-->
Receptor
PDB id Resolution Class Description Source Keywords
1APZ 2.3 Å EC: 3.5.1.26 HUMAN ASPARTYLGLUCOSAMINIDASE COMPLEX WITH REACTION PRODUCT HOMO SAPIENS ASPARTYLGLUCOSAMINIDASE GLYCOSYLASPARAGINASE COMPLEX (HYDRPEPTIDE) COMPLEX (HYDROLASE-PEPTIDE) COMPLEX
Ref.: THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMAL ASPARTYLGLUCOSAMINIDASE. NAT.STRUCT.BIOL. V. 2 1102 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ASP B:551;
D:552;
Valid;
Valid;
none;
none;
submit data
133.103 C4 H7 N O4 C([C@...
NAG A:501;
B:511;
C:521;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
NAG NAG BMA D:531;
Part of Protein;
none;
submit data
570.545 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1APZ 2.3 Å EC: 3.5.1.26 HUMAN ASPARTYLGLUCOSAMINIDASE COMPLEX WITH REACTION PRODUCT HOMO SAPIENS ASPARTYLGLUCOSAMINIDASE GLYCOSYLASPARAGINASE COMPLEX (HYDRPEPTIDE) COMPLEX (HYDROLASE-PEPTIDE) COMPLEX
Ref.: THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMAL ASPARTYLGLUCOSAMINIDASE. NAT.STRUCT.BIOL. V. 2 1102 1995
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1APZ - ASP C4 H7 N O4 C([C@@H](C....
2 2GL9 - ASN NAG n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ASP; Similar ligands found: 32
No: Ligand ECFP6 Tc MDL keys Tc
1 DAS 1 1
2 ASP 1 1
3 ASN 0.636364 0.793103
4 DSN 0.545455 0.714286
5 ABA 0.545455 0.692308
6 2RA 0.545455 0.689655
7 SER 0.545455 0.714286
8 DBB 0.545455 0.692308
9 CYS 0.521739 0.703704
10 C2N 0.521739 0.666667
11 DCY 0.521739 0.703704
12 SD4 0.5 0.648649
13 GGL 0.481481 0.846154
14 DGL 0.481481 0.846154
15 GLU 0.481481 0.846154
16 DAB 0.48 0.612903
17 HSE 0.48 0.758621
18 NVA 0.461538 0.62069
19 HCS 0.461538 0.655172
20 CSO 0.461538 0.6875
21 AS2 0.461538 0.916667
22 LEU 0.461538 0.642857
23 API 0.461538 0.75
24 CSD 0.444444 0.615385
25 CSS 0.444444 0.633333
26 11C 0.433333 0.814815
27 UN1 0.433333 0.814815
28 GLN 0.428571 0.7
29 DGN 0.428571 0.7
30 NPI 0.40625 0.785714
31 NCD 0.4 0.705882
32 ONL 0.4 0.7
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1APZ; Ligand: ASP; Similar sites found with APoc: 351
This union binding pocket(no: 1) in the query (biounit: 1apz.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 6BSX E7S None
2 6BSX GDP None
3 1WF3 GNP 1.23457
4 6FA4 GNP 2.46914
5 1RL4 BRR 2.46914
6 5WDR GNP 2.83688
7 1KAO GDP 2.83688
8 4PIO AVI 3.08642
9 4PIO SAH 3.08642
10 6F3M NAD 3.08642
11 2YVK MRU 3.08642
12 5UQW GDP 3.1746
13 2EW1 GNP 3.48259
14 4LX0 BEF GDP 3.5461
15 2HV8 GTP 3.5461
16 2BD0 NAP 3.5461
17 5WLB GNP 3.61446
18 5IRR GSP 3.7037
19 3CIF G3H 3.7037
20 3CIF NAD 3.7037
21 1IY8 NAD 3.7037
22 1IBR GNP 4.25532
23 4C3Y FAD 4.25532
24 4C3Y ANB 4.25532
25 6AU6 GDP 4.25532
26 1RPN NDP 4.25532
27 6DEF GCP 4.25532
28 3ZZL TRP 4.28571
29 4FN4 NAD 4.32099
30 3RG9 WRA 4.32099
31 3RG9 NDP 4.32099
32 1VHN FMN 4.32099
33 1S8F GDP 4.32099
34 1GJW GLC 4.32099
35 3H9E NAD 4.32099
36 3H2K BOG 4.32099
37 1QS8 IVA VAL VAL STA ALA STA 4.32099
38 2W2X GSP 4.83871
39 4GOJ GNP 4.93827
40 2J59 GTP 4.93827
41 4LHW GNP 4.93827
42 1V8K ANP 4.93827
43 1LVK MNT BEF 4.93827
44 3DC4 ADP 4.93827
45 2WKQ GTP 4.96454
46 1TU3 GNP 4.96454
47 1MH1 GNP 4.96454
48 1R2Q GNP 4.96454
49 3BMN NAP 4.96454
50 5K6A NAP 4.96454
51 2VZ0 D64 4.96454
52 2VZ0 NAP 4.96454
53 3JQF NAP 4.96454
54 4CM9 NAP 4.96454
55 3JQB NAP 4.96454
56 3JQ8 NAP 4.96454
57 4CMI NAP 4.96454
58 4CLR NAP 4.96454
59 3BMQ NAP 4.96454
60 4CM4 NAP 4.96454
61 3JQ7 NAP 4.96454
62 4CM8 NAP 4.96454
63 4CME NAP 4.96454
64 4CLO NAP 4.96454
65 3JQ9 NAP 4.96454
66 4KVG GTP 5.35714
67 4CO3 ATP 5.35714
68 3QBT GNP 5.55556
69 1YZN GNP 5.55556
70 5O2T GSP 5.55556
71 5BRT FAD 5.55556
72 5WS9 AMP 5.55556
73 3RWO GDP 5.55556
74 3MKH FAD 5.55556
75 3B1J NAD 5.55556
76 3OVR 5SP 5.55556
77 5Y9D FAD 5.55556
78 3WBZ ATP 5.55556
79 5XC5 GTP 5.67376
80 1KMQ GNP 5.67376
81 6BCA GSP 5.67376
82 4XOI GTP 5.67376
83 1CXZ GSP 5.67376
84 6BCB GSP 5.67376
85 5OCG GNP 5.67376
86 2GCO GNP 5.67376
87 5K5Z ANP 5.67376
88 1X1R GDP 5.67376
89 4IDN GNP 5.67376
90 4JIQ 1L5 5.67376
91 4JIQ FMN 5.67376
92 6FP4 FAD 5.67376
93 4NAT ADP 5.67376
94 4NAT 2W5 5.67376
95 3KJS NAP 5.67376
96 4Z0H NAD 5.67376
97 5HWK BEZ 5.67376
98 1POC GEL 5.97015
99 2C5L GTP 6.17284
100 3X1Z GNP 6.17284
101 1TB3 FMN 6.17284
102 1N07 ADP 6.17284
103 4UTU LRY 6.17284
104 1RM4 NDP 6.17284
105 3RYC GTP 6.17284
106 1GWN GTP 6.38298
107 1M7B GTP 6.38298
108 1TX4 ALF GDP 6.38298
109 2XTZ GSP 6.38298
110 4RD0 GDP 6.38298
111 3ZLQ 6T9 6.38298
112 1NFU RRP 6.38298
113 3F4F UMP 6.38298
114 4D0G GTP 6.38298
115 3ZKI WZV 6.38298
116 1OSS BEN 6.38298
117 1Z0J GTP 6.79012
118 2FXU ATP 6.79012
119 2I7C AAT 6.79012
120 2PT9 2MH 6.79012
121 1PN0 FAD 6.79012
122 1PN0 IPH 6.79012
123 3CQD ATP 6.79012
124 2B8W ALF 5GP 6.79012
125 3DJL FAD 6.79012
126 3OID NDP 6.79012
127 2PT9 S4M 6.79012
128 4X9X OLA 7.02341
129 2FH5 GTP 7.0922
130 4ZG4 VO4 ADP 7.0922
131 3VPD CIT 7.0922
132 2FJU GSP 7.0922
133 1CT9 GLN 7.0922
134 1N62 FAD 7.0922
135 3QKT ANP 7.0922
136 2QZX IVA VAL VAL STA ALA STA 7.0922
137 4CQM NAP 7.0922
138 2X6T NAP 7.0922
139 3ZOD FMN 7.0922
140 3ZOD HQE 7.0922
141 2QTR NXX 7.0922
142 5N0J FAD 7.40741
143 5NQR 958 7.40741
144 4NCN GTP 7.40741
145 4TMZ GSP 7.40741
146 3V1Y NAD 7.40741
147 1VLJ NAP 7.80142
148 4USI ATP 7.80142
149 3TA2 AKG 7.80142
150 5YEC ATP 7.80142
151 3ENV ABF 7.80142
152 5WKC AUJ 8.02469
153 4B1W ATP 8.02469
154 5WKC TP9 8.02469
155 1OZH HE3 8.02469
156 4A59 AMP 8.02469
157 3OIX FMN 8.02469
158 1CER NAD 8.02469
159 1T9D P22 8.02469
160 5UWS GNP 8.39161
161 5UWJ GNP 8.39161
162 5DI9 GNP 8.39161
163 5UWP GNP 8.39161
164 5DHF GNP 8.39161
165 6DIO NAD 8.51064
166 4RJK TPP 8.51064
167 1XF1 CIT 8.51064
168 2IHU TP9 8.51064
169 5L3S GNP 8.51064
170 3IID APR 8.53081
171 4HAT GNP 8.57143
172 3VMF GTP 8.64198
173 1V5F FAD 8.64198
174 1V5F TPP 8.64198
175 2Z49 AMG 8.64198
176 2Z48 A2G 8.64198
177 1BZL FAD 8.64198
178 4XV1 904 8.64198
179 2ICY UPG 8.64198
180 2NXW TPP 8.64198
181 3MJY FMN 8.64198
182 3MJY IJZ 8.64198
183 4WZH FMN 8.64198
184 3E5H GNP 9.21986
185 1WDT GTP 9.21986
186 1RYH GNP 9.21986
187 6GAS FAD 9.21986
188 2BVN GNP 9.21986
189 1G6O ADP 9.21986
190 1OVD ORO 9.21986
191 4USQ FAD 9.21986
192 1OVD FMN 9.21986
193 5ZBR ANP 9.21986
194 3C3N FMN 9.21986
195 3RAB GNP 9.25926
196 1NF3 GNP 9.25926
197 2ZRU FMN 9.25926
198 3EWP APR 9.25926
199 2X7J TPP 9.87654
200 2WMO GTP 9.87654
201 5UPK GNP 9.87654
202 3B96 MYA 9.87654
203 1FFU FAD 9.87654
204 1KBJ FMN 9.87654
205 3WYF GTP 9.92908
206 3M1I GTP 9.92908
207 4U5X GNP 9.92908
208 2UZI GTP 9.92908
209 6BVJ GNP 9.92908
210 6D5M GNP 9.92908
211 6BVK GNP 9.92908
212 1LFD GNP 9.92908
213 6D5H GNP 9.92908
214 6BVM GNP 9.92908
215 6BVL GNP 9.92908
216 6BVI GNP 9.92908
217 6D5J GNP 9.92908
218 6D5V GNP 9.92908
219 6D5G GNP 9.92908
220 6D56 GNP 9.92908
221 6D59 GNP 9.92908
222 3DDC GNP 9.92908
223 1NVV GNP 9.92908
224 4K81 GTP 9.92908
225 3AXK NDP 9.92908
226 5I60 67W 9.92908
227 6AMI TRP 9.92908
228 1CLU DBG 9.92908
229 3VKC FPQ 9.92908
230 6CUZ FEV 9.92908
231 2WQQ CSF 9.92908
232 3SBD GNP 10.4938
233 4YRY FAD 10.4938
234 2BNE U5P 10.4938
235 6CI9 NAP 10.4938
236 4I4B NAD 10.6383
237 4YC7 GNP 10.6383
238 3WXM GTP 10.6383
239 5GSN NAP 10.6383
240 5GSN FAD 10.6383
241 3EEL 53T 10.6383
242 5V49 8WA 10.6383
243 2VB6 ADP BEF 10.6383
244 5G5G MCN 11.1111
245 1GUA GNP 11.1111
246 1WKR IVA VAL VAL STA ALA STA 11.1111
247 1KSH GDP 11.3475
248 3AB1 FAD 11.3475
249 5LY3 ADP 11.3475
250 1X7D NAD 11.3475
251 1ZC3 GNP 11.5044
252 3NKV GNP 11.7284
253 1UPT GTP 11.7284
254 5SZH GNP 11.7284
255 5EE5 GTP 11.7284
256 1DL5 SAH 11.7284
257 1JQI FAD 11.7284
258 5EF7 5OJ 11.7284
259 2J9C ATP 11.7647
260 3VET TOY 12.0567
261 2XBP ATP 12.0567
262 2C42 TPP 12.0567
263 2C42 PYR 12.0567
264 3IAE D7K 12.0567
265 2UZ1 TPP 12.0567
266 3ZFD ANP 12.3457
267 1R4A GNP 12.3457
268 5C2N NAG 12.5
269 2Y8E GNP 12.766
270 2GJ8 ALF GDP 12.766
271 5UR0 NAD 12.766
272 2JLD AG1 12.766
273 3LU1 NAD 12.766
274 1I0S FMN 12.963
275 1I0S NAP 12.963
276 4R74 F6P 12.963
277 2BME GNP 13.4409
278 4RSL FAD 13.4752
279 2ZXI FAD 13.4752
280 5JM8 ATP 13.4752
281 1WA5 GTP 13.5802
282 3PCR GTP 13.5802
283 5Z2M GTP 13.5802
284 1VG8 GNP 13.5802
285 5NUE NAD 13.5802
286 5NUF NAD 13.5802
287 3WYG GTP 13.7363
288 1UAD GNP 14.1414
289 3TKL GTP 14.1844
290 2F5Z FAD 14.1844
291 3EMY IVA VAL VAL STA ALA STA 14.1844
292 1FEC FAD 14.1975
293 1QO8 FAD 14.1975
294 3RUV ANP 14.1975
295 1Z0K GTP 14.5349
296 1OIX GDP 14.8148
297 4M52 FAD 14.8148
298 1OIV GDP 14.8148
299 3GJX GTP 14.8936
300 2E5V FAD 14.8936
301 4CBU ATP 14.9606
302 5B47 PYR 15.4321
303 5B47 TPP 15.4321
304 5B48 TDN 15.4321
305 2B4R NAD 15.4321
306 2NVK FAD 15.6028
307 3HRD MCN 15.6028
308 3HRD FAD 15.6028
309 3MN6 ATP 16.0494
310 3MN7 ATP 16.0494
311 5XFV FMN 16.0494
312 4ZI2 GNP 16.5414
313 2C78 GNP 16.6667
314 2VVL FAD 16.6667
315 3BC1 GNP 17.0213
316 1YZQ GNP 17.0213
317 1XKQ NDP 17.0213
318 1OJ7 NZQ 17.0213
319 1F5N GNP 17.284
320 6H3O FAD 17.284
321 4HDO GNP 17.7305
322 4HDQ GNP 17.7305
323 1G0N PHH 17.7305
324 1G0N NDP 17.7305
325 2HJR APR 17.9012
326 5L3R GCP 18.4397
327 2YGM GLA NAG GAL FUC 18.4397
328 1Z08 GNP 18.5185
329 5DI3 GNP 18.5185
330 1LYB IVA VAL VAL STA ALA STA 18.5185
331 2ZWA SAH 18.5185
332 4YDU ADP 18.5185
333 5EXE 5SR 19.8582
334 1RJ9 GCP 20.9877
335 5LEF GTP 21.2121
336 1PFK ADP 21.2766
337 5JCA FAD 21.6049
338 6DVH FMN 22.2222
339 3F8D FAD 22.695
340 3KFL ME8 22.8395
341 1R6B ADP 23.4043
342 4KQI NIO 25.9259
343 2FFQ GSP 26.2411
344 3MJH GTP 26.4706
345 2Q28 TPP 27.6596
346 3NZW BOC TY5 ALA RE0 ABN 35.8025
347 4G4S LDZ 35.8025
348 6H39 FGY 35.8025
349 4O48 ASP 41.844
350 4PVR ASP 42.5532
351 4PU6 ASP 46.8085
Pocket No.: 2; Query (leader) PDB : 1APZ; Ligand: ASP; Similar sites found with APoc: 89
This union binding pocket(no: 2) in the query (biounit: 1apz.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 2D7C GTP 2.46914
2 4C4P GNP 2.46914
3 4MDH NAD 3.08642
4 4ZFL 4NK 3.5461
5 1AL8 FMN 3.5461
6 4BAS GNP 3.7037
7 1NRJ GTP 4.25532
8 1ZUI SKM 4.25532
9 1J2J GTP 4.32099
10 6ER9 NAP 4.93827
11 6ER9 FAD 4.93827
12 3REF GDP 4.93827
13 6BE3 NAG 4.96454
14 1MJH ATP 4.96454
15 3B20 NAD 5.55556
16 5NMX NAP 5.67376
17 5NMX FAD 5.67376
18 4XSH GSP 5.67376
19 5Q0F 9FA 5.67376
20 1EK0 GNP 6.17284
21 1BH2 GSP 6.38298
22 1HSK FAD 6.38298
23 1VBO MAN MAN MAN 6.71141
24 1VBO MAN 6.71141
25 4Q0A 4OA 7.0922
26 2GV8 FAD 7.0922
27 2GVC FAD 7.0922
28 1EQ2 NAP 7.0922
29 6GKV SAH 7.0922
30 5J7X FAD 7.40741
31 1GZ4 ATP 7.40741
32 6CEP NAD 7.40741
33 6CEP OXM 7.40741
34 2ODE ALF GDP 7.80142
35 5UWO GNP 8.39161
36 5UWU GNP 8.39161
37 5UWW GNP 8.39161
38 5UWT GNP 8.39161
39 6CIT GNP 8.39161
40 5UWI GNP 8.39161
41 5DIF GNP 8.39161
42 2IHT TPP 8.51064
43 1UPA TPP 8.51064
44 4RJK TDL 8.51064
45 5DHU 5A8 8.51064
46 2Z48 NGA 8.64198
47 5TWB FAD 8.64198
48 4X1Z FUC GAL NDG 9.21986
49 5YB7 ORN 9.21986
50 4GLW NMN 9.87654
51 4L9Z COA 9.87654
52 1KBI FMN 9.87654
53 2QTV GNP 9.92908
54 6D5L GNP 9.92908
55 6D55 GNP 9.92908
56 6D5E GNP 9.92908
57 1M2O GNP 9.92908
58 5L2Z 70C 10.3448
59 6BC0 GSP 11.3333
60 4ZKD GDP 11.7284
61 3QVP FAD 12.0567
62 4M9Q GNP 12.3457
63 4KAX GTP 12.963
64 2W83 GTP 12.963
65 2XVF FAD 13.4752
66 1GJC 130 13.4752
67 4JB0 ENO 13.4752
68 4JB0 FER 13.4752
69 5I0H ADP BEF 14.1844
70 5Y6Q MCN 14.8148
71 3GD4 NAD 16.0494
72 2C77 GNP 16.6667
73 2A5F GTP 17.0213
74 2Q4W FAD 17.0213
75 3CX8 GSP 17.0213
76 6GAR FAD 18.4397
77 1TAD ALF 18.4397
78 1TAD GDP 18.4397
79 4XVU ATP 18.4397
80 3HB5 NAP 19.1358
81 3H4V NAP 19.1489
82 3IHG FAD 20.3704
83 1VPE ANP 21.2766
84 5EFQ ADP 21.9858
85 3ZQ6 ADP ALF 22.2222
86 3ZS9 ADP ALF 23.6842
87 5UWR GNP 37.037
88 5UWQ GNP 45.4545
89 5UWH GNP 45.4545
APoc FAQ
Feedback