Receptor
PDB id Resolution Class Description Source Keywords
1KYD 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY SER ASP PRO TRP LYS P:341;
 Valid;
 none;
 submit data
630.679 n/a O=C([...
SO4 A:200;
 Invalid;
 none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLY SER ASP PRO TRP LYS; Similar ligands found: 87
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER ASP PRO TRP LYS 1 1
2 GLY SER ASP PRO PHE LYS 0.713043 0.934426
3 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.588235 0.9375
4 PHE SER ASP PRO TRP GLY GLY 0.578571 0.983871
5 TRP PRO TRP 0.547009 0.83871
6 LYS TRP LYS 0.530435 0.770492
7 ASN GLN DPR TRP GLN 0.525926 0.870968
8 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.521212 0.893939
9 SER PRO LEU ASP SER LEU TRP TRP ILE 0.517007 0.910448
10 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.514286 0.846154
11 ALA VAL PRO TRP 0.512 0.828125
12 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.509677 0.904762
13 MET TYR TRP TYR PRO TYR 0.506944 0.760563
14 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.506579 0.876923
15 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.506579 0.736111
16 ASN ASP TRP LEU LEU PRO SER TYR 0.503185 0.871429
17 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.5 0.805556
18 SER TRP PHE PRO 0.5 0.951613
19 ASP GLU ASP LYS TRP ASP ASP PHE 0.488722 0.790323
20 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.484076 0.835616
21 ACE PRO TRP ALA THR CYS ASP SER NH2 0.48 0.910448
22 ASP TYR ASN PRO TYR LEU LEU PHE LEU LYS 0.47973 0.814286
23 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.476471 0.814286
24 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.474286 0.813333
25 LYS TRP 0.473684 0.721311
26 LYS PRO HIS SER ASP 0.470588 0.920635
27 MDL 0.469697 0.690141
28 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.467532 0.797101
29 PCA LYS TRP 0.464567 0.790323
30 ALA LEU ASP LYS TRP ALA SER 0.464286 0.8
31 MET TRP ARG PRO TRP 0.463576 0.702703
32 ALA LEU ASP LYS TRP ASP 0.462687 0.753846
33 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.461988 0.767123
34 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.456647 0.794521
35 GLU ALA ASP LYS TRP GLN SER 0.455172 0.854839
36 ALA SER LEU ASN LEU PRO ALA VAL SER TRP 0.45283 0.924242
37 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.45 0.786667
38 GLU ASP ASN ASP TRP ASN 0.449153 0.709677
39 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.447674 0.871429
40 ALA PRO ALA TRP LEU PHE GLU ALA 0.44586 0.80597
41 GLU LEU ASP LYS TRP ALA SER 0.445205 0.8
42 GLU ASN ASP LYS TRP ALA SER 0.445205 0.84127
43 ARG PHE PRO LEU THR PHE GLY TRP 0.443787 0.808219
44 ACE TRP ARG VAL PRO 0.443662 0.760563
45 GLU GLU ASN ASP PRO ASP TYR 0.442748 0.830769
46 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.442529 0.824324
47 GLU GLN ASP LYS TRP ALA SER 0.442177 0.854839
48 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.44186 0.785714
49 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.440994 0.833333
50 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.439024 0.897059
51 PRO GLY LEU TRP LYS SER 0.438356 0.753846
52 ILE SER PRO ARG THR LEU ASP ALA TRP 0.434286 0.835616
53 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.434286 0.813333
54 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.429412 0.805556
55 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.427778 0.810811
56 ARG TYR PRO LEU THR PHE GLY TRP 0.426136 0.786667
57 GLU LEU GLU LYS TRP ALA SER 0.424658 0.784615
58 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.421622 0.789474
59 GLY ASP CYS PHE SER LYS PRO ARG 0.421384 0.838235
60 TRP GLU TYR ILE PRO ASN VAL 0.420732 0.802817
61 ALA TRP VAL ILE PRO ALA 0.42029 0.761194
62 ASP TRP ASN 0.418033 0.709677
63 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.416667 0.792208
64 GLU LYS PRO SER SER SER 0.415385 0.901639
65 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.414286 0.768116
66 MET HIS PRO ALA GLN THR SER GLN TRP 0.413793 0.859155
67 GLU LEU ASP LYS TRP ALA ASN 0.413333 0.757576
68 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.413043 0.782051
69 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.412903 0.815385
70 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.412121 0.833333
71 SER SER GLY LYS VAL PRO LEU 0.410072 0.830769
72 ACE ASN PRO ASP TRP ASP PHE ASN NH2 0.409722 0.825397
73 GLU LEU ASP ORN TRP ALA SER 0.409396 0.784615
74 THR LYS PRO ARG 0.408 0.701493
75 PRO SER ARG TRP 0.407143 0.791045
76 ARG LEU TRP SER 0.405797 0.676056
77 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.405229 0.657534
78 ILE ASP TRP PHE ASP GLY LYS GLU 0.405063 0.757576
79 ILE ASP TRP PHE GLU GLY LYS GLU 0.405063 0.757576
80 LEU PRO PHE ASP LYS THR THR ILE MET 0.404908 0.788732
81 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.404908 0.865672
82 LEU PRO PHE ASP LYS SER THR ILE MET 0.404762 0.802817
83 ALA LEU ASP LYS TRP GLN ASN 0.402878 0.738462
84 LYS PRO LYS 0.401709 0.770492
85 SER SER GLY LYS VAL PRO LEU SER 0.401408 0.846154
86 ILE ASP TRP PHE ASP GLY LYS ASP 0.4 0.757576
87 ASP SER TRP LYS ASP GLY CYS TYR 0.4 0.818182
Similar Ligands (3D)
Ligand no: 1; Ligand: GLY SER ASP PRO TRP LYS; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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