Receptor
PDB id Resolution Class Description Source Keywords
1KY6 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE SER ASP PRO TRP GLY GLY P:375;
Valid;
none;
submit data
763.785 n/a O=C([...
SO4 P:200;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PHE SER ASP PRO TRP GLY GLY; Similar ligands found: 83
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE SER ASP PRO TRP GLY GLY 1 1
2 GLY SER ASP PRO TRP LYS 0.619403 0.983607
3 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.574074 0.785714
4 SER TRP PHE PRO 0.569231 0.967213
5 SER PRO LEU ASP SER LEU TRP TRP ILE 0.567568 0.924242
6 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.539877 0.9375
7 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.538462 0.846154
8 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.538462 0.805556
9 ARG PHE PRO LEU THR PHE GLY TRP 0.536585 0.808219
10 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.532934 0.767123
11 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.522581 0.861538
12 TRP PRO TRP 0.52 0.852459
13 ARG TYR PRO LEU THR PHE GLY TRP 0.517647 0.786667
14 MET TYR TRP TYR PRO TYR 0.517007 0.771429
15 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.515723 0.846154
16 ASN ASP TRP LEU LEU PRO SER TYR 0.515528 0.871429
17 GLY SER ASP PRO PHE LYS 0.514706 0.918033
18 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.506024 0.855072
19 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.505682 0.810811
20 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.503106 0.875
21 MDL 0.5 0.714286
22 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.497076 0.863636
23 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.494318 0.786667
24 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.491329 0.788732
25 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.489796 0.859375
26 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.489011 0.789474
27 PRO GLN PRO VAL ASP SER TRP VAL 0.484663 0.923077
28 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.482143 0.763889
29 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.481013 0.865672
30 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.479042 0.869565
31 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.478261 0.776316
32 THR LEU PRO TRP ASP LEU TRP THR THR 0.477419 0.893939
33 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.473054 0.786667
34 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.472973 0.907692
35 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.471591 0.789474
36 ALA VAL PRO TRP 0.466667 0.796875
37 PHE SER HIS PRO GLN ASN THR 0.461538 0.893939
38 MET TRP ARG PRO TRP 0.455128 0.702703
39 ALA PRO ALA TRP LEU PHE GLU ALA 0.453988 0.818182
40 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.448649 0.767123
41 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.444444 0.84058
42 TRP GLU TYR ILE PRO ASN VAL 0.443114 0.802817
43 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.442424 0.712329
44 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.43956 0.769231
45 LEU PHE GLY TYR PRO VAL TYR VAL 0.43949 0.779412
46 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.4375 0.780822
47 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.436709 0.80597
48 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.432927 0.771429
49 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.431818 0.84507
50 LYS PRO HIS SER ASP 0.431507 0.904762
51 GLU PRO GLN ALA PRO TRP MET GLU 0.430303 0.771429
52 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.427673 0.797101
53 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.426136 0.780822
54 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.421965 0.811594
55 MET HIS PRO ALA GLN THR SER GLN TRP 0.421348 0.833333
56 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.420732 0.779412
57 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.420732 0.779412
58 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.420213 0.782051
59 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.41875 0.794521
60 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.418605 0.771429
61 ILE SER PRO ARG THR LEU ASP ALA TRP 0.418478 0.810811
62 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.417647 0.842857
63 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.416667 0.720588
64 ACE TRP ARG VAL PRO 0.414474 0.736111
65 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.413613 0.782051
66 PHE ASN ARG PRO VAL 0.412162 0.708333
67 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.412121 0.753425
68 GLU ALA ASP PRO THR GLY HIS SER TYR 0.411429 0.867647
69 ASP ARG VAL TYR ILE HIS PRO PHE 0.40884 0.727273
70 TYR TYR SER ILE ILE PRO HIS SER ILE 0.408537 0.842857
71 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.408537 0.842857
72 LYS ARG ARG ARG HIS PRO SER GLY 0.407643 0.811594
73 SER ASP ILE LEU PHE PRO ALA ASP SER 0.407643 0.833333
74 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.40625 0.826087
75 ACE ASN PRO ASP TRP ASP PHE ASN NH2 0.405229 0.809524
76 PHE SER ALA PTR PRO SER GLU GLU ASP 0.404762 0.805556
77 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.402685 0.890625
78 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.401235 0.835821
79 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.4 0.773333
80 ASP GLU ASP LYS TRP ASP ASP PHE 0.4 0.786885
81 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.4 0.811594
82 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.4 0.768116
83 SER SER VAL VAL GLY VAL TRP TYR LEU 0.4 0.735294
Similar Binding Sites (Proteins are less than 50% similar to leader)
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