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Receptor
PDB id Resolution Class Description Source Keywords
1KY7 2.15 Å NON-ENZYME: OTHER THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER PHE PHE GLU ASP ASN PHE VAL PRO GLU P:322;
Valid;
none;
submit data
1084.17 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER PHE PHE GLU ASP ASN PHE VAL PRO GLU; Similar ligands found: 113
No: Ligand ECFP6 Tc MDL keys Tc
1 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 1 1
2 PHE GLU ASP ASN PHE VAL PRO 0.689076 0.952381
3 GLU THR LEU LEU ASP LEU ASP PHE ASP PRO 0.534884 0.892308
4 ILE THR ASP GLN VAL PRO PHE SER VAL 0.531034 0.893939
5 ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG 0.530769 0.72
6 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.517986 0.731343
7 SER ASP PTR MET ASN MET THR PRO 0.517483 0.769231
8 ILE MET ASP GLN VAL PRO PHE SER VAL 0.516779 0.855072
9 ASP PHE GLU ASP TYR GLU PHE ASP 0.516667 0.617647
10 SER ILE ILE ASN PHE GLU LYS LEU 0.514925 0.753846
11 ALA VAL ALA PHE TYR ILE PRO ASP GLN ALA 0.503759 0.794118
12 VAL ASN ASP ILE PHE GLU ALA ILE 0.496241 0.646154
13 SER PRO ILE VAL PRO SER PHE ASP MET 0.493243 0.857143
14 SER HIS PHE ASN GLU TYR GLU 0.492857 0.73913
15 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.489209 0.723077
16 ASP PHE GLU GLU ILE PRO GLU GLU TYS 0.486486 0.666667
17 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.485075 0.779412
18 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.484076 0.810811
19 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.481481 0.826667
20 ASP PHE GLU GLU ILE PRO GLY GLU PTR 0.477707 0.75
21 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.477707 0.884058
22 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.470588 0.676056
23 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.468966 0.685714
24 ACE PRO ASP PTR GLU ASN LEU 0.467626 0.75
25 THR ASN GLU PHE TYR ALA 0.464567 0.681818
26 GLU ILE ILE ASN PHE GLU LYS LEU 0.463768 0.681818
27 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.463576 0.893939
28 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.462025 0.84058
29 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.461538 0.953846
30 GLU PHE SER PRO 0.459016 0.857143
31 ILE ASN PHE ASP PHE ASN THR ILE 0.456 0.666667
32 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.455128 0.69863
33 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.453988 0.833333
34 GLU VAL PTR GLU SER PRO 0.453237 0.808219
35 SER THR SEP PRO THR PHE ASN LYS 0.452229 0.805556
36 SER PTR VAL ASN VAL GLN ASN 0.451128 0.657534
37 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.450704 0.716418
38 ASP ILE ASN TYR TYR THR SER GLU PRO 0.449664 0.911765
39 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.448718 0.826087
40 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.448052 0.80303
41 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.446667 0.863636
42 SER TRP PHE GLN THR ASP LEU 0.445946 0.776119
43 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.445255 0.723077
44 ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO 0.444444 0.703125
45 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.44375 0.821918
46 TRP GLU TYR ILE PRO ASN VAL 0.44375 0.830986
47 LEU GLU PHE GLN GLY 0.443548 0.65625
48 THR ASN GLU PHE TYR PHE 0.442623 0.621212
49 THR ASN GLU PHE ALA PHE 0.442623 0.634921
50 SER ASP ILE LEU PHE PRO ALA ASP SER 0.441379 0.907692
51 LEU PRO SER PHE GLU THR ALA LEU 0.439189 0.907692
52 ACE GLN PM3 GLU GLU ILE PRO 0.438849 0.722222
53 THR ASN GLU TYR TYR VAL 0.438017 0.666667
54 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.43787 0.849315
55 ASP ILE ASN TYR TYR ALA SER GLU PRO 0.437086 0.911765
56 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.435374 0.723077
57 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.434783 0.895522
58 SER LEU PHE ASN THR VAL ALA THR LEU 0.434783 0.676923
59 ASP PHE GLU GLU ILE PRO GLY GLU TYS LEU 0.434783 0.690476
60 MET PHE SER ILE ASP ASN ILE LEU ALA 0.434483 0.681159
61 PHE ASN PHE PRO GLN ILE THR 0.434483 0.893939
62 THR LYS ASN TYR LYS GLN PHE SER VAL 0.431655 0.787879
63 ARG GLU ARG SER PRO THR ARG 0.429688 0.757143
64 VAL GLN GLN GLU SER SER PHE VAL MET 0.42963 0.676471
65 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.429577 0.865672
66 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.42953 0.776119
67 LYS PRO PHE PTR VAL ASN VAL NH2 0.428571 0.797297
68 THR PRO TYR ASP ILE ASN GLN MET LEU 0.427673 0.819444
69 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.427632 0.611111
70 ALA PRO SER PTR VAL ASN VAL GLN ASN 0.427632 0.824324
71 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.427536 0.661765
72 ASP ILE ASN TYS TYS THR SER GLU PRO 0.426667 0.746988
73 SER PHE ALA ASN GLY 0.42623 0.698413
74 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.423841 0.938462
75 GLY SER ASP PRO PHE LYS 0.423358 0.875
76 SER GLN TYR TYR TYR ASN SER LEU 0.423077 0.731343
77 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.421769 0.686567
78 GLU GLN TYR LYS PHE TYR SER VAL 0.421429 0.746269
79 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.41844 0.742424
80 LEU ASN PHE PRO ILE SER PRO 0.41844 0.924242
81 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.41844 0.686567
82 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.418301 0.835821
83 GLU ASN LEU TYR PHE GLN 0.41791 0.671642
84 ACE VAL PHE PHE ALA GLU ASP NH2 0.417323 0.634921
85 VAL VAL SER HIS PHE ASN ASP 0.417266 0.772727
86 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.416667 0.823529
87 GLU THR PHE TYR VAL ASP GLY 0.416058 0.742424
88 VAL SER PHE ASN FRD PRO GLN ILE THR ALA 0.415094 0.910448
89 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.413793 0.731343
90 SER LEU ARG PHE LEU TYR GLU GLY 0.413793 0.684932
91 GLU THR VAL ARG PHE GLN SER ASP 0.412162 0.657143
92 GLU VAL ASN 1OL ALA GLU PHE 0.410959 0.661538
93 SER LEU LYS ILE ASP ASN GLU ASP 0.410072 0.723077
94 LEU PRO PHE ASP LYS SER THR ILE MET 0.409639 0.830986
95 LYS GLN TRP ASP ASN TYR GLU PTR ILE TRP 0.409357 0.641026
96 THR ASN GLU TYR LYS VAL 0.409091 0.712121
97 SER LEU PHE ASN THR ILE ALA VAL LEU 0.408163 0.666667
98 SER GLU ILE GLU PHE ALA ARG LEU 0.408163 0.647887
99 LEU PRO PHE GLU LYS SER THR VAL MET 0.407407 0.842857
100 GLU ASN GLN LYS GLU TYR PHE PHE 0.407407 0.686567
101 SER ILE ILE GLY PHE GLU LYS LEU 0.406897 0.738462
102 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.40678 0.84058
103 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.406061 0.84058
104 PHE ASN ARG PRO VAL 0.405594 0.811594
105 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.405405 0.671642
106 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.404255 0.69697
107 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.403974 0.73913
108 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.401316 0.648649
109 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.401316 0.910448
110 LEU PRO PHE ASP LYS THR THR ILE MET 0.401235 0.816901
111 SER SER ILE GLU PHE ALA ARG LEU 0.4 0.661972
112 TRP ASN TRP PHE ASP ILE THR ASN LYS 0.4 0.695652
113 ACE SER LEU ASN JG3 ILE VME 0.4 0.880597
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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