Receptor
PDB id Resolution Class Description Source Keywords
1KY6 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE SER ASP PRO TRP GLY GLY P:375;
Valid;
none;
submit data
763.785 n/a O=C(N...
SO4 P:200;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PHE SER ASP PRO TRP GLY GLY; Similar ligands found: 70
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE SER ASP PRO TRP GLY GLY 1 1
2 GLY SER ASP PRO TRP LYS 0.597122 0.983871
3 SER TRP PHE PRO 0.560606 0.967742
4 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.537975 0.848485
5 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.535294 0.780822
6 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.524096 0.869565
7 SER PRO LEU ASP SER LEU TRP TRP ILE 0.519481 0.925373
8 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.518987 0.863636
9 ASN ASP TRP LEU LEU PRO SER TYR 0.515337 0.885714
10 ARG PHE PRO LEU THR PHE GLY TRP 0.508876 0.821918
11 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.506173 0.848485
12 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.503067 0.890625
13 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.502857 0.808219
14 TRP PRO TRP 0.5 0.854839
15 ARG TYR PRO LEU THR PHE GLY TRP 0.497143 0.8
16 MDL 0.49635 0.704225
17 ASN GLN DPR TRP GLN 0.486301 0.857143
18 PRO GLN PRO VAL ASP SER TRP VAL 0.484472 0.938462
19 THR LEU PRO TRP ASP LEU TRP THR THR 0.480769 0.895522
20 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.480663 0.824324
21 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.480226 0.909091
22 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.48 0.861538
23 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.479042 0.884058
24 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.478261 0.8
25 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.476744 0.777778
26 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.47619 0.824324
27 GLY SER ASP PRO PHE LYS 0.475177 0.919355
28 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.473118 0.802632
29 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.470199 0.909091
30 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.463687 0.802817
31 ALA VAL PRO TRP 0.459854 0.815385
32 ACE PRO TRP ALA THR CYS ASP SER NH2 0.45625 0.897059
33 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.455026 0.789474
34 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.454054 0.802632
35 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.447514 0.813333
36 GLU TYR GLY PRO LYS TRP ASN LYS 0.445783 0.878788
37 TRP GLU TYR ILE PRO ASN VAL 0.443787 0.816901
38 MET TRP ARG PRO TRP 0.440994 0.716216
39 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.436047 0.842857
40 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.434524 0.726027
41 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.431694 0.802632
42 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.430108 0.782051
43 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.428571 0.820895
44 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.427711 0.785714
45 GLU PRO GLN ALA PRO TRP MET GLU 0.427711 0.785714
46 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.426316 0.780822
47 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.424419 0.826087
48 ILE SER PRO ARG THR LEU ASP ALA TRP 0.423913 0.824324
49 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.423529 0.84507
50 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.420765 0.794521
51 MET HIS PRO ALA GLN THR SER GLN TRP 0.41989 0.847222
52 ACE ASN PRO ASP TRP ASP PHE ASN NH2 0.417219 0.84127
53 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.417178 0.785714
54 LEU PHE GLY TYR PRO VAL TYR VAL 0.4125 0.782609
55 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.411458 0.794872
56 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.411111 0.794521
57 TYR PRO PHE PHE NH2 0.408759 0.784615
58 TYR TYR SER ILE ILE PRO HIS SER ILE 0.408537 0.84507
59 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.408537 0.84507
60 PHE ASN ARG PRO VAL 0.407895 0.722222
61 ASP SER TRP LYS ASP GLY CYS TYR 0.407186 0.833333
62 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.405128 0.794872
63 PHE SER ALA PTR PRO SER GLU GLU ASP 0.405063 0.780822
64 SER ASP ILE LEU PHE PRO ALA ASP SER 0.405063 0.835821
65 PHE ALA PRO GLY ASN TYR PRO ALA LEU 0.404762 0.816901
66 GLY PRO SER SER GLY GLY 0.40458 0.870968
67 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.403727 0.84058
68 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.402299 0.859155
69 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.401316 0.90625
70 GLU ALA ASP PRO THR GLY HIS SER TYR 0.40113 0.869565
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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