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Receptor
PDB id Resolution Class Description Source Keywords
1L6O 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE XENOPUS DISHEVELLED PDZ DOMAIN XENOPUS LAEVIS DISHEVELLED WNT PATHWAY PDZ MOLECULAR RECOGNITION GENE REGULATION
Ref.: DAPPER, A DISHEVELLED-ASSOCIATED ANTAGONIST OF BETA-CATENIN AND JNK SIGNALING, IS REQUIRED FOR NOTOCHORD FORMATION DEV.CELL V. 2 449 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER LEU LYS LEU MET THR THR VAL D:1;
E:1;
F:1;
Valid;
Valid;
Valid;
none;
none;
none;
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893.138 n/a S(CCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1L6O 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE XENOPUS DISHEVELLED PDZ DOMAIN XENOPUS LAEVIS DISHEVELLED WNT PATHWAY PDZ MOLECULAR RECOGNITION GENE REGULATION
Ref.: DAPPER, A DISHEVELLED-ASSOCIATED ANTAGONIST OF BETA-CATENIN AND JNK SIGNALING, IS REQUIRED FOR NOTOCHORD FORMATION DEV.CELL V. 2 449 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar ligands found: 87
No: Ligand ECFP6 Tc MDL keys Tc
1 SER LEU LYS LEU MET THR THR VAL 1 1
2 LEU LYS THR LYS LEU LEU 0.588889 0.862745
3 SER LEU LYS ILE ASP ASN MET ASP 0.572727 0.907407
4 SER LEU LEU LYS LYS LEU LEU ASP 0.566667 0.865385
5 LYS THR LYS LEU LEU 0.566667 0.862745
6 SER LEU LEU LYS LYS LEU LEU LEU ALA 0.551724 0.843137
7 PHE GLU ALA LYS LYS LEU VAL 0.550562 0.764706
8 CYS LEU GLY GLY LEU LEU THR MET VAL 0.54717 0.923077
9 LYS LEU VAL GLN LEU LEU THR THR THR 0.54 0.882353
10 ILE LYS LEU GLU THR LYS LYS THR LYS LEU 0.515789 0.833333
11 LEU THR THR LYS LEU THR ASN THR ASN ILE 0.514563 0.833333
12 MET ABA LEU ARG MET THR ALA VAL MET 0.508621 0.810345
13 ASN LEU VAL PRW MET VAL ALA THR VAL 0.504348 0.886792
14 ACE VAL LYS GLU SER LEU VAL 0.5 0.862745
15 MET CYS LEU ARG MET THR ALA VAL MET 0.495798 0.842105
16 SER LEU LYS ILE ASP ASN LEU ASP 0.490909 0.833333
17 ASN ARG LEU MET LEU THR GLY 0.490741 0.827586
18 THR LYS CYS VAL VAL MET 0.49 0.98
19 ALA LEU LYS ILE ASP ASN MET ASP 0.482456 0.851852
20 GLU ALA THR GLN LEU MET ASN 0.477064 0.882353
21 GLY SER LYS MET GLU GLU VAL ASP 0.476636 0.924528
22 HIS LYS LEU VAL GLN LEU LEU THR THR THR 0.474576 0.725806
23 SER GLN LEU LYS ASN ASN ALA LYS GLU ILE 0.473684 0.818182
24 SER ASP LYS ILE ASP ASN LEU ASP 0.468468 0.833333
25 ACE CSO ARG ALA THR LYS MET LEU 0.466667 0.753846
26 LYS MET LYS 0.465909 0.803922
27 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.464286 0.758621
28 MET CYS LEU ARG NLE THR ALA VAL MET 0.459677 0.827586
29 ASN LEU VAL PRO MET VAL ALA THR VAL 0.456 0.75
30 SER LEU LEU MET TRP ILE THR GLN LEU 0.453846 0.761905
31 SER LEU LYS ILE ASP ASN GLU ASP 0.452991 0.833333
32 LYS SER LEU LEU GLN GLN LEU LEU THR GLU 0.451327 0.884615
33 SER LEU LEU MET TRP ILE THR GLN SER 0.450382 0.761905
34 SER LEU ALA ASN THR VAL ALA THR LEU 0.448598 0.788462
35 LYS LEU LYS 0.448276 0.764706
36 GLU LEU LYS ARG LYS MET ILE TYR MET 0.44697 0.692308
37 SER LEU LEU MET TRP ILE THR GLN ALA 0.44697 0.761905
38 LYS MET ASN THR GLN PHE THR ALA VAL 0.445312 0.875
39 GLU LEU ARG ARG LYS MET MET TYR MET 0.443548 0.71875
40 SER LEU LEU MET TRP ILE THR GLN CYS 0.440298 0.761905
41 LYS ALA VAL TYR ASN LEU ALA THR MET 0.438462 0.844828
42 ALA ILE PHE GLN SER SER MET THR LYS 0.436508 0.875
43 CYS THR GLU LEU LYS LEU SER ASP TYR 0.436508 0.824561
44 ALA PRO ALA LEU ARG VAL VAL LYS 0.433962 0.684211
45 GLY THR LEU SER ASN ARG ALA SER LYS LEU 0.43299 0.88
46 SER ARG MET GLU GLU VAL ASP 0.432432 0.903846
47 SER ALA LYS ILE ASP ASN LEU ASP 0.432203 0.833333
48 ARG ARG ALA THR LYS MET NH2 0.429825 0.824561
49 SER GLU LEU GLU ILE LYS ARG TYR 0.429688 0.692308
50 SER ARG LYS ILE ASP ASN LEU ASP 0.427419 0.737705
51 GLN ILE LYS VAL ARG VAL ASP MET VAL 0.427419 0.745763
52 LYS THR LYS 0.426966 0.803922
53 SER LEU TYR LEU THR VAL ALA THR LEU 0.426087 0.732143
54 LYS CYS VAL VAL MET 0.424242 0.88
55 THR LYS ASN TYR LYS GLN THR SER VAL 0.424 0.762712
56 LEU PRO PHE GLU LYS SER THR VAL MET 0.422535 0.757576
57 ALA THR LYS ILE ASP ASN LEU ASP 0.422414 0.833333
58 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.421875 0.671875
59 ASP LEU LYS ILE ASP ASN LEU ASP 0.421053 0.777778
60 HIS GLU GLU LEU ALA LYS LEU 0.42 0.764706
61 THR LYS CYS VAL PHE MET 0.418803 0.924528
62 GLU LEU ASN ARG LYS MET ILE TYR MET 0.41844 0.712121
63 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.417323 0.793103
64 ALA SER ASN GLU ASN MET GLU THR MET 0.416667 0.886792
65 SER LEU LEU MET TRP ILE THR GLN VAL 0.416058 0.746032
66 ALA LEU GLY ILE GLY ILE LEU THR VAL 0.415094 0.773585
67 VAL THR THR ASP ILE GLN VAL LYS VAL 0.413793 0.865385
68 ALA ALA GLY ILE GLY ILE LEU THR VAL 0.412844 0.773585
69 GLN ARG ALA THR LYS MET NH2 0.411765 0.793103
70 ASN SER THR LEU GLN 0.411765 0.807692
71 PHE LEU SER THR LYS 0.410714 0.849057
72 ACE MET LEU SER VAL GLU GLU GLU GLY 0.409091 0.867925
73 THR SER ARG HIS LYS ALY LEU MET ALA 0.408759 0.746269
74 THR LYS THR ALA THR ILE ASN ALA SER 0.408696 0.849057
75 LYS ALA LEU TYR ASN PHE ALA THR MET 0.407407 0.816667
76 ALA LEU ALA GLY ILE GLY ILE LEU THR VAL 0.405405 0.773585
77 LEU ALA GLY ILE GLY ILE LEU THR VAL 0.405405 0.773585
78 LYS LYS LYS ALA 0.404494 0.705882
79 ALA ARG LYS LEU ASP 0.403846 0.689655
80 ALA LEU LYS ILE ASP ASN LEU ASP 0.403509 0.777778
81 THR ASN GLU TYR LYS VAL 0.403509 0.724138
82 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.403101 0.647059
83 ALA SER ASN GLU ASP MET GLU THR MET 0.401786 0.886792
84 GLU LEU ALA GLY ILE GLY ILE LEU THR VAL 0.401709 0.792453
85 LYS SER LYS THR CMT GER 0.401709 0.925926
86 ASN LEU LEU GLN LYS LYS 0.4 0.735849
87 LYS PRO VAL LEU ARG THR ALA 0.4 0.637681
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found with APoc: 147
This union binding pocket(no: 1) in the query (biounit: 1l6o.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5CHR 4NC None
2 5V4R MGT None
3 1UUY PPI None
4 5IUC SIA GAL A2G None
5 3QX9 ATP None
6 3RV5 DXC None
7 4G0P U5P None
8 3UEC ALA ARG TPO LYS None
9 3F5A SIA GAL NAG None
10 5AOV GLV None
11 2V9M CIT None
12 4TV1 36M None
13 3B6O TMP None
14 4OHU NAD None
15 4OHU 2TK None
16 1RV1 IMZ None
17 1USF NAP None
18 1USF FMN None
19 3BFF FPM None
20 4OAS 2SW None
21 1N13 AG2 None
22 5WHT SIA GAL GLC None
23 4TUZ 36J None
24 2VSS ACO None
25 4MGA 27L None
26 1BWO LPC None
27 1UVC STE None
28 6FX2 FUC C4W NAG BMA MAN NAG GAL None
29 2QQC AG2 None
30 3CHT 4NB None
31 1MT1 AG2 None
32 4XCL AGS None
33 4R57 ACO None
34 2BVE PH5 None
35 3ROE THM None
36 5XJ7 87O None
37 1MID LAP None
38 5TBM 79A None
39 6CB2 OLC 2.10526
40 3RS8 ALA TRP LEU PHE GLU ALA 3.15789
41 1T0S BML 4.21053
42 1GPE FAD 4.21053
43 1GPM AMP 4.21053
44 4O4K 2PK 4.21053
45 6GNO XDI 4.21053
46 2GU8 796 4.21053
47 3E70 GDP 4.21053
48 3E9I XAH 4.21053
49 4RHS SIA SIA GAL 4.91803
50 5NM7 GLY 5.26316
51 1OUK 084 5.26316
52 5YJS SAL 5.26316
53 4XDZ 40E 5.26316
54 5J5Z FAD 5.26316
55 2XXP DSL 5.26316
56 2F5Z FAD 5.26316
57 1HFU NAG NDG 5.26316
58 1FUT 2GP 5.26316
59 5FUS DAO 5.26316
60 3KRU FMN 5.26316
61 6MJ7 ARG 5.45455
62 3I7V B4P 6.31579
63 4Z3X 4KX 6.31579
64 4Z3E GAL NGA GLA BGC GAL 6.31579
65 4HA6 FAD 6.31579
66 4MRP GSH 6.31579
67 4XWM CBI 6.31579
68 5J62 FMN 6.31579
69 4LY9 1YY 6.31579
70 4LY9 S6P 6.31579
71 3ZLR X0B 6.31579
72 3BNK FMN 6.31579
73 3SJK LYS PRO VAL LEU ARG THR ALA 7.36842
74 5LWY OLB 7.36842
75 2Z9I GLY ALA THR VAL 7.36842
76 1DCP HBI 7.36842
77 3KYQ DPV 7.36842
78 1XUJ BOZ 7.36842
79 2ED4 FAD 7.36842
80 1Z0N BCD 7.36842
81 4U03 GTP 7.36842
82 4U03 TLL 7.36842
83 5LX9 OLB 7.36842
84 2Q6B HR2 7.36842
85 4F06 PHB 7.36842
86 3COW 52H 7.36842
87 2Q2V NAD 7.36842
88 5A04 BGC 7.36842
89 1JG9 GLC 8.42105
90 2JLD ALA GLY GLY ALA ALA ALA ALA ALA 8.42105
91 5OSW DIU 8.42105
92 1ZED PNP 8.42105
93 5U1M ACE LEU TYR ALA SER SER ASN PRO ALA PTR 8.42105
94 4L1F COS 8.42105
95 5Y72 DST 8.42105
96 4FWE FAD 8.42105
97 4GUT FAD 8.42105
98 3RNM FAD 8.62069
99 2OBD PCW 9.47368
100 5Z84 PGV 9.47368
101 6I6X H6B 9.47368
102 2DYR PGV 9.47368
103 5W97 CHD 9.47368
104 2DYS PGV 9.47368
105 6A46 DCM 9.47368
106 5ZCO PGV 9.47368
107 5Z84 CHD 9.47368
108 1X8X TYR 10.5263
109 1IYK MYA 10.5263
110 3KJS NAP 10.5263
111 3LAD FAD 11.5789
112 2A8X FAD 12.6316
113 2EXX NAP 12.6316
114 4M52 FAD 12.6316
115 1PVC ILE SER GLU VAL 13.6842
116 3AI3 SOE 13.6842
117 3R9V DXC 13.6842
118 4N14 WR7 13.6842
119 3S6X SIA GAL BGC 13.6842
120 1TDF NAP 13.6842
121 6DEF GCP 13.6842
122 5T63 ALA ALA ALA ALA 13.6842
123 3THR C2F 13.6842
124 1KOR ANP 13.6842
125 1KOR ARG 13.6842
126 1KOR SIN 13.6842
127 1LVK MNT BEF 13.6842
128 6H3O FAD 15.7895
129 4ORM ORO 15.7895
130 4ORM FMN 15.7895
131 4ORM 2V6 15.7895
132 3GXO MQA 15.7895
133 1H3F TYE 16.8421
134 5OVV ACE ILE GLU SER THR GLU ILE 17.8862
135 5UC9 MYR 17.8947
136 3O5N BR0 19.6429
137 5OCA 9QZ 21.0526
138 4LO6 SIA GAL 21.0526
139 1RZX ACE VAL LYS GLU SER LEU VAL 22.1053
140 4OGQ 7PH 22.5806
141 4OGQ 1O2 22.5806
142 5OVC ACE GLU ALA GLN THR ARG LEU 22.9167
143 1Q3P GLU ALA GLN THR ARG LEU 24.2105
144 3BJK CIT 25.2632
145 5VWK PRO ALA TRP ASP GLU THR ASN LEU 36.8421
146 6BJO DUY 36.8421
147 1MFG GLU TYR LEU GLY LEU ASP VAL PRO VAL 40
Pocket No.: 2; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found with APoc: 43
This union binding pocket(no: 2) in the query (biounit: 1l6o.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 4UYW H1S None
2 1XZ3 ICF None
3 1FK5 OLA None
4 5C1M OLC None
5 2ZX2 RAM None
6 4B1X LAB None
7 2XMY CDK None
8 3WUR O4B None
9 5CSD ACD 2.10526
10 4B2H C3F 4.05405
11 1U25 IHS 4.21053
12 5U98 1KX 4.21053
13 4C2X NHW 5.26316
14 5VKM GAL SIA 5.26316
15 5ZZA LAB 5.26316
16 2W5P CL8 6.31579
17 5MU6 KFK 6.31579
18 5MU6 MYA 6.31579
19 2HBL AMP 6.31579
20 2NZ5 226 7.36842
21 1DTL BEP 7.36842
22 5AZC PGT 7.36842
23 3B6C SDN 7.36842
24 2BCG GER 8.42105
25 5IUY BOG 8.42105
26 4LPG 1MV 8.42105
27 3QDV NDG 8.42105
28 3QDW NDG 8.42105
29 3QDY CBS 8.42105
30 3RMK BML 9.47368
31 2W9S TOP 9.47368
32 5VRH OLB 11.5789
33 1XVB 3BR 12.6316
34 5L2R MLA 12.6316
35 4CVN ADP 12.6316
36 5C9J DAO 13.6842
37 1WLJ U5P 13.6842
38 2Z8L NAG FUC SIA GAL 14.7368
39 3P48 DUP 15.7895
40 4JDR FAD 17.8947
41 4C2C ALA ALA ALA 18.9474
42 1ZPD CIT 20
43 4DFU QUE 23.1579
Pocket No.: 3; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found with APoc: 43
This union binding pocket(no: 3) in the query (biounit: 1l6o.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 1PWB GLC None
2 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU None
3 3KU0 ADE None
4 3KO0 TFP None
5 1JOC ITP None
6 2HIM ASP None
7 1ZEI CRS None
8 3L1N PLM 2.10526
9 5Z3I ADE 3.15789
10 1Y2W NAG 3.15789
11 3C3D FO1 3.15789
12 2BHW NEX 4.21053
13 2OFE NAG 4.21053
14 4Z2S NDG 4.21053
15 4Z2S NAG 4.21053
16 2OFD NGA 4.21053
17 5E4R 40E 5.26316
18 1Q5H DUD 5.26316
19 4OOP DUP 5.26316
20 1USR SIA WIA 6.31579
21 4C2G ALA ALA ALA ALA 6.31579
22 1USR SIA 6.31579
23 3ZPG 5GP 6.31579
24 1K1Y MAL 6.31579
25 2VWA PTY 6.31579
26 6GKV F2W 6.31579
27 2B6N ALA PRO THR 7.36842
28 6BVI EC4 7.36842
29 6BVL EBY 7.36842
30 2P3I MNA 8.42105
31 3IVV ASP GLU VAL THR SER THR THR SER SER SER 8.42105
32 2XG5 EC5 8.42105
33 2XG5 EC2 8.42105
34 5ZCO PEK 9.47368
35 5IJJ I6P 9.47368
36 3HO6 IHP 10.5263
37 2CIX CEJ 12.6316
38 5IM3 DTP 12.6316
39 6EOM ALA LYS 12.6316
40 4DXG NDG FUC SIA GAL 15.7895
41 1NC4 DOF 20
42 1NC2 DOE 20
43 3PA8 IHP 31.5789
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