Receptor
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE TYR ARG ALA LEU MET P:1;
Valid;
none;
submit data
801.003 n/a S(CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PHE TYR ARG ALA LEU MET; Similar ligands found: 187
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE TYR ARG ALA LEU MET 1 1
2 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.720339 0.885246
3 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.677165 0.885246
4 GLU LEU ARG ARG LYS MET MET TYR MET 0.675214 0.903226
5 PHE LEU ALA TYR LYS 0.663636 0.779661
6 PHE ARG TYR LEU GLY 0.657895 0.9
7 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.612403 0.857143
8 GLU LEU LYS ARG LYS MET ILE TYR MET 0.607692 0.903226
9 ARG VAL LEU PHE GLU ALA MET 0.606299 0.836066
10 LYS ALA LEU TYR ASN PHE ALA THR MET 0.590909 0.784615
11 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.587302 0.809524
12 PHE LEU SER TYR LYS 0.577586 0.746032
13 GLU LEU ASN ARG LYS MET ILE TYR MET 0.568345 0.861538
14 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.56338 0.830769
15 SER ASP TYR GLN ARG LEU 0.559322 0.866667
16 TYR GLY GLY PHE MET 0.547009 0.786885
17 LEU PRO PHE GLU ARG ALA THR VAL MET 0.543046 0.706667
18 ACE ALC ARG ALA MET CY1 SER LEU NH2 0.533333 0.772727
19 LEU PRO PHE GLU ARG ALA THR ILE MET 0.532468 0.697368
20 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.528571 0.784615
21 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.528455 0.796875
22 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.526316 0.725806
23 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.524476 0.901639
24 ALA GLN PHE SER ALA SER ALA SER ARG 0.516393 0.71875
25 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.510949 0.866667
26 ARG ARG PHE AIB ALA MET LEU ALA 0.507463 0.822581
27 SER GLU ILE GLU PHE ALA ARG LEU 0.507463 0.75
28 GLU ASN LEU TYR PHE GLN 0.504065 0.725806
29 GLY GLY ARG LYS LYS TYR LYS LEU 0.504 0.83871
30 GLY GLY LYS LYS LYS TYR ARG LEU 0.504 0.83871
31 GLY GLY LYS LYS ARG TYR LYS LEU 0.504 0.83871
32 MET ABA LEU ARG MET THR ALA VAL MET 0.503876 0.793651
33 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.5 0.753247
34 ARG GLY TYR LEU TYR GLN GLY LEU 0.5 0.9
35 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.496774 0.865672
36 LYS ALA VAL TYR ASN LEU ALA THR MET 0.496403 0.753846
37 LYS ALA VAL TYR ASN PHE ALA THR MET 0.496403 0.784615
38 SER SER ILE GLU PHE ALA ARG LEU 0.49635 0.738462
39 VAL ALA PHE ARG SER 0.495868 0.766667
40 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.493421 0.776119
41 VAL MET ALA PRO ARG THR LEU PHE LEU 0.493333 0.706667
42 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.492958 0.83871
43 ARG TYR GLY PHE VAL ALA ASN PHE 0.492754 0.84127
44 ALA VAL TYR ASN PHE ALA THR MET 0.492537 0.75
45 GLY ASN PHE LEU GLN SER ARG 0.492424 0.727273
46 MET CYS LEU ARG MET THR ALA VAL MET 0.492424 0.793651
47 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.489362 0.868852
48 THR TYR PHE ALA VAL LEU MET VAL SER 0.489209 0.774194
49 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.488722 0.714286
50 SER SER ARG LYS GLU TYR TYR ALA 0.487805 0.852459
51 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.487654 0.780822
52 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.485714 0.707692
53 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.485294 0.730159
54 ALA ARG THR GLU LEU TYR ARG SER LEU 0.485294 0.8
55 ARG PRO MET THR TYR LYS GLY ALA LEU 0.484277 0.736842
56 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.481752 0.734375
57 GLU LEU ASP LYS TYR ALA SER 0.48062 0.703125
58 LEU PRO PHE ASP ARG THR THR ILE MET 0.480519 0.688312
59 MET CYS LEU ARG NLE THR ALA VAL MET 0.477941 0.78125
60 GLU LEU LYS TPO GLU ARG TYR 0.47482 0.732394
61 PHE LEU GLU LYS 0.474138 0.65
62 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.473684 0.657143
63 THR PHE GLN ALA PSA LEU ARG GLU 0.472973 0.784615
64 ACE PHE LYS PHE TA2 ALA LEU ARG NH2 0.471831 0.769231
65 ARG PRO MET THR PHE LYS GLY ALA LEU 0.471698 0.697368
66 TYR GLY GLY PHE LEU 0.471074 0.737705
67 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.470588 0.736111
68 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.470199 0.662338
69 LEU GLU LYS ALA ARG GLY SER THR TYR 0.469799 0.776119
70 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.469512 0.736842
71 GLY LEU MET TRP LEU SER TYR PHE VAL 0.469388 0.714286
72 GLY ASN TYR SER PHE TYR ALA LEU 0.46875 0.681818
73 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.468085 0.825397
74 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.468085 0.662162
75 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.463087 0.638889
76 ARG HIS LYS ALY LEU MET PHE LYS 0.462585 0.761194
77 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.4625 0.675676
78 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.462121 0.730159
79 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.461538 0.868852
80 ASP ALA GLU PHE ARG HIS ASP SER 0.460432 0.686567
81 SER GLU LEU GLU ILE LYS ARG TYR 0.460432 0.787879
82 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.459016 0.645161
83 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.457746 0.793651
84 SER ARG TYR TRP ALA ILE ARG THR ARG 0.457516 0.746479
85 CYS VAL PHE MET 0.456897 0.694915
86 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.45679 0.706667
87 VAL PRO LEU ARG PRO MET THR TYR 0.453947 0.746667
88 PTR LEU ARG VAL ALA 0.453846 0.772727
89 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.453333 0.757143
90 ALA ARG THR MLY GLN THR ALA ARG TYR 0.453237 0.797101
91 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.452703 0.648649
92 TYR GLN PHE 0.451327 0.677966
93 GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA 0.451128 0.721311
94 MET LEU TRP GLY TYR LEU GLN TYR VAL 0.449664 0.787879
95 ARG GLY TYR VAL TYR GLN GLY LEU 0.449275 0.9
96 ARG ARG LEU ILE PHE NH2 0.448819 0.75
97 FME TYR PHE ILE ASN ILE LEU THR LEU 0.447552 0.753846
98 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.446043 0.730159
99 LYS ALA VAL PHE ASN PHE ALA THR MET 0.446043 0.738462
100 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.445946 0.701493
101 THR TYR LYS PHE PHE GLU GLN 0.445312 0.6875
102 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.445312 0.6875
103 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.445205 0.638889
104 MET ALA ARG 0.444444 0.810345
105 ARG ABA PHE ILE PHE ALA ASN ILE 0.441176 0.761905
106 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.440678 0.728814
107 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.440298 0.692308
108 ASP ALA ASP GLU TYR LEU 0.44 0.672131
109 ACE PHE ALA TYR M3L SER NH2 0.439394 0.710145
110 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.4375 0.648649
111 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.435714 0.680556
112 ACE ALC ARG MPQ MET ALA SER TBG NH2 0.435374 0.779412
113 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.434109 0.625
114 LYS MET ASN THR GLN PHE THR ALA VAL 0.433566 0.69697
115 TYR GLN SER LYS LEU 0.432 0.71875
116 ASP GLU LEU GLU ILE LYS ALA TYR 0.431655 0.698413
117 GLU ASN GLN LYS GLU TYR PHE PHE 0.430769 0.68254
118 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.430556 0.71875
119 ACE GLN LEU ALA LEU PHE 0.429752 0.616667
120 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.42953 0.710145
121 PHE GLU ALA ASN GLY ASN LEU ILE 0.428571 0.630769
122 LYS TYR LYS 0.427273 0.666667
123 ALA THR VAL ARG THR TYR SER CYS 0.426471 0.825397
124 GLY LEU TYR ALA SER LYS LEU ALA 0.426357 0.676923
125 MET LEU ILE TYR SER MET TRP GLY LYS 0.425926 0.69863
126 THR LYS CYS VAL PHE MET 0.424242 0.730159
127 ARG LEU TRP SER 0.423077 0.757576
128 ASN ARG LEU MET LEU THR GLY 0.423077 0.78125
129 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.422535 0.776119
130 ALA LYS PHE ARG HIS ASP 0.422222 0.676471
131 GLU GLN TYR LYS PHE TYR SER VAL 0.422222 0.723077
132 PHQ LEU VAL ARG TYR 0.421429 0.870968
133 BP4 CYS DAR TYR PEA 0.421429 0.806452
134 ARG ABA VAL ILE PHE ALA ASN ILE 0.421429 0.746032
135 ACE CSO ARG ALA THR LYS MET LEU 0.421429 0.694444
136 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.421384 0.788732
137 THR ASN LEU TYR MET LEU 0.421053 0.71875
138 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.420382 0.6
139 LYS ALA ARG VAL LEU ALA GLU ALA MET 0.419118 0.813559
140 ASP ALA GLU PHE ARG HIS ASP 0.419118 0.686567
141 LYS ALA ARG VAL LEU ALA GLU ALA MET SER 0.419118 0.813559
142 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.41844 0.73913
143 TYR HIS SEP VAL VAL ARG TYR ALA 0.418301 0.684211
144 THR ASN GLU PHE TYR PHE 0.418033 0.655738
145 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.417219 0.723077
146 GLY GLY LYS LYS LYS TYR LYS LEU 0.416 0.725806
147 LEU ALA ILE TYR SER 0.416 0.688525
148 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.415584 0.623377
149 ARG TYR PRO LEU THR PHE GLY TRP 0.412791 0.701299
150 GLN TYR PHE MET TPO GLU PTR VAL ALA 0.4125 0.732394
151 SER LEU TYR LEU THR VAL ALA THR LEU 0.412214 0.650794
152 GLY GLY LYS LYS LYS TYR GLN LEU 0.412214 0.741935
153 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.412121 0.675325
154 ASP ARG VAL TYR ILE HIS PRO PHE 0.411765 0.710526
155 ALA ALA LEU THR ARG ALA 0.41129 0.737705
156 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.410959 0.661538
157 ARG ARG ALA THR LYS MET NH2 0.410853 0.75
158 ALA TYR ARG 0.410256 0.827586
159 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.410256 0.767123
160 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.409396 0.628571
161 TYR LEU PHE VAL GLN ARG ASP SER LYS GLU 0.409091 0.655172
162 ARG ARG ALA ALA 0.409091 0.711864
163 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.408805 0.61039
164 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.408163 0.617647
165 THR PRO ASP TYR PHE LEU 0.407692 0.69697
166 VAL GLN GLN GLU SER SER PHE VAL MET 0.407407 0.703125
167 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.407143 0.714286
168 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.406667 0.727273
169 GLY ARG PHE GLN VAL THR 0.40625 0.733333
170 ARG GLY PHE ALA LEU M3L SER THR HIS GLY 0.406061 0.670886
171 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.406015 0.730159
172 DTY ILE ARG LEU LPD 0.405594 0.71831
173 TYR PRO LYS ARG ILE ALA 0.405405 0.708333
174 GLU THR VAL ARG PHE GLN SER ASP 0.405405 0.75
175 PRO LEU GLU PSA ARG LEU 0.405405 0.710145
176 ALA PTR ARG 0.404959 0.727273
177 THR ASN GLU PHE TYR ALA 0.40458 0.65625
178 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.403974 0.684932
179 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.403974 0.635135
180 ARG ASP ARG ALA ALA LYS LEU 0.403361 0.733333
181 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.402367 0.688312
182 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.402367 0.688312
183 GLN ARG ALA THR LYS MET NH2 0.401515 0.75
184 THR SER ARG HIS LYS ALY LEU MET ALA 0.401316 0.736111
185 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.401198 0.736111
186 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.4 0.643836
187 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.4 0.608696
Similar Binding Sites (Proteins are less than 50% similar to leader)
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