd = 4 uM GOP C11 H22 N2 O8 C(CC(=O)N)....
43 4ZV1 Kd = 5.73 uM ARG C6 H15 N4 O2 C(C[C@@H](....
44 4ZV2 Kd = 1170 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
45 5ORG Kd = 0.009 uM 6DB C9 H18 N4 O4 [H]/N=C(/N....
46 4KQP Kd = 0.9 uM GLN C5 H10 N2 O3 C(CC(=O)N)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ORN; Similar ligands found: 57
No: Ligand ECFP6 Tc MDL keys Tc
1 ORN 1 1
2 DLY 0.714286 0.961538
3 API 0.653846 0.785714
4 DAB 0.615385 0.888889
5 NLE 0.566667 0.724138
6 2YH 0.564103 0.757576
7 11C 0.548387 0.724138
8 UN1 0.548387 0.724138
9 0TF 0.536585 0.714286
10 LYS 0.53125 0.925926
11 DHH 0.53125 0.7
12 ONH 0.515152 0.735294
13 NPI 0.515152 0.7
14 2RA 0.5 0.785714
15 HSE 0.5 0.733333
16 6CL 0.5 0.758621
17 26P 0.5 0.65625
18 CIR 0.485714 0.735294
19 HCS 0.482759 0.814815
20 NVA 0.482759 0.714286
21 ARG 0.472222 0.757576
22 2NP 0.472222 0.6
23 DAR 0.472222 0.757576
24 MLZ 0.472222 0.757576
25 MLY 0.472222 0.631579
26 CUW 0.470588 0.833333
27 2YJ 0.465116 0.714286
28 MSE 0.454545 0.636364
29 2YG 0.454545 0.714286
30 DGN 0.451613 0.677419
31 DGL 0.451613 0.689655
32 GGL 0.451613 0.689655
33 GLU 0.451613 0.689655
34 GLN 0.451613 0.677419
35 DSN 0.444444 0.689655
36 ABA 0.444444 0.666667
37 DBB 0.444444 0.666667
38 SER 0.444444 0.689655
39 5CT 0.44186 0.735294
40 WT2 0.439024 0.78125
41 ILO 0.435897 0.757576
42 HRG 0.435897 0.757576
43 ALY 0.435897 0.735294
44 AS2 0.433333 0.62069
45 C2N 0.428571 0.703704
46 CYS 0.428571 0.740741
47 DCY 0.428571 0.740741
48 NOT 0.425 0.705882
49 EXY 0.425 0.611111
50 ONL 0.424242 0.625
51 2FM 0.416667 0.677419
52 HAR 0.414634 0.625
53 NMM 0.414634 0.714286
54 VUR 0.414634 0.735294
55 4JK 0.414634 0.714286
56 MET 0.411765 0.65625
57 MED 0.411765 0.65625
Similar Ligands (3D)
Ligand no: 1; Ligand: ORN; Similar ligands found: 879
No: Ligand Similarity coefficient
1 1M2 1.0000
2 2CO 0.9975
3 KMT 0.9841
4 HL5 0.9772
5 AKG 0.9758
6 MPJ 0.9731
7 LYN 0.9713
8 OGA 0.9692
9 FAN 0.9686
10 LEU 0.9656
11 S2G 0.9654
12 ASP 0.9649
13 9ON 0.9647
14 SHV 0.9609
15 AL0 0.9607
16 KQY 0.9585
17 OAA 0.9580
18 2IT 0.9578
19 SME 0.9571
20 HPN 0.9565
21 69O 0.9561
22 HTX 0.9545
23 CRN 0.9544
24 SD4 0.9543
25 SKJ 0.9540
26 MHO 0.9539
27 CSS 0.9526
28 PEA 0.9521
29 VKC 0.9520
30 9X7 0.9517
31 SLZ 0.9515
32 DAV 0.9507
33 LMR 0.9505
34 N6C 0.9498
35 GUA 0.9495
36 MD0 0.9487
37 URQ 0.9486
38 ASN 0.9485
39 HY1 0.9480
40 258 0.9480
41 PEL 0.9473
42 268 0.9472
43 7C3 0.9472
44 HSM 0.9470
45 6NA 0.9469
46 49F 0.9464
47 COI 0.9459
48 ACA 0.9456
49 TZE 0.9452
50 CXF 0.9447
51 YRL 0.9444
52 NLP 0.9443
53 AG2 0.9441
54 2HG 0.9432
55 CEE 0.9429
56 98J 0.9408
57 3OL 0.9403
58 3OM 0.9403
59 MLT 0.9403
60 HE2 0.9402
61 JZ7 0.9399
62 ILE 0.9392
63 PG3 0.9391
64 SGL 0.9383
65 MHN 0.9382
66 DIR 0.9377
67 5XA 0.9376
68 9J3 0.9372
69 2FT 0.9371
70 FP1 0.9370
71 BHH 0.9366
72 BNF 0.9364
73 SHO 0.9361
74 UGC 0.9360
75 DZA 0.9355
76 HP6 0.9355
77 ITN 0.9350
78 40E 0.9348
79 HE4 0.9347
80 BSX 0.9343
81 GJZ 0.9342
82 OCT 0.9340
83 PRA 0.9336
84 O8Y 0.9333
85 DHR 0.9332
86 ISZ 0.9330
87 1SP 0.9327
88 6XA 0.9324
89 GLY GLY 0.9323
90 SRT 0.9322
91 NMH 0.9321
92 I38 0.9321
93 ABU 0.9318
94 MLE 0.9317
95 IXW 0.9316
96 VAL 0.9314
97 8SZ 0.9313
98 PG0 0.9311
99 NTU 0.9311
100 271 0.9311
101 HBA 0.9309
102 264 0.9308
103 PEP 0.9307
104 O45 0.9307
105 THE 0.9307
106 MPH 0.9307
107 NWH 0.9304
108 N4B 0.9304
109 YIV 0.9301
110 A8C 0.9297
111 1DJ 0.9296
112 SIN 0.9295
113 0VT 0.9294
114 DPF 0.9293
115 S8V 0.9293
116 OK7 0.9290
117 16D 0.9290
118 NIZ 0.9287
119 IHG 0.9287
120 TAR 0.9287
121 2EH 0.9286
122 KOJ 0.9286
123 DAS 0.9281
124 CFI 0.9279
125 URP 0.9278
126 4JM 0.9278
127 261 0.9277
128 TZL 0.9277
129 LEA 0.9276
130 2LP 0.9276
131 QY9 0.9275
132 AJ3 0.9274
133 PHU 0.9272
134 CMS 0.9270
135 JYD 0.9269
136 TEO 0.9269
137 51F 0.9267
138 PZI 0.9264
139 SSN 0.9261
140 FOC 0.9258
141 42J 0.9258
142 THR 0.9258
143 B3M 0.9257
144 SPV 0.9257
145 NYL 0.9256
146 7OD 0.9256
147 PAC 0.9254
148 8GL 0.9253
149 LT1 0.9249
150 4VP 0.9248
151 LDP 0.9248
152 4XR 0.9248
153 JZ4 0.9245
154 PHB 0.9244
155 HGA 0.9244
156 CIZ 0.9244
157 HZP 0.9243
158 AEF 0.9241
159 263 0.9241
160 PGA 0.9240
161 1KA 0.9238
162 XRG 0.9238
163 PEQ 0.9237
164 DE5 0.9235
165 SEP 0.9235
166 MNN 0.9233
167 9YL 0.9231
168 OPE 0.9230
169 NF3 0.9227
170 GOJ 0.9225
171 7BC 0.9225
172 HC4 0.9224
173 BEZ 0.9224
174 DAL DAL 0.9221
175 I1E 0.9221
176 266 0.9220
177 4FA 0.9219
178 BHO 0.9215
179 RUJ 0.9211
180 SSB 0.9210
181 TIH 0.9209
182 MXN 0.9209
183 2RH 0.9207
184 OKG 0.9203
185 SKG 0.9202
186 RSO 0.9202
187 VAH 0.9202
188 BHL 0.9201
189 M4T 0.9200
190 DYT 0.9191
191 FEH 0.9191
192 SYM 0.9187
193 0L1 0.9186
194 3HG 0.9185
195 ZGL 0.9182
196 AC6 0.9181
197 FBJ 0.9179
198 OCA 0.9174
199 HX3 0.9172
200 PPR 0.9171
201 M3P 0.9170
202 A20 0.9169
203 HIS 0.9169
204 H8N 0.9166
205 3SL 0.9165
206 PAB 0.9163
207 TPA 0.9160
208 INO 0.9157
209 IOM 0.9156
210 LNO 0.9155
211 7WG 0.9155
212 HBX 0.9153
213 MSL 0.9151
214 OEG 0.9149
215 SYN 0.9148
216 PRY 0.9146
217 9YT 0.9143
218 BP9 0.9140
219 2AS 0.9139
220 J0Z 0.9139
221 XBT 0.9139
222 2BG 0.9137
223 2HO 0.9136
224 I4B 0.9136
225 4SD 0.9135
226 TLA 0.9135
227 OSE 0.9133
228 FK8 0.9133
229 1LN 0.9132
230 MAE 0.9131
231 Q9Z 0.9129
232 1DU 0.9129
233 ZBT 0.9128
234 TYL 0.9126
235 GZ3 0.9126
236 PAH 0.9125
237 ABN 0.9122
238 KMH 0.9119
239 KIV 0.9118
240 JFJ 0.9117
241 CHB 0.9117
242 MUC 0.9116
243 8EW 0.9113
244 SHA 0.9112
245 XLS 0.9111
246 NPO 0.9109
247 CCU 0.9108
248 HPV 0.9105
249 FUM 0.9102
250 BHU 0.9101
251 DHB 0.9101
252 3PG 0.9100
253 DCL 0.9100
254 HHI 0.9099
255 MEV 0.9099
256 NNO 0.9098
257 AHB 0.9097
258 4A3 0.9096
259 5XC 0.9096
260 6PC 0.9096
261 RBL 0.9095
262 BZ3 0.9095
263 GLY ALA 0.9093
264 717 0.9088
265 BEN 0.9088
266 1SH 0.9085
267 EV0 0.9085
268 F9P 0.9085
269 HDA 0.9085
270 P72 0.9082
271 6JN 0.9080
272 NSD 0.9080
273 2MI 0.9079
274 PBZ 0.9077
275 2AL 0.9076
276 BUB 0.9075
277 93K 0.9075
278 IZC 0.9074
279 BNS 0.9073
280 IHB 0.9073
281 0V5 0.9071
282 XIY 0.9071
283 1GP 0.9071
284 OOG 0.9071
285 FHB 0.9069
286 4NC 0.9068
287 9X6 0.9067
288 DPJ 0.9067
289 NBE 0.9067
290 TFB 0.9066
291 QDK 0.9066
292 ALA ALA 0.9065
293 PBC 0.9065
294 HIO 0.9064
295 XUL 0.9061
296 3LR 0.9061
297 HX2 0.9060
298 RB5 0.9060
299 RB0 0.9060
300 XYL 0.9060
301 DHI 0.9059
302 GRO 0.9057
303 HL4 0.9056
304 PYF 0.9055
305 4MV 0.9054
306 OEM 0.9051
307 PLU 0.9050
308 FPI 0.9050
309 PRO 0.9049
310 SS2 0.9049
311 BAM 0.9049
312 5XB 0.9047
313 TMH 0.9047
314 RBJ 0.9042
315 DEE 0.9042
316 9TW 0.9042
317 9CL 0.9041
318 DYA 0.9040
319 NXA 0.9039
320 ICF 0.9039
321 MEQ 0.9038
322 2PG 0.9038
323 FBM 0.9036
324 OVV 0.9030
325 Q07 0.9030
326 MRY 0.9028
327 7N0 0.9028
328 PYJ 0.9028
329 R9M 0.9027
330 PCA 0.9025
331 AMC 0.9025
332 7UC 0.9025
333 B24 0.9024
334 LLQ 0.9023
335 GAB 0.9022
336 3HM 0.9021
337 P9P 0.9020
338 HG3 0.9020
339 HSO 0.9019
340 4WL 0.9019
341 JLZ 0.9017
342 PO6 0.9017
343 TCA 0.9017
344 1F1 0.9015
345 6NT 0.9015
346 1AB 0.9015
347 3HB 0.9014
348 H95 0.9013
349 4JL 0.9013
350 EHM 0.9013
351 OTR 0.9012
352 AHN 0.9012
353 IF7 0.9011
354 URO 0.9009
355 XIZ 0.9009
356 1SA 0.9009
357 SS1 0.9008
358 URS 0.9005
359 ACH 0.9004
360 CCE 0.9003
361 PY7 0.9003
362 2ZM 0.9003
363 FW5 0.9002
364 XX2 0.9002
365 MWJ 0.9001
366 XSP 0.8998
367 OHG 0.8998
368 0HN 0.8998
369 M58 0.8997
370 APY 0.8996
371 BPW 0.8996
372 AE3 0.8996
373 K6V 0.8995
374 QOS 0.8995
375 MYJ 0.8995
376 AT3 0.8993
377 DHS 0.8993
378 R67 0.8992
379 SPD 0.8992
380 54D 0.8992
381 ROR 0.8991
382 R2B 0.8991
383 PHE 0.8989
384 3NY 0.8989
385 B3U 0.8983
386 FBB 0.8981
387 MZG 0.8981
388 NCA 0.8981
389 GLY CYS 0.8979
390 DHY 0.8978
391 FQI 0.8978
392 GAL 0.8978
393 AS3 0.8978
394 13P 0.8977
395 SMN 0.8977
396 4HP 0.8977
397 JZ5 0.8975
398 14J 0.8975
399 RJY 0.8975
400 1CO 0.8974
401 OC9 0.8973
402 R1X 0.8973
403 MRZ 0.8969
404 282 0.8968
405 AHR 0.8968
406 I2M 0.8967
407 4HA 0.8967
408 5FX 0.8966
409 4P5 0.8965
410 RMN 0.8962
411 HBD 0.8962
412 6NI 0.8961
413 GDE 0.8961
414 3SS 0.8961
415 AX3 0.8959
416 RNS 0.8959
417 K34 0.8959
418 MZT 0.8958
419 FBA 0.8958
420 53C 0.8957
421 069 0.8957
422 EOU 0.8957
423 NM3 0.8957
424 MZW 0.8952
425 0HO 0.8951
426 DGJ 0.8951
427 C2B 0.8949
428 URF 0.8948
429 G4D 0.8946
430 Y8I 0.8946
431 LDU 0.8945
432 3HP 0.8944
433 COM 0.8944
434 B40 0.8944
435 0OC 0.8943
436 J9T 0.8940
437 DSS 0.8940
438 NIO 0.8939
439 T9G 0.8939
440 1MR 0.8939
441 PE9 0.8937
442 FUD 0.8935
443 HYA 0.8933
444 M6W 0.8933
445 GLC 0.8932
446 MR1 0.8932
447 PUT 0.8932
448 IVL 0.8931
449 K6H 0.8929
450 DTL 0.8928
451 PGH 0.8928
452 BXO 0.8928
453 CHH 0.8927
454 45L 0.8926
455 LER 0.8924
456 RTK 0.8923
457 4LR 0.8923
458 P7Y 0.8923
459 KTA 0.8923
460 8X3 0.8923
461 3S5 0.8921
462 JZ3 0.8920
463 SC2 0.8919
464 97T 0.8919
465 650 0.8918
466 4ZA 0.8918
467 3YP 0.8917
468 5JC 0.8917
469 LPK 0.8917
470 RNT 0.8916
471 SOL 0.8915
472 8OZ 0.8914
473 LNR 0.8914
474 Z82 0.8914
475 SR1 0.8913
476 G3P 0.8913
477 CXP 0.8913
478 IP8 0.8912
479 DQY 0.8912
480 EDG 0.8910
481 ODV 0.8910
482 ASC 0.8909
483 LTL 0.8909
484 1H1 0.8907
485 SOR 0.8907
486 F9Y 0.8905
487 YPN 0.8904
488 HDH 0.8904
489 5OB 0.8903
490 173 0.8901
491 GPJ 0.8898
492 3OC 0.8898
493 3C4 0.8898
494 QMP 0.8897
495 NMG 0.8896
496 5HY 0.8894
497 OHP 0.8893
498 CCD 0.8892
499 SHF 0.8890
500 3PP 0.8890
501 TIU 0.8890
502 J9Q 0.8888
503 3NT 0.8887
504 PBA 0.8887
505 GPF 0.8887
506 3AL 0.8886
507 AEG 0.8886
508 4CL 0.8886
509 PNZ 0.8885
510 4XV 0.8885
511 JZ2 0.8885
512 AML 0.8885
513 PZM 0.8884
514 NFM 0.8883
515 A09 0.8883
516 152 0.8882
517 2HC 0.8882
518 4XS 0.8881
519 JDN 0.8879
520 PZA 0.8879
521 NOJ 0.8878
522 PIM 0.8877
523 MTL 0.8876
524 P3K 0.8874
525 GLO 0.8873
526 KDG 0.8872
527 MCT 0.8872
528 RAT 0.8871
529 PMB 0.8871
530 HCI 0.8870
531 3MB 0.8869
532 ORO 0.8865
533 3BU 0.8864
534 3AB 0.8863
535 IVA 0.8862
536 PAF 0.8862
537 J9N 0.8862
538 27Y 0.8862
539 8WO 0.8861
540 9RW 0.8861
541 SYC 0.8861
542 LUQ 0.8860
543 V55 0.8854
544 R9S 0.8854
545 GP9 0.8853
546 AOS 0.8852
547 LFC 0.8852
548 8WT 0.8852
549 VGL 0.8851
550 NTN 0.8851
551 C5A 0.8849
552 ABI 0.8849
553 129 0.8848
554 7VD 0.8848
555 HPS 0.8848
556 E4P 0.8847
557 E79 0.8846
558 CRS 0.8845
559 CDV 0.8843
560 ETX 0.8843
561 OVM 0.8843
562 PMF 0.8842
563 FB2 0.8840
564 BR9 0.8840
565 82I 0.8839
566 RIB 0.8839
567 ZZ3 0.8839
568 DMJ 0.8838
569 VPR 0.8837
570 UYA 0.8836
571 DHK 0.8835
572 G3H 0.8835
573 PBN 0.8832
574 23A 0.8830
575 AC0 0.8830
576 M45 0.8829
577 XM0 0.8827
578 3MV 0.8827
579 3H2 0.8826
580 XYD 0.8826
581 CP 0.8826
582 MLI 0.8824
583 4CS 0.8823
584 5AC 0.8822
585 ES9 0.8822
586 BML 0.8821
587 C2A 0.8820
588 5NI 0.8820
589 TAU 0.8819
590 278 0.8819
591 3XX 0.8818
592 23W 0.8817
593 PRO GLY 0.8817
594 K7M 0.8816
595 ETM 0.8816
596 HUI 0.8816
597 LYL 0.8813
598 2AC 0.8813
599 4JJ 0.8811
600 B2J 0.8811
601 41K 0.8810
602 PSJ 0.8807
603 R2P 0.8806
604 PDC 0.8806
605 JND 0.8806
606 X1S 0.8804
607 PYD 0.8802
608 TEG 0.8801
609 0MK 0.8801
610 P92 0.8800
611 IFL 0.8800
612 9SB 0.8800
613 DMV 0.8799
614 AEH 0.8798
615 EFS 0.8797
616 3A9 0.8797
617 KP6 0.8797
618 MAH 0.8796
619 0R0 0.8795
620 Q88 0.8794
621 AAE 0.8794
622 D1X 0.8793
623 HYP 0.8792
624 ABV 0.8792
625 H76 0.8791
626 QSC 0.8789
627 MPD 0.8789
628 FOM 0.8788
629 G2H 0.8786
630 9SE 0.8785
631 FSG 0.8782
632 HVQ 0.8781
633 HQJ 0.8781
634 PSE 0.8780
635 ANN 0.8778
636 3QM 0.8776
637 S76 0.8776
638 IMR 0.8775
639 ESP 0.8774
640 POA 0.8773
641 2A7 0.8773
642 SSC 0.8773
643 CYX 0.8772
644 RUU 0.8772
645 OXC 0.8770
646 PKU 0.8770
647 R20 0.8770
648 OVP 0.8770
649 L99 0.8770
650 2YU 0.8769
651 2BX 0.8768
652 OMD 0.8766
653 286 0.8766
654 A1U 0.8766
655 BRT 0.8766
656 VX 0.8766
657 BZX 0.8765
658 S2P 0.8765
659 54G 0.8763
660 DOR 0.8762
661 4HM 0.8762
662 32O 0.8762
663 BUA 0.8761
664 SYV 0.8760
665 MZ0 0.8759
666 2EZ 0.8757
667 KPL 0.8754
668 P80 0.8753
669 34A 0.8753
670 TPO 0.8753
671 I3A 0.8752
672 L5V 0.8752
673 CHT 0.8751
674 MAN 0.8751
675 FYU 0.8751
676 HGQ 0.8751
677 7MU 0.8749
678 2MP 0.8749
679 G8M 0.8749
680 HFA 0.8748
681 MNM 0.8748
682 7A8 0.8747
683 SKM 0.8746
684 BZ2 0.8746
685 BAL 0.8746
686 P81 0.8746
687 2HE 0.8746
688 03W 0.8743
689 2KT 0.8739
690 S0H 0.8739
691 DTU 0.8739
692 DFB 0.8736
693 IFM 0.8734
694 OW4 0.8733
695 XBZ 0.8730
696 GVM 0.8729
697 OXZ 0.8728
698 6TZ 0.8728
699 F06 0.8726
700 PAE 0.8725
701 8H8 0.8725
702 ESX 0.8724
703 NBN 0.8724
704 HMH 0.8724
705 GZL 0.8724
706 ISD 0.8723
707 MLA 0.8723
708 GLA 0.8721
709 B85 0.8719
710 4CH 0.8719
711 IOL 0.8718
712 BVC 0.8718
713 XPO 0.8717
714 MWM 0.8717
715 52C 0.8717
716 BDR 0.8716
717 2D0 0.8716
718 AMH 0.8716
719 NFA 0.8715
720 PPY 0.8713
721 MPV 0.8710
722 QSB 0.8710
723 F12 0.8709
724 EKZ 0.8704
725 HMU 0.8703
726 APG 0.8702
727 N9J 0.8701
728 4SX 0.8700
729 MSF 0.8699
730 SLP 0.8699
731 HT4 0.8698
732 WCE 0.8697
733 KVP 0.8693
734 TYE 0.8693
735 GIF 0.8692
736 E5X 0.8692
737 PIY 0.8691
738 LY0 0.8690
739 F0J 0.8690
740 EMZ 0.8688
741 23J 0.8687
742 FUB 0.8686
743 EUG 0.8686
744 T6C 0.8686
745 AGK 0.8685
746 NVI 0.8684
747 GTQ 0.8683
748 2D8 0.8682
749 CPZ 0.8681
750 H7Y 0.8678
751 SHI 0.8678
752 A3M 0.8677
753 X0V 0.8677
754 R8A 0.8676
755 RM1 0.8676
756 5M0 0.8674
757 2F6 0.8673
758 8GC 0.8672
759 ASO 0.8671
760 PRI 0.8670
761 PEZ 0.8670
762 DTT 0.8668
763 1P3 0.8667
764 HHH 0.8666
765 OW7 0.8666
766 PC 0.8664
767 SAF 0.8663
768 VOH 0.8661
769 34D 0.8661
770 4HS 0.8661
771 SPA 0.8661
772 BMD 0.8660
773 Z6J 0.8657
774 ZZT 0.8657
775 AZF 0.8656
776 FA0 0.8654
777 ZXD 0.8654
778 J6W 0.8654
779 TH0 0.8653
780 6LW 0.8653
781 5RG 0.8653
782 FJO 0.8652
783 NSP 0.8652
784 A5E 0.8651
785 8ZE 0.8647
786 TB6 0.8646
787 X6X 0.8646
788 3PY 0.8646
789 ES2 0.8645
790 6M4 0.8644
791 DII 0.8644
792 5HN 0.8643
793 2FG 0.8638
794 QSH 0.8636
795 DOB 0.8636
796 1DV 0.8635
797 MTG 0.8635
798 4FH 0.8634
799 2PN 0.8632
800 2H5 0.8630
801 G2F 0.8629
802 JB8 0.8627
803 IT2 0.8626
804 A29 0.8625
805 BPN 0.8624
806 259 0.8623
807 IPU 0.8622
808 BNL 0.8622
809 KTW 0.8620
810 PCT 0.8619
811 GCO 0.8617
812 PRZ 0.8615
813 ITU 0.8614
814 TSS 0.8613
815 MBG 0.8612
816 SMV 0.8611
817 F4E 0.8610
818 IPB 0.8609
819 3HL 0.8608
820 2DR 0.8607
821 AX7 0.8607
822 BHA 0.8607
823 24B 0.8607
824 PPV 0.8606
825 URC 0.8606
826 8TX 0.8605
827 RUY 0.8605
828 4M0 0.8604
829 GBN 0.8604
830 P2D 0.8603
831 A3B 0.8601
832 5MK 0.8600
833 149 0.8599
834 SNU 0.8599
835 7MH 0.8598
836 GVG 0.8598
837 SAT 0.8598
838 3BB 0.8596
839 4NM 0.8596
840 N7I 0.8595
841 HDL 0.8593
842 3DM 0.8593
843 BMA 0.8592
844 4LW 0.8590
845 FCR 0.8590
846 1P8 0.8589
847 SMB 0.8587
848 TBP 0.8587
849 6FZ 0.8585
850 DGY 0.8581
851 GAF 0.8581
852 1L5 0.8580
853 2HU 0.8580
854 MES 0.8580
855 PRS 0.8579
856 174 0.8578
857 ICB 0.8577
858 N2I 0.8576
859 1A7 0.8576
860 1GN 0.8576
861 HX4 0.8575
862 IFP 0.8575
863 AW5 0.8569
864 HF2 0.8568
865 4JT 0.8558
866 AFS 0.8557
867 BVG 0.8556
868 P7I 0.8556
869 DPN 0.8554
870 1BN 0.8554
871 PH3 0.8546
872 FA1 0.8541
873 EOL 0.8538
874 8K2 0.8533
875 KVV 0.8531
876 GLY PRO 0.8522
877 40F 0.8520
878 5VM 0.8520
879 JF6 0.8519
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6MLE; Ligand: ARG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6mle.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
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