Receptor
PDB id Resolution Class Description Source Keywords
1KZO 2.2 Å EC: 2.5.1.21 PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RA PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND S IMULTANEOUSLY RATTUS NORVEGICUS FTASE PFT PFTASE FT FPT FARNESYLTRANSFERASE FARNESYL TRANSFERASE FARNESYL PROTEIN TRANSFERASE CAAX RAS CANCEPRODUCT SUBSTRATE TRANSFERASE-TRANSFERASE SUBSTRATE COMPL
Ref.: THE REACTION PATH OF PROTEIN FARNESYLTRANSFERASE AT RESOLUTION NATURE V. 419 645 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACY B:3002;
 Invalid;
 none;
 submit data
60.052 C2 H4 O2 CC(=O...
FAR C:12;
 Invalid;
 none;
 submit data
206.367 C15 H26 CC=C(...
FPP B:1002;
 Valid;
 none;
 Kd = 5 nM
382.326 C15 H28 O7 P2 CC(=C...
ZN B:1001;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KZO 2.2 Å EC: 2.5.1.21 PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RA PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND S IMULTANEOUSLY RATTUS NORVEGICUS FTASE PFT PFTASE FT FPT FARNESYLTRANSFERASE FARNESYL TRANSFERASE FARNESYL PROTEIN TRANSFERASE CAAX RAS CANCEPRODUCT SUBSTRATE TRANSFERASE-TRANSFERASE SUBSTRATE COMPL
Ref.: THE REACTION PATH OF PROTEIN FARNESYLTRANSFERASE AT RESOLUTION NATURE V. 419 645 2002
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: FPP; Similar ligands found: 39
No: Ligand ECFP6 Tc MDL keys Tc
1 VTP 1 0.975
2 GRG 1 1
3 OTP 1 0.975
4 FPP 1 1
5 ZTP 1 0.975
6 GPP 0.911111 0.974359
7 DSL 0.744681 0.9
8 0K3 0.744681 0.9
9 FJP 0.744681 0.923077
10 FDF 0.727273 0.904762
11 FFF 0.714286 0.928571
12 HZZ 0.680851 0.897436
13 FGG 0.590164 0.928571
14 FPF 0.57377 0.928571
15 2CF 0.57377 0.928571
16 ELU 0.571429 0.951219
17 ELR 0.571429 0.951219
18 10E 0.568627 0.702128
19 10D 0.568627 0.785714
20 MGM 0.5625 0.764706
21 DMA 0.5625 0.846154
22 A4S 0.558824 0.698113
23 3E9 0.555556 0.951219
24 FPS 0.551724 0.880952
25 GGS 0.551724 0.880952
26 H6P 0.54902 0.785714
27 FPQ 0.539683 0.826087
28 10G 0.538462 0.767442
29 FII 0.507937 0.666667
30 GST 0.482759 0.857143
31 PS7 0.48 0.906977
32 C0X 0.477612 0.744681
33 FHP 0.473684 0.761905
34 1NH 0.457831 0.770833
35 0FV 0.442623 0.904762
36 LA6 0.442623 0.904762
37 SZH 0.428571 0.655172
38 749 0.428571 0.897436
39 9GB 0.415094 0.825
Similar Ligands (3D)
Ligand no: 1; Ligand: FPP; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1KZO; Ligand: FPP; Similar sites found with APoc: 4
This union binding pocket(no: 1) in the query (biounit: 1kzo.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 3SFX JAN 48.8064
2 3SFX FII 48.8064
3 3Q78 FPS 48.8064
4 3DST GRG 49.8489
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