Receptor
PDB id Resolution Class Description Source Keywords
1KYD 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY SER ASP PRO TRP LYS P:341;
 Valid;
 none;
 submit data
631.687 n/a O=C([...
SO4 A:200;
 Invalid;
 none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1579 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1312 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1130 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY SER ASP PRO TRP LYS; Similar ligands found: 93
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER ASP PRO TRP LYS 1 1
2 GLY SER ASP PRO PHE LYS 0.706897 0.934426
3 PHE SER ASP PRO TRP GLY GLY 0.597122 0.983871
4 SER TRP PHE PRO 0.580645 0.951613
5 TRP PRO TRP 0.568965 0.83871
6 LYS TRP LYS 0.566372 0.770492
7 ACE LEU TRP TRP PRO ASP 0.564885 0.80597
8 ASN GLN DPR TRP GLN 0.544776 0.870968
9 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.536585 0.893939
10 THR LEU PRO TRP ASP LEU TRP THR THR 0.534722 0.880597
11 SER PRO LEU ASP SER LEU TRP TRP ILE 0.534247 0.910448
12 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.523179 0.876923
13 ALA VAL PRO TRP 0.52 0.828125
14 ASN ASP TRP LEU LEU PRO SER TYR 0.519231 0.871429
15 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.516129 0.904762
16 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.515152 0.805556
17 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.514286 0.846154
18 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.5 0.835821
19 LYS PRO HIS SER ASP 0.488889 0.920635
20 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.488506 0.813333
21 PRO GLN PRO VAL ASP SER TRP VAL 0.487013 0.953125
22 GLU TYR GLY PRO LYS TRP ASN LYS 0.483871 0.863636
23 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.482353 0.814286
24 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.480769 0.736111
25 MET TRP ARG PRO TRP 0.48 0.702703
26 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.479532 0.794521
27 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.478261 0.835616
28 ACE PRO TRP ALA THR CYS ASP SER NH2 0.476821 0.910448
29 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.476471 0.767123
30 ASP GLU ASP LYS TRP ASP ASP PHE 0.474074 0.790323
31 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.474074 0.768116
32 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.474026 0.797101
33 GLU PRO GLN ALA PRO TRP MET GLU 0.474026 0.797101
34 GLU ALA ASP LYS TRP GLN SER 0.472222 0.854839
35 GLU LEU ASP LYS TRP ALA SER 0.472222 0.8
36 ALA LEU ASP LYS TRP ALA SER 0.471429 0.8
37 ALA LEU ASP LYS TRP ASP 0.470149 0.753846
38 LYS TRP 0.469565 0.737705
39 MDL 0.466165 0.690141
40 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.463687 0.786667
41 GLU ASN ASP LYS TRP ALA SER 0.462069 0.84127
42 PCA LYS TRP 0.460938 0.790323
43 GLU GLN ASP LYS TRP ALA SER 0.458904 0.854839
44 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.45625 0.833333
45 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.453988 0.897059
46 GLU LEU GLU LYS TRP ALA SER 0.451389 0.784615
47 ARG PHE PRO LEU THR PHE GLY TRP 0.449704 0.808219
48 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.448276 0.824324
49 GLU LYS PRO SER SER SER 0.445312 0.901639
50 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.443787 0.805556
51 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.44 0.813333
52 GLU ASP ASN ASP TRP ASN 0.438017 0.709677
53 ASP TRP ASN 0.438017 0.709677
54 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.437909 0.815385
55 SER LEU ILE PRO TPO PRO ASP LYS 0.437086 0.756757
56 TRP GLU TYR ILE PRO ASN VAL 0.435583 0.802817
57 GLU LEU ASP ORN TRP ALA SER 0.435374 0.784615
58 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.434483 0.738462
59 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.433333 0.810811
60 ILE SER PRO ARG THR LEU ASP ALA TRP 0.431818 0.835616
61 ARG TYR PRO LEU THR PHE GLY TRP 0.431818 0.786667
62 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.430168 0.792208
63 GLU LEU ASP LYS TRP ALA ASN 0.42953 0.757576
64 MET HIS PRO ALA GLN THR SER GLN TRP 0.427746 0.859155
65 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.426829 0.833333
66 PRO GLY LEU TRP LYS SER 0.425676 0.753846
67 ASP SER TRP LYS ASP GLY CYS TYR 0.424051 0.818182
68 LYS PRO LYS 0.422414 0.770492
69 GLU LEU ASP LYS TRP ALA GLY 0.421769 0.727273
70 ILE ASP TRP PHE GLU GLY LYS GLU 0.420382 0.757576
71 ILE ASP TRP PHE ASP GLY LYS GLU 0.420382 0.757576
72 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.419753 0.865672
73 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.419355 0.789474
74 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.418478 0.782051
75 SER TRP PHE GLN THR ASP LEU 0.418301 0.746269
76 ILE ASP TRP PHE ASP GLY LYS ASP 0.415584 0.757576
77 ARG LEU TRP SER 0.413043 0.676056
78 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.412791 0.855072
79 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.411765 0.657534
80 LEU PRO PHE ASP LYS THR THR ILE MET 0.411043 0.788732
81 LEU PRO PHE ASP LYS SER THR ILE MET 0.410714 0.802817
82 ALA LEU ASP LYS TRP GLN ASN 0.410072 0.738462
83 LEU LEU TRP ASN GLY PRO MET ALA VAL 0.408284 0.814286
84 GLU LEU ASP HIS TRP ALA SER 0.405229 0.746269
85 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.405229 0.710145
86 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.404255 0.782051
87 SER ASP ILE LEU PHE PRO ALA ASP SER 0.403974 0.848485
88 SER SER CYS PRO LEU SER LYS 0.402878 0.80303
89 SER SER CYS SER SER CYS PRO LEU SER LYS 0.402516 0.763889
90 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.401274 0.648649
91 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.401198 0.871429
92 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.4 0.830769
93 LEU PRO PHE GLU LYS SER THR VAL MET 0.4 0.814286
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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