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Receptor
PDB id Resolution Class Description Source Keywords
1FQK 2.3 Å EC: 3.-.-.- CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DO RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALP( ALF4-)-(MG2+)] BOS TAURUS, RATTUS NORVEGICUS RGS9 TRANSDUCIN G PROTEIN PHOTOTRANSDUCTION ROD RGS GASIGNALING PROTEIN
Ref.: STRUCTURAL DETERMINANTS FOR REGULATION OF PHOSPHODI BY A G PROTEIN AT 2.0 A. NATURE V. 409 1071 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALF A:362;
C:363;
Valid;
Valid;
none;
none;
submit data
102.975 Al F4 F[Al-...
GDP A:360;
C:361;
Valid;
Valid;
none;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
MG A:352;
C:352;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1FQK 2.3 Å EC: 3.-.-.- CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DO RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALP( ALF4-)-(MG2+)] BOS TAURUS, RATTUS NORVEGICUS RGS9 TRANSDUCIN G PROTEIN PHOTOTRANSDUCTION ROD RGS GASIGNALING PROTEIN
Ref.: STRUCTURAL DETERMINANTS FOR REGULATION OF PHOSPHODI BY A G PROTEIN AT 2.0 A. NATURE V. 409 1071 2001
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 1FQK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1FQK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 1FQK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 2ODE - ALF GDP n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALF; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ALF 1 1
Ligand no: 2; Ligand: GDP; Similar ligands found: 161
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 9GM 0.839506 0.973684
6 GNP 0.839506 0.973684
7 G 0.828947 0.986486
8 5GP 0.828947 0.986486
9 G1R 0.82716 0.986667
10 GCP 0.82716 0.973684
11 GSP 0.817073 0.948718
12 GAV 0.797619 0.961039
13 GMV 0.792683 0.973684
14 G2P 0.77381 0.961039
15 G2R 0.770115 0.961039
16 GP2 0.756098 0.961039
17 GDC 0.747253 0.961039
18 GKE 0.747253 0.961039
19 GDD 0.747253 0.961039
20 GPG 0.741573 0.961039
21 G3D 0.732558 0.986486
22 ALF 5GP 0.729412 0.888889
23 Y9Z 0.728261 0.902439
24 G5P 0.723404 0.973684
25 GFB 0.72043 0.961039
26 GTG 0.72043 0.936709
27 GDR 0.72043 0.961039
28 G4P 0.715909 0.986486
29 G3A 0.712766 0.973684
30 6CK 0.712766 0.936709
31 GDP AF3 0.7 0.888889
32 ALF GDP 0.7 0.888889
33 GDP ALF 0.7 0.888889
34 YGP 0.698925 0.901235
35 GKD 0.697917 0.961039
36 JB2 0.697917 0.961039
37 GDX 0.690722 0.973684
38 GPD 0.690722 0.925
39 GMP 0.684211 0.88
40 0O2 0.666667 0.986486
41 JB3 0.656863 0.948718
42 NGD 0.650485 0.961039
43 DGI 0.636364 0.923077
44 GDP 7MG 0.636364 0.911392
45 U2G 0.634615 0.936709
46 GPX 0.634409 0.946667
47 G G 0.632653 0.948052
48 IDP 0.632184 0.972973
49 2MD 0.632075 0.891566
50 CAG 0.62963 0.880952
51 CG2 0.622642 0.936709
52 FEG 0.619048 0.879518
53 MGD 0.614679 0.891566
54 ZGP 0.613208 0.869048
55 GH3 0.612903 0.973333
56 3GP 0.611765 0.946667
57 MD1 0.607143 0.891566
58 PGD 0.59292 0.925
59 DGT 0.591398 0.923077
60 BGO 0.588785 0.924051
61 TPG 0.582609 0.840909
62 DBG 0.582609 0.948718
63 2GP 0.574713 0.96
64 FE9 0.570175 0.776596
65 GCP G 0.56 0.921053
66 A G 0.553571 0.935065
67 G A A A 0.553571 0.923077
68 MGP 0.553191 0.961039
69 U A G G 0.548673 0.935065
70 G4M 0.548387 0.880952
71 6G0 0.547368 0.961039
72 G1R G1R 0.542373 0.924051
73 P2G 0.527473 0.883117
74 PGD O 0.525 0.850575
75 ADP 0.522222 0.92
76 R5I 0.520833 0.946667
77 R7I 0.520833 0.946667
78 GGM 0.517544 0.901235
79 DGP 0.516484 0.910256
80 DG 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G U 0.513274 0.9
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 AKW 0.504425 0.890244
86 G C 0.504348 0.9
87 GPC 0.491525 0.879518
88 G7M 0.483871 0.948052
89 6AD 0.479592 0.841463
90 ATP 0.473684 0.92
91 HEJ 0.473684 0.92
92 G2Q 0.471154 0.961039
93 5FA 0.46875 0.92
94 AQP 0.46875 0.92
95 GTA 0.468468 0.936709
96 7DD 0.468085 0.906667
97 G G G RPC 0.466102 0.875
98 SGP 0.463158 0.82716
99 01G 0.462963 0.902439
100 HFD 0.459184 0.873418
101 B4P 0.457447 0.894737
102 AP5 0.457447 0.894737
103 A2D 0.456522 0.894737
104 6YZ 0.455446 0.896104
105 G G G C 0.455285 0.9125
106 5GP 5GP 0.454545 0.883117
107 ANP 0.454545 0.896104
108 ACQ 0.454545 0.896104
109 AT4 0.452632 0.884615
110 A G C C 0.451613 0.911392
111 APC G U 0.45082 0.886076
112 PRT 0.449541 0.959459
113 G U34 0.449153 0.888889
114 DG DG 0.448598 0.865854
115 ITT 0.447917 0.868421
116 BA3 0.446809 0.894737
117 C2E 0.444444 0.921053
118 PCG 0.444444 0.933333
119 35G 0.444444 0.933333
120 MGO 0.441176 0.864198
121 AN2 0.4375 0.907895
122 G C C C 0.4375 0.924051
123 M33 0.43299 0.883117
124 UCG 0.429688 0.911392
125 A G U 0.42963 0.888889
126 ACP 0.428571 0.896104
127 MGQ 0.424528 0.935897
128 AR6 0.424242 0.894737
129 7DT 0.424242 0.906667
130 APR 0.424242 0.894737
131 93A 0.42268 0.833333
132 A4P 0.420168 0.869048
133 G8D 0.42 0.875
134 AD9 0.42 0.896104
135 SAP 0.42 0.873418
136 AGS 0.42 0.873418
137 CA0 0.418367 0.896104
138 ATF 0.417476 0.884615
139 AGO 0.414634 0.888889
140 A G U U 0.414286 0.888889
141 NIA 0.413043 0.82716
142 MGV 0.412844 0.890244
143 TAT 0.411765 0.884615
144 T99 0.411765 0.884615
145 ADQ 0.411215 0.871795
146 A1R 0.411215 0.839506
147 RGT 0.410714 0.909091
148 CGP 0.409836 0.86747
149 C1Z 0.409091 0.986486
150 A 0.408602 0.893333
151 AMP 0.408602 0.893333
152 UP5 0.40678 0.873418
153 AMZ 0.406593 0.918919
154 C2R 0.406593 0.906667
155 JBT 0.405882 0.778947
156 A22 0.40566 0.907895
157 25L 0.405405 0.907895
158 ADX 0.40404 0.809524
159 8OD 0.401961 0.946667
160 50T 0.4 0.883117
161 4TC 0.4 0.851852
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1FQK; Ligand: GDP; Similar sites found with APoc: 614
This union binding pocket(no: 1) in the query (biounit: 1fqk.bio2) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 2CBZ ATP 1.68776
2 1SVM ATP 2.04082
3 4IOK XPO 2.15385
4 4IOK ADP 2.15385
5 1X1R GDP 2.24719
6 1F76 ORO 2.46154
7 2OBM ADP 2.46154
8 2GNK ATP 2.67857
9 2QQ0 ANP 2.71739
10 2QQ0 ADP 2.71739
11 2QQ0 TMP 2.71739
12 2QQ0 THM 2.71739
13 1Z2A GDP 2.72109
14 2GK6 ADP 2.72109
15 3DZD ADP 2.76923
16 4FRZ ADP 2.76923
17 1G41 ADP 3.07692
18 1OFH ADP 3.22581
19 2PEZ DAT 3.35196
20 2PEZ GGZ 3.35196
21 2W58 ADP 3.40136
22 5KSZ GCP 3.40136
23 5AHM IMP 3.40136
24 1VHT BA3 3.66972
25 2XT3 ADP 3.69231
26 2OFW ADX 3.84615
27 4NCN GTP 4
28 4TMZ GSP 4
29 3E70 GDP 4
30 1QF5 GDP 4
31 1QF5 RPL 4
32 3P4X ADP 4
33 1KK1 GNP 4.08163
34 5XKT GNP 4.08163
35 4B47 GDP 4.08163
36 5KSP GDP 4.08163
37 4H1V GNP 4.08163
38 4IEE AGS 4.08163
39 2BEK ATP 4.08163
40 1Z6T ADP 4.08163
41 4Q1A UDP 4.08163
42 4Q1A 2XZ 4.08163
43 1DKU AP2 4.08163
44 5FJJ MAN 4.08163
45 1F5N GNP 4.08163
46 5M7P ADP 4.08163
47 2VOH CIT 4.08163
48 2Q8M AMP 4.08163
49 5ZXD ATP 4.08163
50 4HE2 AMP 4.08163
51 3LRE ADP 4.08163
52 4WZ6 ATP 4.08163
53 3B5J 12D 4.11523
54 2WIC GNP 4.11985
55 3BOS CDP 4.13223
56 1JXN MFU 4.13223
57 2XUA SHF 4.13534
58 2IYL GDP 4.22535
59 4NON GDP 4.23077
60 1G6H ADP 4.28016
61 2V2G BEZ 4.29185
62 1RJ9 GCP 4.33333
63 1GXU 2HP 4.3956
64 1S3G AP5 4.60829
65 5H68 AGS 4.61538
66 3T34 GDP 4.7619
67 2CE7 ADP 4.7619
68 4LYA ATP 4.7619
69 3FWY ADP 4.7619
70 3ZFD ANP 4.7619
71 1P9B GDP 4.7619
72 3DKP ADP 4.7619
73 2C6Q NDP 4.7619
74 2UVO NDG 4.7619
75 2NCD ADP 4.7619
76 5IRR GSP 4.87013
77 2AWN ADP 4.92308
78 2ZR9 DTP 4.92308
79 5CK5 GDP 5.06329
80 1HTW ADP 5.06329
81 5X40 ACP 5.13699
82 1QF9 ALF 5.15464
83 1QF9 ADP 5.15464
84 1QF9 C5P 5.15464
85 2RCN GDP 5.23077
86 5BQ5 ADP BEF 5.29101
87 2HF9 GSP 5.30973
88 1N13 AG2 5.30973
89 2QQC AG2 5.35714
90 1JJ7 ADP 5.38462
91 5FG3 GDP 5.44218
92 1IWE IMP 5.44218
93 5HCN GCP 5.44218
94 1NJF ADP 5.44218
95 2GKS ADP 5.44218
96 1NJF AGS 5.44218
97 3BFV ADP 5.44218
98 4RZ3 ADP 5.44218
99 2ZPA ADP 5.44218
100 1P72 ADP 5.44218
101 3FKQ ATP 5.44218
102 1D8C SOR 5.44218
103 1K6M AGS 5.44218
104 1YOE RIB 5.44218
105 2CDC XYS 5.44218
106 3CV2 OXL 5.44218
107 4R43 GDP 5.44218
108 1JI0 ATP 5.44218
109 3F9W SAH 5.44218
110 2V5K OXM 5.44218
111 3W6G FLC 5.44218
112 3IUY AMP 5.44218
113 4COQ SAN 5.44218
114 4PX9 ADP 5.47945
115 4JDR FAD 5.53846
116 1YRB GDP 5.72519
117 3DEF GDP 5.72519
118 4U00 ADP 5.7377
119 1CR1 TTP 5.74324
120 1XMV ADP 5.84615
121 2ZJ5 ADP 5.84615
122 4U8P UDP 5.84615
123 1D2N ANP 5.88235
124 5U32 GDP 5.9322
125 4ZKD GDP 6.12245
126 4RD0 GDP 6.12245
127 4E03 ADP 6.12245
128 2F9L GDP 6.12245
129 1WDT GTP 6.12245
130 2WHX ADP 6.12245
131 1R0X ATP 6.12245
132 1XX6 ADP 6.12245
133 1FP6 ADP 6.12245
134 5ZBR ANP 6.12245
135 3KTA AP5 6.12245
136 3RC3 ANP 6.12245
137 2JLR ANP 6.12245
138 1W5T ADP 6.12245
139 3TBK ANP 6.12245
140 4PJ3 ANP 6.12245
141 2ZTS ADP 6.12245
142 2FAH GDP 6.12245
143 1W5T ANP 6.12245
144 3FVQ ATP 6.12245
145 5HR5 ADP 6.12245
146 3BFX A3P 6.12245
147 2Q2Y ADP 6.12245
148 4UP4 NDG 6.12245
149 2Q2Y MKR 6.12245
150 1XEX ATP 6.12245
151 3QKT ANP 6.12245
152 5VHC BEF ADP 6.12245
153 1RRC ADP 6.12245
154 4IXH IMP 6.12245
155 6HL7 CP 6.12245
156 1G7S GDP 6.15385
157 6B4K ANP 6.15385
158 3FSY SCA 6.15385
159 4LJ9 ACP 6.19469
160 1TE2 PGA 6.19469
161 1OIX GDP 6.28272
162 1OIV GDP 6.28272
163 3KJI ADP 6.29921
164 3TNF GNP 6.32184
165 4LHW GNP 6.32184
166 1XPJ TLA 6.34921
167 3W5J GDP 6.37255
168 2WJG GDP 6.38298
169 1UKZ ADP 6.40394
170 1ZIN AP5 6.45161
171 2VVG ADP 6.46154
172 6A20 ADP 6.46154
173 5Z69 AGS 6.46154
174 3RWO GDP 6.48649
175 5J1S ATP 6.50407
176 5JCZ GDP 6.70391
177 4FCW ADP 6.75241
178 1VG8 GNP 6.76329
179 4LX0 BEF GDP 6.77966
180 2C77 GNP 6.80272
181 2C78 GNP 6.80272
182 2EW1 GNP 6.80272
183 3B9Q MLI 6.80272
184 5TSH ANP 6.80272
185 5TSH ADP 6.80272
186 1W0J ADP 6.80272
187 5L3R GCP 6.80272
188 3IO3 ADP 6.80272
189 5I0H ADP BEF 6.80272
190 5E5U MLI 6.80272
191 1VKJ A3P 6.80272
192 1W0J ADP BEF 6.80272
193 2C9O ADP 6.80272
194 1SQ5 ADP 6.80272
195 2RGX AP5 6.80272
196 4XFR CIT 6.80272
197 3KC1 2T6 6.80272
198 5Y0N ATP 6.80272
199 6B8B ADP 6.80272
200 2QZ4 ADP 6.87023
201 5OCG GNP 6.87831
202 4MKF AP5 6.91244
203 6CS8 F9Y 6.93069
204 4DKX GDP 6.94444
205 1TU3 GNP 7.01754
206 1R2Q GNP 7.05882
207 2ZEJ GDP 7.06522
208 1LVG ADP 7.07071
209 5MZN ADP 7.07692
210 5G3Y ADP 7.07965
211 4YMU ATP 7.08333
212 4YMU ARG 7.08333
213 3QVV A3P 7.11864
214 5G41 AP5 7.17489
215 1KO8 6PG 7.42857
216 4JLV ADP 7.43494
217 4LPS GDP 7.43802
218 4J0Q GDP 7.48299
219 5GOE GDP 7.48299
220 2OG2 MLI 7.48299
221 3EZ2 ADP 7.48299
222 3ZQ6 ADP ALF 7.48299
223 4KVA GTP 7.48299
224 1OYY AGS 7.48299
225 2FSH ANP 7.48299
226 5NM7 GLY 7.48299
227 3EWA ANP 7.48299
228 4Z0G 5GP 7.48299
229 2O0J ADP 7.48299
230 1VG1 GDP 7.56757
231 5UPK GNP 7.56757
232 5ZB0 ADP 7.57576
233 5ZB0 TYD 7.57576
234 5WDR GNP 7.60234
235 4QM7 GTP 7.60234
236 1YVD GNP 7.69231
237 3Q85 GNP 7.69231
238 6C90 ADP 7.69231
239 5I34 GDP 7.69231
240 1U8Z GDP 7.7381
241 1BO4 COA 7.7381
242 3IIJ ADP 7.77778
243 2CJW GDP 7.8125
244 2Y8E GNP 7.82123
245 1CLU DBG 7.83133
246 4MKG AP5 7.8341
247 5Z2M GTP 7.95455
248 4BQS ADP 7.95455
249 4BQS K2Q 7.95455
250 2YIP YIO 7.97101
251 5FTB ANP 8
252 5FHD ADP ALF 8
253 1F9V ADP 8
254 1SKQ GDP 8.16327
255 3U6B GDP 8.16327
256 2BVN GNP 8.16327
257 4PC3 GDP 8.16327
258 1VG0 GDP 8.16327
259 5JBQ GDP 8.16327
260 4P3Y GDP 8.16327
261 4G5G GDP 8.16327
262 5M04 GDP 8.16327
263 1D8T GDP 8.16327
264 2HCJ GDP 8.16327
265 3U6K GDP 8.16327
266 1VG9 GDP 8.16327
267 1H65 GDP 8.16327
268 5J1J ANP 8.16327
269 1Y63 ADP 8.16327
270 4X8O AP5 8.16327
271 1OS1 PYR 8.16327
272 5L3W GDP 8.16327
273 4IDN GNP 8.16327
274 1T0S BML 8.16327
275 4LHD GLY 8.16327
276 1Z83 AP5 8.16327
277 3FYH ADP 8.16327
278 5H4S RAM 8.16327
279 3L6C MLI 8.16327
280 1OS1 ATP 8.16327
281 2FFQ GSP 8.18713
282 1YZQ GNP 8.23529
283 1EK0 GNP 8.23529
284 1GWN GTP 8.29268
285 5BN3 ADP 8.30769
286 1B7T ADP 8.33333
287 1KAO GDP 8.38323
288 4HDO GNP 8.38323
289 3X1Z GNP 8.38323
290 3E5H GNP 8.42697
291 1KK8 BEF ADP 8.44156
292 4D81 ADP 8.48057
293 2J0V GDP 8.49057
294 3QBT GNP 8.57143
295 1IHU AF3 8.61539
296 1IHU ADP 8.61539
297 2HT6 GDP 8.62069
298 3PQC GDP 8.71795
299 4YDS ATP 8.77193
300 1Z08 GNP 8.82353
301 1S8F GDP 8.84354
302 5W7Q GDP 8.84354
303 4DID GDP 8.84354
304 2WMO GTP 8.84354
305 5K5Z ANP 8.84354
306 5XDR ADP 8.84354
307 1X6V ADP 8.84354
308 4NU0 AP5 8.84354
309 1JJV ATP 8.84354
310 1DAK ADP 8.84354
311 1DAK DPU 8.84354
312 4QOS ADP 8.84354
313 5HZ7 BGC 8.84354
314 1OXV ANP 8.84354
315 3QXY SAM 8.84354
316 2Z8L NAG FUC SIA GAL 8.84354
317 4ITR GDP 8.86076
318 5IFS ADP 8.86076
319 1ZUI SKM 8.92857
320 1FNN ADP 9.23077
321 1M7B GTP 9.23913
322 2Z5F A3P 9.39597
323 4YC7 GNP 9.52381
324 5L3S GNP 9.52381
325 4XGU ADP 9.52381
326 1U0J ADP 9.52381
327 5L3V GDP 9.52381
328 2VB6 ADP BEF 9.52381
329 4PFO ADP 9.52381
330 2D7D ADP 9.52381
331 4A4Z ANP 9.52381
332 3MKN DNB 9.52381
333 2GWH A3P 9.52381
334 5GOP FRU 9.52381
335 5GOO FRU 9.52381
336 1F2U ATP 9.52381
337 4YJ1 ADP 9.52381
338 1EWK GLU 9.52381
339 2YOH WMJ 9.52381
340 2CDN ADP 9.52381
341 4JLS 3ZE 9.52381
342 1XP8 AGS 9.52381
343 2DPY ADP 9.53846
344 4TQK NAG 9.53846
345 3B7G ANP 9.56522
346 5URY PAM 9.58904
347 5OEC GDP 9.64467
348 2BME GNP 9.67742
349 5GVR LMR 9.82906
350 4R98 GNH 9.9631
351 5H67 ATP 10
352 5N69 ADP 10.0503
353 4U5X GNP 10.1124
354 3CPJ GDP 10.1538
355 3FB4 AP5 10.1852
356 1WA5 GTP 10.2041
357 1NRJ GTP 10.2041
358 2PZE ATP 10.2041
359 1V8K ANP 10.2041
360 1G3Q ADP 10.2041
361 1YTM ATP 10.2041
362 5VGR GDP 10.2041
363 3B12 FAH 10.2041
364 1L2T ATP 10.2128
365 1G8S MET 10.4348
366 1Z0K GTP 10.4651
367 3GJ7 GDP 10.8844
368 3GJ4 GDP 10.8844
369 2WJH GDP 10.8844
370 1TQ4 GDP 10.8844
371 3CH5 GDP 10.8844
372 3GJ8 GDP 10.8844
373 4V03 ADP 10.8844
374 2WJH FLC 10.8844
375 3ZS9 ADP ALF 10.8844
376 2WOJ ADP ALF 10.8844
377 4XVU ATP 10.8844
378 2CHG ANP 10.8844
379 1LVK MNT BEF 10.8844
380 4TL6 ANP 10.8844
381 2BIF SIN 10.8844
382 2BIF ANP 10.8844
383 5L2R MLA 10.8844
384 4OHY ANP 10.8844
385 3RLF ANP 10.8844
386 1NY5 ADP 10.8844
387 4R2I ANP 10.9524
388 1AKY AP5 11.3636
389 1ION ADP 11.5226
390 2Y65 ADP 11.5646
391 1DAR GDP 11.5646
392 1M7G AV2 11.5646
393 4KVG GTP 11.5646
394 2EFE GNH 11.5646
395 1M7G ADX 11.5646
396 1M7G ADP 11.5646
397 2OZE AGS 11.5646
398 5WC2 ADP 11.5646
399 3Q9L ATP 11.5646
400 4ZNL BEF ADP 11.5646
401 5AK0 8V1 11.5646
402 5EXT ADP 11.5646
403 2QN6 GDP 11.828
404 4PPF FLC 12.2449
405 1D2E GDP 12.2449
406 1KY3 GDP 12.2449
407 4P4T GDP 12.2449
408 1IN4 ADP 12.2449
409 5UIV ADP 12.2449
410 6FAA ADP 12.2449
411 2ZFI ADP 12.2449
412 3QXC ATP 12.2449
413 3DC4 ADP 12.2449
414 5MVR ADP 12.3457
415 3H4S ADP 12.5926
416 5W75 GDP 12.9231
417 4DCT GDP 12.9231
418 3WYG GTP 12.9252
419 4HAT GNP 12.9252
420 5UWP GNP 12.9252
421 5DIF GNP 12.9252
422 5UWW GNP 12.9252
423 5UWI GNP 12.9252
424 6CIT GNP 12.9252
425 5UWO GNP 12.9252
426 5UWT GNP 12.9252
427 5UWH GNP 12.9252
428 3WYF GTP 12.9252
429 3M1I GTP 12.9252
430 4D0G GTP 12.9252
431 5UWJ GNP 12.9252
432 1B0U ATP 12.9252
433 1Z0F GDP 12.9252
434 5LB3 ADP 12.9252
435 4WEI GLC GAL 12.9252
436 1CT9 GLN 12.9252
437 4TTQ ATP 13.0233
438 3NHB ADP 13.0719
439 4CVN ADP 13.1387
440 2C5L GTP 13.2308
441 2UZI GTP 13.2308
442 5E95 GDP 13.2308
443 4K81 GTP 13.2308
444 5UQW GDP 13.2308
445 3QOX SAH 13.2308
446 5IRN ADP 13.5385
447 1ZC3 GNP 13.6054
448 3WYA GDP 13.6054
449 1UAD GNP 13.6054
450 2A9K GDP 13.6054
451 4IHQ ADP 13.6054
452 1W7J ADP BEF 13.6054
453 1NN5 2DT 13.6054
454 1NN5 ANP 13.6054
455 5Y0T TAT 13.6054
456 1NST A3P 13.6054
457 1G7C 5GP 13.8298
458 3BC1 GNP 13.8462
459 5O2T GSP 13.9037
460 2QG6 NMN 14.0704
461 1PUJ GNP 14.2857
462 3SFV GDP 14.2857
463 4NE2 SH2 14.2857
464 4NE2 ADP 14.2857
465 1RJW ETF 14.2857
466 1T5C ADP 14.2857
467 3AI3 SOE 14.2857
468 1KR3 113 14.2857
469 3VGL BGC 14.3302
470 1Z0A GDP 14.3678
471 3Q72 GNP 14.4578
472 3GJ5 GDP 14.7059
473 1PVC ILE SER GLU VAL 14.7059
474 1TUK PGM 14.9254
475 5O74 GDP 14.966
476 3VMF GTP 14.966
477 1MKY GDP 14.966
478 5SZH GNP 14.966
479 3WXM GTP 14.966
480 3NKV GNP 14.966
481 3TKL GTP 14.966
482 3DDC GNP 14.966
483 1AQU A3P 14.966
484 4GBM A3P 14.966
485 2KIN ADP 15.126
486 3GJ3 GDP 15.1515
487 3TMK T5A 15.2778
488 4HDQ GNP 15.3846
489 5H7J GCP 15.6463
490 5H7K GDP 15.6463
491 3COB ADP 15.6463
492 2BCG GDP 15.6463
493 4HI0 GDP 15.748
494 1XKV ATP 16.3265
495 2PL3 ADP 16.3265
496 3A4M ADP 16.3265
497 1E2K TMC 16.3265
498 5MEX PAP 16.4596
499 3CBG FER 16.8103
500 1Z06 GNP 16.9312
501 1Z0J GTP 16.9492
502 3T1O GDP 17.6768
503 5Y6N ADP 17.6871
504 4WZA ACP 17.6871
505 4WZA ADP 17.6871
506 1RV0 NDG 17.6871
507 2IS6 ADP 17.8462
508 4M9Q GNP 18.0617
509 4BAS GNP 18.0905
510 1G16 GDP 18.2353
511 4ZG4 VO4 ADP 18.3673
512 4ZI2 GNP 18.4211
513 4GOJ GNP 18.5185
514 5UWR GNP 18.5185
515 5JCP GDP ALF 18.7692
516 1BG2 ADP 19.0476
517 2FH5 GTP 19.0476
518 2FNA ADP 19.0476
519 4OI4 ATP 19.1304
520 1RYH GNP 19.2118
521 1DS6 GDP 19.2708
522 1FZQ GDP 19.337
523 3GJX GTP 19.7279
524 1UJ2 ADP 19.7279
525 1UJ2 C5P 19.7279
526 1ZJ6 G3D 20.3209
527 4C4P GNP 20.5607
528 3T12 GDP ALF 20.5882
529 3MJH GTP 20.5882
530 2WKQ GTP 20.6154
531 2QTV GNP 20.9581
532 3A1S GDP 21.0884
533 1YZN GNP 21.0884
534 6BSX GDP 21.0884
535 6BSX E7S 21.0884
536 5LTJ ADP 21.0884
537 4HSE ADP 21.0884
538 5LEF GTP 21.2121
539 3DOE GTP 21.3542
540 1M2O GNP 21.5789
541 3T5G GDP 21.7105
542 5TB5 GDP 22
543 2CK3 ANP 22
544 2V7Q ATP 22
545 2CK3 ADP 22
546 2V7Q ADP 22
547 1KSH GDP 22.043
548 3KUD GDP 22.2222
549 1GUA GNP 22.2222
550 5TAR GDP 22.2973
551 1YZG GDP 22.3464
552 4GOX A3P 22.449
553 5UWQ GNP 22.7273
554 3ZIA ATP 22.9508
555 3ZIA ADP 22.9508
556 1D5C GDP 23.1293
557 3CNL GNP 23.6641
558 2A5J GDP 23.8095
559 1ZD9 GDP 23.9362
560 1MR3 G3D 24.3094
561 2X77 GDP 24.3386
562 5KUT GDP 24.3386
563 4V0K GDP 24.8521
564 1DCP HBI 25
565 1UPT GTP 25.1462
566 3UIE ANP 25.1701
567 1F6B GDP 25.2525
568 5DI3 GNP 25.4054
569 2W2X GSP 25.9459
570 5EE5 GTP 26.3158
571 4XOI GTP 26.6667
572 3AQ4 GDP 27.1739
573 3TK1 GDP 27.2109
574 2A5F GTP 27.4286
575 4KAX GTP 27.8107
576 1R4A GNP 27.8788
577 1GOJ ADP 27.8912
578 3QF7 ANP 28
579 2J59 GTP 28.3133
580 1O3Y GTP 28.3133
581 1J2J GTP 28.3133
582 4YLG GDP 28.3237
583 2W83 GTP 28.4848
584 5DI9 GNP 28.5714
585 5W76 GDP 29.2517
586 2XAU ADP 29.2517
587 1S9D GDP 29.2683
588 1RE0 GDP 29.2683
589 3N5C GDP 29.6296
590 3PCR GTP 29.6296
591 4XTR ATP 29.7297
592 4XTR ADP 29.7297
593 2GCO GNP 30.3483
594 2GCN GDP 30.3483
595 5DHF GNP 31.5789
596 2BVE PH5 31.9328
597 4D0N GDP 32.973
598 6BCB GSP 32.973
599 6BCA GSP 32.973
600 5HPY GDP 32.973
601 6BC0 GSP 32.973
602 3LXR GDP 32.973
603 5YT0 GDP 33.3333
604 4XSH GSP 34.0782
605 5UWU GNP 35
606 1E96 GTP 35.4167
607 3SBD GNP 35.8289
608 1I4D GDP 35.9375
609 1MH1 GNP 37.0968
610 3WY9 GDP 37.5
611 1G4U GDP 37.5
612 2FJU GSP 38.764
613 1HE1 GDP 39.2045
614 5UWS GNP 40.9091
Pocket No.: 2; Query (leader) PDB : 1FQK; Ligand: ALF; Similar sites found with APoc: 286
This union binding pocket(no: 2) in the query (biounit: 1fqk.bio2) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 1X1R GDP 2.24719
2 4ADC PLP 2.76923
3 3BER AMP 2.81124
4 3ZNN 4WL 3.07692
5 3ZNN FAD 3.07692
6 4NTD FAD 3.07692
7 2GU8 796 3.38462
8 2NVA PL2 3.38462
9 4WHZ 3NL 3.40136
10 5O96 SAM 3.40136
11 1X7D NAD 3.40136
12 4NCN GTP 4
13 4TMZ GSP 4
14 1U2Z SAH 4
15 2WOE AR6 4.01338
16 1F5N GNP 4.08163
17 3LL5 ADP 4.08163
18 3LL5 IPE 4.08163
19 1Q19 APC 4.08163
20 3LL5 ATP 4.08163
21 5XKT GNP 4.08163
22 1ZOS MTM 4.08163
23 3LL9 ADP 4.08922
24 2WIC GNP 4.11985
25 2E1T MLC 4.30769
26 1RJ9 GCP 4.33333
27 3ZFD ANP 4.7619
28 3HGM ATP 4.7619
29 3DKP ADP 4.7619
30 4TXJ THM 4.7619
31 5IRR GSP 4.87013
32 4BMX ADE 5.17928
33 2HF9 GSP 5.30973
34 4WOP CTP 5.33333
35 4FFS BIG 5.43933
36 4ZCC NAI 5.44218
37 4ZCC FAD 5.44218
38 1U1F 183 5.44218
39 6H3O FAD 5.44218
40 5UAO FAD 5.44218
41 1UP7 NAD 5.44218
42 5VYQ FON 5.44218
43 1IYK MIM 5.44218
44 2D1K ATP 5.44218
45 5IOK ACE GLN THR ALA ARG KCR SER THR 5.6338
46 1RP0 AHZ 5.6338
47 1Q7E MET 5.84615
48 2FLI DX5 5.90909
49 4RD0 GDP 6.12245
50 4ZKD GDP 6.12245
51 1WDT GTP 6.12245
52 2R4J FAD 6.12245
53 2R4J 13P 6.12245
54 2Q2Y MKR 6.12245
55 2Q2Y ADP 6.12245
56 4YRY FAD 6.12245
57 2XVF FAD 6.12245
58 4USI ATP 6.12245
59 5EYP GTP 6.12245
60 5EIB GTP 6.12245
61 5G09 6DF 6.12245
62 2OQ2 A3P 6.13027
63 4Z94 ATP 6.13497
64 3GE7 AFQ 6.15385
65 3FSY SCA 6.15385
66 3KIH GDL 6.18557
67 1OIX GDP 6.28272
68 3TNF GNP 6.32184
69 4LHW GNP 6.32184
70 3RWO GDP 6.48649
71 4YV5 SVR 6.55738
72 5JCZ GDP 6.70391
73 3GD8 GOL 6.72646
74 1VG8 GNP 6.76329
75 2OO0 PLP 6.76923
76 4LX0 BEF GDP 6.77966
77 2EW1 GNP 6.80272
78 2C78 GNP 6.80272
79 2C77 GNP 6.80272
80 5I0H ADP BEF 6.80272
81 16PK BIS 6.80272
82 1WDK NAD 6.80272
83 1SSQ CYS 6.80272
84 1S7G NAD 6.80272
85 1S7G APR 6.80272
86 5XVG 8FX 6.80272
87 4NDO ATP 6.80272
88 5OCG GNP 6.87831
89 1TU3 GNP 7.01754
90 1R2Q GNP 7.05882
91 3BL6 FMC 7.3913
92 2O66 FLC 7.40741
93 1NB9 RBF 7.48299
94 1NB9 ADP 7.48299
95 1QAN SAH 7.48299
96 3ZQ6 ADP ALF 7.48299
97 2J9C ATP 7.56302
98 5UPK GNP 7.56757
99 5WDR GNP 7.60234
100 4C81 CDP 7.6087
101 1TL2 NDG 7.62712
102 1YVD GNP 7.69231
103 2VHW NAI 7.69231
104 1U8Z GDP 7.7381
105 2Y8E GNP 7.82123
106 1CLU DBG 7.83133
107 5Z2M GTP 7.95455
108 2ZRU FMN 8
109 4IDN GNP 8.16327
110 1AJ8 COA 8.16327
111 2CNE DFJ 8.16327
112 3OII SAH 8.16327
113 2BVN GNP 8.16327
114 2Q2V NAD 8.16327
115 2E7Z MGD 8.16327
116 2NP9 YE1 8.16327
117 2FFQ GSP 8.18713
118 4PL8 ATP 8.21918
119 1EK0 GNP 8.23529
120 1YZQ GNP 8.23529
121 1GWN GTP 8.29268
122 4HDO GNP 8.38323
123 1KAO GDP 8.38323
124 3X1Z GNP 8.38323
125 3E5H GNP 8.42697
126 1KK8 BEF ADP 8.44156
127 3QBT GNP 8.57143
128 1Z08 GNP 8.82353
129 2WMO GTP 8.84354
130 1S8F GDP 8.84354
131 5XWV 8H6 8.84354
132 1WY7 SAH 8.84354
133 2RIO ADP 8.84354
134 1JA9 NDP 8.84354
135 3NTD FAD 8.84354
136 1ZUI SKM 8.92857
137 5O3Q CMP 9.16667
138 1M7B GTP 9.23913
139 3DCJ THH 9.30233
140 4YC7 GNP 9.52381
141 5HCY 60D 9.52381
142 2E5V FAD 9.52381
143 2VB6 ADP BEF 9.52381
144 1GVF PGH 9.52381
145 3VV5 SLZ 9.52381
146 3QWI CUE 9.62963
147 3QWI NAP 9.62963
148 2BME GNP 9.67742
149 6AIC AMP 9.81308
150 5N69 ADP 10.0503
151 4U5X GNP 10.1124
152 5VJE GOS 10.1538
153 1WA5 GTP 10.2041
154 1NRJ GTP 10.2041
155 2AQJ FAD 10.2041
156 4CBX ATP 10.2041
157 1V8K ANP 10.2041
158 1Z0K GTP 10.4651
159 5KVM THR TYR PHE ALA VAL LEU MET VAL SER 10.5263
160 1VBO MAN 10.7383
161 4OHY ANP 10.8844
162 1LVK MNT BEF 10.8844
163 4M52 FAD 10.8844
164 3ZS9 ADP ALF 10.8844
165 2WOJ ADP ALF 10.8844
166 2WJH FLC 10.8844
167 4XGX ADP 10.8844
168 3B9O FMN 10.8844
169 6BQ6 TER 10.8844
170 4KVG GTP 11.5646
171 1FIQ FAD 11.6923
172 2V3V MGD 12
173 5UWI GNP 12.9252
174 5UWP GNP 12.9252
175 5UWT GNP 12.9252
176 5UWO GNP 12.9252
177 5UWH GNP 12.9252
178 5DIF GNP 12.9252
179 6CIT GNP 12.9252
180 4HAT GNP 12.9252
181 5UWW GNP 12.9252
182 3M1I GTP 12.9252
183 3WYG GTP 12.9252
184 3WYF GTP 12.9252
185 4D0G GTP 12.9252
186 5UWJ GNP 12.9252
187 5OJ7 AR6 12.9252
188 2QQF A1R 12.9252
189 1SZD APR 12.9252
190 1GEE NAD 12.9252
191 2C5L GTP 13.2308
192 5UQW GDP 13.2308
193 2UZI GTP 13.2308
194 4K81 GTP 13.2308
195 1UAD GNP 13.6054
196 1ZC3 GNP 13.6054
197 1W7J ADP BEF 13.6054
198 4D9M 0JO 13.6054
199 3BC1 GNP 13.8462
200 5O2T GSP 13.9037
201 1PUJ GNP 14.2857
202 1COY FAD 14.2857
203 4MO2 FDA 14.2857
204 5SZH GNP 14.966
205 3TKL GTP 14.966
206 3NKV GNP 14.966
207 3VMF GTP 14.966
208 3WXM GTP 14.966
209 3DDC GNP 14.966
210 4HDQ GNP 15.3846
211 4RT1 C2E 16.0714
212 5W19 9TD 16.3265
213 2PL3 ADP 16.3265
214 4B2D FBP 16.3265
215 4PIV NDP 16.3265
216 1Z06 GNP 16.9312
217 1Z0J GTP 16.9492
218 1V3S ATP 17.2414
219 4WZA ACP 17.6871
220 4WZA ADP 17.6871
221 1W85 TDP 17.6871
222 1H5T TYD 17.6871
223 1H5S TMP 17.6871
224 4M9Q GNP 18.0617
225 4BAS GNP 18.0905
226 4ZG4 VO4 ADP 18.3673
227 4ZI2 GNP 18.4211
228 5UWR GNP 18.5185
229 4GOJ GNP 18.5185
230 5JCP GDP ALF 18.7692
231 2FH5 GTP 19.0476
232 5UR1 YY9 19.0476
233 2FV5 541 19.0476
234 1RYH GNP 19.2118
235 3GJX GTP 19.7279
236 4C4P GNP 20.5607
237 3T12 GDP ALF 20.5882
238 3MJH GTP 20.5882
239 2WKQ GTP 20.6154
240 2QTV GNP 20.9581
241 6BSX E7S 21.0884
242 6BSX GDP 21.0884
243 1YZN GNP 21.0884
244 3A1S GDP 21.0884
245 5LEF GTP 21.2121
246 3DOE GTP 21.3542
247 1M2O GNP 21.5789
248 1KSH GDP 22.043
249 1GUA GNP 22.2222
250 3KUD GDP 22.2222
251 5UWQ GNP 22.7273
252 2VNF ALA ARG THR M3L GLN THR ALA ARG LYS SER 23.3333
253 1UPT GTP 25.1462
254 3WB0 FEG 25.1701
255 5DI3 GNP 25.4054
256 2W2X GSP 25.9459
257 5EE5 GTP 26.3158
258 4XOI GTP 26.6667
259 2A5F GTP 27.4286
260 4KAX GTP 27.8107
261 1R4A GNP 27.8788
262 1J2J GTP 28.3133
263 1O3Y GTP 28.3133
264 2J59 GTP 28.3133
265 2W83 GTP 28.4848
266 5DI9 GNP 28.5714
267 3PCR GTP 29.6296
268 2GCN GDP 30.3483
269 2GCO GNP 30.3483
270 5DHF GNP 31.5789
271 6BC0 GSP 32.973
272 6BCB GSP 32.973
273 6BCA GSP 32.973
274 5HPY GDP 32.973
275 4XSH GSP 34.0782
276 5UWU GNP 35
277 1E96 GTP 35.4167
278 3SBD GNP 35.8289
279 1GY8 NAD 36.0544
280 1MH1 GNP 37.0968
281 1G4U AF3 37.5
282 3KIF GDL 38.6792
283 2FJU GSP 38.764
284 1HE1 AF3 39.2045
285 1HE1 GDP 39.2045
286 5UWS GNP 40.9091
Pocket No.: 3; Query (leader) PDB : 1FQK; Ligand: ALF; Similar sites found with APoc: 152
This union binding pocket(no: 3) in the query (biounit: 1fqk.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 2CBZ ATP 1.68776
2 1SVM ATP 2.04082
3 3BP1 GUN 2.06897
4 1D9I 00P 2.43056
5 2QQ0 ANP 2.71739
6 2QQ0 ADP 2.71739
7 2QQ0 TMP 2.71739
8 1Z2A GDP 2.72109
9 3B20 NAD 2.76923
10 5KSZ GCP 3.40136
11 2W58 ADP 3.40136
12 1HEX NAD 3.40136
13 5A5W GUO 3.55731
14 2NT8 ATP 3.58744
15 2XNJ NAP 3.7594
16 2DXU BT5 3.82979
17 2OFW ADX 3.84615
18 1QF5 GDP 4
19 1QF5 RPL 4
20 2BEK ATP 4.08163
21 5UIJ TYD 4.08163
22 4ONA UW1 4.08163
23 3CI3 5AD 4.12371
24 3CI3 3PO 4.12371
25 2BNF UTP 4.14938
26 3RYC GTP 4.1958
27 4NON GDP 4.23077
28 5JZJ AN2 4.3771
29 4XCZ T3Q 4.61538
30 4XCZ FON 4.61538
31 1RYI GOA 4.7619
32 1RYI FAD 4.7619
33 2BLN U5P 4.91803
34 3BW2 FMN 4.92308
35 5X40 ACP 5.13699
36 4D7E FAD 5.23077
37 2D2I NAP 5.23077
38 5NMX NAP 5.44218
39 5NMX FAD 5.44218
40 3MN7 ATP 5.44218
41 2V51 ATP 5.44218
42 3SSO SAH 5.44218
43 1IUP ALQ 5.44218
44 4QWT ACD 5.44218
45 3DEF GDP 5.72519
46 5VFC 9BA 5.78778
47 3FVQ ATP 6.12245
48 2XVE FAD 6.12245
49 5ZBR ANP 6.12245
50 2JLR ANP 6.12245
51 2F9L GDP 6.12245
52 5VHC BEF ADP 6.12245
53 1A59 COA 6.12245
54 4E03 ADP 6.12245
55 4L2I FAD 6.12245
56 3QKT ANP 6.12245
57 1FP6 ADP 6.12245
58 1OIV GDP 6.28272
59 3W5J GDP 6.37255
60 4EFH ADP 6.76923
61 5L3R GCP 6.80272
62 5CB8 ADX 6.80272
63 1W0J ADP 6.80272
64 5DMZ ADP 6.80272
65 3LZW FAD 7.48299
66 4QRH 0O2 8.09524
67 4N02 FNR 8.16327
68 4X8O AP5 8.16327
69 3GBR PRP 8.16327
70 5J1J ANP 8.16327
71 5H4S RAM 8.16327
72 1H65 GDP 8.16327
73 5M04 GDP 8.16327
74 6BKA FMN 8.16327
75 1B7T ADP 8.33333
76 2J0V GDP 8.49057
77 1IHU ADP 8.61539
78 3PQC GDP 8.71795
79 4C8E C5P 8.79121
80 5XWV NDP 8.84354
81 5K5Z ANP 8.84354
82 4ITR GDP 8.86076
83 4YFY 1YJ 9.05512
84 5XDT MB3 9.41558
85 4PFO ADP 9.52381
86 5L3S GNP 9.52381
87 3C3N FMN 9.52381
88 4K26 NDP 9.52381
89 4UZI IMD 10.2041
90 2PZE ATP 10.2041
91 5WS9 AMP 10.2041
92 5VGR GDP 10.2041
93 5W4W 9WG 10.7692
94 3GJ7 GDP 10.8844
95 3GJ4 GDP 10.8844
96 2WJH GDP 10.8844
97 2BIF ANP 10.8844
98 4XVU ATP 10.8844
99 2AMT 1AA 11.3208
100 5AK0 8V1 11.5646
101 1M7G ADP 11.5646
102 1M7G ADX 11.5646
103 2OZE AGS 11.5646
104 4ZNL BEF ADP 11.5646
105 4FJU NAI 12.2449
106 4FJU GLV 12.2449
107 1O94 AMP 12.5
108 2ZE7 DST 12.6482
109 3IID APR 12.7962
110 4DCT GDP 12.9231
111 4WNK 453 12.9252
112 5E95 GDP 13.2308
113 2A9K GDP 13.6054
114 5J7X FAD 13.6054
115 1NN5 2DT 13.6054
116 1NN5 ANP 13.6054
117 2QG6 NMN 14.0704