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Showing PDB: 1CA7

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Receptor | Ligand | View in 3D

Family: 90% | 70% | 50% | site

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      Structure Biounit | Ligand Information

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Family 90% : .ZIP | .CSV

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Receptor

PDB id	Resolution	Class	Description	Source	Keywords
1CA7	2.5 Å	EC: 5.3.2.1	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHEN	HOMO SAPIENS	PROTEIN HORMONE CYTOKINE ENZYME
Ref.:	PRO-1 OF MACROPHAGE MIGRATION INHIBITORY FACTOR FUN A CATALYTIC BASE IN THE PHENYLPYRUVATE TAUTOMERASE BIOCHEMISTRY V. 38 7346 1999

Ligand

Ligand	Chain:Residue	Validity	Ligand Warnings	Binding Data	NGL Viewer	Molecular Weight (Da)	Formula	SMILES
ENO	A:501; B:601; C:701;	Valid; Valid; Valid;	none; none; none;	submit data		180.157	C9 H8 O4	c1cc(...

View in 3D viewer

90% Homology Family

Leader

PDB id	Resolution	Class	Description	Source	Keywords
3L5R	1.94 Å	EC: 5.3.2.1	CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR PHENYLCHROMENONE INHIBITOR AT 1.94A RESOLUTION	HOMO SAPIENS	PROTEIN-LIGAND COMPLEX CYTOKINE CYTOPLASM IMMUNE RESPONSEINFLAMMATORY RESPONSE INNATE IMMUNITY ISOMERASE PHOSPHOPSECRETED ACETYLATION
Ref.:	FRAGMENT SCREENING OF INHIBITORS FOR MIF TAUTOMERAS A CRYPTIC SURFACE BINDING SITE. BIOORG.MED.CHEM.LETT. V. 20 1821 2010

Members (27)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 2 families.
1	1LJT	ic50 = 7 uM	HDI	C12 H13 N O4	COC(=O)C[C....
2	3L5R	ic50 = 38 nM	47X	C15 H10 O5	c1cc(c(cc1....
3	5J7Q	Ki = 26.6 uM	6H2	C13 H10 N2 O2	c1ccn2cc(n....
4	5HVT	Kd = 0.055 uM	NVS	C15 H13 N O4	COc1ccc(cc....
5	5B4O	-	6DQ	C13 H8 N2 O S	c1ccc2c(c1....
6	1GCZ	Ki = 7.4 uM	YZ9	C12 H10 O5	CCOC(=O)C1....
7	3L5P	-	428	C9 H11 N3 O	CC(C)c1cn2....
8	5HVS	Kd = 0.071 uM	65V	C24 H15 F N4 O4	c1cc(cc(c1....
9	6B1C	Kd = 0.111 uM	C9J	C17 H12 F N5 O2	CN1C=Cc2cc....
10	3L5T	-	956	C20 H18 N4 O2 S	CN1c2ccccc....
11	3IJJ	-	EN1	C9 H8 O4	c1cc(ccc1/....
12	6CBG	Ki = 113 uM	EWG	C10 H8 N2 O2	c1cc(cc(c1....
13	4K9G	-	1Q1	C12 H12 F N O3	CC(=O)C[C@....
14	3IJG	Kd = 54 uM	AVR	C13 H17 N3 O	C[C@H](C(=....
15	4WRB	Ki = 0.65 uM	3TW	C20 H18 N4 O3	COCCOc1ccc....
16	1CA7	-	ENO	C9 H8 O4	c1cc(ccc1C....
17	2OOH	ic50 = 1.3 uM	OX3	C14 H17 N O3	c1cc(ccc1C....
18	2OOZ	ic50 = 7 uM	OX5	C13 H17 N O3	CC(C)(C)CC....
19	3DJI	-	3E1	C16 H16 N2 O4	CC(=O)Nc1c....
20	6CBF	Ki = 6.8 uM	EWD	C16 H12 N2 O3	c1ccc(cc1)....
21	3L5U	-	ZEC	C7 H6 N2 O3 S2	c1cc2c(cc1....
22	6CB5	Ki = 4.3 uM	EV7	C20 H14 N2 O3	c1ccc2cc(c....
23	6B1K	Kd = 0.213 uM	C9G	C17 H13 N5 O2	CN1C=Cc2cc....
24	3L5S	-	88X	C15 H13 N3 O2	CCC1=CC(=O....
25	6CBH	Ki = 0.51 uM	EWJ	C20 H13 F N2 O3	c1ccc2cc(c....
26	3U18	ic50 = 0.81 uM	Y0X	C34 H28 N6 O16 S4	COc1c(ccc(....
27	6B2C	Kd = 0.094 uM	C9Y	C18 H12 F N5 O4	c1cc(c(cc1....

70% Homology Family (28)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 2 families.
1	1LJT	ic50 = 7 uM	HDI	C12 H13 N O4	COC(=O)C[C....
2	3L5R	ic50 = 38 nM	47X	C15 H10 O5	c1cc(c(cc1....
3	5J7Q	Ki = 26.6 uM	6H2	C13 H10 N2 O2	c1ccn2cc(n....
4	5HVT	Kd = 0.055 uM	NVS	C15 H13 N O4	COc1ccc(cc....
5	5B4O	-	6DQ	C13 H8 N2 O S	c1ccc2c(c1....
6	1GCZ	Ki = 7.4 uM	YZ9	C12 H10 O5	CCOC(=O)C1....
7	3L5P	-	428	C9 H11 N3 O	CC(C)c1cn2....
8	5HVS	Kd = 0.071 uM	65V	C24 H15 F N4 O4	c1cc(cc(c1....
9	6B1C	Kd = 0.111 uM	C9J	C17 H12 F N5 O2	CN1C=Cc2cc....
10	3L5T	-	956	C20 H18 N4 O2 S	CN1c2ccccc....
11	3IJJ	-	EN1	C9 H8 O4	c1cc(ccc1/....
12	6CBG	Ki = 113 uM	EWG	C10 H8 N2 O2	c1cc(cc(c1....
13	4K9G	-	1Q1	C12 H12 F N O3	CC(=O)C[C@....
14	3IJG	Kd = 54 uM	AVR	C13 H17 N3 O	C[C@H](C(=....
15	4WRB	Ki = 0.65 uM	3TW	C20 H18 N4 O3	COCCOc1ccc....
16	1CA7	-	ENO	C9 H8 O4	c1cc(ccc1C....
17	2OOH	ic50 = 1.3 uM	OX3	C14 H17 N O3	c1cc(ccc1C....
18	2OOZ	ic50 = 7 uM	OX5	C13 H17 N O3	CC(C)(C)CC....
19	3DJI	-	3E1	C16 H16 N2 O4	CC(=O)Nc1c....
20	6CBF	Ki = 6.8 uM	EWD	C16 H12 N2 O3	c1ccc(cc1)....
21	3L5U	-	ZEC	C7 H6 N2 O3 S2	c1cc2c(cc1....
22	6CB5	Ki = 4.3 uM	EV7	C20 H14 N2 O3	c1ccc2cc(c....
23	6B1K	Kd = 0.213 uM	C9G	C17 H13 N5 O2	CN1C=Cc2cc....
24	3L5S	-	88X	C15 H13 N3 O2	CCC1=CC(=O....
25	6CBH	Ki = 0.51 uM	EWJ	C20 H13 F N2 O3	c1ccc2cc(c....
26	3U18	ic50 = 0.81 uM	Y0X	C34 H28 N6 O16 S4	COc1c(ccc(....
27	6B2C	Kd = 0.094 uM	C9Y	C18 H12 F N5 O4	c1cc(c(cc1....
28	1MFI	Ki = 2.6 uM	FHC	C9 H6 F O3	c1cc(ccc1C....

50% Homology Family (32)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 2 families.
1	1LJT	ic50 = 7 uM	HDI	C12 H13 N O4	COC(=O)C[C....
2	3L5R	ic50 = 38 nM	47X	C15 H10 O5	c1cc(c(cc1....
3	5J7Q	Ki = 26.6 uM	6H2	C13 H10 N2 O2	c1ccn2cc(n....
4	5HVT	Kd = 0.055 uM	NVS	C15 H13 N O4	COc1ccc(cc....
5	5B4O	-	6DQ	C13 H8 N2 O S	c1ccc2c(c1....
6	1GCZ	Ki = 7.4 uM	YZ9	C12 H10 O5	CCOC(=O)C1....
7	3L5P	-	428	C9 H11 N3 O	CC(C)c1cn2....
8	5HVS	Kd = 0.071 uM	65V	C24 H15 F N4 O4	c1cc(cc(c1....
9	6B1C	Kd = 0.111 uM	C9J	C17 H12 F N5 O2	CN1C=Cc2cc....
10	3L5T	-	956	C20 H18 N4 O2 S	CN1c2ccccc....
11	3IJJ	-	EN1	C9 H8 O4	c1cc(ccc1/....
12	6CBG	Ki = 113 uM	EWG	C10 H8 N2 O2	c1cc(cc(c1....
13	4K9G	-	1Q1	C12 H12 F N O3	CC(=O)C[C@....
14	3IJG	Kd = 54 uM	AVR	C13 H17 N3 O	C[C@H](C(=....
15	4WRB	Ki = 0.65 uM	3TW	C20 H18 N4 O3	COCCOc1ccc....
16	1CA7	-	ENO	C9 H8 O4	c1cc(ccc1C....
17	2OOH	ic50 = 1.3 uM	OX3	C14 H17 N O3	c1cc(ccc1C....
18	2OOZ	ic50 = 7 uM	OX5	C13 H17 N O3	CC(C)(C)CC....
19	3DJI	-	3E1	C16 H16 N2 O4	CC(=O)Nc1c....
20	6CBF	Ki = 6.8 uM	EWD	C16 H12 N2 O3	c1ccc(cc1)....
21	3L5U	-	ZEC	C7 H6 N2 O3 S2	c1cc2c(cc1....
22	6CB5	Ki = 4.3 uM	EV7	C20 H14 N2 O3	c1ccc2cc(c....
23	6B1K	Kd = 0.213 uM	C9G	C17 H13 N5 O2	CN1C=Cc2cc....
24	3L5S	-	88X	C15 H13 N3 O2	CCC1=CC(=O....
25	6CBH	Ki = 0.51 uM	EWJ	C20 H13 F N2 O3	c1ccc2cc(c....
26	3U18	ic50 = 0.81 uM	Y0X	C34 H28 N6 O16 S4	COc1c(ccc(....
27	6B2C	Kd = 0.094 uM	C9Y	C18 H12 F N5 O4	c1cc(c(cc1....
28	4Q3F	-	TLA	C4 H6 O6	[C@@H]([C@....
29	6C5F	Ki = 33 uM	7L9	C14 H9 N O6	c1cc(cc(c1....
30	3RF5	Ki = 2.37 uM	FUZ	C12 H11 N O3	c1ccc(c(c1....
31	3RF4	Ki = 0.56 uM	FUN	C12 H11 Cl N2 O5 S	c1cc(oc1)C....
32	1MFI	Ki = 2.6 uM	FHC	C9 H6 F O3	c1cc(ccc1C....

Polypharmacology

Similar Ligands (2D)

Ligand no: 1; Ligand: ENO; Similar ligands found: 5

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	ENO	1	1
2	4HP	0.625	0.782609
3	PPY	0.542857	0.772727
4	HPP	0.447368	0.791667
5	34H	0.414634	0.875

Similar Ligands (3D)

Ligand no: 1; Ligand: ENO; Similar ligands found: 1095

No:	Ligand	Similarity coefficient
1	EN1	0.9992
2	TYR	0.9961
3	PFF	0.9960
4	DTY	0.9959
5	4BF	0.9897
6	TYC	0.9852
7	PHI	0.9809
8	2UB	0.9809
9	ISA	0.9749
10	FHC	0.9733
11	TYE	0.9721
12	HNK	0.9719
13	PPT	0.9709
14	C82	0.9686
15	PH3	0.9685
16	F90	0.9670
17	MMS	0.9670
18	GT4	0.9652
19	DAH	0.9646
20	0A1	0.9630
21	HXY	0.9629
22	PHE	0.9629
23	HFA	0.9616
24	IYR	0.9606
25	YIE	0.9601
26	DPN	0.9590
27	YOF	0.9585
28	4LW	0.9582
29	R9J	0.9574
30	EQW	0.9569
31	4CF	0.9556
32	N2Y	0.9546
33	HF2	0.9544
34	RQD	0.9541
35	4FP	0.9537
36	P81	0.9531
37	S0W	0.9528
38	HWD	0.9523
39	HNL	0.9514
40	56D	0.9509
41	TMG	0.9508
42	M6H	0.9501
43	HC4	0.9498
44	92G	0.9492
45	AHC	0.9488
46	E0O	0.9487
47	4LV	0.9485
48	IPO	0.9478
49	NFA	0.9478
50	BRH	0.9466
51	RA7	0.9442
52	AOT	0.9439
53	A5E	0.9437
54	SOJ	0.9436
55	1BN	0.9434
56	Z70	0.9427
57	795	0.9425
58	A5H	0.9421
59	HIC	0.9419
60	Y4L	0.9418
61	PO6	0.9417
62	6ZX	0.9413
63	FTV	0.9412
64	K7M	0.9399
65	1Z6	0.9398
66	4PN	0.9398
67	HX8	0.9397
68	HX4	0.9396
69	LO1	0.9396
70	0NX	0.9393
71	B3U	0.9388
72	GVY	0.9386
73	4ZD	0.9382
74	CH8	0.9376
75	HCI	0.9375
76	KDG	0.9369
77	CFA	0.9367
78	MJ5	0.9364
79	BNL	0.9359
80	FPL	0.9358
81	B40	0.9351
82	E3X	0.9351
83	GB5	0.9350
84	BPW	0.9348
85	P58	0.9346
86	JAH	0.9345
87	YPN	0.9344
88	LTT	0.9341
89	MSR	0.9339
90	QH3	0.9335
91	5OO	0.9335
92	QIV	0.9333
93	B41	0.9332
94	GWM	0.9331
95	4XF	0.9327
96	7VP	0.9324
97	API	0.9324
98	M5E	0.9323
99	XCG	0.9321
100	5WZ	0.9320
101	ERZ	0.9317
102	LVD	0.9312
103	3ZB	0.9311
104	2B4	0.9308
105	CPZ	0.9307
106	3QO	0.9307
107	6FB	0.9307
108	2PV	0.9307
109	TCA	0.9306
110	C53	0.9304
111	2PK	0.9303
112	33S	0.9302
113	SNU	0.9301
114	SWX	0.9300
115	9VQ	0.9293
116	C1M	0.9292
117	IC9	0.9291
118	N9J	0.9290
119	2LT	0.9288
120	SHI	0.9288
121	DEW	0.9288
122	F4K	0.9285
123	4BX	0.9284
124	3CR	0.9284
125	EYJ	0.9280
126	DHC	0.9280
127	IWD	0.9278
128	4AF	0.9278
129	FWD	0.9273
130	AEG	0.9273
131	492	0.9273
132	BIK	0.9273
133	BWD	0.9272
134	0A9	0.9272
135	CWD	0.9271
136	GO2	0.9271
137	TZF	0.9270
138	L22	0.9269
139	FZM	0.9268
140	HIS	0.9266
141	1VK	0.9263
142	9B3	0.9261
143	TYL	0.9261
144	PCS	0.9260
145	36M	0.9257
146	GB4	0.9257
147	4HB	0.9255
148	X0U	0.9255
149	FK8	0.9254
150	M74	0.9253
151	0BP	0.9250
152	JGB	0.9249
153	X48	0.9248
154	BPY	0.9248
155	XIZ	0.9245
156	BP7	0.9244
157	J9N	0.9241
158	P80	0.9240
159	2QC	0.9240
160	2HC	0.9239
161	HHI	0.9237
162	4VY	0.9236
163	SZ7	0.9234
164	J0Z	0.9232
165	HHH	0.9230
166	1A7	0.9228
167	HJH	0.9227
168	F06	0.9226
169	4BY	0.9225
170	5O6	0.9224
171	RLG	0.9224
172	JZA	0.9224
173	DA3	0.9222
174	S2P	0.9221
175	363	0.9220
176	7N8	0.9218
177	IWT	0.9216
178	DXG	0.9215
179	5LA	0.9215
180	11X	0.9214
181	LGT	0.9213
182	BZQ	0.9212
183	GZ2	0.9210
184	EGV	0.9209
185	50C	0.9209
186	4I8	0.9206
187	TZM	0.9204
188	KTJ	0.9204
189	PBA	0.9202
190	LL2	0.9202
191	4V2	0.9200
192	ESX	0.9199
193	XDK	0.9195
194	AN3	0.9194
195	YF3	0.9193
196	Q9Z	0.9193
197	1L5	0.9191
198	HNT	0.9190
199	CK2	0.9189
200	MP5	0.9186
201	PF1	0.9185
202	9UL	0.9184
203	61M	0.9182
204	I2E	0.9181
205	8U3	0.9180
206	M3H	0.9179
207	R2P	0.9178
208	K80	0.9176
209	DDU	0.9176
210	LNR	0.9174
211	428	0.9173
212	3TC	0.9172
213	9W5	0.9171
214	M5H	0.9169
215	QUS	0.9168
216	7R4	0.9168
217	GVG	0.9168
218	XI7	0.9167
219	S7S	0.9166
220	C0H	0.9165
221	LTN	0.9164
222	7OD	0.9164
223	36Y	0.9164
224	HNH	0.9163
225	2FX	0.9163
226	BZJ	0.9163
227	Q06	0.9162
228	4Z9	0.9160
229	ALE	0.9159
230	15E	0.9158
231	6KT	0.9157
232	HNM	0.9157
233	3VQ	0.9155
234	LL1	0.9155
235	S0F	0.9155
236	GLR	0.9154
237	BQ2	0.9152
238	NCT	0.9151
239	TRP	0.9149
240	CS2	0.9148
241	F4E	0.9147
242	ITW	0.9146
243	PBN	0.9145
244	XRX	0.9145
245	4BL	0.9145
246	UNJ	0.9144
247	KYN	0.9142
248	J4K	0.9142
249	QME	0.9142
250	D3G	0.9142
251	LSQ	0.9141
252	IS2	0.9140
253	3QM	0.9140
254	PRL	0.9140
255	4TB	0.9139
256	NFM	0.9138
257	MPV	0.9138
258	Y3L	0.9137
259	DTR	0.9136
260	GNW	0.9134
261	2NP	0.9134
262	H4E	0.9133
263	9CA	0.9133
264	SQ4	0.9133
265	TB8	0.9132
266	JBZ	0.9132
267	DYT	0.9130
268	TIH	0.9129
269	FMQ	0.9128
270	3IL	0.9127
271	3H2	0.9126
272	A7Q	0.9126
273	ODK	0.9124
274	5TY	0.9121
275	80G	0.9120
276	OQC	0.9119
277	CH9	0.9118
278	TOH	0.9117
279	LR8	0.9117
280	3VS	0.9117
281	HGA	0.9116
282	CXH	0.9114
283	DHI	0.9113
284	YIP	0.9113
285	3VW	0.9110
286	4MP	0.9110
287	BSA	0.9110
288	MXD	0.9110
289	XDE	0.9109
290	6J5	0.9109
291	ESP	0.9109
292	P7Y	0.9105
293	BL0	0.9105
294	PUE	0.9104
295	PJW	0.9104
296	SQ7	0.9104
297	3YP	0.9103
298	6FZ	0.9101
299	9FL	0.9101
300	6QF	0.9101
301	1IT	0.9100
302	DHY	0.9100
303	OOG	0.9099
304	2BX	0.9099
305	6C5	0.9096
306	DTE	0.9095
307	657	0.9094
308	CXP	0.9093
309	1PS	0.9092
310	1X4	0.9090
311	ANC	0.9090
312	PPN	0.9089
313	OHJ	0.9088
314	7O4	0.9087
315	1A5	0.9087
316	6MW	0.9087
317	Q04	0.9084
318	ICB	0.9084
319	THU	0.9084
320	3R4	0.9083
321	D1Y	0.9082
322	CIR	0.9080
323	BVS	0.9079
324	ZEC	0.9079
325	EYV	0.9079
326	ARG	0.9079
327	DAR	0.9079
328	IAR	0.9079
329	F52	0.9078
330	M02	0.9075
331	EQA	0.9073
332	XRS	0.9071
333	BZ2	0.9071
334	JCZ	0.9070
335	JRB	0.9069
336	ZZA	0.9069
337	78Y	0.9067
338	HL4	0.9067
339	M3E	0.9066
340	4OG	0.9063
341	MES	0.9063
342	PJL	0.9063
343	4Z1	0.9062
344	9R5	0.9062
345	OJD	0.9061
346	22F	0.9059
347	JA5	0.9058
348	J6W	0.9058
349	3IP	0.9057
350	N4B	0.9056
351	KLE	0.9056
352	848	0.9055
353	S7A	0.9055
354	4FE	0.9054
355	SYC	0.9053
356	GCO	0.9051
357	D2G	0.9051
358	UA5	0.9048
359	1KN	0.9048
360	PIM	0.9048
361	4NP	0.9047
362	7ZL	0.9047
363	G14	0.9047
364	6HO	0.9047
365	4NS	0.9042
366	NY4	0.9042
367	IAC	0.9042
368	M45	0.9041
369	L03	0.9041
370	DCZ	0.9040
371	833	0.9038
372	XK0	0.9038
373	JG8	0.9038
374	L99	0.9037
375	A51	0.9035
376	11C	0.9035
377	A6H	0.9034
378	0UL	0.9034
379	R20	0.9034
380	CLT	0.9034
381	JF6	0.9034
382	BNF	0.9033
383	9VZ	0.9033
384	AMQ	0.9029
385	2D2	0.9028
386	BZE	0.9028
387	54F	0.9026
388	PRA	0.9025
389	X11	0.9024
390	7Q1	0.9023
391	S0D	0.9021
392	MJW	0.9021
393	HDH	0.9020
394	3C4	0.9019
395	LT1	0.9017
396	LZ5	0.9017
397	W29	0.9017
398	2K8	0.9017
399	0OY	0.9016
400	7QS	0.9016
401	AHN	0.9015
402	5H6	0.9015
403	S24	0.9014
404	RUY	0.9013
405	MD6	0.9012
406	SOR	0.9012
407	6SD	0.9011
408	FQX	0.9010
409	PLP	0.9009
410	FF2	0.9009
411	1FD	0.9008
412	E1T	0.9008
413	ITE	0.9008
414	C6Z	0.9007
415	94W	0.9003
416	JB8	0.9002
417	6C9	0.9001
418	F2W	0.9001
419	CK1	0.9000
420	DRG	0.9000
421	SYE	0.8999
422	CTE	0.8998
423	MF3	0.8997
424	PYU	0.8997
425	9BF	0.8996
426	344	0.8995
427	JX7	0.8994
428	UN1	0.8994
429	LPK	0.8994
430	JAW	0.8994
431	GAE	0.8993
432	FCD	0.8993
433	0HN	0.8993
434	1F1	0.8991
435	PTU	0.8990
436	DI6	0.8990
437	30G	0.8990
438	9PL	0.8990
439	GXG	0.8989
440	OTR	0.8989
441	PIY	0.8989
442	3VX	0.8988
443	B1J	0.8988
444	FUD	0.8986
445	QBM	0.8985
446	I3E	0.8985
447	K7H	0.8985
448	ENW	0.8984
449	5LD	0.8983
450	PMF	0.8982
451	0JD	0.8981
452	KPV	0.8979
453	E4P	0.8979
454	URO	0.8979
455	27K	0.8976
456	SBK	0.8975
457	ESI	0.8975
458	JDN	0.8974
459	4MB	0.8973
460	KTW	0.8973
461	8OE	0.8973
462	T03	0.8970
463	NK5	0.8970
464	RES	0.8969
465	ZIQ	0.8968
466	DE5	0.8968
467	PLR	0.8967
468	PIR	0.8966
469	BTM	0.8966
470	K4V	0.8965
471	DEZ	0.8965
472	8OB	0.8964
473	DUR	0.8964
474	XYH	0.8962
475	5VU	0.8962
476	YIH	0.8961
477	5O5	0.8961
478	LJ3	0.8961
479	N91	0.8960
480	SOL	0.8960
481	NAL	0.8959
482	PNP	0.8959
483	LDC	0.8959
484	1WC	0.8959
485	GGB	0.8958
486	TZP	0.8957
487	0QW	0.8956
488	LX1	0.8954
489	6P3	0.8954
490	T2D	0.8952
491	3A9	0.8951
492	E7S	0.8951
493	JPQ	0.8950
494	268	0.8949
495	HRM	0.8949
496	YZM	0.8949
497	4FF	0.8948
498	S7G	0.8948
499	A9K	0.8947
500	EVF	0.8944
501	SLY	0.8944
502	6NT	0.8944
503	MTL	0.8943
504	36E	0.8943
505	NYL	0.8942
506	MUK	0.8942
507	ZME	0.8942
508	DCN	0.8940
509	SLS	0.8940
510	AAN	0.8940
511	68A	0.8940
512	4AU	0.8939
513	HHS	0.8939
514	SNO	0.8938
515	4NB	0.8937
516	PQS	0.8937
517	5F5	0.8936
518	R9M	0.8935
519	EUH	0.8934
520	5TT	0.8934
521	K97	0.8933
522	X0W	0.8932
523	28A	0.8932
524	2O8	0.8932
525	B85	0.8932
526	OA1	0.8931
527	N1E	0.8931
528	9FH	0.8931
529	A7H	0.8930
530	TT4	0.8930
531	AKG	0.8930
532	0OL	0.8930
533	LLH	0.8929
534	15N	0.8929
535	88L	0.8928
536	8NB	0.8927
537	SDD	0.8926
538	O45	0.8926
539	WV7	0.8926
540	VC3	0.8924
541	8D6	0.8924
542	12T	0.8924
543	9RW	0.8924
544	5DS	0.8923
545	SQV	0.8923
546	8XL	0.8922
547	LQ2	0.8921
548	0XR	0.8920
549	E9P	0.8920
550	ZYR	0.8920
551	6TZ	0.8920
552	7UZ	0.8919
553	3VR	0.8919
554	4JQ	0.8917
555	RP3	0.8916
556	SX2	0.8915
557	RVE	0.8914
558	S60	0.8914
559	RNO	0.8913
560	RJY	0.8912
561	6HN	0.8911
562	2JJ	0.8911
563	2JX	0.8911
564	6J9	0.8911
565	173	0.8910
566	ZON	0.8909
567	R52	0.8909
568	Q03	0.8908
569	CLU	0.8906
570	FOM	0.8906
571	2ZM	0.8906
572	5TO	0.8905
573	TCR	0.8904
574	7Y3	0.8904
575	HLP	0.8903
576	BVA	0.8903
577	HQJ	0.8903
578	AVA	0.8903
579	14N	0.8902
580	1FE	0.8902
581	BGU	0.8902
582	5GV	0.8902
583	9FG	0.8902
584	SSC	0.8901
585	S8V	0.8901
586	ENG	0.8900
587	5VL	0.8900
588	PQT	0.8899
589	M01	0.8898
590	S0E	0.8897
591	3W1	0.8897
592	X6W	0.8897
593	M3P	0.8897
594	ANF	0.8894
595	EUE	0.8893
596	2P3	0.8892
597	4WL	0.8892
598	PH2	0.8892
599	46P	0.8892
600	SV4	0.8891
601	N4E	0.8891
602	5WN	0.8890
603	TAG	0.8890
604	0HO	0.8890
605	E79	0.8889
606	3QV	0.8889
607	SB7	0.8888
608	ATX	0.8887
609	ZZU	0.8887
610	54E	0.8886
611	GRQ	0.8885
612	A4T	0.8884
613	PLP PMP	0.8884
614	L15	0.8882
615	55D	0.8882
616	H4B	0.8882
617	2J5	0.8880
618	CWJ	0.8880
619	IOP	0.8879
620	PEY	0.8879
621	L13	0.8878
622	6FG	0.8878
623	9ZE	0.8876
624	2BG	0.8876
625	4ZA	0.8876
626	3NF	0.8876
627	M1Z	0.8875
628	KPA	0.8874
629	FCW	0.8874
630	QBP	0.8874
631	RKV	0.8873
632	9NB	0.8873
633	BP3	0.8872
634	AOY	0.8871
635	A4N	0.8871
636	3NY	0.8871
637	MAJ	0.8870
638	AMR	0.8869
639	MQN	0.8869
640	CC5	0.8868
641	7BC	0.8866
642	TGX	0.8865
643	6NI	0.8865
644	NAG	0.8864
645	JF8	0.8864
646	0OO	0.8863
647	S7V	0.8863
648	5FL	0.8863
649	0TU	0.8863
650	S3C	0.8862
651	EGR	0.8862
652	0K7	0.8862
653	5E5	0.8861
654	BCU	0.8860
655	7MW	0.8859
656	A29	0.8859
657	TCL	0.8859
658	3BU	0.8858
659	M4T	0.8858
660	LVP	0.8857
661	0FR	0.8857
662	K82	0.8857
663	3HP	0.8855
664	DER	0.8854
665	HBO	0.8854
666	EOU	0.8854
667	ABF	0.8853
668	KLS	0.8853
669	3SU	0.8852
670	5GT	0.8852
671	VM1	0.8852
672	DC5	0.8852
673	5SP	0.8851
674	HSX	0.8850
675	C0W	0.8850
676	EAT	0.8850
677	THA	0.8849
678	FHV	0.8847
679	AWE	0.8847
680	FB4	0.8847
681	HPS	0.8847
682	L14	0.8846
683	LEL	0.8846
684	0SY	0.8846
685	JMG	0.8845
686	J9Q	0.8845
687	2HU	0.8844
688	5F8	0.8844
689	CUT	0.8842
690	2C2	0.8842
691	PAC	0.8838
692	BY5	0.8837
693	QBS	0.8837
694	URI	0.8835
695	5QY	0.8834
696	5NI	0.8833
697	FER	0.8831
698	AA	0.8831
699	ZSP	0.8831
700	GZQ	0.8831
701	TID	0.8830
702	14W	0.8829
703	L5V	0.8829
704	1ZC	0.8828
705	KJU	0.8827
706	CCU	0.8827
707	27B	0.8827
708	A7K	0.8826
709	3PF	0.8826
710	V1T	0.8826
711	C4E	0.8825
712	CNI	0.8825
713	97T	0.8824
714	GF4	0.8824
715	ZHA	0.8823
716	OGA	0.8823
717	KW8	0.8821
718	1HN	0.8821
719	1XS	0.8820
720	0LO	0.8820
721	NMM	0.8820
722	GLO	0.8820
723	HA5	0.8820
724	IOS	0.8819
725	A3M	0.8818
726	4P5	0.8818
727	LJ4	0.8817
728	8G6	0.8817
729	1EB	0.8816
730	2UZ	0.8816
731	TIA	0.8815
732	ING	0.8814
733	5GU	0.8813
734	4RU	0.8813
735	6RQ	0.8813
736	QY9	0.8813
737	SNV	0.8812
738	MPK	0.8811
739	GXD	0.8809
740	258	0.8809
741	N3W	0.8809
742	6C4	0.8808
743	GJZ	0.8808
744	2FQ	0.8808
745	P9E	0.8806
746	N2I	0.8805
747	GJP	0.8805
748	EWG	0.8805
749	1XA	0.8804
750	ANN	0.8804
751	ABI	0.8804
752	SDF	0.8804
753	PQM	0.8803
754	EXG	0.8803
755	URS	0.8802
756	RSV	0.8802
757	AEF	0.8801
758	SG3	0.8800
759	NFZ	0.8800
760	264	0.8799
761	78U	0.8799
762	MLZ	0.8797
763	MPP	0.8796
764	D48	0.8795
765	YRL	0.8794
766	2FY	0.8794
767	505	0.8790
768	1YO	0.8790
769	KMY	0.8789
770	2WU	0.8789
771	G3E	0.8788
772	1AJ	0.8787
773	8OZ	0.8786
774	YI6	0.8785
775	PHU	0.8785
776	68B	0.8784
777	HSO	0.8784
778	263	0.8783
779	GVA	0.8783
780	PNZ	0.8783
781	PSJ	0.8782
782	4WF	0.8782
783	S46	0.8781
784	CUQ	0.8781
785	4FA	0.8780
786	DBE	0.8780
787	RMN	0.8780
788	KDV	0.8780
789	HH6	0.8780
790	92P	0.8780
791	5B2	0.8779
792	L1T	0.8779
793	1OH	0.8778
794	HMS	0.8776
795	RCV	0.8774
796	P93	0.8774
797	GNM	0.8774
798	RBJ	0.8773
799	ETV	0.8773
800	5AD	0.8773
801	JF5	0.8773
802	8HC	0.8773
803	3AE	0.8773
804	JF2	0.8773
805	N0Z	0.8772
806	GRO	0.8772
807	4Z3	0.8771
808	AMH	0.8771
809	SEP	0.8771
810	A9P	0.8770
811	MS9	0.8770
812	4TP	0.8769
813	0ON	0.8768
814	DHR	0.8768
815	8ZE	0.8768
816	86L	0.8767
817	2HG	0.8767
818	II4	0.8767
819	0XT	0.8767
820	5TZ	0.8767
821	QMP	0.8766
822	CTN	0.8765
823	4G2	0.8765
824	0FK	0.8765
825	ZYQ	0.8765
826	B21	0.8764
827	U13	0.8762
828	HBI	0.8762
829	AJG	0.8761
830	3HG	0.8760
831	FBF	0.8760
832	I4B	0.8758
833	FDR	0.8758
834	J5I	0.8757
835	TSR	0.8755
836	NIZ	0.8755
837	M1T	0.8754
838	7MX	0.8754
839	S7D	0.8754
840	J1K	0.8754
841	R9Y	0.8754
842	3XH	0.8753
843	4NZ	0.8752
844	549	0.8752
845	YE6	0.8751
846	4BZ	0.8751
847	SE2	0.8750
848	NVU	0.8749
849	ZRK	0.8748
850	HJ7	0.8748
851	A6P	0.8747
852	BIO	0.8747
853	4YO	0.8747
854	9RH	0.8747
855	94X	0.8745
856	5RP	0.8745
857	9JH	0.8745
858	LYS	0.8744
859	C2Y	0.8744
860	SSB	0.8743
861	M4E	0.8742
862	APG	0.8741
863	39O	0.8740
864	TEG	0.8740
865	M4N	0.8739
866	GLY GLY GLY	0.8738
867	F18	0.8738
868	SAF	0.8737
869	RP5	0.8736
870	ID2	0.8736
871	AJY	0.8736
872	3PG	0.8736
873	4EU	0.8734
874	ODO	0.8734
875	D9Z	0.8732
876	SKF	0.8730
877	HO6	0.8730
878	54X	0.8730
879	E5X	0.8730
880	B4O	0.8729
881	HHR	0.8729
882	7C3	0.8728
883	L06	0.8728
884	AVX	0.8728
885	THM	0.8728
886	H2B	0.8728
887	TSU	0.8728
888	SMN	0.8728
889	N2Z	0.8727
890	0L1	0.8724
891	S2G	0.8724
892	BZS	0.8723
893	J27	0.8721
894	650	0.8720
895	3J8	0.8719
896	6C8	0.8719
897	LDP	0.8718
898	S98	0.8717
899	N2M	0.8717
900	YX1	0.8717
901	STZ	0.8717
902	SYM	0.8716
903	SQP	0.8716
904	GJK	0.8715
905	EXD	0.8715
906	LR5	0.8713
907	Q02	0.8713
908	FF3	0.8713
909	MQB	0.8712
910	4TU	0.8712
911	H48	0.8712
912	LR2	0.8711
913	YTX	0.8710
914	8NX	0.8708
915	GLU	0.8708
916	CBE	0.8707
917	DGN	0.8707
918	ISZ	0.8707
919	CFI	0.8705
920	0OK	0.8705
921	JP2	0.8703
922	27L	0.8702
923	6L6	0.8701
924	8CC	0.8701
925	AHL	0.8700
926	60L	0.8700
927	A9B	0.8700
928	2UD	0.8699
929	GVQ	0.8699
930	52C	0.8697
931	G6P	0.8695
932	PXP	0.8694
933	LLT	0.8693
934	54Z	0.8692
935	DGL	0.8691
936	2IT	0.8691
937	X1P	0.8691
938	M78	0.8691
939	AC6	0.8691
940	NIY	0.8690
941	AZM	0.8690
942	PMP	0.8689
943	F02	0.8689
944	3D8	0.8689
945	EPE	0.8688
946	UKV	0.8687
947	QLI	0.8686
948	2GQ	0.8686
949	AVI	0.8686
950	VXX	0.8684
951	JVN	0.8682
952	TPA	0.8682
953	3N1	0.8681
954	535	0.8681
955	LFC	0.8680
956	DPT	0.8680
957	CX6	0.8677
958	CSN	0.8672
959	GO8	0.8671
960	DXK	0.8671
961	MR6	0.8669
962	GLN	0.8668
963	K3D	0.8668
964	4CM	0.8667
965	CIY	0.8667
966	96Z	0.8666
967	3Y7	0.8666
968	9JT	0.8664
969	4SX	0.8660
970	AJV	0.8660
971	MN9	0.8660
972	R9S	0.8660
973	ZEA	0.8660
974	X04	0.8659
975	APS	0.8659
976	TLM	0.8659
977	6HP	0.8658
978	AES	0.8658
979	3C5	0.8655
980	TU0	0.8653
981	XEN	0.8653
982	42J	0.8653
983	MUC	0.8652
984	AMS	0.8650
985	ES2	0.8650
986	9FE	0.8650
987	R8Y	0.8648
988	4JC	0.8647
989	1CY	0.8647
990	2J1	0.8646
991	OIA	0.8645
992	2O6	0.8645
993	SAN	0.8644
994	A8K	0.8644
995	J9T	0.8644
996	BB4	0.8644
997	IQ5	0.8643
998	5S9	0.8641
999	ASC	0.8641
1000	LUM	0.8640
1001	8WO	0.8640
1002	0W1	0.8640
1003	DJN	0.8640
1004	SJK	0.8640
1005	A7N	0.8639
1006	69K	0.8637
1007	S7J	0.8637
1008	JQ5	0.8636
1009	DHZ	0.8636
1010	B09	0.8635
1011	ARP	0.8635
1012	GLP	0.8634
1013	5XC	0.8633
1014	PAU	0.8633
1015	XIY	0.8632
1016	AY4	0.8630
1017	GZL	0.8630
1018	A5Q	0.8630
1019	STT	0.8629
1020	NF3	0.8627
1021	JA3	0.8627
1022	7AP	0.8626
1023	VJJ	0.8626
1024	OLU	0.8625
1025	AU8	0.8624
1026	4J8	0.8623
1027	PIQ	0.8623
1028	1M2	0.8622
1029	PBZ	0.8621
1030	GNV	0.8620
1031	NGA	0.8620
1032	27M	0.8620
1033	1Z8	0.8620
1034	DE3	0.8620
1035	47V	0.8618
1036	PHB	0.8618
1037	CHQ	0.8615
1038	ZEZ	0.8611
1039	INO	0.8611
1040	M4S	0.8610
1041	272	0.8610
1042	64Z	0.8610
1043	M2E	0.8609
1044	HJ8	0.8607
1045	A5P	0.8606
1046	7MK	0.8606
1047	BPN	0.8606
1048	F5C	0.8602
1049	BHO	0.8601
1050	HBD	0.8600
1051	0DN	0.8600
1052	N7I	0.8599
1053	0F9	0.8599
1054	ROI	0.8598
1055	JA8	0.8592
1056	152	0.8591
1057	ONR	0.8590
1058	DNQ	0.8589
1059	DX3	0.8589
1060	7ME	0.8589
1061	F9P	0.8589
1062	22L	0.8587
1063	2FT	0.8587
1064	5UD	0.8586
1065	069	0.8584
1066	YZ9	0.8582
1067	2LW	0.8581
1068	TR4	0.8581
1069	KMH	0.8579
1070	SRO	0.8579
1071	9CE	0.8571
1072	ST3	0.8571
1073	R7T	0.8570
1074	2MR	0.8570
1075	DED	0.8570
1076	DNF	0.8569
1077	49F	0.8565
1078	DHB	0.8563
1079	E1K	0.8561
1080	FT2	0.8559
1081	EV2	0.8559
1082	SYV	0.8554
1083	BHS	0.8553
1084	TSS	0.8553
1085	IDZ	0.8550
1086	CLW	0.8550
1087	HNE	0.8541
1088	GJB	0.8539
1089	C5A	0.8534
1090	57O	0.8531
1091	M6Z	0.8530
1092	FBM	0.8524
1093	Q0K	0.8524
1094	BRD	0.8520
1095	3MF	0.8520

Similar Binding Sites (Proteins are less than 50% similar to leader)

Pocket No.: 1; Query (leader) PDB : 3L5R; Ligand: 47X; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.

This union binding pocket(no: 1) in the query (biounit: 3l5r.bio1) has 79 residues
No:	Leader PDB	Ligand	Sequence Similarity

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