Receptor
PDB id Resolution Class Description Source Keywords
1EJH 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE EIF4E/EIF4G PEPTIDE/7-METHYL-GDP MUS MUSCULUS EIF4E/EIF4GII PEPTIDE/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M7G A:1001;
B:1002;
C:1003;
D:1004;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
459.243 C11 H19 N5 O11 P2 CN1CN...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1EJH 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE EIF4E/EIF4G PEPTIDE/7-METHYL-GDP MUS MUSCULUS EIF4E/EIF4GII PEPTIDE/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 309 families.
1 1EJH - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 5EHC - 5NX C21 H20 Cl N6 O7 c1cc(cc(c1....
2 5EI3 Kd = 56.5 uM 5O8 C18 H20 F3 N6 O6 S c1ccc(cc1)....
3 1EJH - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 221 families.
1 5EHC - 5NX C21 H20 Cl N6 O7 c1cc(cc(c1....
2 5EI3 Kd = 56.5 uM 5O8 C18 H20 F3 N6 O6 S c1ccc(cc1)....
3 5ZJZ - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
4 5ZJY - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
5 1EJH - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
6 5ZK5 - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M7G; Similar ligands found: 11
No: Ligand ECFP6 Tc MDL keys Tc
1 M7G 1 1
2 MGT 0.910256 1
3 M7M 0.541667 0.963855
4 G8D 0.537634 0.914634
5 TPG 0.525 0.920455
6 8GT 0.494845 0.914634
7 CDP 0.43617 0.829268
8 UDP 0.430108 0.780488
9 8GM 0.412371 0.902439
10 8OD 0.411765 0.77907
11 8GD 0.407767 0.872093
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1EJH; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1ejh.bio2) has 9 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1EJH; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1ejh.bio4) has 9 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 1EJH; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1ejh.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1EJH; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1ejh.bio3) has 10 residues
No: Leader PDB Ligand Sequence Similarity
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