Receptor
PDB id Resolution Class Description Source Keywords
1I7A 2.24 Å NON-ENZYME: SIGNAL_HORMONE EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 MUS MUSCULUS EVH1 DOMAIN HOMER VESL X-RAY CRYSTAL STRUCTURE BRAIN SIGNALING PROTEIN
Ref.: THE N-TERMINAL DOMAIN OF HOMER/VESL IS A NEW CLASS II EVH1 DOMAIN. J.MOL.BIOL. V. 309 155 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FLC A:301;
B:302;
Valid;
Valid;
none;
none;
submit data
189.1 C6 H5 O7 C(C(=...
PHE A:403;
B:402;
D:401;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
165.189 C9 H11 N O2 c1ccc...
PHE ALA PHE E:201;
Invalid;
none;
submit data n/a n/a n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1I7A 2.24 Å NON-ENZYME: SIGNAL_HORMONE EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 MUS MUSCULUS EVH1 DOMAIN HOMER VESL X-RAY CRYSTAL STRUCTURE BRAIN SIGNALING PROTEIN
Ref.: THE N-TERMINAL DOMAIN OF HOMER/VESL IS A NEW CLASS II EVH1 DOMAIN. J.MOL.BIOL. V. 309 155 2001
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FLC; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 FLC 1 1
2 FE CIT 0.95 0.875
Ligand no: 2; Ligand: PHE; Similar ligands found: 23
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE 1 1
2 DPN 1 1
3 NFA 0.657143 0.666667
4 PBF 0.577778 0.814815
5 TYR 0.564103 0.814815
6 DTY 0.564103 0.814815
7 0A9 0.560976 0.692308
8 PFF 0.55 0.814815
9 4BF 0.55 0.814815
10 PHI 0.55 0.814815
11 4AF 0.52381 0.846154
12 0A1 0.52381 0.733333
13 4CF 0.511628 0.88
14 ING 0.511628 0.666667
15 TFQ 0.5 0.785714
16 33S 0.488889 0.814815
17 NAL 0.44898 0.846154
18 DAH 0.444444 0.6875
19 E42 0.442308 0.733333
20 BP5 0.433962 0.6875
21 2LT 0.422222 0.647059
22 IYR 0.416667 0.666667
23 TIH 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: 1
This union binding pocket(no: 1) in the query (biounit: 1i7a.bio8) has 6 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3D72 FAD 0.01405 0.40502 None
Pocket No.: 2; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1i7a.bio8) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: 5
This union binding pocket(no: 3) in the query (biounit: 1i7a.bio8) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4OKZ 3E9 0.02246 0.40868 None
2 3C56 PH4 0.01242 0.40511 None
3 5UOX 8GY 0.01126 0.40798 9.90991
4 1FDQ HXA 0.006677 0.40547 9.90991
5 5A7C 5D4 0.006533 0.40426 17.1171
Pocket No.: 4; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: 3
This union binding pocket(no: 4) in the query (biounit: 1i7a.bio4) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5C8W PCG 0.001576 0.42103 None
2 5X40 ACP 0.01194 0.40115 None
3 1LO8 4CA 0.01649 0.44095 8.10811
Pocket No.: 5; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1i7a.bio1) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: 2
This union binding pocket(no: 6) in the query (biounit: 1i7a.bio1) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1WB4 SXX 0.0002617 0.46306 2.7027
2 2CM4 RCL 0.0002475 0.48705 6.30631
Pocket No.: 7; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 1i7a.bio10) has 3 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 1i7a.bio10) has 4 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 1i7a.bio5) has 6 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 1i7a.bio5) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 11; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 11) in the query (biounit: 1i7a.bio5) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 12; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 1i7a.bio2) has 3 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 13; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 13) in the query (biounit: 1i7a.bio2) has 4 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 14; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: 8
This union binding pocket(no: 14) in the query (biounit: 1i7a.bio7) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2WTX UDP 0.009428 0.42546 4.5045
2 4B1V LAB 0.01499 0.41658 4.5045
3 5X0J SEP 0.02824 0.41722 5.40541
4 1QZR ANP 0.01921 0.41605 5.40541
5 1ZXM ANP 0.02032 0.41571 7.20721
6 4A9C B5F 0.004186 0.41626 9.00901
7 5K04 COA 0.04531 0.40109 9.90991
8 1O75 PDX PDX 0.001562 0.47263 15.3153
Pocket No.: 15; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: 49
This union binding pocket(no: 15) in the query (biounit: 1i7a.bio7) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1WWZ ACO 0.006938 0.46097 None
2 1HYH NAD 0.003879 0.44218 None
3 4OFG PCG 0.009751 0.40924 None
4 1LVG 5GP 0.02031 0.40921 None
5 4QRH 0O2 0.02629 0.4092 None
6 5CLO NS8 0.005168 0.40864 None
7 1XPK CAA 0.0216 0.40834 None
8 1LFO OLA 0.01578 0.40196 None
9 2YNE NHW 0.04725 0.41053 2.7027
10 2YNE YNE 0.04725 0.41053 2.7027
11 5OFW 9TW 0.01117 0.40923 2.7027
12 4LY9 S6P 0.02735 0.41746 3.6036
13 3I59 N6S 0.004879 0.42951 4.5045
14 5KBE IPH 0.005089 0.41708 4.5045
15 3E2M E2M 0.0188 0.40716 4.5045
16 3I54 CMP 0.006727 0.40694 4.5045
17 2EAE LBT 0.008298 0.40467 4.5045
18 3LSJ COA PLM 0.003172 0.43205 5.40541
19 4S1D 41M 0.01213 0.41087 5.40541
20 1QFT HSM 0.009704 0.40265 5.40541
21 5UWA 8ND 0.01146 0.43486 6.30631
22 2OFV 242 0.02476 0.41356 6.30631
23 4QCK ASD 0.04151 0.41293 6.30631
24 4D3F NAP 0.008144 0.41081 6.30631
25 3AGC RCC 0.004076 0.40418 6.30631
26 4QED NAP 0.02788 0.40293 6.30631
27 2IF8 ADP 0.0005184 0.43837 7.20721
28 5BU3 4W9 0.007852 0.41244 7.20721
29 2AAZ CB3 0.01736 0.40357 7.20721
30 3TPV ADE 0.008945 0.40141 7.20721
31 4D4U FUC NDG GAL FUC 0.003998 0.41917 8.10811
32 4MNS 2AX 0.02211 0.41465 8.10811
33 4MUV PCG 0.007243 0.41061 8.10811
34 4D52 GIV 0.003825 0.40885 8.10811
35 1W2D 4IP 0.001955 0.43236 9.90991
36 1W2D ADP 0.000778 0.43143 9.90991
37 5DKK FMN 0.005582 0.42425 10.8108
38 3KCC CMP 0.008047 0.42009 10.8108
39 1TT8 PHB 0.00855 0.41969 11.7117
40 5TZ1 VT1 0.01155 0.40298 11.7117
41 1F0X FAD 0.007806 0.42652 12.6126
42 2AQX ATP 0.001846 0.42403 12.6126
43 4P8K 38C 0.0192 0.40695 13.5135
44 4P8K FAD 0.01878 0.40695 13.5135
45 1MUU NAD 0.02254 0.40974 14.4144
46 4AZP A9M 0.008546 0.40512 16.2162
47 1MV8 NAD 0.02052 0.41518 19.8198
48 1NCQ W11 0.02489 0.40568 19.8198
49 1ZM1 BGC BGC BGC 0.02274 0.40131 25.2252
Pocket No.: 16; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 16) in the query (biounit: 1i7a.bio11) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 17; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 17) in the query (biounit: 1i7a.bio11) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 18; Query (leader) PDB : 1I7A; Ligand: FLC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 18) in the query (biounit: 1i7a.bio6) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 19; Query (leader) PDB : 1I7A; Ligand: PHE; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 19) in the query (biounit: 1i7a.bio6) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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