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Receptor
PDB id Resolution Class Description Source Keywords
1KAE 1.7 Å EC: 1.1.1.23 L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH L HISTIDINOL (SUBSTRATE), ZINC AND NAD (COFACTOR) ESCHERICHIA COLI L-HISTIDINOL DEHYDROGENASE HOMODIMER ROSSMANN FOLD 4 DOMAHISD L-HISTIDINE BIOSYNTHESIS NAD COFACTOR OXIDOREDUCTAS
Ref.: MECHANISM OF ACTION AND NAD+-BINDING MODE REVEALED CRYSTAL STRUCTURE OF L-HISTIDINOL DEHYDROGENASE. PROC.NATL.ACAD.SCI.USA V. 99 1859 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DTT A:901;
Invalid;
none;
submit data
154.251 C4 H10 O2 S2 C([C@...
GOL B:801;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
HSO A:1001;
Valid;
none;
submit data
142.179 C6 H12 N3 O c1c([...
IMD B:902;
Invalid;
none;
submit data
69.085 C3 H5 N2 c1c[n...
NAD A:1201;
B:1202;
Valid;
Valid;
none;
none;
submit data
663.425 C21 H27 N7 O14 P2 c1cc(...
SO4 A:702;
A:704;
B:701;
B:703;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
ZN A:1101;
B:1102;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KAE 1.7 Å EC: 1.1.1.23 L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH L HISTIDINOL (SUBSTRATE), ZINC AND NAD (COFACTOR) ESCHERICHIA COLI L-HISTIDINOL DEHYDROGENASE HOMODIMER ROSSMANN FOLD 4 DOMAHISD L-HISTIDINE BIOSYNTHESIS NAD COFACTOR OXIDOREDUCTAS
Ref.: MECHANISM OF ACTION AND NAD+-BINDING MODE REVEALED CRYSTAL STRUCTURE OF L-HISTIDINOL DEHYDROGENASE. PROC.NATL.ACAD.SCI.USA V. 99 1859 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1KAE - HSO C6 H12 N3 O c1c([nH+]c....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1KAE - HSO C6 H12 N3 O c1c([nH+]c....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1KAE - HSO C6 H12 N3 O c1c([nH+]c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: HSO; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 HSO 1 1
2 HIS 0.52381 0.846154
3 DHI 0.52381 0.846154
Ligand no: 2; Ligand: NAD; Similar ligands found: 230
No: Ligand ECFP6 Tc MDL keys Tc
1 A3D 0.872727 0.986111
2 NHD 0.821429 0.972222
3 NAP 0.811966 0.986111
4 NFD 0.791304 0.946667
5 NXX 0.765766 0.972603
6 DND 0.765766 0.972603
7 AMP NAD 0.74359 0.972222
8 ZID 0.737705 0.986111
9 NAQ 0.729508 0.934211
10 NAE 0.721311 0.959459
11 NA0 0.712 0.972603
12 TAP 0.704 0.921053
13 NDE 0.689922 0.972603
14 NAJ 0.683333 0.972222
15 NDC 0.679389 0.934211
16 NDO 0.674603 0.958904
17 N01 0.656 0.972222
18 CNA 0.642276 0.972603
19 NBP 0.621212 0.922078
20 8ID 0.609756 0.922078
21 A2D 0.576923 0.958333
22 ADP 0.575472 0.931507
23 NGD 0.574803 0.922078
24 BA3 0.566038 0.958333
25 M33 0.564815 0.918919
26 ADP PO3 0.563636 0.957747
27 B4P 0.560748 0.958333
28 AP5 0.560748 0.958333
29 AN2 0.555556 0.918919
30 AT4 0.555556 0.894737
31 GAP 0.553571 0.932432
32 OOB 0.551724 0.972222
33 CA0 0.550459 0.932432
34 9JJ 0.546053 0.898734
35 HEJ 0.545455 0.931507
36 ACP 0.545455 0.906667
37 ATP 0.545455 0.931507
38 DQV 0.544 0.972222
39 ADP ALF 0.54386 0.883117
40 ALF ADP 0.54386 0.883117
41 DAL AMP 0.543103 0.945205
42 APR 0.540541 0.931507
43 AQP 0.540541 0.931507
44 AR6 0.540541 0.931507
45 5FA 0.540541 0.931507
46 ADP VO4 0.53913 0.945205
47 VO4 ADP 0.53913 0.945205
48 AD9 0.535714 0.906667
49 SAP 0.535714 0.883117
50 AGS 0.535714 0.883117
51 WAQ 0.533333 0.896104
52 ABM 0.53271 0.905405
53 DLL 0.529412 0.972222
54 00A 0.529412 0.921053
55 ACQ 0.526316 0.906667
56 NJP 0.526316 0.959459
57 ANP 0.526316 0.906667
58 OAD 0.525 0.932432
59 ADX 0.522523 0.839506
60 5AL 0.521739 0.945205
61 A1R 0.521008 0.871795
62 9SN 0.520325 0.909091
63 A 0.518868 0.930556
64 AMP 0.518868 0.930556
65 50T 0.517857 0.893333
66 ATF 0.517241 0.894737
67 1ZZ 0.516393 0.851852
68 3OD 0.516393 0.932432
69 SON 0.513514 0.92
70 PRX 0.513274 0.881579
71 6YZ 0.512821 0.906667
72 SRP 0.512821 0.92
73 9X8 0.512397 0.883117
74 ADP BMA 0.512397 0.932432
75 3UK 0.512397 0.958904
76 MYR AMP 0.512195 0.851852
77 NAJ PZO 0.510949 0.909091
78 NMN 0.509434 0.875
79 A3R 0.508333 0.871795
80 B5V 0.508197 0.945946
81 AMP DBH 0.507937 0.906667
82 A22 0.504202 0.945205
83 ATP A A A 0.504 0.971831
84 B5M 0.504 0.933333
85 FA5 0.504 0.945946
86 8QN 0.5 0.945205
87 NAX 0.496183 0.886076
88 TYR AMP 0.496063 0.933333
89 PR8 0.495935 0.8625
90 AMO 0.495868 0.92
91 ADQ 0.495868 0.932432
92 4AD 0.495868 0.933333
93 PAJ 0.495868 0.873418
94 A12 0.495495 0.894737
95 AP2 0.495495 0.894737
96 AHZ 0.492308 0.851852
97 YAP 0.492063 0.933333
98 FYA 0.491935 0.918919
99 AHX 0.491803 0.884615
100 4UU 0.488372 0.933333
101 5SV 0.487603 0.8375
102 TAT 0.487179 0.894737
103 T99 0.487179 0.894737
104 APC 0.486957 0.894737
105 SRA 0.486239 0.881579
106 6V0 0.484848 0.909091
107 NAI 0.484848 0.921053
108 GTA 0.484615 0.898734
109 A A 0.483871 0.958333
110 LAD 0.483871 0.873418
111 AU1 0.482456 0.906667
112 F2R 0.481752 0.831325
113 OMR 0.481203 0.841463
114 TXE 0.481203 0.921053
115 AF3 ADP 3PG 0.481203 0.873418
116 LAQ 0.480916 0.851852
117 G3A 0.48062 0.909091
118 B5Y 0.480315 0.933333
119 NB8 0.48 0.884615
120 TXA 0.48 0.92
121 BIS 0.48 0.871795
122 ME8 0.48 0.851852
123 PTJ 0.48 0.884615
124 139 0.477941 0.886076
125 LPA AMP 0.477273 0.851852
126 AFH 0.476923 0.873418
127 AR6 AR6 0.476923 0.958333
128 G5P 0.476923 0.909091
129 ARG AMP 0.476923 0.841463
130 25L 0.47619 0.945205
131 NAJ PYZ 0.475524 0.864198
132 25A 0.47541 0.958333
133 9ZA 0.47541 0.896104
134 9ZD 0.47541 0.896104
135 DZD 0.47482 0.897436
136 TXD 0.473684 0.921053
137 4UV 0.472868 0.933333
138 TYM 0.470149 0.945946
139 RBY 0.470085 0.894737
140 ADV 0.470085 0.894737
141 4TA 0.467626 0.864198
142 48N 0.466165 0.884615
143 XAH 0.465116 0.851852
144 4UW 0.462687 0.897436
145 M24 0.461538 0.886076
146 80F 0.460993 0.853659
147 IOT 0.459854 0.821429
148 T5A 0.456522 0.853659
149 EAD 0.455782 0.886076
150 MAP 0.455285 0.883117
151 GA7 0.454545 0.894737
152 BT5 0.453901 0.821429
153 A4P 0.452555 0.833333
154 UP5 0.451852 0.933333
155 PAP 0.445378 0.917808
156 4TC 0.445255 0.909091
157 AP0 0.445255 0.884615
158 YLP 0.444444 0.831325
159 P1H 0.443709 0.864198
160 AOC 0.442478 0.810811
161 Z5A 0.439189 0.833333
162 LMS 0.4375 0.817073
163 2A5 0.436975 0.857143
164 A G 0.43662 0.921053
165 G A A A 0.43662 0.909091
166 COD 0.43662 0.802326
167 ADJ 0.435714 0.841463
168 YLB 0.434783 0.831325
169 YLC 0.434783 0.851852
170 U A G G 0.433566 0.921053
171 ATR 0.433333 0.90411
172 7MD 0.432836 0.851852
173 8X1 0.432 0.764045
174 G5A 0.429752 0.790698
175 PO4 PO4 A A A A PO4 0.429688 0.943662
176 TAD 0.42963 0.873418
177 5AS 0.42735 0.770115
178 BTX 0.426573 0.831325
179 YLA 0.425532 0.831325
180 DSZ 0.425197 0.790698
181 NCN 0.424779 0.805556
182 UPA 0.42446 0.921053
183 8PZ 0.424242 0.811765
184 VMS 0.424 0.8
185 54H 0.424 0.8
186 9K8 0.423077 0.744444
187 N0B 0.422819 0.853659
188 6AD 0.422764 0.85
189 AYB 0.422535 0.821429
190 7D3 0.422414 0.844156
191 YLY 0.421769 0.821429
192 TSB 0.420635 0.809524
193 ODP 0.41958 0.922078
194 AV2 0.419355 0.855263
195 FB0 0.419355 0.775281
196 A5A 0.419355 0.819277
197 NNR 0.419048 0.739726
198 A A A 0.418605 0.918919
199 U A 0.417808 0.946667
200 649 0.417266 0.775281
201 NMN AMP PO4 0.416667 0.933333
202 SSA 0.416 0.790698
203 P5A 0.415385 0.755556
204 LSS 0.414062 0.772727
205 A2R 0.412698 0.918919
206 52H 0.412698 0.790698
207 JB6 0.412214 0.896104
208 5N5 0.411215 0.783784
209 YSA 0.410448 0.811765
210 53H 0.409449 0.790698
211 5CA 0.409449 0.790698
212 ITT 0.408333 0.878378
213 7D4 0.408333 0.844156
214 NA7 0.407692 0.894737
215 LEU LMS 0.407692 0.784091
216 5CD 0.407407 0.794521
217 0WD 0.406897 0.909091
218 A3P 0.40678 0.930556
219 HFD 0.406504 0.883117
220 AVV 0.40625 0.860759
221 RAB 0.40566 0.808219
222 XYA 0.40566 0.808219
223 ADN 0.40566 0.808219
224 FDA 0.405063 0.823529
225 GSU 0.40458 0.790698
226 7MC 0.404255 0.831325
227 NSS 0.403101 0.811765
228 6FA 0.402516 0.853659
229 PPS 0.4 0.817073
230 NVA LMS 0.4 0.784091
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1KAE; Ligand: NAD; Similar sites found with APoc: 55
This union binding pocket(no: 1) in the query (biounit: 1kae.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 3LF0 ATP None
2 5L13 6ZE 1.38249
3 3VZ3 SSN 1.6129
4 4I3V NAD 1.6129
5 3VZ3 NAP 1.6129
6 1T90 NAD 1.6129
7 1KY8 NAP 1.84332
8 6FP4 FAD 1.84332
9 3AB4 THR 1.90024
10 3HAZ NAD 2.07373
11 6B5G CQY 2.30415
12 6B5G NAD 2.30415
13 5IUW IAC 2.30415
14 4ARE FLC 2.30415
15 5IUW NAD 2.30415
16 5JFL NAD 2.30415
17 3JQF AX2 2.43056
18 4OOE NDP 2.72277
19 4ZUL UN1 2.76498
20 4PXL NAD 2.76498
21 2QE0 NAP 2.76498
22 3JQA DX4 2.77778
23 4CLR FDB 2.77778
24 6FK3 PPI 2.99539
25 5KF6 NAD 2.99539
26 3F8D FAD 3.09598
27 1O8B ABF 3.65297
28 3G5S FAD 3.68664
29 6H3O FAD 3.68664
30 3FPF TNA 3.69128
31 3FPF MTA 3.69128
32 5NB7 8NQ 3.91304
33 2IMP NAI 3.91705
34 1SIV PSI 4.0404
35 3RHJ NAP 4.14747
36 2BJK NAD 4.37788
37 5G41 AP5 4.4843
38 4LH0 GLV 4.83871
39 1JAY F42 5.18868
40 3ITJ CIT 5.32544
41 4YWV SSN 5.99078
42 5NGZ 2BG 6.09137
43 5N5S NAP 6.2212
44 1BAI 0Q4 6.45161
45 5YSI NCA 6.57895
46 6HT0 GQ8 7.09677
47 2O4N TPV 8.08081
48 2J4K U5P 8.84956
49 5T2Z 017 9.09091
50 4A0M NAD 9.21659
51 5LOG SAH 9.44206
52 4PZ2 NAD 9.447
53 4I8P NAD 9.67742
54 3MQ2 SAH 10.5505
55 3QFA FAD 13.7931
Pocket No.: 2; Query (leader) PDB : 1KAE; Ligand: NAD; Similar sites found with APoc: 14
This union binding pocket(no: 2) in the query (biounit: 1kae.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 6FX2 FUC C4W NAG BMA MAN NAG GAL None
2 5SWI BMA 1.15207
3 6GNC FAD 2.04082
4 1O5Q PYR 2.29508
5 4Z87 5GP 2.99539
6 5J60 FAD 4.6875
7 2J9D ADP 5.04202
8 2J9D AMP 5.04202
9 4BV6 FAD 6.91244
10 2WPF WPF 7.60369
11 2WPF FAD 7.60369
12 4EMJ FAD 8.52535
13 4J56 FAD 14.0351
14 2F5Z FAD 14.0625
Pocket No.: 3; Query (leader) PDB : 1KAE; Ligand: HSO; Similar sites found with APoc: 19
This union binding pocket(no: 3) in the query (biounit: 1kae.bio1) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 3C3N FMN 1.60256
2 4I6G FAD 1.6129
3 1P1M MET 1.72414
4 2J4D FAD 2.30415
5 3CH6 311 2.44755
6 3CH6 NAP 2.44755
7 1MZC FPP 3.14136
8 1MZC BNE 3.14136
9 3H78 BE2 3.34262
10 4S1B 2BA 4.05405
11 1N9L FMN 4.58716
12 2CI5 HCS 5.6338
13 2Q7D ANP 6.93642
14 4EKQ NPO 6.95187
15 3UXL CFI 7.04961
16 4EXS X8Z 8.45588
17 6GG9 FMN 9.87654
18 1N62 MCN 10.8434
19 2ET1 GLV 12.4378
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