Receptor
PDB id Resolution Class Description Source Keywords
1KYD 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY SER ASP PRO TRP LYS P:341;
 Valid;
 none;
 submit data
631.687 n/a O=C([...
SO4 A:200;
 Invalid;
 none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY SER ASP PRO TRP LYS; Similar ligands found: 92
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER ASP PRO TRP LYS 1 1
2 GLY SER ASP PRO PHE LYS 0.706897 0.934426
3 PHE SER ASP PRO TRP GLY GLY 0.597122 0.983871
4 SER TRP PHE PRO 0.580645 0.951613
5 TRP PRO TRP 0.568965 0.83871
6 LYS TRP LYS 0.566372 0.770492
7 ASN GLN DPR TRP GLN 0.544776 0.870968
8 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.536585 0.893939
9 THR LEU PRO TRP ASP LEU TRP THR THR 0.534722 0.880597
10 SER PRO LEU ASP SER LEU TRP TRP ILE 0.534247 0.910448
11 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.523179 0.876923
12 ALA VAL PRO TRP 0.52 0.828125
13 ASN ASP TRP LEU LEU PRO SER TYR 0.519231 0.871429
14 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.516129 0.904762
15 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.515152 0.805556
16 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.514286 0.846154
17 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.5 0.835821
18 LYS PRO HIS SER ASP 0.488889 0.920635
19 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.488506 0.813333
20 PRO GLN PRO VAL ASP SER TRP VAL 0.487013 0.953125
21 GLU TYR GLY PRO LYS TRP ASN LYS 0.483871 0.863636
22 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.482353 0.814286
23 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.480769 0.736111
24 MET TRP ARG PRO TRP 0.48 0.702703
25 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.479532 0.794521
26 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.478261 0.835616
27 ACE PRO TRP ALA THR CYS ASP SER NH2 0.476821 0.910448
28 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.476471 0.767123
29 ASP GLU ASP LYS TRP ASP ASP PHE 0.474074 0.790323
30 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.474074 0.768116
31 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.474026 0.797101
32 GLU PRO GLN ALA PRO TRP MET GLU 0.474026 0.797101
33 GLU LEU ASP LYS TRP ALA SER 0.472222 0.8
34 GLU ALA ASP LYS TRP GLN SER 0.472222 0.854839
35 ALA LEU ASP LYS TRP ALA SER 0.471429 0.8
36 ALA LEU ASP LYS TRP ASP 0.470149 0.753846
37 LYS TRP 0.469565 0.737705
38 MDL 0.466165 0.690141
39 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.463687 0.786667
40 GLU ASN ASP LYS TRP ALA SER 0.462069 0.84127
41 PCA LYS TRP 0.460938 0.790323
42 GLU GLN ASP LYS TRP ALA SER 0.458904 0.854839
43 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.45625 0.833333
44 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.453988 0.897059
45 GLU LEU GLU LYS TRP ALA SER 0.451389 0.784615
46 ARG PHE PRO LEU THR PHE GLY TRP 0.449704 0.808219
47 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.448276 0.824324
48 GLU LYS PRO SER SER SER 0.445312 0.901639
49 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.443787 0.805556
50 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.44 0.813333
51 GLU ASP ASN ASP TRP ASN 0.438017 0.709677
52 ASP TRP ASN 0.438017 0.709677
53 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.437909 0.815385
54 SER LEU ILE PRO TPO PRO ASP LYS 0.437086 0.756757
55 TRP GLU TYR ILE PRO ASN VAL 0.435583 0.802817
56 GLU LEU ASP ORN TRP ALA SER 0.435374 0.784615
57 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.434483 0.738462
58 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.433333 0.810811
59 ARG TYR PRO LEU THR PHE GLY TRP 0.431818 0.786667
60 ILE SER PRO ARG THR LEU ASP ALA TRP 0.431818 0.835616
61 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.430168 0.792208
62 GLU LEU ASP LYS TRP ALA ASN 0.42953 0.757576
63 MET HIS PRO ALA GLN THR SER GLN TRP 0.427746 0.859155
64 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.426829 0.833333
65 PRO GLY LEU TRP LYS SER 0.425676 0.753846
66 ASP SER TRP LYS ASP GLY CYS TYR 0.424051 0.818182
67 LYS PRO LYS 0.422414 0.770492
68 GLU LEU ASP LYS TRP ALA GLY 0.421769 0.727273
69 ILE ASP TRP PHE ASP GLY LYS GLU 0.420382 0.757576
70 ILE ASP TRP PHE GLU GLY LYS GLU 0.420382 0.757576
71 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.419753 0.865672
72 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.419355 0.789474
73 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.418478 0.782051
74 SER TRP PHE GLN THR ASP LEU 0.418301 0.746269
75 ILE ASP TRP PHE ASP GLY LYS ASP 0.415584 0.757576
76 ARG LEU TRP SER 0.413043 0.676056
77 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.412791 0.855072
78 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.411765 0.657534
79 LEU PRO PHE ASP LYS THR THR ILE MET 0.411043 0.788732
80 LEU PRO PHE ASP LYS SER THR ILE MET 0.410714 0.802817
81 ALA LEU ASP LYS TRP GLN ASN 0.410072 0.738462
82 LEU LEU TRP ASN GLY PRO MET ALA VAL 0.408284 0.814286
83 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.405229 0.710145
84 GLU LEU ASP HIS TRP ALA SER 0.405229 0.746269
85 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.404255 0.782051
86 SER ASP ILE LEU PHE PRO ALA ASP SER 0.403974 0.848485
87 SER SER CYS PRO LEU SER LYS 0.402878 0.80303
88 SER SER CYS SER SER CYS PRO LEU SER LYS 0.402516 0.763889
89 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.401274 0.648649
90 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.401198 0.871429
91 LEU PRO PHE GLU LYS SER THR VAL MET 0.4 0.814286
92 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.4 0.830769
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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