Receptor
PDB id Resolution Class Description Source Keywords
1APZ 2.3 Å EC: 3.5.1.26 HUMAN ASPARTYLGLUCOSAMINIDASE COMPLEX WITH REACTION PRODUCT HOMO SAPIENS ASPARTYLGLUCOSAMINIDASE GLYCOSYLASPARAGINASE COMPLEX (HYDRPEPTIDE) COMPLEX (HYDROLASE-PEPTIDE) COMPLEX
Ref.: THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMAL ASPARTYLGLUCOSAMINIDASE. NAT.STRUCT.BIOL. V. 2 1102 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ASP B:551;
D:552;
Valid;
Valid;
none;
none;
submit data
133.103 C4 H7 N O4 C([C@...
NAG A:501;
B:511;
C:521;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
NAG NAG BMA D:531;
Part of Protein;
none;
submit data
570.545 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1APZ 2.3 Å EC: 3.5.1.26 HUMAN ASPARTYLGLUCOSAMINIDASE COMPLEX WITH REACTION PRODUCT HOMO SAPIENS ASPARTYLGLUCOSAMINIDASE GLYCOSYLASPARAGINASE COMPLEX (HYDRPEPTIDE) COMPLEX (HYDROLASE-PEPTIDE) COMPLEX
Ref.: THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMAL ASPARTYLGLUCOSAMINIDASE. NAT.STRUCT.BIOL. V. 2 1102 1995
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
2 2GL9 - ASN NAG n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ASP; Similar ligands found: 32
No: Ligand ECFP6 Tc MDL keys Tc
1 DAS 1 1
2 ASP 1 1
3 ASN 0.636364 0.793103
4 DSN 0.545455 0.714286
5 ABA 0.545455 0.692308
6 2RA 0.545455 0.689655
7 SER 0.545455 0.714286
8 DBB 0.545455 0.692308
9 CYS 0.521739 0.703704
10 C2N 0.521739 0.666667
11 DCY 0.521739 0.703704
12 SD4 0.5 0.648649
13 GGL 0.481481 0.846154
14 DGL 0.481481 0.846154
15 GLU 0.481481 0.846154
16 DAB 0.48 0.612903
17 HSE 0.48 0.758621
18 NVA 0.461538 0.62069
19 HCS 0.461538 0.655172
20 CSO 0.461538 0.6875
21 AS2 0.461538 0.916667
22 LEU 0.461538 0.642857
23 API 0.461538 0.75
24 CSD 0.444444 0.615385
25 CSS 0.444444 0.633333
26 11C 0.433333 0.814815
27 UN1 0.433333 0.814815
28 GLN 0.428571 0.7
29 DGN 0.428571 0.7
30 NPI 0.40625 0.785714
31 NCD 0.4 0.705882
32 ONL 0.4 0.7
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1APZ; Ligand: ASP; Similar sites found with APoc: 3
This union binding pocket(no: 1) in the query (biounit: 1apz.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 4O48 ASP 41.844
2 4PVR ASP 42.5532
3 4PU6 ASP 46.8085
Pocket No.: 2; Query (leader) PDB : 1APZ; Ligand: ASP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1apz.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
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