Receptor
PDB id Resolution Class Description Source Keywords
1D8D 2 Å EC: 2.5.1.21 CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG A T 2.0A RESOLUTION RATTUS NORVEGICUS FTASE PFT PFTASE FARNESYLTRANSFERASE FARNESYL TRANSFERASE CAAX RAS CANCER
Ref.: THE BASIS FOR K-RAS4B BINDING SPECIFICITY TO PROTEIN FARNESYLTRANSFERASE REVEALED BY 2 A RESOLUTION TERNARY COMPLEX STRUCTURES. STRUCTURE FOLD.DES. V. 8 209 2000
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT B:3002;
B:3003;
P:3000;
P:3001;
 Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
 submit data
59.044 C2 H3 O2 CC(=O...
FII B:1000;
 Valid;
 none;
 submit data
359.398 C17 H30 N O5 P CC(=C...
ZN A:1001;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KZO 2.2 Å EC: 2.5.1.21 PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RA PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND S IMULTANEOUSLY RATTUS NORVEGICUS FTASE PFT PFTASE FT FPT FARNESYLTRANSFERASE FARNESYL TRANSFERASE FARNESYL PROTEIN TRANSFERASE CAAX RAS CANCEPRODUCT SUBSTRATE TRANSFERASE-TRANSFERASE SUBSTRATE COMPL
Ref.: THE REACTION PATH OF PROTEIN FARNESYLTRANSFERASE AT RESOLUTION NATURE V. 419 645 2002
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1KZO Kd = 5 nM FPP C15 H28 O7 P2 CC(=CCC/C(....
2 1D8D - FII C17 H30 N O5 P CC(=CCC/C(....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: FII; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FII 1 1
2 DSL 0.553571 0.603448
3 0K3 0.553571 0.603448
4 FJP 0.553571 0.614035
5 GRG 0.507937 0.666667
6 FPP 0.507937 0.666667
7 VTP 0.507937 0.655172
8 OTP 0.507937 0.655172
9 ZTP 0.507937 0.655172
10 FPQ 0.5 0.683333
11 GPP 0.444444 0.649123
12 C0X 0.444444 0.622951
13 FPS 0.41791 0.6
14 GGS 0.41791 0.6
15 FFF 0.402778 0.633333
Similar Ligands (3D)
Ligand no: 1; Ligand: FII; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1KZO; Ligand: FPP; Similar sites found with APoc: 4
This union binding pocket(no: 1) in the query (biounit: 1kzo.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 3SFX JAN 48.8064
2 3SFX FII 48.8064
3 3Q78 FPS 48.8064
4 3DST GRG 49.8489
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