STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-
PDB id Source Resolution
2JDR HOMO SAPIENS 2.3 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
L20 Valid ic50 =  0.5 nM   launch gocavviewer-lite   397.472
C24 H23 N5 O
 Cc1c2cc(ccc2[nH]n1)c3cc(cnc3)OC[C@H](Cc4c[nH]c5c4cccc5)N
GLY ARG PRO ARG THR THR SER PHE ALA GLU Valid submit data   launch gocavviewer-lite   1284.63 n/a O=C([O-])C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1N(C(=O)C(NC(=O)CN)CCC[N+]=C(N)N)CCC1)CCC[N+]=C(N)N)C(O)C)C(O)C)CO)Cc1ccccc1)C)CCC(=O)[O-]

A STRUCTURAL COMPARISON OF INHIBITOR BINDING TO PKB, PKA AND PKA-PKB CHIMERA. J.MOL.BIOL. V. 367 882 2007

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90% Homology Family

The Class containing this family consists of a total of 27 families.
Leader:    2JDR
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-
PDB id Binding data Representative ligand
2JDR ic50 = 0.5 nM L20
1O6K   GLY-ARG-PRO-ARG-THR-THR-SER-PHE-ALA-GLU
1O6L   GLY-ARG-PRO-ARG-THR-THR-SER-PHE-ALA-GLU
2JDO ic50 = 0.23 uM I5S
2UW9   GVP
3D0E ic50 = 13.0 nM G93