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Receptor
PDB id Resolution Class Description Source Keywords
1I7A 2.24 Å NON-ENZYME: SIGNAL_HORMONE EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 MUS MUSCULUS EVH1 DOMAIN HOMER VESL X-RAY CRYSTAL STRUCTURE BRAIN SIPROTEIN
Ref.: THE N-TERMINAL DOMAIN OF HOMER/VESL IS A NEW CLASS DOMAIN. J.MOL.BIOL. V. 309 155 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FLC A:301;
B:302;
Valid;
Valid;
none;
none;
submit data
189.1 C6 H5 O7 C(C(=...
PHE A:403;
B:402;
D:401;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
165.189 C9 H11 N O2 c1ccc...
PHE ALA PHE E:201;
Invalid;
none;
submit data n/a n/a n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1I7A 2.24 Å NON-ENZYME: SIGNAL_HORMONE EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 MUS MUSCULUS EVH1 DOMAIN HOMER VESL X-RAY CRYSTAL STRUCTURE BRAIN SIPROTEIN
Ref.: THE N-TERMINAL DOMAIN OF HOMER/VESL IS A NEW CLASS DOMAIN. J.MOL.BIOL. V. 309 155 2001
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FLC; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 FLC 1 1
Ligand no: 2; Ligand: PHE; Similar ligands found: 25
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE 1 1
2 DPN 1 1
3 NFA 0.657143 0.666667
4 PBF 0.577778 0.814815
5 TYR 0.564103 0.814815
6 DTY 0.564103 0.814815
7 0A9 0.560976 0.692308
8 4BF 0.55 0.814815
9 PHI 0.55 0.814815
10 PFF 0.55 0.814815
11 0A1 0.52381 0.733333
12 7N8 0.52381 0.666667
13 4AF 0.52381 0.846154
14 ING 0.511628 0.666667
15 4CF 0.511628 0.88
16 TFQ 0.5 0.785714
17 33S 0.488889 0.814815
18 NAL 0.44898 0.846154
19 DAH 0.444444 0.6875
20 E42 0.442308 0.733333
21 BP5 0.433962 0.6875
22 2LT 0.422222 0.647059
23 YOF 0.416667 0.666667
24 IYR 0.416667 0.666667
25 TIH 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 1i7a.bio8) has 6 residues
No: Leader PDB Ligand Sequence Similarity
1 3D72 FAD None
Pocket No.: 2; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: 3
This union binding pocket(no: 2) in the query (biounit: 1i7a.bio8) has 5 residues
No: Leader PDB Ligand Sequence Similarity
1 5C8W PCG None
2 5X40 ACP None
3 1LO8 4CA 8.10811
Pocket No.: 3; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: 8
This union binding pocket(no: 3) in the query (biounit: 1i7a.bio8) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 4OKZ 3E9 None
2 3C56 PH4 None
3 5W19 9TD 3.6036
4 2ZRU FMN 3.6036
5 3WB0 FEG 4.5045
6 1P7L MET 9.00901
7 1FDQ HXA 9.90991
8 5A7C 5D4 17.1171
Pocket No.: 4; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1i7a.bio4) has 5 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1i7a.bio1) has 5 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: 2
This union binding pocket(no: 6) in the query (biounit: 1i7a.bio1) has 5 residues
No: Leader PDB Ligand Sequence Similarity
1 1WB4 SXX 2.7027
2 2CM4 RCL 6.30631
Pocket No.: 7; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 1i7a.bio10) has 3 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 1i7a.bio10) has 4 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 1i7a.bio5) has 6 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 1i7a.bio5) has 5 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 11; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: 1
This union binding pocket(no: 11) in the query (biounit: 1i7a.bio5) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 5N0L ILE None
Pocket No.: 12; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 1i7a.bio2) has 3 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 13; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 13) in the query (biounit: 1i7a.bio2) has 4 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 14; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: 14
This union binding pocket(no: 14) in the query (biounit: 1i7a.bio7) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1DFO FFO None
2 4PB2 5UD 2.7027
3 6CBO DOW 4.5045
4 5X0J SEP 5.40541
5 3OJF NDP 5.40541
6 1ZXM ANP 7.20721
7 4A9C B5F 9.00901
8 2CJ9 SSA 9.00901
9 2VHJ ADP 9.90991
10 4FE2 ADP 9.90991
11 5K04 COA 9.90991
12 1EU8 TRE 12.6126
13 2IHU TP9 13.5135
14 1O75 PDX PDX 15.3153
Pocket No.: 15; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: 54
This union binding pocket(no: 15) in the query (biounit: 1i7a.bio7) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1WWZ ACO None
2 1HYH NAD None
3 4NVP 7CH None
4 4QRH 0O2 None
5 1LVG 5GP None
6 4IE6 UN9 None
7 5CLO NS8 None
8 1XPK CAA None
9 1LFO OLA None
10 4L80 1VU 2.7027
11 2PTM CMP 3.6036
12 4LY9 S6P 3.6036
13 6C1S EFV 4.5045
14 3I54 CMP 4.5045
15 3I59 N6S 4.5045
16 5KBE IPH 4.5045
17 3E2M E2M 4.5045
18 2EAE LBT 4.5045
19 3LSJ COA PLM 5.40541
20 5C1P ADP 5.40541
21 4S1D 41M 5.40541
22 1QFT HSM 5.40541
23 5UWA 8ND 6.30631
24 4QCK ASD 6.30631
25 2OFV 242 6.30631
26 3AGC RCC 6.30631
27 4D3F NAP 6.30631
28 4NTK ZSP 6.30631
29 2IF8 ADP 7.20721
30 5BU3 4W9 7.20721
31 2AAZ CB3 7.20721
32 3TPV ADE 7.20721
33 4D4U FUC NDG GAL FUC 8.10811
34 4MUV PCG 8.10811
35 4D52 GIV 8.10811
36 4YUS FMN 9.00901
37 1W2D 4IP 9.90991
38 1W2D ADP 9.90991
39 4N9I PCG 10.8108
40 3KCC CMP 10.8108
41 1TT8 PHB 11.7117
42 1F0X FAD 12.6126
43 2AQX ATP 12.6126
44 4NBU NAI 12.6126
45 3CTL S6P 12.6126
46 1MUU NAD 14.4144
47 2R5V HHH 15.3153
48 4AZP A9M 16.2162
49 4J56 FAD 18.9189
50 3OYZ ACO 18.9189
51 1MV8 NAD 19.8198
52 1NN5 2DT 24.3243
53 1NN5 ANP 24.3243
54 1ZM1 BGC BGC BGC 25.2252
Pocket No.: 16; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 16) in the query (biounit: 1i7a.bio11) has 5 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 17; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 17) in the query (biounit: 1i7a.bio11) has 5 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 18; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found with APoc: 4
This union binding pocket(no: 18) in the query (biounit: 1i7a.bio6) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 2WTX UDP 4.5045
2 4B1V LAB 4.5045
3 1QZR ANP 5.40541
4 3B8I OXL 12.6126
Pocket No.: 19; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found with APoc: 17
This union binding pocket(no: 19) in the query (biounit: 1i7a.bio6) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1KDK DHT None
2 2IYG FMN None
3 4OFG PCG None
4 2YNE NHW 2.7027
5 2YNE YNE 2.7027
6 5OFW 9TW 2.7027
7 4QED NAP 6.30631
8 6FCX FAD 7.20721
9 5G09 6DF 7.20721
10 4MNS 2AX 8.10811
11 5DKK FMN 10.8108
12 3NRR D16 10.8108
13 3NRR UMP 10.8108
14 5TZ1 VT1 11.7117
15 4P8K FAD 13.5135
16 4P8K 38C 13.5135
17 4J36 FAD 18.018
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