Receptor
PDB id Resolution Class Description Source Keywords
1HPG 1.5 Å EC: 3.4.21.82 A GLUTAMIC ACID SPECIFIC SERINE PROTEASE UTILIZES A NOVEL HI TRIAD IN SUBSTRATE BINDING STREPTOMYCES GRISEUS SERINE PROTEASE HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: A GLUTAMIC ACID SPECIFIC SERINE PROTEASE UTILIZES A HISTIDINE TRIAD IN SUBSTRATE BINDING. BIOCHEMISTRY V. 32 11469 1993
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BOC ALA ALA PRO GLU B:300;
Valid;
none;
submit data
484.506 n/a O=C(O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1HPG 1.5 Å EC: 3.4.21.82 A GLUTAMIC ACID SPECIFIC SERINE PROTEASE UTILIZES A NOVEL HI TRIAD IN SUBSTRATE BINDING STREPTOMYCES GRISEUS SERINE PROTEASE HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: A GLUTAMIC ACID SPECIFIC SERINE PROTEASE UTILIZES A HISTIDINE TRIAD IN SUBSTRATE BINDING. BIOCHEMISTRY V. 32 11469 1993
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1HPG - BOC ALA ALA PRO GLU n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1HPG - BOC ALA ALA PRO GLU n/a n/a
2 5SGA - ACE PRO ALA PRO TYR n/a n/a
3 4SGA Ki = 50 nM ACE PRO ALA PRO PHE n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1HPG - BOC ALA ALA PRO GLU n/a n/a
2 5SGA - ACE PRO ALA PRO TYR n/a n/a
3 4SGA Ki = 50 nM ACE PRO ALA PRO PHE n/a n/a
4 2OUA - AES C8 H10 F N O2 S c1cc(ccc1C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: BOC ALA ALA PRO GLU; Similar ligands found: 17
No: Ligand ECFP6 Tc MDL keys Tc
1 BOC ALA ALA PRO GLU 1 1
2 BOC ALA ALA PRO PVA 0.630952 0.825397
3 BOC ALA ALA PRO PVA LAC ALA 0.610526 0.84127
4 PRO GLU ALA THR ALA PRO PRO GLU GLU 0.449153 0.769231
5 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.429752 0.769231
6 SIN ALA ALA PRO LYS 0.428571 0.779661
7 ACE ALA PRO ALA 0.428571 0.803571
8 LYS PRO LYS 0.423913 0.745763
9 ACE GLU VAL ASN ALA PRO VAL LPD 0.419643 0.793651
10 ALA VAL PRO ILE ALA GLN 0.416667 0.830508
11 ILE PRO LEU THR GLU GLU ALA GLU LEU 0.411765 0.78125
12 VAL PRO LEU 0.409091 0.810345
13 ACE PRO ALA PRO TYR 0.407767 0.738462
14 ACE PRO ILE GLN GLU GLU 0.403846 0.803279
15 SER GLU CYS THR THR PRO CYS 0.403509 0.753846
16 ACE PRO ALA PRO PHE 0.401961 0.758065
17 VAL PRO LEU THR GLU ASP ALA GLU LEU 0.401639 0.793651
Similar Ligands (3D)
Ligand no: 1; Ligand: BOC ALA ALA PRO GLU; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1HPG; Ligand: BOC ALA ALA PRO GLU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1hpg.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback