STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5- SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL) A MIDE
PDB id Source Resolution
2JDO 1.8 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
I5S Valid ic50 =  0.23 uM   launch gocavviewer-lite   419.925
C20 H22 Cl N3 O3 S
 c1cc2cnccc2c(c1)S(=O)(=O)NCCNCCOCc3ccc(cc3)Cl
EDO Invalid            
GLY ARG PRO ARG THR THR SER PHE ALA GLU Valid submit data   launch gocavviewer-lite n/a  n/a n/a n/a

A STRUCTURAL COMPARISON OF INHIBITOR BINDING TO PKB, PKA AND PKA-PKB CHIMERA J.MOL.BIOL. V. 367 882 2007

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90% Homology Family

The Class containing this family consists of a total of 56 families.
Leader:    2JDR
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE
INHIBITOR A- 443654
PDB id Binding data Representative ligand
2JDR ic50 = 0.5 nM L20
1O6K   GLY-ARG-PRO-ARG-THR-THR-SER-PHE-ALA-GLU
1O6L   GLY-ARG-PRO-ARG-THR-THR-SER-PHE-ALA-GLU
2JDO ic50 = 0.23 uM I5S
2UW9   GVP
2X39 ic50 = 30.0 nM X39
3D0E ic50 = 13.0 nM G93
3E87   G95
3E88 Ki = 2.0 nM G96