CRYSTAL STRUCTURE OF TGF-BETA RECEPTOR I KINASE WITH INHIBITOR
PDB id Source Resolution
1PY5 HOMO SAPIENS 2.3 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
PY1 Valid ic50 =  51.0 nM   launch gocavviewer-lite   272.304
C17 H12 N4
 c1ccc2c(c1)c(ccn2)c3c[nH]nc3c4ccccn4
SO4 Invalid            

SYNTHESIS AND ACTIVITY OF NEW ARYL- AND HETEROARYL-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE DOMAIN. BIOORG.MED.CHEM.LETT. V. 14 3581 2004

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90% Homology Family

The Class containing this family consists of a total of 3 families.
Leader:    1VJY
CRYSTAL STRUCTURE OF A NAPHTHYRIDINE INHIBITOR
OF HUMAN TGF- BETA TYPE I RECEPTOR
PDB id Binding data Representative ligand
1VJY Ki = 0.023 uM 460
1PY5 ic50 = 51.0 nM PY1
1RW8 ic50 = 0.175 uM 580
2WOT ic50 = 44.0 nM ZZG
2WOU ic50 = 72.0 nM ZZF
3GXL ic50 = 0.025 uM QIG
3HMM ic50 = 0.025 uM 855