Receptor
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY SER ASP PRO PHE LYS P:628;
Valid;
none;
submit data
592.65 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY SER ASP PRO PHE LYS; Similar ligands found: 107
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER ASP PRO PHE LYS 1 1
2 GLY SER ASP PRO TRP LYS 0.706897 0.934426
3 LEU PRO PHE ASP LYS THR THR ILE MET 0.531915 0.835821
4 LEU PRO PHE ASP LYS SER THR ILE MET 0.527397 0.850746
5 TYR PRO PHE PHE NH2 0.522523 0.761905
6 LEU PRO PHE GLU LYS SER THR VAL MET 0.517483 0.863636
7 1IP CYS PHE SER LYS PRO ARG 0.514286 0.850746
8 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.514286 0.770492
9 SER ASP ILE LEU PHE PRO ALA ASP SER 0.51145 0.903226
10 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.51145 0.890625
11 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.511111 0.875
12 LYS THR PHE PRO PRO THR GLU PRO LYS 0.510949 0.918033
13 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.510791 0.919355
14 GLU PHE SER PRO 0.504505 0.947368
15 GLY GLY CYS PHE SER LYS PRO LYS MYR 0.5 0.904762
16 GLU LYS PRO SER SER SER 0.5 0.964912
17 SER THR SEP PRO THR PHE ASN LYS 0.496552 0.823529
18 LYS PRO HIS SER ASP 0.496 0.918033
19 TRP ASP ILE PRO PHE 0.495652 0.819672
20 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.495652 0.819672
21 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.492958 0.852459
22 THR PRO PRO SER PRO PHE 0.491379 0.916667
23 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.489655 0.861538
24 SER PRO ILE VAL PRO SER PHE ASP MET 0.489362 0.850746
25 SER LEU ILE PRO TPO PRO ASP LYS 0.481752 0.774648
26 LYS PRO LYS 0.480392 0.824561
27 MAA LYS PRO PHE 0.478992 0.8
28 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.476562 0.887097
29 PHE SER ASP PRO TRP GLY GLY 0.475177 0.919355
30 LEU SER SER PRO VAL THR LYS SER PHE 0.47482 0.887097
31 PHE PRO THR LYS ASP VAL ALA LEU 0.471831 0.903226
32 LYS PRO PHE PTR VAL ASN VAL NH2 0.471831 0.716216
33 DPN PRO ARG 0.469565 0.761905
34 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.468354 0.767123
35 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.466667 0.861538
36 ILE THR ASP GLN VAL PRO PHE SER VAL 0.465278 0.888889
37 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.463768 0.876923
38 HIS PRO PHE 0.46087 0.774194
39 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.460526 0.72973
40 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.460123 0.833333
41 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.456954 0.764706
42 SER TRP PHE PRO 0.456 0.887097
43 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.453947 0.797101
44 LEU ASN PHE PRO ILE SER PRO 0.453846 0.890625
45 LEU PRO SER PHE GLU THR ALA LEU 0.453237 0.903226
46 ILE MET ASP GLN VAL PRO PHE SER VAL 0.452703 0.848485
47 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.449612 0.822581
48 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.44898 0.739726
49 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.448 0.901639
50 GLY PHE GLU PRO 0.447368 0.877193
51 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.445205 0.823529
52 LEU PRO PHE ASP ARG THR THR ILE MET 0.444444 0.767123
53 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.442953 0.791045
54 SER SER GLY LYS VAL PRO LEU 0.440945 0.885246
55 PHE ASN ARG PRO VAL 0.439394 0.776119
56 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.439024 0.675325
57 ALA DAL PRO PHE NIT 0.439024 0.635135
58 PHE LEU SER TYR LYS 0.439024 0.641791
59 ALA THR PRO PHE GLN GLU 0.438596 0.833333
60 SER SER GLY LYS VAL PRO LEU SER 0.438462 0.901639
61 PHE ASN PHE PRO GLN ILE THR 0.437956 0.830769
62 SER SER CYS PRO LEU SER LYS 0.436508 0.854839
63 DPN PRO DAR CYS NH2 0.435484 0.75
64 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.432432 0.820895
65 ACE PHE HIS PRO ALA NH2 0.432 0.723077
66 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.430556 0.828125
67 ACE PRO ALA PRO PHE 0.429825 0.774194
68 ALA PHE ARG ILE PRO LEU THR ARG 0.428571 0.797101
69 ARG PRO MET THR PHE LYS GLY ALA LEU 0.425926 0.753425
70 DPN PRO DAR DTH NH2 0.425197 0.8
71 ARG THR PHE SER PRO THR TYR GLY LEU 0.424837 0.767123
72 ARG SEP PRO VAL PHE SER 0.424658 0.736111
73 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.423358 0.875
74 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.423077 0.80597
75 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.422078 0.863636
76 GLY PHE ARG PRO 0.421488 0.793651
77 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.421384 0.696203
78 LEU ASP PRO ARG 0.419355 0.731343
79 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.416667 0.80597
80 SIN ALA LEU PRO PHE NIT 0.416058 0.644737
81 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.415584 0.826087
82 SER PRO LYS ARG ILE ALA 0.415385 0.787879
83 SIN ALA ALA PRO PHE NIT 0.414815 0.675676
84 DPN PRO DAR ILE NH2 0.414062 0.701493
85 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.41358 0.746667
86 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.413043 0.765625
87 LEU PHE GLY TYR PRO VAL TYR VAL 0.412587 0.761194
88 ASP PHE GLU GLU ILE PRO GLU GLU TYS 0.412162 0.634146
89 SER SER CYS SER SER CYS PRO LEU SER LYS 0.412162 0.782609
90 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.410714 0.746667
91 PRO ALA PRO PHE ALA SER ALA 0.410448 0.885246
92 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.408163 0.764706
93 LYS TYR LYS 0.407407 0.655738
94 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.407407 0.788732
95 PKF 0.407143 0.716216
96 GLU THR LEU LEU ASP LEU ASP PHE ASP PRO 0.406015 0.857143
97 PRO PHQ PHE 0.405405 0.741935
98 THR LYS PRO ARG 0.405172 0.746032
99 PHE SER ALA PTR PRO SER GLU GLU ASP 0.404255 0.760563
100 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.403974 0.73913
101 DHI PRO PHE HIS LEU LEU VAL TYR 0.403846 0.714286
102 LYS LEU TYR GLN ASN PRO THR THR TYR ILE 0.403846 0.797101
103 LEU PRO PHE GLU ARG ALA THR VAL MET 0.403727 0.763889
104 VAL LYS PRO GLY 0.403509 0.816667
105 SER ILE ILE ASN PHE GLU LYS LEU 0.40146 0.714286
106 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.40146 0.80303
107 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.4 0.735294
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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