Receptor
PDB id Resolution Class Description Source Keywords
1C39 1.85 Å NON-ENZYME: SIGNAL_HORMONE STRUCTURE OF CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR B PENTAMANNOSYL PHOSPHATE BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECT TRANSPORT SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF PHOSPHORYLATED MANNOSE OLIGOSACCHARIDES BY THE CATION-DEPENDENT MA 6-PHOSPHATE RECEPTOR. J.BIOL.CHEM. V. 274 29889 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:199;
B:199;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
NAG NAG A:201;
B:201;
Part of Protein;
Part of Protein;
none;
none;
submit data
408.404 n/a O=C(N...
P3M A:1200;
B:2200;
Valid;
Valid;
none;
none;
submit data
584.417 C18 H33 O19 P C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: P3M; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 P3M 1 1
2 BGC BGC BGC GLC BGC BGC 0.754386 0.767442
3 GLC BGC BGC BGC BGC BGC BGC 0.754386 0.767442
4 MAN GLC 0.666667 0.767442
5 M3M 0.666667 0.767442
6 NGR 0.666667 0.767442
7 LB2 0.666667 0.767442
8 XYT 0.630769 1
9 T6P 0.616667 1
10 GLA GAL GAL 0.552239 0.767442
11 BMA MAN MAN MAN 0.544118 0.767442
12 GAL GAL SO4 0.542857 0.722222
13 BGC BGC BGC BGC BGC BGC BGC BGC 0.542857 0.767442
14 MAN BMA MAN 0.536232 0.767442
15 MAN BMA MAN MAN MAN 0.534247 0.767442
16 M5S 0.534247 0.767442
17 MAN BMA NAG 0.5 0.6
18 GLA GAL NAG 0.5 0.6
19 MAN MAN MAN GLC 0.493151 0.767442
20 MDM 0.492308 0.733333
21 GAL MBG 0.492308 0.733333
22 M13 0.492308 0.733333
23 MAN MAN BMA MAN 0.48 0.767442
24 MAN MAN MAN MAN 0.48 0.767442
25 CGC 0.471429 0.727273
26 BG6 0.466667 0.906977
27 A6P 0.466667 0.906977
28 G6P 0.466667 0.906977
29 M6D 0.466667 0.906977
30 BGP 0.466667 0.906977
31 M6P 0.466667 0.906977
32 NAG GAL 0.465753 0.6
33 GAL NAG 0.465753 0.6
34 BGC GAL NAG GAL 0.457831 0.6
35 GAL NAG GAL GLC 0.457831 0.6
36 BMA MAN MAN MAN MAN 0.455696 0.767442
37 GAL NGA GLA BGC GAL 0.453488 0.6
38 LAT NAG GAL 0.447059 0.6
39 GLC GAL NAG GAL 0.447059 0.6
40 2M4 0.446154 0.767442
41 G16 0.446154 0.866667
42 RI2 0.444444 0.782609
43 NGA GLA GAL BGC 0.44186 0.6
44 RP5 0.440678 0.822222
45 ABF 0.440678 0.822222
46 HSX 0.440678 0.822222
47 MAN MAN MAN BMA MAN 0.439024 0.767442
48 BQZ 0.435484 0.697674
49 AAL GAL AAL GLA 0.435294 0.702128
50 GAL AAL GAL AAL GAL AAL 0.435294 0.702128
51 AAL GAL AAL GAL 0.435294 0.702128
52 GAL FUC 0.434783 0.727273
53 NAG GAL BGC 0.433735 0.6
54 MAN MAN MAN MAN MAN MAN MAN 0.430233 0.767442
55 PRP 0.426471 0.804348
56 MAN MMA MAN 0.421053 0.733333
57 NAG BMA MAN MAN MAN MAN 0.419355 0.6
58 A2G GAL 0.418919 0.6
59 GAL A2G 0.418919 0.6
60 GAL NGA 0.418919 0.6
61 GLA GAL 0.41791 0.767442
62 B2G 0.41791 0.767442
63 N9S 0.41791 0.767442
64 GLC GAL 0.41791 0.767442
65 BGC GAL 0.41791 0.767442
66 GLA GLA 0.41791 0.767442
67 MAL 0.41791 0.767442
68 LBT 0.41791 0.767442
69 BGC BMA 0.41791 0.767442
70 MAB 0.41791 0.767442
71 BMA GAL 0.41791 0.767442
72 CBK 0.41791 0.767442
73 GAL BGC 0.41791 0.767442
74 LAT 0.41791 0.767442
75 CBI 0.41791 0.767442
76 NAG MAN BMA 0.414634 0.6
77 MT7 0.414286 0.767442
78 BMA BMA BMA BMA BMA 0.414286 0.767442
79 BGC BGC BGC BGC BGC 0.414286 0.767442
80 BGC GLC GLC 0.414286 0.767442
81 BMA MAN BMA 0.414286 0.767442
82 MAN BMA BMA BMA BMA 0.414286 0.767442
83 GLA GAL BGC 0.414286 0.767442
84 MAN MAN BMA BMA BMA BMA 0.414286 0.767442
85 GLC BGC BGC BGC BGC 0.414286 0.767442
86 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.414286 0.767442
87 CE6 0.414286 0.767442
88 MLR 0.414286 0.767442
89 MAN BMA BMA 0.414286 0.767442
90 DXI 0.414286 0.767442
91 GLC GLC BGC 0.414286 0.767442
92 CTT 0.414286 0.767442
93 BMA BMA BMA BMA BMA BMA 0.414286 0.767442
94 BGC BGC GLC 0.414286 0.767442
95 BGC BGC BGC 0.414286 0.767442
96 BGC BGC BGC GLC 0.414286 0.767442
97 GLC BGC BGC BGC 0.414286 0.767442
98 GLC BGC BGC BGC BGC BGC 0.414286 0.767442
99 GLC GAL GAL 0.414286 0.767442
100 CEX 0.414286 0.767442
101 GLC GLC GLC GLC GLC 0.414286 0.767442
102 CE5 0.414286 0.767442
103 BGC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
104 BMA BMA BMA 0.414286 0.767442
105 CTR 0.414286 0.767442
106 GLC BGC BGC 0.414286 0.767442
107 B4G 0.414286 0.767442
108 CEY 0.414286 0.767442
109 GLC BGC GLC 0.414286 0.767442
110 BGC BGC BGC BGC 0.414286 0.767442
111 GAL GAL GAL 0.414286 0.767442
112 BGC GLC GLC GLC GLC 0.414286 0.767442
113 CE8 0.414286 0.767442
114 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
115 MTT 0.414286 0.767442
116 MAN BMA BMA BMA BMA BMA 0.414286 0.767442
117 BGC BGC BGC BGC BGC BGC 0.414286 0.767442
118 GLA GAL GLC 0.414286 0.767442
119 BGC GLC GLC GLC 0.414286 0.767442
120 CT3 0.414286 0.767442
121 PPC 0.405797 0.791667
122 AAL GAL 0.405405 0.702128
123 47N 0.405405 0.702128
124 MAN MAN MAN MAN MAN MAN MAN MAN 0.404255 0.708333
125 FUC BGC GAL 0.402597 0.75
126 BMA BMA 0.4 0.711111
127 GLC GLC GLC BGC 0.4 0.767442
128 BGC BGC 0.4 0.711111
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
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