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Receptor
PDB id Resolution Class Description Source Keywords
1GPJ 1.95 Å EC: 1.2.1.- GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI METHANOPYRUS KANDLERI REDUCTASE TRNA-DEPENDENT TETRAPYRROLE BIOSYNTHESIS GLUTAMYREDUCTASE
Ref.: V-SHAPED STRUCTURE OF GLUTAMYL-TRNA REDUCTASE, THE ENZYME OF TRNA-DEPENDENT TETRAPYRROLE BIOSYNTHESIS. EMBO J. V. 20 6583 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CIT A:1407;
Valid;
none;
submit data
192.124 C6 H8 O7 C(C(=...
GLU GMC A:1406;
Valid;
none;
submit data n/a n/a n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1GPJ 1.95 Å EC: 1.2.1.- GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI METHANOPYRUS KANDLERI REDUCTASE TRNA-DEPENDENT TETRAPYRROLE BIOSYNTHESIS GLUTAMYREDUCTASE
Ref.: V-SHAPED STRUCTURE OF GLUTAMYL-TRNA REDUCTASE, THE ENZYME OF TRNA-DEPENDENT TETRAPYRROLE BIOSYNTHESIS. EMBO J. V. 20 6583 2001
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 1GPJ - GLU GMC n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1GPJ - GLU GMC n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1GPJ - GLU GMC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: CIT; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 CIT 1 1
2 7QD 0.653846 0.958333
3 HCA 0.576923 0.884615
4 MAH 0.44 0.807692
Ligand no: 2; Ligand: GLU GMC; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1GPJ; Ligand: CIT; Similar sites found with APoc: 317
This union binding pocket(no: 1) in the query (biounit: 1gpj.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 5VKI THR NGA GAL NAG None
2 3WSJ MK1 None
3 5O2N FLC 1.23762
4 1WD4 AHR 1.48515
5 3PFD FDA 1.52672
6 6FC1 MGP 1.5544
7 3LXN MI1 1.57233
8 2A9D MTE 1.6129
9 1SOX MTE 1.71674
10 5BSR AMP 1.73267
11 5GQX GLC GLC GLC GLC 1.73267
12 3ETG NDP 1.73267
13 3ETG GLU 1.73267
14 4B7X NAP 1.78571
15 1BXK NAD 1.97183
16 2D4V NAD 1.9802
17 4I4B NAD 1.9802
18 4I4B 1CV 1.9802
19 3SSO SAH 1.9802
20 2PQB GG9 1.9802
21 4XAQ 40F 1.9802
22 1GZ4 ATP 1.9802
23 2X06 NAD 2.03488
24 5EYY MDM 2.04082
25 1EJH M7G 2.10526
26 3VPB ADP 2.12766
27 3ZM6 2GN 2.22772
28 3V8S 0HD 2.22772
29 1GA8 UPF 2.2508
30 1GA8 DEL 2.2508
31 2YGM GLA NAG GAL FUC 2.25989
32 3C0G 3AM 2.2792
33 2AKO ADP 2.39044
34 4F06 PHB 2.42588
35 4B5W PYR 2.47525
36 4UP4 GAL NAG 2.49377
37 1RV0 NDG 2.5
38 2J9C ATP 2.52101
39 3KO8 NAD 2.5641
40 1R6D DAU 2.67062
41 1R6D NAD 2.67062
42 1EWK GLU 2.72277
43 1RF6 GPJ 2.72277
44 1RF6 S3P 2.72277
45 3FV3 IVA VAL VAL STA ALA STA 2.72277
46 2IHK CSF 2.75689
47 1SB8 UD2 2.84091
48 1SB8 NAD 2.84091
49 4IQY AR6 2.91667
50 5X2N ALA 2.92887
51 5ZUN 9JX 2.95082
52 4MS4 2C0 2.9703
53 1JG3 ADN 2.97872
54 1M3U KPL 3.0303
55 2PA4 UPG 3.09598
56 1O7Q UDP 3.11419
57 1V84 UDP 3.16206
58 3JUK UPG 3.20285
59 5Z6T NAP 3.207
60 1EM6 NBG 3.21782
61 2BD0 NAP 3.27869
62 2J0V GDP 3.30189
63 3B8X G4M 3.33333
64 1T57 FMN 3.39806
65 3U2U UDP 3.42205
66 2CXG GLC G6D ACI GLC 3.46535
67 5UQK U2F 3.46535
68 5UCD NAP 3.46535
69 1V59 NAD 3.46535
70 5ZZO FLC 3.48259
71 3CH6 NAP 3.4965
72 3CH6 311 3.4965
73 1KOL NAD 3.51759
74 3TKY SAH 3.53261
75 4YNM SAM 3.53982
76 2TCL RO4 3.5503
77 4WOP CTP 3.55556
78 3VYW SAM 3.57143
79 2V2V V12 3.69004
80 1YNH SUO 3.71287
81 2WOX NDP 3.71287
82 2YVJ NAI 3.71287
83 2WME NAP 3.71287
84 1BC5 SAH 3.71747
85 2BME GNP 3.76344
86 1GSA GSH 3.79747
87 1DUB CAA 3.83142
88 4D81 ADP 3.88693
89 2DX7 CIT 3.94737
90 4A59 AMP 3.9604
91 6BWL NAD 3.96341
92 3C1M ANP 4.01691
93 1XSE NDP 4.0678
94 2FLI DX5 4.09091
95 5WA0 MSS 4.10959
96 4NTD FAD 4.11765
97 3LU1 NAD 4.12088
98 1ZEM NAD 4.19847
99 1HYH NAD 4.20712
100 6F3M NAD 4.20792
101 4NON GDP 4.23077
102 3EKK GS2 4.23453
103 5Y6Q FAD 4.32099
104 2FH5 GTP 4.32432
105 1GWN GTP 4.39024
106 5CK5 GDP 4.43038
107 3H8V ATP 4.45205
108 3IP6 PRO 4.45545
109 1PJS NAD 4.45545
110 4QMN DB8 4.51613
111 3B1Q NOS 4.60123
112 4DID GDP 4.66321
113 4LGY ADP 4.70297
114 4I8P NAD 4.70297
115 4A0S NAP 4.70297
116 5XFV FMN 4.70297
117 4GIM PSU 4.77612
118 1O3Y GTP 4.81928
119 1DJL NAP 4.83092
120 2F5Z FAD 4.85232
121 3RFV 15L 4.86891
122 1G4U GDP 4.8913
123 5UWQ GNP 4.8951
124 1Y8Q ATP 4.91329
125 4A0M NAD 4.9505
126 2GCO GNP 4.97512
127 4POO SAM 5
128 6BSW CE6 5.02959
129 1GY8 NAD 5.03778
130 4BMO FMN 5.04202
131 5GM1 SAH 5.05051
132 4ZAH T5K 5.05051
133 3VZS NAP 5.05837
134 3VZS CAA 5.05837
135 5G1N PAL 5.09554
136 5HRA DAS 5.10638
137 1HE1 GDP 5.11364
138 4E1Z 0MX 5.15464
139 3UA1 08Y 5.19802
140 3FSY SCA 5.19802
141 4Z4P SAH 5.19802
142 5GUD NDP 5.19802
143 1SC6 NAD 5.19802
144 2QV6 GTP 5.22388
145 3K1X DBX 5.38462
146 5HPY GDP 5.40541
147 4D0N GDP 5.40541
148 4Y30 SAH 5.41311
149 4Y30 49L 5.41311
150 3FSM 2NC 5.41872
151 1MXH NAP 5.43478
152 1MXH DHF 5.43478
153 1D4O NAP 5.43478
154 6BQ6 TER 5.43807
155 1UAY ADN 5.44554
156 1GQ2 NAP 5.44554
157 1USI PHE 5.49133
158 4XOI GTP 5.55556
159 3ZOK NAD 5.55556
160 2W2X GSP 5.69307
161 5WDR GNP 5.84795
162 5JCJ NAP 5.90278
163 3JQ8 NAP 5.90278
164 5JDI NAP 5.90278
165 3JQ9 NAP 5.90278
166 5JDC NAP 5.90278
167 3JQA NAP 5.90278
168 3BMN NAP 5.90278
169 5K6A NAP 5.90278
170 4Q5M ROC 5.91133
171 1RYH GNP 5.91133
172 1IK4 PGH 5.92105
173 4PNE SAH 5.96026
174 2V1O COA 5.96026
175 5D4V SAH 5.97015
176 2DM6 NAP 6.00601
177 2DM6 IMN 6.00601
178 5T2Z 017 6.06061
179 6FSG FMN 6.12245
180 5TWJ SAM 6.17284
181 3DCM SAM 6.25
182 2D5A COA 6.25
183 4FN4 NAD 6.29921
184 2WD7 NAP 6.34328
185 5Z2M GTP 6.52174
186 3DDC GNP 6.62651
187 2PHR MAN MAN BMA MAN 6.74603
188 2PHF MAN MAN BMA MAN 6.74603
189 2PHU MAN MAN MAN BMA MAN 6.74603
190 1Q8V MAN MAN MAN 6.74603
191 2AUY NAG MAN MMA 6.74603
192 2GND MAN MMA 6.74603
193 2CJW GDP 6.77083
194 6EL3 NAP 6.82415
195 1BDB NAD 6.85921
196 2BVL UDP 6.93069
197 2BVL GLC 6.93069
198 6GAS FAD 6.93069
199 5AVF TAU 7.00389
200 3FGC FMN 7.04225
201 1KMQ GNP 7.06522
202 2QQD AG2 7.14286
203 1N62 FAD 7.22892
204 1N62 MCN 7.22892
205 1ZVX FIN 7.36196
206 4BQS ADP 7.38636
207 4BQS K2Q 7.38636
208 5KUT GDP 7.40741
209 4ITR GDP 7.42574
210 4WNP 3RJ 7.42574
211 1OW3 GDP 7.43802
212 1RM6 PCD 7.45342
213 5MGZ SAH 7.62712
214 2ZB3 NDP 7.64873
215 4ARU TLA 7.67327
216 1XPK HMG 7.67327
217 2NGR GDP 7.69231
218 1LO8 4CA 7.80142
219 2ZB4 NAP 7.84314
220 2ZB4 5OP 7.84314
221 3WYG GTP 7.89474
222 1TT8 PHB 7.92683
223 1EP2 ORO 8.04598
224 1SIV PSI 8.08081
225 1UP7 NAD 8.16832
226 3TNF GNP 8.16832
227 3WV1 WHH 8.18713
228 6BCB GSP 8.21918
229 2RDT 2RD 8.41584
230 4RVU NDP 8.43373
231 4PW9 MSS 8.49057
232 2WSB NAD 8.66142
233 4ZI2 GNP 8.66337
234 4WZV E40 8.75
235 4K81 GTP 8.77193
236 4IV9 FAD 8.91089
237 6BVI GNP 8.91089
238 6BVL GNP 8.91089
239 6D5G GNP 8.91089
240 6BVM GNP 8.91089
241 6D5J GNP 8.91089
242 6BVJ GNP 8.91089
243 6D5H GNP 8.91089
244 6BVK GNP 8.91089
245 6D56 GNP 8.91089
246 6D59 GNP 8.91089
247 6D5V GNP 8.91089
248 6D5M GNP 8.91089
249 6D5L GNP 8.91089
250 6D5E GNP 8.91089
251 6D55 GNP 8.91089
252 1NVV GNP 8.91089
253 1FK8 NAD 8.94942
254 4Y1B NAP 9.15842
255 2PQ9 GG9 9.15842
256 3SLS 77D 9.21053
257 1VG8 GNP 9.40594
258 1BAI 0Q4 9.67742
259 1Z08 GNP 10
260 2AZC 3TL 10.101
261 3NWQ 2NC 10.101
262 1TU3 GNP 10.1266
263 5YJI 8WO 10.2113
264 5YJI SAH 10.2113
265 1B1C FMN 10.4972
266 6BCA GSP 10.596
267 4UXL 5P8 10.8696
268 4USI ATP 11.039
269 3MWS 017 11.1111
270 4P5E N6P 11.1842
271 3OVR 5SP 11.4035
272 4H2D FMN 11.5152
273 3KAP FMN 11.5646
274 4I4Z 2NE 11.6364
275 4XYM A12 11.7391
276 4G86 BNT 11.9718
277 4HDO GNP 11.976
278 3X1Z GNP 11.976
279 4M8X KGQ 12.1212
280 2P3B 3TL 12.1212
281 4YHQ G10 12.1212
282 2FXD DR7 12.1212
283 3DEF GDP 12.5954
284 1LDN NAD 12.6582
285 3U7S 017 13.1313
286 6C8X BVR 13.1313
287 1GUA GNP 13.1737
288 1OVD ORO 13.1833
289 1OVD FMN 13.1833
290 5O98 NAP 13.2492
291 3AIA SAM 13.2701
292 3MAX LLX 13.3515
293 4GA6 AMP 14.1089
294 3RKR NAP 14.1221
295 5O2T GSP 14.4385
296 1H65 GDP 14.4444
297 1YZN GNP 14.5946
298 1DR1 HBI 14.8148
299 1DR1 NAP 14.8148
300 4PZ2 NAD 14.8515
301 3IQE F42 15.1943
302 3IQE H4M 15.1943
303 3AY6 NAI 15.6134
304 4CQM NAP 15.9836
305 2VL8 CTS 16.0891
306 2VL8 UDP 16.0891
307 5XKT GNP 16.5
308 1UXG FUM 17.1521
309 1UXG NAD 17.1521
310 1VLH PNS 17.9191
311 4II2 ATP 19.2771
312 4HI0 GDP 20.4724
313 2HMT NAI 21.5278
314 2W83 GTP 22.0779
315 4RDH AMP 25.6944
316 3S43 478 32.3232
317 4NJS G08 32.3232
Pocket No.: 2; Query (leader) PDB : 1GPJ; Ligand: CIT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1gpj.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
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