Receptor
PDB id Resolution Class Description Source Keywords
1KY7 2.15 Å NON-ENZYME: OTHER THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER PHE PHE GLU ASP ASN PHE VAL PRO GLU P:322;
Valid;
none;
submit data
1084.17 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER PHE PHE GLU ASP ASN PHE VAL PRO GLU; Similar ligands found: 127
No: Ligand ECFP6 Tc MDL keys Tc
1 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 1 1
2 PHE GLU ASP ASN PHE VAL PRO 0.706897 0.952381
3 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.583333 0.6875
4 GLU THR LEU LEU ASP LEU ASP PHE ASP PRO 0.542636 0.876923
5 ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG 0.530769 0.706667
6 SER ILE ILE ASN PHE GLU LYS LEU 0.526718 0.753846
7 SER ASP PTR MET ASN MET THR PRO 0.521127 0.769231
8 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.517986 0.731343
9 ILE THR ASP GLN VAL PRO PHE SER VAL 0.510204 0.893939
10 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.509804 0.797297
11 ASP PHE GLU ASP TYR GLU PHE ASP 0.504132 0.606061
12 ARG PRO GLY ASN PHE PHE GLN SER ARG PRO 0.5 0.84507
13 ILE MET ASP GLN VAL PRO PHE SER VAL 0.496689 0.855072
14 SER HIS PHE ASN GLU TYR GLU 0.492857 0.73913
15 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.492647 0.707692
16 ALA VAL ALA PHE TYR ILE PRO ASP GLN ALA 0.492537 0.779412
17 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.490323 0.869565
18 VAL ASN ASP ILE PHE GLU ALA ILE 0.485075 0.646154
19 ARG PRO GLY ASN PHE LEU GLN SER SER PRO 0.484277 0.84507
20 ASP PHE GLU GLU ILE PRO GLU GLU TYS 0.483221 0.670732
21 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.482014 0.938462
22 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.481481 0.813333
23 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.478873 0.685714
24 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.477612 0.707692
25 SER THR SEP PRO THR PHE ASN LYS 0.477124 0.805556
26 ASP PHE GLU GLU ILE PRO GLY GLU PTR 0.474684 0.736842
27 THR ASN GLU PHE TYR ALA 0.472441 0.681818
28 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.47205 0.833333
29 GLU ILE ILE ASN PHE GLU LYS LEU 0.470588 0.666667
30 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.467532 0.676056
31 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.462585 0.863636
32 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.461039 0.69863
33 PHE ASN PHE PRO GLN ILE THR 0.457746 0.893939
34 LYS PRO PHE PTR VAL ASN VAL NH2 0.456954 0.783784
35 GLU VAL PTR GLU SER PRO 0.456522 0.794521
36 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.455696 0.826087
37 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.454545 0.849315
38 SER PTR VAL ASN VAL GLN ASN 0.454545 0.657534
39 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.454545 0.707692
40 GLU PHE SER PRO 0.454545 0.84127
41 ALA GLU THR PHE TYR VAL ASP GLY 0.454545 0.666667
42 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.453947 0.787879
43 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.453901 0.701493
44 ILE ASN PHE ASP PHE ASN THR ILE 0.448819 0.666667
45 ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO 0.448 0.703125
46 ARG GLU ARG SER PRO THR ARG 0.448 0.757143
47 MET PHE SER ILE ASP ASN ILE LEU ALA 0.447552 0.681159
48 ASP PHE GLU GLU ILE PRO GLY GLU TYS LEU 0.446541 0.695122
49 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.44586 0.909091
50 LEU GLU PHE GLN GLY 0.443548 0.65625
51 THR ASN GLU PHE TYR PHE 0.442623 0.606061
52 THR ASN GLU PHE ALA PHE 0.442623 0.619048
53 ACE GLN PM3 GLU GLU ILE PRO 0.442029 0.722222
54 SER ASP ILE LEU PHE PRO ALA ASP SER 0.441379 0.892308
55 THR LYS ASN TYR LYS GLN PHE SER VAL 0.441176 0.787879
56 SER LEU PHE ASN THR VAL ALA THR LEU 0.441176 0.676923
57 TRP GLU TYR ILE PRO ASN VAL 0.440252 0.830986
58 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.43949 0.811594
59 THR ASN GLU TYR TYR VAL 0.438017 0.651515
60 GLY SER ASP PRO PHE LYS 0.437037 0.859375
61 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.436242 0.787879
62 GLU THR VAL ARG PHE GLN SER ASP 0.435374 0.671429
63 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.435065 0.808824
64 ALA PRO SER PTR VAL ASN VAL GLN ASN 0.434211 0.824324
65 GLU VAL ASN 1OL ALA GLU PHE 0.433566 0.661538
66 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.433333 0.893939
67 ASP PHE GLU GLU ILE PRO GLU GLU TYS LEU 0.432927 0.695122
68 PHE SER HIS PRO GLN ASN THR 0.430464 0.895522
69 VAL GLN GLN GLU SER SER PHE VAL MET 0.42963 0.676471
70 GLY ASP GLU VAL LYS VAL PHE ARG 0.429577 0.628571
71 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.428571 0.742424
72 PHE ASN ARG PRO VAL 0.427536 0.811594
73 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.426901 0.811594
74 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.426667 0.776119
75 SER GLN TYR TYR TYR ASN SER LEU 0.426357 0.731343
76 SER PHE ALA ASN GLY 0.42623 0.698413
77 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.425676 0.648649
78 SER LEU PHE ASN THR ILE ALA VAL LEU 0.425532 0.681818
79 ACE PRO ASP PTR GLU ASN LEU 0.423611 0.75
80 GLU GLN TYR LYS PHE TYR SER VAL 0.423358 0.746269
81 GLU THR PHE TYR VAL ASP GLY 0.423358 0.727273
82 LYS GLN TRP ASP ASN TYR GLU PTR ILE TRP 0.422619 0.641026
83 SER ILE ILE GLY PHE GLU LYS LEU 0.422535 0.723077
84 LEU ASN PHE PRO ILE SER PRO 0.422535 0.924242
85 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.421769 0.724638
86 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.421769 0.686567
87 GLU ASN GLN LYS GLU TYR PHE PHE 0.421053 0.656716
88 SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.42 0.724638
89 LEU PRO PHE GLU LYS SER THR VAL MET 0.41875 0.828571
90 VAL SER PHE ASN FRD PRO GLN ILE THR ALA 0.41875 0.910448
91 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.418301 0.820895
92 PHE SER ALA PTR PRO SER GLU GLU ASP 0.417722 0.808219
93 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.417647 0.808219
94 ALA THR ARG ASN PHE SER GLY 0.417266 0.671429
95 THR ASN GLU TYR LYS VAL 0.415385 0.681818
96 LYS MET ASN THR GLN PHE THR ALA VAL 0.414966 0.671429
97 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.414286 0.666667
98 ACE VAL PHE PHE ALA GLU ASP NH2 0.414062 0.619048
99 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.413793 0.716418
100 SER GLU ILE GLU PHE ALA ARG LEU 0.413793 0.647887
101 GLU ASN LEU TYR PHE GLN 0.413534 0.671642
102 SER LEU LYS ILE ASP ASN GLU ASP 0.413043 0.723077
103 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.412698 0.630769
104 GLU LEU ASP 1OL VAL GLU PHE 0.412587 0.615385
105 LEU PRO PHE ASP LYS SER THR ILE MET 0.412121 0.816901
106 GLN ASN GLY PTR GLU ASN PRO THR TYR 0.411765 0.780822
107 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.411348 0.671642
108 THR PRO TYR ASP ILE ASN GLN MET LEU 0.411043 0.819444
109 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.410959 0.671642
110 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.409639 0.84058
111 THR LYS ASN TYR LYS GLN THR SER VAL 0.408451 0.746269
112 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.407186 0.819444
113 VAL VAL SER HIS PHE ASN ASP 0.407143 0.772727
114 TRP ASN TRP PHE ASP ILE THR ASN LYS 0.406452 0.695652
115 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.405882 0.821918
116 SER SER ILE GLU PHE ALA ARG LEU 0.405405 0.661972
117 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.405229 0.808824
118 PHE PRO THR LYS ASP VAL ALA LEU 0.405229 0.848485
119 ASP PHE SER ILE 0.404959 0.630769
120 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.404908 0.871429
121 LYS VAL ILE THR PHE ILE ASP LEU 0.404255 0.681818
122 LEU PRO PHE ASP LYS THR THR ILE MET 0.403727 0.788732
123 PRO GLU GLY ASP PM3 GLU GLU VAL LEU 0.401408 0.628571
124 ALA ASP PBF PTR LEU ILE PRO 0.401235 0.76
125 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.4 0.895522
126 PHE GLU ALA ASN GLY ASN LEU ILE 0.4 0.707692
127 ALA GLU THR PHE 0.4 0.609375
Similar Binding Sites (Proteins are less than 50% similar to leader)
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