Receptor
PDB id Resolution Class Description Source Keywords
1EJ4 2.25 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE MUS MUSCULUS EIF4E/4E-BP/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M7G A:1000;
 Valid;
 none;
 submit data
459.243 C11 H19 N5 O11 P2 CN1CN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1EJ4 2.25 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE MUS MUSCULUS EIF4E/4E-BP/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 1WKW - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
3 2V8W Kd = 146 nM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
4 2V8Y Kd = 1.96 uM MGV C17 H20 F N5 O8 P c1cc(ccc1C....
5 2V8X Kd = 6.95 uM MGQ C17 H21 N5 O8 P c1ccc(cc1)....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 1WKW - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 3HXG Kd = 0.27 uM GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
3 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
4 2V8W Kd = 146 nM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
5 2V8Y Kd = 1.96 uM MGV C17 H20 F N5 O8 P c1cc(ccc1C....
6 2V8X Kd = 6.95 uM MGQ C17 H21 N5 O8 P c1ccc(cc1)....
7 3M94 - M7M C13 H23 N5 O11 P2 CN1CN(C2=C....
8 2JGB Ka = 410000 M^-1 MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: M7G; Similar ligands found: 12
No: Ligand ECFP6 Tc MDL keys Tc
1 M7G 1 1
2 MGT 0.910256 1
3 M7M 0.541667 0.963855
4 G8D 0.537634 0.914634
5 TPG 0.525 0.920455
6 8GT 0.494845 0.914634
7 CDP 0.43617 0.829268
8 UDP 0.430108 0.780488
9 M7G A2M G 0.42953 0.88764
10 8GM 0.412371 0.902439
11 8OD 0.411765 0.77907
12 8GD 0.407767 0.872093
Similar Ligands (3D)
Ligand no: 1; Ligand: M7G; Similar ligands found: 55
No: Ligand Similarity coefficient
1 ADP 0.9527
2 GDP 0.9411
3 ADP MG 0.9264
4 7DD 0.9218
5 DAT 0.9211
6 MGO 0.9132
7 DGI 0.9119
8 AP2 0.9114
9 KG4 0.9110
10 GDP BEF 0.9094
11 GDP MG 0.9094
12 MGP 0.9078
13 AN2 0.9051
14 TYD 0.9023
15 A12 0.9022
16 GP2 0.9019
17 M33 0.8967
18 ADX 0.8959
19 G7M 0.8950
20 IDP 0.8945
21 O02 0.8923
22 CA0 0.8922
23 GNH 0.8921
24 CUU 0.8884
25 G 0.8859
26 5GP 0.8859
27 PRX 0.8856
28 KB7 0.8844
29 XMP 0.8832
30 SAH 0.8830
31 GAP 0.8824
32 WSA 0.8810
33 A5A 0.8810
34 ATP 0.8804
35 GJV 0.8789
36 ANP 0.8756
37 SAM 0.8755
38 9ZD 0.8740
39 IMU 0.8738
40 AMP 0.8735
41 5AS 0.8718
42 IMP 0.8716
43 7D3 0.8710
44 2A5 0.8698
45 DGP 0.8681
46 ADP AF3 0.8679
47 AU1 0.8668
48 DG 0.8667
49 GPX 0.8658
50 6CG 0.8638
51 6AD 0.8632
52 EEM 0.8588
53 AGS 0.8576
54 8DG 0.8565
55 ACP 0.8562
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1EJ4; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1ej4.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback