Receptor
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE TYR ARG ALA LEU MET P:1;
Valid;
none;
submit data
801.003 n/a S(CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PHE TYR ARG ALA LEU MET; Similar ligands found: 173
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE TYR ARG ALA LEU MET 1 1
2 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.716667 0.885246
3 PHE ARG TYR LEU GLY 0.675439 0.9
4 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.674419 0.885246
5 GLU LEU ARG ARG LYS MET MET TYR MET 0.658537 0.903226
6 PHE LEU ALA TYR LYS 0.640351 0.813559
7 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.614754 0.825397
8 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.606061 0.857143
9 GLU LEU LYS ARG LYS MET ILE TYR MET 0.6 0.903226
10 SER LEU ARG PHE LEU TYR GLU GLY 0.59375 0.84375
11 ARG VAL LEU PHE GLU ALA MET 0.592308 0.836066
12 SER ASP TYR GLN ARG LEU 0.575 0.866667
13 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.569444 0.830769
14 LYS ALA LEU TYR ASN PHE ALA THR MET 0.569343 0.8
15 GLU LEU ASN ARG LYS MET ILE TYR MET 0.5625 0.861538
16 PHE LEU SER TYR LYS 0.558333 0.761905
17 TYR GLY GLY PHE MET 0.533333 0.803279
18 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.531034 0.901639
19 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.527559 0.796875
20 ASP ALA GLU PHE ARG HIS ASP 0.52381 0.75
21 ALA GLN PHE SER ALA SER ALA SER ARG 0.52 0.71875
22 SER GLU ILE GLU PHE ALA ARG LEU 0.514706 0.75
23 LEU PRO PHE GLU ARG ALA THR VAL MET 0.512821 0.706667
24 LEU PRO PHE GLU ARG ALA THR ILE MET 0.506329 0.697368
25 ARG GLY TYR LEU TYR GLN GLY LEU 0.503759 0.9
26 ARG ARG PHE AIB ALA MET LEU ALA 0.50365 0.822581
27 SER SER ILE GLU PHE ALA ARG LEU 0.503597 0.738462
28 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.5 0.75
29 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.5 0.725806
30 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.496855 0.865672
31 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.496454 0.866667
32 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.493671 0.753247
33 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.493421 0.736111
34 ALA ARG THR GLU LEU TYR ARG SER LEU 0.492754 0.8
35 GLY ASN PHE LEU GLN SER ARG 0.492537 0.727273
36 GLY GLY LYS LYS ARG TYR LYS LEU 0.492308 0.83871
37 GLY GLY LYS LYS LYS TYR ARG LEU 0.492308 0.83871
38 GLY GLY ARG LYS LYS TYR LYS LEU 0.492308 0.83871
39 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.490909 0.780822
40 VAL MET ALA PRO ARG THR LEU PHE LEU 0.490196 0.706667
41 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.489655 0.83871
42 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.489655 0.868852
43 ARG TYR GLY PHE VAL ALA ASN PHE 0.489362 0.84127
44 ALA VAL TYR ASN PHE ALA THR MET 0.488889 0.75
45 GLU ASN LEU TYR PHE GLN 0.488189 0.725806
46 VAL ALA PHE ARG SER 0.487805 0.766667
47 THR TYR PHE ALA VAL LEU MET VAL SER 0.485714 0.790323
48 SER SER ARG LYS GLU TYR TYR ALA 0.484375 0.852459
49 ACE PHE LYS PHE TA2 ALA LEU ARG NH2 0.482269 0.769231
50 MET ABA LEU ARG MET THR ALA VAL MET 0.481481 0.793651
51 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.480769 0.726027
52 ILE GLY PRO GLY ARG ALA PHE TYR VAL 0.480769 0.75
53 THR PHE GLN ALA PSA LEU ARG GLU 0.48 0.784615
54 LYS ALA VAL TYR ASN PHE ALA THR MET 0.479167 0.8
55 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.478571 0.734375
56 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.477419 0.776119
57 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.475862 0.868852
58 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.475524 0.825397
59 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.47482 0.746032
60 LEU GLU LYS ALA ARG GLY SER THR TYR 0.473684 0.776119
61 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.472973 0.815385
62 LYS ALA VAL TYR ASN LEU ALA THR MET 0.472222 0.769231
63 MET CYS LEU ARG MET THR ALA VAL MET 0.471014 0.793651
64 GLU LEU LYS TPO GLU ARG TYR 0.468966 0.732394
65 ASP ALA GLU PHE ARG HIS ASP SER 0.468085 0.686567
66 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.467153 0.714286
67 ARG PRO MET THR TYR LYS GLY ALA LEU 0.466667 0.736842
68 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.466216 0.701493
69 SER GLU LEU GLU ILE LYS ARG TYR 0.464789 0.787879
70 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.463415 0.675676
71 TYR GLY GLY PHE LEU 0.463415 0.754098
72 LEU PRO PHE ASP ARG THR THR ILE MET 0.462025 0.688312
73 SER ARG TYR TRP ALA ILE ARG THR ARG 0.461538 0.746479
74 MET CYS LEU ARG NLE THR ALA VAL MET 0.460993 0.78125
75 ARG PRO MET THR PHE LYS GLY ALA LEU 0.460606 0.697368
76 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.460123 0.706667
77 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.459459 0.710145
78 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.458333 0.707692
79 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.457516 0.662338
80 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.456954 0.757143
81 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.456954 0.652778
82 ARG ARG LEU ILE PHE NH2 0.456693 0.75
83 GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA 0.455224 0.737705
84 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.455172 0.653333
85 PTR LEU ARG VAL ALA 0.454545 0.772727
86 ALA ARG THR MLY GLN THR ALA ARG TYR 0.453901 0.797101
87 GLY ASN TYR SER PHE TYR ALA LEU 0.453846 0.681818
88 ACE PHE ALA TYR M3L SER NH2 0.453125 0.714286
89 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.452941 0.736842
90 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.452055 0.793651
91 GLU LEU ASP LYS TYR ALA SER 0.451852 0.71875
92 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.450331 0.648649
93 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.450331 0.723077
94 ARG HIS LYS ALY LEU MET PHE LYS 0.450331 0.761194
95 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.449275 0.730159
96 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.448819 0.745763
97 PHQ LEU VAL ARG TYR 0.448529 0.870968
98 ALA PHE ARG ILE PRO LEU THR ARG 0.447368 0.644737
99 CYS VAL PHE MET 0.445378 0.711864
100 VAL PRO LEU ARG PRO MET THR TYR 0.445161 0.746667
101 ARG GLY TYR VAL TYR GLN GLY LEU 0.443662 0.9
102 ASN ARG LEU MET LEU THR GLY 0.44186 0.78125
103 FME TYR PHE ILE ASN ILE LEU THR LEU 0.441379 0.753846
104 ASP ALA ASP GLU TYR LEU 0.440945 0.688525
105 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.440945 0.651515
106 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.438272 0.685714
107 ALA THR VAL ARG THR TYR SER CYS 0.437956 0.825397
108 MET ALA ARG 0.4375 0.810345
109 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.435115 0.703125
110 THR TYR LYS PHE PHE GLU GLN 0.435115 0.703125
111 TYR GLN PHE 0.434783 0.677966
112 THR ASN GLU PHE TYR PHE 0.434426 0.645161
113 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.433566 0.680556
114 GLU ASN GLN LYS GLU TYR PHE PHE 0.431818 0.6875
115 ASP GLU LEU GLU ILE LYS ALA TYR 0.429577 0.730159
116 GLY LEU MET TRP LEU SER TYR PHE VAL 0.427632 0.728571
117 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.427536 0.707692
118 PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU 0.426035 0.662162
119 ACE CSO ARG ALA THR LYS MET LEU 0.425532 0.694444
120 ARG THR PHE SER PRO THR TYR GLY LEU 0.425 0.710526
121 ACE GLN LEU ALA LEU PHE 0.425 0.616667
122 LYS ALA ARG VAL LEU ALA GLU ALA MET 0.42446 0.813559
123 LYS ALA ARG VAL LEU ALA GLU ALA MET SER 0.42446 0.813559
124 LYS ALA VAL PHE ASN PHE ALA THR MET 0.423611 0.753846
125 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.423313 0.788732
126 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.423313 0.648649
127 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.421769 0.647059
128 ALA LYS PHE ARG HIS ASP 0.421429 0.676471
129 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.421053 0.652778
130 ACE ALA ARG THR GLU VAL TYR NH2 0.42029 0.822581
131 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.41958 0.776119
132 ARG ABA PHE ILE PHE ALA ASN ILE 0.41844 0.761905
133 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.417722 0.767123
134 ALA ALA LEU THR ARG ALA 0.416 0.737705
135 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.415493 0.730159
136 PHE GLU ALA ASN GLY ASN LEU ILE 0.415493 0.630769
137 THR LYS CYS VAL PHE MET 0.414815 0.746032
138 ALA PTR ARG 0.414634 0.727273
139 TYR GLN SER LYS LEU 0.414062 0.71875
140 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.413333 0.657143
141 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.412903 0.657534
142 TYR HIS SEP VAL VAL ARG TYR ALA 0.412903 0.684211
143 LEU ALA ILE TYR SER 0.412698 0.704918
144 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.410714 0.675325
145 MET LEU TRP GLY TYR LEU GLN TYR VAL 0.410256 0.787879
146 ARG ABA VAL ILE PHE ALA ASN ILE 0.409722 0.746032
147 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.409091 0.625
148 ILE SER TYR GLY ASN ASP ALA LEU MET PRO 0.408537 0.641026
149 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.407643 0.623377
150 ARG GLY PHE ALA LEU M3L SER THR HIS GLY 0.407186 0.670886
151 BP4 CYS DAR TYR PEA 0.407143 0.806452
152 ARG ARG ALA ALA 0.40708 0.711864
153 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.406977 0.688312
154 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.40625 0.613333
155 DTY ILE ARG LEU LPD 0.405594 0.71831
156 GLU THR VAL ARG PHE GLN SER ASP 0.405405 0.761905
157 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.405405 0.661538
158 GLN TYR PHE MET TPO GLU PTR VAL ALA 0.404908 0.732394
159 ARG LEU TRP SER 0.404412 0.757576
160 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.40411 0.71875
161 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.403974 0.727273
162 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.403509 0.679487
163 ASP PHE GLU ASP TYR GLU PHE ASP 0.403101 0.693548
164 ACE ARG ARG LEU ASN FCL NH2 0.402985 0.676471
165 ARG ARG ALA THR LYS MET NH2 0.402985 0.75
166 GLY LEU TYR ALA SER LYS LEU ALA 0.402985 0.692308
167 ACE GLN ALA ASP LEU PHE 0.401575 0.606557
168 THR ASN GLU PHE TYR ALA 0.401515 0.65625
169 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.40146 0.730159
170 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.401361 0.73913
171 SER LEU TYR LEU THR VAL ALA THR LEU 0.4 0.666667
172 MET LEU ILE TYR SER MET TRP GLY LYS 0.4 0.712329
173 GLU ALA GLN THR ARG LEU 0.4 0.741935
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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